Anthony V Incognito

Anthony V Incognito
The University of Calgary | HBI · Department of Physiology and Pharmacology

Doctor of Philosophy

About

48
Publications
6,668
Reads
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488
Citations
Introduction
Integrative physiologist studying the autonomic nervous system in health and disease
Additional affiliations
January 2015 - present
University of Guelph/ University of Guelph-Humber
Position
  • Research Assistant
Description
  • Biological Concepts of Health (BIOL*1080) Exercise Physiology (KIN*3010) Applied Human Kinetics II (HK*4600) Human Anatomy II (KIN*1040) Biochemistry and Metabolism I (KIN*1070)
September 2014 - present
University of Guelph
Position
  • PhD Student
June 2014 - August 2014
University of Toronto
Position
  • Research Assistant
Education
September 2016 - August 2020
University of Guelph
Field of study
  • Human Health and Nutritional Sciences
September 2014 - August 2016
University of Guelph
Field of study
  • Human Health and Nutritional Sciences
September 2010 - August 2014
University of Toronto
Field of study
  • Kinesiology and Physical Education

Publications

Publications (48)
Article
Cerebral hypoxia is a serious consequence of several cardiorespiratory illnesses. Measuring the retinal microvasculature at high altitude provides a surrogate for cerebral microvasculature, offering potential insight into cerebral hypoxia in critical illness. Additionally, while sex-specific differences in cardiovascular diseases are strongly suppo...
Article
Key points: Acute isocapnic hypoxia resets the arterial baroreflex and permits long-lasting sympathoexcitation called sympathetic long-term facilitation. Our understanding of sympathetic long-term facilitation following hypoxia in humans is based on multiunit muscle sympathetic nerve activity and does not fully characterize the underlying barorefl...
Article
Introduction: Baroreflex resetting permits sympathetic long-term facilitation (sLTF) following hypoxia. Muscle sympathetic nerve activity (MSNA) bursts are generated by synchronous discharge of varying-amplitude action potentials (APs), with medium APs under strong baroreflex control. AP discharge strategies and baroreflex control of AP clusters f...
Article
Full-text available
The autonomic nervous system maintains homeostasis of cardiovascular, respiratory, gastrointestinal, urinary, immune, and thermoregulatory function. Homeostasis involves a variety of feedback mechanisms involving peripheral afferents, many of which contain molecular receptors sensitive to mechanical deformation, termed mechanosensors. Here we focus...
Article
Signal-averaged sympathetic transduction of blood pressure (BP) is inversely related to resting MSNA burst frequency in healthy cohorts. Whether this represents a physiological compensatory adaptation or a methodological limitation, remains unclear. The current analysis aimed to determine the contribution of methodological limitations by evaluating...
Article
Calculating the blood pressure (BP) response to a burst of muscle sympathetic nerve activity (MSNA), termed sympathetic transduction, may be influenced by an individual's resting burst frequency. We examined the relationships between sympathetic transduction and MSNA in 107 healthy males and females and developed a normalized sympathetic transducti...
Article
Coronavirus-19 (COVID-19), the infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has wreaked havoc across the globe since its emergence in December 2019. Reports of patients presenting with syncope and pre-syncope, as well as hypoxemia without symptoms of dyspnea (“silent hypoxemia”), have led rese...
Article
A small proportion of postganglionic muscle sympathetic single units can be inhibited during sympathoexcitatory stressors in humans. However, whether these responses are dependent on the specific stressor or the level of sympathoexcitation remains unclear. We hypothesize that, when matched by sympathoexcitatory magnitude, different stressors can ev...
Article
Purpose: In normotensive patients with OSA, the muscle sympathetic nerve activity (MSNA) response to exercise is increased while metaboreflex control of MSNA is decreased. We tested the hypotheses that acute intermittent hypercapnic hypoxia (IHH) in males free from OSA and associated comorbidities would augment the MSNA response to exercise but at...
Article
Full-text available
Spinal cord injury (SCI) induces haemodynamic instability that threatens survival1,2,3, impairs neurological recovery4,5, increases the risk of cardiovascular disease6,7, and reduces quality of life8,9. Haemodynamic instability in this context is due to the interruption of supraspinal efferent commands to sympathetic circuits located in the spinal...
