Antar Ahmed Abdelhamid

Sohag University · Department of Chemistry

Recent studies have shown that combining kinase inhibitors has additive and synergistic effects. BRAFV600E and p38α have been extensively studied as potential therapeutic targets for a variety of diseases. In keeping with our interest in developing multi-targeted anticancer agents, a series of novel triaryl-imidazole-based analogues containing 3-ar...

A novel series of tri-aryl imidazole derivatives 5a–n carrying benzene sulfonamide moiety has been designed for their selective inhibitory against hCA IX and XII activity. Six compounds were found to be potent and selective CA IX inhibitors with the order of 5g > 5b > 5d > 5e > 5g > 5n (Ki = 0.3–1.3 μM, and selectivity ratio for hCA IX over hCA XII...

A novel series of ciprofloxacin hybrids comprising various heterocycle derivatives has been synthesized and structurally elucidated using 1H NMR, 13C NMR, and elementary analyses. Using ciprofloxacin as a reference, compounds 1-21 were screened in vitro against Gram-positive bacterial strains such as Staphylococcus aureus and Bacillus subtilis and...

Although salens and imidazoles are well‐studied motifs among bioactive and therapeutic agents, their properties when combined in transition metal complexes are not well developed. To explore the structure/reactivity of this class of compounds, a salen‐based ligand, namely (2,2′‐{1,2‐ethanediylbis[nitrilo(E)methylylidene]}diphenol, S), and its binar...

New imidazolidindiones and tetra-substituted imidazole derivatives were designed, synthesized, and evaluated for the anticonvulsant activity through pentylenetetrazole (PTZ)-induced seizures and maximal electroshock (MES) tests using valproate sodium and phenytoin sodium as reference drugs, respectively. Most of the target compounds showed excellen...

The novel oxonine 2, 4 have been synthesized by the reaction of 1,3-indandione with 4-bromo-2-hydroxybenzaldehyde and/or 2-hydroxy-1-naphthaldehyde in the presence of 1,3-diaminopropan-2-ol as green basic catalyst. On the other hand, the reaction of 1,3-cyclohexanediones with 2-hydroxy aromatic aldehydes under the same reaction condition afforded x...

The pyrrolidinium hydrogen sulfate (PHS) was used as an excellent ionic liquid catalyst for the preparation of many imidazoles moiety, which have biologically application via one‐pot multicomponent reaction. Imidazoles were afforded through the reaction of equimolar from 1,2‐diphenylethane‐1,2‐dione, ammonium acetate, different aromatic aldehydes,...

Designing new metal-based molecular antibiotics is an efficient approach to overcome the growing threat of antimicrobial resistance. In this paper, novel Cr(III), Fe(III) and Cu(II) complexes comprising substituted aryl imidazole ligand (MSEB), namely (2-(1-(2-hydroxyethyl)-4,5-diphenyl-1H-imidazole-2-yl)(4-bromophenol)) have been synthesized and c...

A simple highly adjustable and effective synthesis of aryl imidazole ligand HL namely (2‐(1‐butyl‐4,5-diphenyl‐1H‐imidazole‐2‐yl) (4-bromophenol) was discussed where it was prepared by cyclo condensation of 5-bromo-2-hydroxybenzaldehyde, benzil and butan-1-amine. Three new Cr(III), Fe(III) and Cu(II) coordination compounds of aryl imidazole ligand...

Piperidinium hydrogen sulfate is used as a very important new catalyst for the synthesis of the biologically active compounds from a series of multi‐substituted imidazole components by the simple reaction of benzyl with different aromatic aldehydes, ammonium acetate, and phenethylamine or butylamine as amine derivatives. The key merits of this meth...

In the structure of the title compound C33H29BrClNO4, (I), the hexa­hydro-2H-acridine ring system has a hy­droxy­ethyl substituent on the N atom and a 3-bromo-6-chloro-2-hy­droxy­phenyl substituent on the central C atom at the 9-position. An unusual feature of the mol­ecule is that the substituents at the 3- and 5-positions of the outer cyclo­hexen...

Here, we reported two methods for the synthesis of multi‐substituted imidazoles, firstly via four‐component cyclocondensation reaction of benzil, aliphatic amines (allylamine or pentylamine), and aromatic aldehyde and ammonium acetate. Using an ionic liquid catalyst namely, diethyl ammonium hydrogen sulfate, and under solvent‐free conditions. Secon...

