Anthony Carr

University of Saskatchewan | U of S · Department of Small Animal Clinical Sciences

A 7‐year‐old, neutered, male miniature pinscher was presented with a 36‐hour history of acute life‐threatening haematochezia and severe anaemia (haematocrit 4.9%). A diagnosis of acquired colonic vascular ectasia was ultimately made from the characteristic gross morphologic vascular abnormalities visualised during colonoscopy. A combination ethinyl...

The objectives of this study were to retrospectively compare blood pressure measurements obtained in clinic with those obtained at home from cats and dogs seen at our hospital and to investigate the potential for white-coat effect (WCE) and white-coat hypertension (WCH) in this population of 10 cats and 7 dogs. Medical records from Western College...

Background Parvoviral enteritis (PE) is a viral gastrointestinal (GI) infection of dogs. Recovery from PE has been associated with persistent GI signs later in life. The objectives of this study were: (i) To determine whether dogs that have recovered from PE (post-parvo dogs) had an increased risk of persistent GI signs compared to uninfected contr...

Objective: To describe the radiation safety behaviors of veterinary specialists performing small animal fluoroscopic procedures and examine potential risk factors for these behaviors, including knowledge of radiation risk and training regarding machine operating parameters. Sample: 197 veterinary specialists and residents in training. Procedures:...

Background: Parvoviral enteritis is a viral gastrointestinal (GI) infection of dogs. Recovery from PE has been associated with persistent GI signs. The objectives of this study were: (i) To determine whether dogs that have recovered from PE (post-parvo dogs) had an increased risk of persistent GI signs compared to uninfected controls. (ii) To inves...

A 12-year-old spayed female German shorthaired pointer dog sustained extensive bite wounds around the neck. At presentation, atrial fibrillation was identified with a rapid ventricular response rate of 300 beats per minute (bpm). The ventricular response rate rapidly decreased to 130 bpm following administration of hydromorphone and oxygen. Based o...

A 2-year-old spayed female Great Pyrenees cross dog was presented following the consumption of pure xylitol sweetener. Blood tests revealed hepatocellular leakage and cholestasis, hyperlactatemia, thrombocytopenia, and prolonged prothrombin and activated partial thromboplastin times. Thoracic radiographs on day 2 of hospitalization were consistent...

Objective To determine if 3 resuscitative fluid therapy strategies increase N‐terminal pro‐brain natriuretic peptide (NT proBNP) levels in healthy dogs. Design Randomized crossover trial. Setting Veterinary teaching hospital. Animals Plasma NT proBNP concentrations were measured in 6 healthy purpose‐bred dogs that received 3 resuscitative fluid...

Whole blood samples were collected from 515 dogs in the practice region surrounding Saskatoon, Saskatchewan, Canada between 2008 and 2010 and evaluated for seroprevalence of vector-borne diseases. Of 515 samples, 12 (2.3%) were positive, with 7 (1.4%) positive for antibodies to Borrelia burgdorferi. These prevalences are higher than those previousl...

Objective: To determine the accuracy of high-definition oscillometry (HDO) for arterial pressure measurement during injectable or inhalation anesthesia in horses. Study design: Prospective, clinical study. Animals: Twenty-four horses anesthetized for procedures requiring lateral recumbency. Methods: Horses were premedicated with xylazine, an...

Seven dogs diagnosed with enteropathogenic Escherichia coli (EPEC) infection in association with acute gastroenteritis are described. Disease severity ranged from mild in adults to fatal disease in young dogs. Enteropathogenic E, coli infection should be considered as a possible differential diagnosis in dogs with diarrhea.

ADDISON'S disease or hypoadrenocorticism generally results from immune-mediated destruction of the adrenal glands and particular dog breeds appear to be overrepresented; for example, West Highland white and wheaten terriers, Portuguese water dogs, duck-tolling retrievers and great danes. Candidate genes for the disease have been identified in sever...

Although dogs with acute necrotizing pancreatitis (ANP) can develop respiratory complications, there are no data describing lung injury in clinical cases of ANP in dogs. Therefore, we conducted a study to characterize lung injury and determine if pulmonary intravascular macrophages (PIMs) are induced in dogs with ANP (n = 21) compared with control...

A 7-year-old, spayed female Shetland sheepdog had sudden onset of right-sided epistaxis. Diagnostic tests revealed Type III von Willebrand's disease and primary hypothyroidism leading to an acute hypothyroid crisis and acquired factor VIII (FVIII) deficiency. Levothyroxine therapy normalized the serum thyroxine and FVIII concentrations. The delayed...

Blood pressure monitoring and management is a vital part of the perianesthetic period. Disturbances in blood pressure, especially hypotension, can have significant impacts on the well-being of small animal patients. There are a variety of mechanisms present to control blood pressure, including ultra-short-, short-, and long-term mechanisms. Several...

The effects of heparin administration, by the oral route, were evaluated in dogs. In single and multiple dose studies (single 7.5 mg/kg, multiple 3 × 7.5 mg/kg per 48 h), plasma, urine, and fecal samples were collected at various times up to 120 h after oral administration of unfractionated heparin. Changes in plasma and urine anti-Xa activity, pla...

