Anssi Manninen

Dominus Nutrition Oy · R&D

This brief commentary challenges the use of the term "energy deficiency" in nutrition and metabolism, providing a critical examination of its scientific and philosophical aspects. It emphasizes the need to consider rare diseases associated with actual energy deficiency, which extend beyond the scope of everyday tiredness or fatigue. By analyzing en...

The fundamental cause of obesity is widely assumed to be an energy imbalance between calories consumed and calories expended (i.e., the energy balance theory). However, this century-old obesity paradigm is fallacious. According to known laws of physics, the actual etiology of obesity is chronic positive mass balance, not positive energy balance. Fu...

It is widely assumed that the fundamental cause of obesity is an energy imbalance between calories consumed and calories expended (i.e., the energy balance theory; EBT). However, this century-old obesity paradigm must be fallacious. According to known laws of physics, chronic positive mass balance is the actual etiology of obesity, not positive ene...

According to known laws of physics, chronic positive mass balance is the actual etiology of obesity, not positive energy balance. The relevant physical law in terms of body mass regulation is the Law of Conservation of Mass, not the Law of Conservation of Energy. It is important to understand that energy balance and mass balance are separate balanc...

According to known laws of physics, chronic positive mass balance is the actual etiology of obesity, not positive energy balance. The relevant physical law in terms of body mass regulation is the Law of Conservation of Mass, not the Law of Conservation of Energy. A recently proposed mass balance model (MBM) describes the temporal evolution of body...

According to known laws of physics, chronic positive mass balance is the actual etiology of obesity, not positive energy balance. The relevant physical law in terms of body mass regulation is the Law of Conservation of Mass, not the Law of Conservation of Energy. A recently proposed mass balance model (MBM) describes the temporal evolution of body...

According to known laws of physics, chronic positive mass balance is the actual etiology of obesity, not positive energy balance. The relevant physical law in terms of body mass regulation is the Law of Conservation of Mass, not the Law of Conservation of Energy. A recently proposed mass balance model (MBM) describes the temporal evolution of body...

According to known laws of physics, chronic positive mass balance is the actual etiology of obesity, not positive energy balance. The relevant physical law in terms of body mass regulation is the Law of Conservation of Mass, not the Law of Conservation of Energy. A recently proposed mass balance model (MBM) describes the temporal evolution of body...

According to known laws of physics, chronic positive mass balance is the actual etiology of obesity, not positive energy balance. The relevant physical law in terms of body mass regulation is the Law of Conservation of Mass, not the Law of Conservation of Energy. A recently proposed mass balance model (MBM) describes the temporal evolution of body...

According to known laws of physics, chronic positive mass balance is the actual etiology of obesity, not positive energy balance. The relevant physical law in terms of body mass regulation is the Law of Conservation of Mass, not the Law of Conservation of Energy. A recently proposed mass balance model (MBM) describes the temporal evolution of body...

According to known laws of physics, chronic positive mass balance is the actual etiology of obesity, not positive energy balance. The relevant physical law in terms of body mass regulation is the Law of Conservation of Mass, not the Law of Conservation of Energy. A recently proposed mass balance model (MBM) describes the temporal evolution of body...

According to known laws of physics, chronic positive mass balance is the actual etiology of obesity, not positive energy balance. The relevant physical law in terms of body mass regulation is the Law of Conservation of Mass, not the Law of Conservation of Energy. A recently proposed mass balance model (MBM) describes the temporal evolution of body...

According to known laws of physics, chronic positive mass balance is the actual etiology of obesity, not positive energy balance. The relevant physical law in terms of body mass regulation is the Law of Conservation of Mass, not the Law of Conservation of Energy. A recently proposed mass balance model (MBM) describes the temporal evolution of body...

According to known laws of physics, chronic positive mass balance is the actual etiology of obesity, not positive energy balance. The relevant physical law in terms of body mass regulation is the Law of Conservation of Mass, not the Law of Conservation of Energy. A recently proposed mass balance model (MBM) describes the temporal evolution of body...

Background & Aims Recently, the validity of mass balance model (MBM) was questioned based on two feeding studies. Thus, we simulated both of these feeding trials. Methods MBM describes the temporal evolution of body weight and body composition under a wide variety of feeding experiments. This computational study simulated, utilizing MBM, the under...

Background & Aims There is an ongoing debate about the role of macronutrient distribution of the diet in weight management and the potential of its modification as an approach to treat obesity. Our aim was to shed light on this highly disputed topic. Methods This computational study utilized the recently proposed mass balance model (MBM) of obesit...

The inability of current recommendations to control the epidemic of diabetes, the specific failure of the prevailing low-fat diets to improve obesity, cardiovascular risk, or general health and the persistent reports of some serious side effects of commonly prescribed diabetic medications, in combination with the continued success of low-carbohydra...

Currently, there is a lack of studies examining the effects of adenosine-5'-triphosphate (ATP) supplementation utilizing a long-term, periodized resistance-training program (RT) in resistance-trained populations. Therefore, we investigated the effects of 12 weeks of 400 mg per day of oral ATP on muscular adaptations in trained individuals. We also...