The title compound, C 24 H 21 N 3 O 3 , crystallizes with two unique but closely r.m.s. overlay fit = 0.215 Å) comparable molecules (1 and 2) in the asymmetric unit of the triclinic unit cell. In molecule 1, the dihedral angles between the central imidazlole ring and the benzene-ring substituents are 42.51 (9), 45.41 (9) and 56.92 (8)°, respectivel...

For a wide spectrum of pharmacological effects of polyhydroquinolines, this study introduces a developed safe, simple, higher yields and fast method for the synthesis of some new hexahydroquinoline derivatives using one-pot three-component cyclocondensation reaction, via the reaction of 1,3-cyclohexanedione with primary amine and arylidinemalononit...

Nanoparticles are key focus of research for a wide range of novel applications. As such, ZnFe2O4 magnetic nanoparticles were synthesized hydrothermally and characterized via scanning and transmission electron microscopies, powder X-ray diffraction, energy-dispersive X-ray and infrared spectroscopies, thermogravimetric analysis and magnetic measurem...

The title compound, C24H21ClN2O, crystallizes with two unique mol-ecules in the asymmetric unit. In each mol-ecule, the central imidazole ring is substituted at the 2-, 4- and 5-positions by benzene rings. The 2-substituted ring carries a Cl atom at the 4-position. One of the imidazole N atoms in each mol-ecule has a propan-2-ol substituent. In the...

Morpholinium hydrogen sulfate as an ionic liquid was employed as a catalyst for the synthesis of a biologically active series of multi-substituted imidazoles by a four-component reaction involving the combination of benzil with different aromatic aldehydes, ammonium acetate, and 1-amino-2-propanol under solvent-free conditions. The key advantages o...

In the title salt, C 6 H 16 N 2 2+ ·2CNS − , the cyclohexane ring adopts a chair conformation. In the crystal, N—H...N hydrogen bonds enclose R 4 2 (8) rings involving two N atoms from the cyclohexane-1,4-diammonium cations as donors with the N atoms of two thiocyanate anions as acceptors. The crystal structure is further stabilized by intermolecul...

In the title compound, C23H24BrNO5, the central 1,4-di-hydro-pyridine ring of the 1,2,3,4,5,6,7,8,9,10-deca-hydro-acridine ring system adopts a half-chair conformation. The two cyclo-hexene rings fused to the central ring both have a twisted-boat conformation. The mean planes of the bromo-hydroxy-phenyl ring and the major and minor components of th...

In the title compound, C 21 H 22 BrNO 4 , the tetrahydroacridine-1,8-dione unit has a bromohydroxyphenyl-substituent on the central carbon atom of the dihydropyridine ring and a 2-hydroxyethyl substituent on the nitrogen atom. An intramolecular O—H...O hydrogen bond forms between the hydroxyl substituent on the benzene ring and a carbonyl oxygen fr...

Citation: Abd-Allah OA, Abdelhamid AA, Mohamed SK (2015) Synthesis and Anti-inflammatory Study of Novel N-substituted Hydro-acridine-1,8-diones and Bis-hexahydroacridine-1,8-dione Derivatives. Med chem S2:004.

Ten 1,2,4,5-tetra-substituted imidazole derivatives have been synthesized with a 2-hydroxyethy substituent at the 1-nitrogen atom and potentially electron releasing hydroxy-, methoxy-, dimethylamino- or nitro substituents in various positions on the benzene ring located on the 2-carbon atom. The prototypical derivative with an unsubstituted phenyl...

In the title compound, C 22 H 22 O, the dihedral angle between the planes of the benzene rings is 53.55 (7)°. Weak C—H...O interactions help to direct the packing, forming sheets lying parallel to (020).

In the title compound, C20H26ClNO4, the central cyclo­hexene ring adopts an approximate envelope conformation with the C atom binding with the hy­droxy group at the tip of the flap. There is an intramolecular N—H⋯O hydrogen bond generating an S(6) ring motif. In the crystal, classical O—H⋯O hydrogen bonds and weak C—H⋯O and C—H⋯Cl inter­actions lin...

In the title hydrate, C16H23BrN2O·2H2O, the organic mol-ecule features a strong intra-molecular O-H⋯N hydrogen bond. The piperidine ring, in addition, adopts a chair conformation with the exocyclic C-N bond in an equatorial orientation. The water molecules of crystallization are disordered (each over two sets of sites with half occupancy. In the cr...