There is evidence that dogs suffering from acute necrotizing pancreatitis (ANP) can develop respiratory disease. However, there are no data describing the lung histopathology in clinical cases of ANP in dogs. Therefore, we hypothesized that lungs of dogs that died due to ANP (n=21) will be inflamed along with recruitment of PIMs, a pro‐inflammatory...

Activated neutrophils live longer, produce toxic metabolites and cause considerable tissue injury, which is central to the pathogenesis of many inflammatory conditions. Retinoids are a class of lipophilic compounds with anti-inflammatory effects. We examined the effect of retinoic acid on apoptosis in normal and activated neutrophils. Our results s...

This study evaluated the effects of an anesthetic protocol using intravenous ketamine and midazolam, and intramuscular buprenorphine on hematologic variables in cats. Twelve healthy adult cats had blood collected for a complete blood count before and after the induction of anesthesia. There were significant decreases in red blood cell counts, hemog...

An 8 yr old male English bulldog receiving treatment for immune-mediated thrombocytopenia was diagnosed with calcinosis cutis 90 days after initiation of corticosteroid therapy. Twenty-four days later, the patient presented in a comatose state after collapsing and was euthanized. Postmortem examination revealed coronary arteriosclerosis and myocard...

Recurrent constipation is a common problem in cats. Laxatives often are the cornerstone for management of recurrent constipation; however, there is a paucity of published research on laxative use in cats. This study investigated the safety and palatability of polyethylene glycol (PEG3350) in normal cats. All cats consumed the PEG3350 laxative for 4...

A 4-year-old nulliparous sexually intact female chinchilla (Chinchilla lanigera) was evaluated because of a 2-month history of blood being sporadically observed in its cage. Results of physical examination of the chinchilla were unremarkable except for the presence of blood-stained fur around the perineum. There were no external lesions to account...

Fresh fecal samples from 124 apparently healthy dogs and 333 random source canine fecal samples from dog walking areas were analyzed by centrifuged flotation in Sheather's solution to determine the prevalence of gastrointestinal parasites in dogs from Saskatoon, Saskatchewan. Fecal flotation was positive in 4.4% of samples. Roundworm species were f...

Neutrophils are the key cellular component of innate immune system. Accumulation of activated neutrophils that live longer cause considerable tissue injury, which is central to the pathogenesis of many inflammatory conditions. Retinoids are a class of lipophilic compounds that include natural vitamin A and its synthetic derivatives which have anti‐...

DIAGNOSIS of pancreatitis in cats can be supported by a number of factors but, for a definitive diagnosis, histological examination of a biopsy is required. This study evaluated the outcome of laparoscopic punch biopsy of the left pancreatic limb in healthy cats. A biopsy of the pancreas was taken

A chronic, partial mesenteric volvulus was found on laparotomy of an adult Bernese mountain dog with a 4-month history of intermittent vomiting, diarrhea, and weight loss. The dog had elevated cholestatic and hepatocellular leakage enzymes, increased bile acids, azotemia, isosthenuria, and a hypokalemic, hypochloremic, metabolic alkalosis. The dog...

Definitive diagnosis of feline pancreatic disease is dependent on histologic examination of biopsies. Laparoscopic punch biopsy of the pancreas does not significantly affect pancreatic health or clinical status of healthy cats, and provides an adequate biopsy sample for histopathology. Eleven healthy female domestic shorthair cats. Effects of lapar...

The complex microbial community of the intestine plays a major role in animal health and diseases. Despite its significance to feline health and the significance of intestinal and fecal populations to the public health, little is known about the actual composition of the normal microbiota of the cat. To create a sequence-based inventory of feline f...

The low molecular weight heparin (LMWH), dalteparin sodium, was administered subcutaneously (100 IU/kg) to 8 healthy cats twice daily for 13 doses. Anti-activated factor X (anti-Xa) activity was measured prior to administration (time 0), and 4, 6, 8, and 12 h after the 1st dose, 4 h after administration of the 3rd dose, and at 4, 6, 8, and 12 h aft...

A hospital-based, case-control study was used to describe clinical and laboratory findings in 83 dogs diagnosed with noninfectious, nonerosive, immune-mediated polyarthritis (IMPA) in western Canada. Case medical records were reviewed. Cases were analyzed as total IMPA cases and as subgroups [breed, systemic lupus erythematosus (SLE), reactive, and...

An 8-year-old, castrated male golden retriever was referred for lethargy and inappetance. Severe pain was elicited on palpation of the left temporomandibular joint region. Computed tomography revealed aggressive bone destruction of the left bulla. Squamous cell carcinoma was diagnosed. Malignant tumor in the canine middle ear is rare.

Bei der Diagnose „Hyperthyreose” ist immer eine Abklarung der mit dieser Erkrankung haufig einhergehenden Sekundarveranderungen notwendig. Insbesondere sollten Herz, Nieren und Blutdruck berucksichtigt werden. Bei der Therapie spielen ACE-Hemmer im Sinne der Kardioprotektion, der Nephroprotektion und unterstutzend auch bei der Blutdrucksenkung eine...