Article
The current study evaluated the influence of resting muscle sympathetic nerve activity (MSNA) burst size and firing pattern on time-to-peak sympathetic transduction in 36 young healthy men and women. Participants underwent a 5–10 min resting baseline with beat-to-beat measures of heart rate, mean arterial pressure (MAP), and MSNA (microneurography)...
Article
Acute respiratory distress syndrome and subsequent respiratory failure remains the leading cause of death (>80%) in patients severely impacted by COVID-19. The lack of clinically effective therapies for COVID-19 calls for the consideration of novel adjunct therapeutic approaches. Though novel antiviral treatments and vaccination hold promise in con...
Article
Fluctuations in diastolic pressure modulates muscle sympathetic nerve activity (MSNA) through the arterial baroreflex. A higher sympathetic baroreflex sensitivity (sBRS) to pressure falls compared to rises has been reported, however, the underlying mechanisms are unclear. We assessed whether beat-to-beat falling and rising diastolic pressures opera...
Article
Muscle sympathetic single units can respond differentially to stress but whether these responses are linked to the degree of sympathoexcitation is unclear. Fifty-three muscle sympathetic single units (microneurography) were recorded in 17 participants (8 women; 24±3 yr). Five 40-second bouts of 10% static handgrip were performed during a 10 min for...
Article
This case study reports the efferent muscle sympathetic nerve activity (MSNA) discharge patterns during a sinus pause observed during a maximal end-expiratory apnea in a young healthy male (age = 26 years). During a 15.3-second end-expiratory apnea following a bout of intermittent hypercapnic hypoxia we observed a 5.2-second (R-R interval) sinus pa...
Article
Muscle sympathetic nerve activity (MSNA) exhibits well-described within-breath respiratory modulation, but the interactive contributions of the arterial baroreflex remain unclear. The present study assessed: 1) within-breath modulation of sympathetic baroreflex sensitivity (BRS), and 2) the effect of acute intermittent hypercapnic hypoxia (IHH) on...
Article
The arterial baroreflex has dominant control over multiunit muscle sympathetic nerve activity (MSNA) burst occurrence, but whether this extends to all single units or is influenced by resting blood pressure status is unclear. In 22 men (32 􏰀 8 yr), we assessed 68 MSNA single units during sequential bolus injections of nitroprusside and phenylephrin...
Article
Key points: The arterial baroreflex controls vasoconstrictor muscle sympathetic nerve activity (MSNA) in a negative feedback manner by increasing or decreasing activity during spontaneous blood pressure falls or elevations, respectively. Spontaneous sympathetic baroreflex sensitivity is quantified as the slope of the relationship between MSNA burs...
Article
The influence of muscle sympathetic nerve activity (MSNA) responses on local vascular conductance during exercise are not well established. Variations in exercise mode and active muscle mass can produce divergent MSNA responses. Therefore, we sought to examine the effects of small vs. large muscle mass dynamic exercise on vascular conductance and M...
Article
We sought to investigate whether the β-adrenergic receptors play a pivotal role in sex-related differences in arterial blood pressure (BP) regulation during isometric exercise. Sixteen volunteers (8 women) performed 2 min of ischemic isometric handgrip exercise (IHE) and 2 min of post exercise circulatory occlusion (PECO). Heart rate (HR) and beat-...
Article
Two subpopulations of muscle sympathetic single units with opposite discharge characteristics have been identified during low-level cardiopulmonary baroreflex loading and unloading in middle-aged adults and patients with heart failure. The present study sought to determine whether similar subpopulations are present in young healthy adults during ca...
Article
Muscle sympathetic nerve activity (MSNA) at rest increases with age. However, the influence of age on MSNA recorded during dynamic leg exercise is unknown. We tested the hypothesis that aging attenuates the sympatho-inhibitory response observed in young subjects performing mild to moderate 1-leg cycling. After pre-determining peak oxygen uptake (VO...
Article
Prior studies demonstrating clinical significance of noninvasive estimates of central blood pressure (BP) and pulse wave reflection have relied primarily on discrete resting measures. The aim of this study was to compare central BP and pulse wave reflection measures sampled during a single resting laboratory visit against those obtained under ambul...