Dietary protein intake and specifically the quality of the protein in the diet has become an area of recent interest. This study determined the relationship between the amount of quality protein, carbohydrate, and dietary fat consumed and the amount of times the ~10 g essential amino acid (EAA) threshold was reached at a meal, with percent central...

It has been suggested that protein hydrolysates providing mainly di- and tripeptides are superior to intact (whole) proteins and free amino acids in terms of skeletal muscle protein anabolism. This review provides a critical examination of protein hydrolysate studies conducted in healthy humans with special reference to sports nutrition. The effect...

While chronic β-Hydroxy β-Methylbutyrate (HMB) supplementation (≥ 2 wk) lowers exercise induced muscle damage, its acute or timing effects have not been examined. The purpose of this study was to investigate the acute and timing effects of oral HMB supplementation on serum creatine kinase (CK), lactate dehydrogenase (LDH), muscle soreness, and maxi...

Kern, BD and Robinson, TL. Effects of b-alanine supplementation on performance and body composition in collegiate wrestlers and football players. J Strength Cond Res 25(7): 1804–1815, 2011—The purpose of this study was to examine the effectiveness of b-alanine as an ergogenic aid in tests of anaerobic power output after 8 weeks of high-intensity in...

Current nutritional approaches to metabolic syndrome and type 2 diabetes generally rely on reductions in dietary fat. The success of such approaches has been limited and therapy more generally relies on pharmacology. The argument is made that a re-evaluation of the role of carbohydrate restriction, the historical and intuitive approach to the probl...

The leucine metabolite beta-hydroxy-beta-methylbutyrate (HMB) has been extensively used as an ergogenic aid; particularly among bodybuilders and strength/power athletes, who use it to promote exercise performance and skeletal muscle hypertrophy. While numerous studies have supported the efficacy of HMB in exercise and clinical conditions, there hav...

Abstract Current nutritional approaches to metabolic syndrome and type 2 diabetes generally rely on reductions in dietary fat. The success of such approaches has been limited and therapy more generally relies on pharmacology. The argument is made that a re-evaluation of the role of carbohydrate restriction, the historical and intuitive approach to...

For optimal health and athletic performance, gaining lean skeletal muscle mass and losing body fat mass is one ideal outcome of a nutritional/exercise intervention desired by athletes and fitness competitors alike. While achieving a lean muscular physique based on proper diet and intense training may be a goal of bodybuilding and fitness population...

Irene Strychar's recent review of diet in the management of weight loss1 contains some incorrect and biased statements. For example, according to the author, during very-low-carbohydrate intake, “the body depletes its glycogen stores, and gluconeogenesis is induced, whereby lean tissue is used to produce glucose as an energy source for the brain.”...

Dietary supplements and other ergogenic aids are popular among athletes. Recent studies have shown that nutritional mixtures containing protein hydrolysates, added leucine, and high-glycaemic carbohydrates greatly augment insulin secretion compared with high-glycaemic carbohydrates only. When post-exercise hyperinsulinaemia is supported by hyperami...

Protein can be hydrolyzed, producing small chains of amino acids called peptides. Several studies have shown that protein hydrolysates containing mostly di- and tripeptides are absorbed more rapidly than free form amino acids and much more rapidly than intact proteins. In addition, there is recent evidence that protein hydrolysate ingestion has str...

Abstract Results of several recent studies show that high-protein, low-carbohydrate weight loss diets indeed have their benefits. However, agencies such as the American Heart Association (AHA) have some concerns about possible health risks. The purpose of this review is to evaluate the scientific validity of AHA Nutrition Committee's statement on...

The first law of thermodynamics dictates that body mass remains constant when caloric intake equals caloric expenditure. It should be noted, however, that different diets lead to different biochemical pathways that are not equivalent when correctly compared through the laws of thermodynamics. It is inappropriate to assume that the only thing that c...

During very low carbohydrate intake, the regulated and controlled production of ketone bodies causes a harmless physiological state known as dietary ketosis. Ketone bodies flow from the liver to extra-hepatic tissues (e.g., brain) for use as a fuel; this spares glucose metabolism via a mechanism similar to the sparing of glucose by oxidation of fat...

Results of several recent studies show that high-protein, low-carbohydrate weight loss diets indeed have their benefits. However, there are always some concerns about high-protein diets. According to the American Heart Association (AHA) Nutrition Committee, highprotein diets may possess significant health risks. The purpose of this review is to eva...

The Most Effective Supplements for Fat Loss Obesity results from an excess of energy intake over energy expenditure. So, if the obese individual wants to shred extra lard, the solution is extremely simple: Energy expenditure must exceed energy intake for a suitable length of time. Obviously, this message is simple only in principle, but very diffic...

In 1972, Dr. Erikson, a Danish general practitioner in Elsinore, Denmark noted unintentional weight loss when he prescribed a compound containing ephedrine, caffeine and Phenobarbital to patients he was treating asthma. 1 By 1977, over 70 000 patients were taking the "Elsinore Pill", and one Danish pharmaceutical house was producing one million tab...