Immune-mediated thrombocytopenia is a common acquired coagulation disorder in dogs resulting from antibody-mediated clearance of platelets though the mononuclear phagocytic system. It is mainly a diagnosis of exclusion. Primary immune-mediated thrombocytopenia is confirmed by ruling out secondary disorders that can mediate platelet destruction by t...

A 7-month-old, intact female, German wire-haired pointer presented with a 3-week history of stranguria, pollakiuria, and dysuria that was nonresponsive to antibiotics. Two prior episodes of dysuria-stranguria appeared to respond to antibiotic therapy. Bladder wall biopsies revealed eosinophilic cystitis and the dog responded well to medical managem...

Consensus Statements of the American College of Veterinary Internal Medicine (ACVIM) provide veterinarians with guidelines regarding the pathophysiology, diagnosis, or treatment of animal diseases. The foundation of the Consensus Statement is evidence-based medicine, but if such evidence is conflicting or lacking, the panel provides interpretive re...

Questionnaires were mailed to veterinarians in western Canada to determine dog and cat deworming protocols and the association between perceived zoonotic risk and perceived prevalence of endoparasites and deworming protocols. Of the responding veterinarians (545), 13% and 39% recommended deworming protocols consistent with established guidelines fo...

The objective of this study was to assess the type and frequency of cardiac dysrhythmias occurring after routine ovariohysterectomy or orchidectomy in young, healthy dogs by using 2 anesthetic protocols (group I: propofol and isoflurane; group II: thiopental and halothane). Fifty dogs under 2 years of age, judged to be clinically normal by physical...

Glutamate dehydrogenase (GLDH) is a mitochondrial enzyme with highest activity in periacinar hepatocytes. It is reported to be a sensitive indicator of hepatic injury; however, results of studies regarding tissue specificity are contradictory. The purpose of the study reported here was to examine the effect of 3 factors on serum GLDH activity in do...

Part of the popular Secrets Series, this new text provides essential, practical information for reviewing canine internal medicine topics commonly encountered in clinical situations. Organized by disorder type, it features numerous photos, a popular question-and-answer format, and a detailed index that makes it easy to find information quickly. In...

Candida krusei was isolated from a gastrostomy tube that failed 175 d after placement in a 13-year-old cat. Fungal colonization of gastrostomy tubes is common in humans and a contributor to tube failure. Veterinarians should be aware of this phenomenon in patients that have long-term indwelling feeding tubes.

An 8-year-old cat was evaluated for recurrent bouts of stranguria, hematuria and pollakiuria. Routine urinalysis, CBC and serum chemistries were unremarkable. Intravenous excretory urography was performed while the cat was sedated. The nephrogram was initially well opacified and increased in opacity during the 40 minutes that the study was performe...

A dog developed icterus, vomiting, and anorexia 2 wk after orthopedic surgery and treatment with meloxicam for approximately 1 y. Exploratory laparotomy revealed a single perforated duodenal ulcer. The most likely cause of the hyperbilirubinemia was intrahepatic cholestasis resulting from peritonitis associated with the perforation.

To determine effects of athletic conditioning on thyroid hormone concentrations in a population of healthy sled dogs. 19 healthy adult sled dogs. Serum concentrations of thyroxine (T4), triiodothyronine (T3), thyroid-stimulating hormone (TSH), free T4 (fT4), free T3 (fT3), and autoantibodies directed against T3, T4, and thyroglobulin were measured...

All leptospirosis microscopic agglutination test titers for the Leptospira serovars icterohaemorrhagiae, canicola, grippotyphosa, bratislava, hardjo, and pomona conducted on 1,260 blood samples from dogs at the University of Illinois Veterinary Diagnostic Laboratory between March 1996 and March 2001 were evaluated. Low titers (1:100 to 1:400) were...

Medical records of 72 dogs diagnosed with immune-mediated hemolytic anemia (IMHA) were reviewed to find risk factors for the disease, for mortality, and for thromboembolism. Coagulation data of 32 patients were evaluated for mortality or thromboembolism risk factors. Cocker Spaniels were at increased risk for IMHA (P = .012). Timing of vaccination...

A 6-year-old, castrated male shorthair was evaluated for chylous effusion in the thorax and abdomen. An underlying disease process was not determined. The cat developed hyponatremia and hyperkalemia, which was attributed to the mechanical drainage of pleural fluid and to the decreased urinary excretion of potassium.

Ferrets are important animal models that have been used to study influenza and other viral diseases. The authors discuss a modified technique that allows placement of gastrostomy tubes without the use of an endoscope, which are generally too large for use in ferrets.

A review of the literature pertaining to the uveodermatological syndrome of dogs is presented. This syndrome is marked by depigmentation of the periocular region, lips and nose in association with severe uveitis. Early diagnosis and therapy can prevent serious vision loss. Symptoms and therapy of the cases described in the literature as well as cas...

A tumor of the third eyelid gland was diagnosed in a 13 year old female Chihuahua. Histopathology of the excised tissue revealed an apocrine adnexoma with squamous metaplasia. The literature regarding prolapse and tumors of the third eyelid gland was reviewed. No case with similar morphology to this tumor was described to our knowledge.