Article
Full-text available
Background: Whether the sympathetic nervous system can directly alter central aortic stiffness remains controversial, mainly because of the difficulty in experimentally augmenting peripheral vasoconstrictor activity without changing blood pressure. Methods and results: To address this limitation, we utilized low-level cardiopulmonary baroreflex...
Article
Full-text available
Purpose: Overload training is hypothesized to alter autonomic regulation, though interpretations using indirect measures of heart rate variability are conflicting. The aim of the present study was to examine the effects of overload training on muscle sympathetic nerve activity (MSNA), a direct measure of central sympathetic outflow, in recreationa...
Article
Purpose: Whether differences in absolute muscle strength impact blood pressure (BP) responses to relative intensity static exercise remains controversial but could contribute to known sex-based differences and influence the interpretation of cross-sectional data. Methods: One hundred thirty-two healthy participants (66 men and 66 women, age: 22±...
Article
Negative and positive muscle sympathetic nerve activity (MSNA) responders have been observed during mental stress. We hypothesized that similar MSNA response patterns could be identified during the first minute of static handgrip and contribute to the inter-individual variability throughout exercise. Supine measurements of multi-unit MSNA (microneu...
Article
The contribution of central command to the peripheral vasoconstrictor response during exercise has been investigated using primarily handgrip exercise. The purpose of the present study was to compare muscle sympathetic nerve activity (MSNA) responses during passive (involuntary) and active (voluntary) zeroload cycling to gain insight into the effec...
Article
Full-text available
Ischemic preconditioning (IPC) has been hypothesized to elicit ergogenic effects by reducing feedback from metabolically sensitive group III/IV muscle afferents during exercise. If so, reflex efferent neural outflow should be attenuated. We investigated the effects of IPC on muscle sympathetic nerve activity (MSNA) during static handgrip (SHG) and...
Article
Acute dietary nitrate supplementation reduces resting blood pressure in healthy normotensives. This response is attributed to increased nitric oxide bioavailability and peripheral vasodilation, though nitric oxide also tonically inhibits central sympathetic outflow. We hypothesized that acute dietary nitrate (NO 3 - ) supplementation using beetroot...
Article
Full-text available
Flow-mediated dilation (FMD) is a method used to measure endothelial-dependent vasodilation, quantified by the change in conduit artery luminal diameter during post-occlusive hyperemia This article is protected by copyright. All rights reserved.
Article
Full-text available
Stimulation of high threshold mechanical nociceptors on the skin can modulate efferent sympathetic outflow. Whether low threshold mechanoreceptors from glabrous skin are similarly capable of modulating autonomic outflow is unclear. Therefore, the purpose of this study was to examine the effects of cutaneous afferent feedback from the hand palm and...
Article
Resting muscle sympathetic nerve activity (MSNA) demonstrates high intra-individual reproducibility when sampled over 5-30 minute epochs, though shorter sampling durations are commonly used prior to, and during, a stress to quantify sympathetic responsiveness. The purpose of the present study was to examine the intra-test validity and reliability o...
Article
Full-text available
Background Ischemic preconditioning (IPC) is the exposure to brief periods of circulatory occlusion and reperfusion in order to protect local or systemic organs against subsequent bouts of ischemia. IPC has also been proposed as a novel intervention to improve exercise performance in healthy and diseased populations. Objective The purpose of this s...
Article
Full-text available
Study design: Review. Objectives: The purpose of this review is to discuss the utility of linear and non-linear heart rate variability (HRV) as well as the QT-variability index (QTVI) as indices of cardiac autonomic control in individuals with spinal cord injury (SCI). Setting: Brock University, Department of Kinesiology, St Catharines, Ontari...

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Project (1)
Project
Blood flow restricted training - applications to exercise training, rehabilitation and adaptive response Ischemic preconditioning - for performance