Annunziata D'Elia

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• PhD
• Research Technologist at Italian National Research Council

all animal imaging systems for a better understanding of brain functioning in health and disease states. Brain imaging in rodent models faces a series of challenges since it acts within the boundaries of current imaging in terms of sensitivity and spatial resolution. Several topics are discussed, including technical considerations regarding the str...

The impact of plastic fragments on human health is currently under investigation, with nanoplastics (NPs) being particularly concerning due to their small size. This allows them to be inhaled, pass through blood barriers, and reach various organs. In this study, we evaluated the effects of airborne NPs on the mouse olfactory system, which is a prim...

Purpose Sentinel lymph node biopsy (SLNB) has been recognized as “the gold standard” for axillary staging in early breast cancer patients with clinically negative lymph nodes, resulting in significant morbidity decrease and quality of life improvement. This study aims to validate the performance of a newly developed handheld portable gamma camera (...

This study aims to validate the performance of the Pocket Gamma CAM (PGC), a handheld gamma camera, in detecting and locating sentinel lymph nodes (SLNs) during the preoperative and intraoperative phases in BC patients compared to conventional gamma camera imaging. European Journal of Nuclear Medicine and Molecular Imaging (2024) 51 (Suppl 1): S71...

The oviduct plays a crucial role in the reproductive process, serving as the stage for fertilization and the early stages of embryonic development. When the environment of this organ has been mimicked, it has been shown to enhance in vitro embryo epigenetic reprogramming and to improve the yield of the system. This study explores the anatomical int...

The prognosis for many pediatric brain tumors, including cerebellar medulloblastoma (MB), remains dismal but there is promise in new therapies. We have previously generated a mouse model developing spontaneous MB at high frequency, Ptch1+/−/Tis21−/−. In this model, reproducing human tumorigenesis, we identified the decline of the Cxcl3 chemokine in...

Tumor associated fibroblasts (TAFs) play a key role in tumor growth and metastatization. TAFs overexpress different biomarkers that are usually expressed at low levels in physiological conditions. Among them are the fibroblast growth factor receptors (FGFRs) that bind the fibroblast growth factors (FGFs). In particular, the overexpression of FGFR-2...

Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder emerging in early life characterized by impairments in social interaction, poor verbal and non-verbal communication, and repetitive patterns of behaviors. Among the best-known genetic risk factors for ASD, there are mutations causing the loss of the Fragile X Messenger Ribonu...

The last 20 years have seen the integration of computed tomography (CT) with positron emission tomography (PET) and single photon emission computed tomography (SPECT). CT represents a fundamental tool for medical diagnosis, but it only provides anatomical details. Since physiological activities can occur even in the absence of anatomical changes, i...

In recent years, portable gamma cameras have become widespread as an aid to the surgeon in the various procedures of radioguided surgery (RGS), especially in combination with gamma probes. The main obstacle that has slowed the rapid spread of these instruments is related to the limited size of the area of investigation, namely field of view (FOV),...

Techniques like single photon emission computed tomography (SPECT) show high potential in small animals in vivo imaging framework. In this context, the spatial resolution represents an important parameter influencing scanner design, given the small size of the anatomical structures to be investigated. The purpose of the present work was to assess t...

The utility of animal models in preclinical research has been increasing by the availability of methods for in vivo imaging. In particular, techniques like single photon emission computed tomography (SPECT) show high potential, which is usually limited by spatial resolution. This represents an important parameter influencing scanner design, given t...

This work used Monte Carlo (MC) simulations in order to investigate the feasibility of the application of a super-resolution method, namely Super Spatial Resolution (SSR), to a preclinical SPECT system. The SSR method is used to obtain a resolution enhancement by combining several images containing slightly different perspectives of the same scene....

Prior work supports the hypothesis that ATP release through connexin hemichannels drives spontaneous Ca²⁺ signaling in non-sensory cells of the greater epithelial ridge (GER) in the developing cochlea; however, direct proof is lacking. To address this issue, we plated cochlear organotypic cultures (COCs) and whole cell-based biosensors with nM ATP...

Aim: To define the impact of rapid prototyping for surgical planning in the surgeon’s decision-making process when dealing with a very complex clinical scenario. Method & framework: A straightforward questionnaire involving four simple questions regarding specific technical aspects was administered to the surgeons to evaluate their basic judgments...

Steel slag is an industrial by-product of steel manufacturing and can be categorized into basic oxygen furnace (BOF) slag, electric arc furnace (EAF) slag, and ladle furnace (LF) slag. The world slag production is about 203 Mt while in Europe slag production is about 21.8 Mt from steel and 23.5 Mt from cast iron. Steel slag is useful in many fields...

In this paper, we describe a new single photon emission computed tomography (SPECT) device made up of two detectors (High Resolution System, HRS) integrated into a rotation structure suitable for preclinical imaging applications. The overall objective is to develop an improved scintigraphic system based on our previous detector having high spatial...

The aim of the work is to describe a new high-performance scintigraphic detector, derived from our previous work based on a Position Sensitive Photomultiplier Tube (PSPMT) with 256 output anodes. This detector is suitable for direct integration into multi-modality imaging systems. Indeed, the detector has been developed in order to be integrated in...

Purpose The sentinel lymph node (SLN) biopsy technique has highly evolved during the last 20 yr. Consequently, the intraoperative use of Gamma Probes (GPs) for SLN mapping is increased. This preliminary study evaluates a novel directional GP prototype. This proof‐of‐concept prototype is designed to identify the direction of radiopharmaceuticals upt...

The Università Campus Bio-Medico (Italy) promotes a summer volunteering work camp (Workcamp Perù) as a social activity for medical and non-medical students. Some junior doctors participate as 'clinical tutors', together with tutors from other professions; all clinical tutors have some teaching experience in our teaching hospital. The campsite is lo...