The title mol-ecule, C16H9BrO3, deviates slightly from planarity. The benzene ring makes a dihedral angle of 1.02 (9)° with the plane defined by the five-membered ring of the indandione moiety. The latter exhibits a minute twist indicated by the dihedral angle of 0.47 (9)° between the planes of the five- and six-membered rings. An intra-molecular C...

In the title compound, C 25 H 22 N 2 O 3 , the central imidazole ring makes dihedral angles of 48.43 (10), 20.23 (10) and 75.38 (11)° with the benzene ring and the two phenyl rings, respectively. The phenyl ring adjacent to the N-bonded 2-hydroxypropyl group shows the greatest twist, presumably to minimize steric interactions. In the crystal, molec...

The title compound C 25 H 29 BrClNO 4 , comprises a 3,3,6,6-tetramethyltetrahydroacridine-1,8-dione ring system that carries a hydroxyethyl substituent on the acridine N atom and a 3-bromo-5-chloro-2-hydroxyphenyl ring on the central methine C atom of the dihydropyridine ring. The benzene ring is inclined to the acridine ring system at an angle of...

In the title compound, C 33 H 27 BrClNO 4 , the dihydropyridine ring adopts a flattened boat conformation. The molecular conformation is stabilized by an intramolecular O—H...O hydrogen bond, with an S (8) ring motif. In the crystal, O—H...O, C—H...O and C—H...Cl hydrogen bonds, and C—H...π interactions link the molecules, forming a three-dimension...

In the xanthenone system of the title compound, C23H20O4, the pyran ring has a maximum deviation of 0.111 (1) Å from planarity and the outer cyclo-hexene ring exhibits a puckered conformation. The three methyl-ene C atoms of the cyclo-hexene ring bonded to the pyran unit are disordered over two sets of sites [occupancies = 0.570 (3) and 0.430 (3)]....

In the title compound, C26H24N2O2, the two phenyl and the 2,5-di­meth­oxy­phen­yl rings are inclined to the imidazole ring at dihedral angles of 30.38 (8), 56.59 (9) and 73.11 (9)°, respectively. In the crystal, mol­ecules are linked by pairs of C—H⋯O inter­actions into centrosymmetric dimers with graph-set notation R 2 2(8). C—H⋯π inter­actions ar...

The title compound, C25H20N2O2, crystallized with two mol-ecules in the asymmetric unit, in one of which the atoms of the terminal propenyl group are disordered over two sets of sites, with a refined occupancy ratio of 0.870 (4):0.130 (4). The central imidazole ring makes dihedral angles of 25.51 (11), 40.73 (11) and 27.36 (11)° with the three pend...

The title compound, C26H24Cl2N2, crystallizes with two independent mol-ecules (1 and 2) in the asymmetric unit. In mol-ecule 1, the two phenyl and 2,6-di-chloro-phenyl rings are inclined to the imidazole ring at angles of 74.12 (14), 26.13 (14) and 67.30 (14)°, respectively. In mol-ecule 2, due to the different mol-ecular environment in the crystal...

The title mol-ecule, C17H11FN2O3, is nearly planar [maximum deviation = 0.197 (1) Å] and the mol-ecular conformation is stabilized by an N-H⋯O hydrogen bond forming an S(6) ring motif. The H atom of the intra-molecular hydrogen bond was found to be disordered over two sites and thus both the hy-droxy and keto tautomers are simultaneously present in...

In the title compound, C19H16BrClO4, both the fused xanthene rings and one of the cyclo­hexane rings adopt envelope conformations, while the other cyclo­hexane ring is in a chair conformation. In the crystal, mol­ecules are linked by C—H⋯O hydrogen bonds, forming infinite chains running along [10-1] incorporating R 2 2(16) ring motifs. In addition,...

The title compound, C26H25N3, crystallizes with four independent mol-ecules, 1-4, in the asymmetric unit of the triclinic unit cell. The allyl substituents on the imidazole rings adopt similar conformations in all four mol-ecules. The imadazole and the 4-and 5-substituted phenyl rings of two pairs of molecules in the asymmetric unit stack parallel...

In the xanthene ring system in the title compound, C19H18O4, the 4H-pyran ring has a maximum deviation of 0.110 (2) Å from planarity and the cyclo­hexene ring exhibits a puckered conformation [puckering parameters Q T = 0.452 (3) Å, θ = 57.0 (4) and ϕ = 131.7 (4)°]. The cyclo­hexene ring attached to the xanthene system adopts an envelope conformati...