Annibale Biggeri

Annibale Biggeri
University of Florence | UNIFI · Dipartimento di Statistica, Informatica, Applicazioni "G. Parenti" (DiSIA)

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454
Publications
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Publications

Publications (454)
Article
Full-text available
Objective: To discuss the results of the KETASER01 trial and the reasons for its failure, particularly in view of future studies. Methods: KETASER01 is a multicenter, randomized, controlled, open-label, sequentially designed, non-profit Italian study that aimed to assess the efficacy of ketamine compared with conventional anesthetics in the trea...
Article
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Vinyl-chloride monomer (VCM) is classified as a known carcinogen of the liver; for lung cancer, some results suggest a potential association with polyvinyl chloride (PVC) dust. We evaluated the relationship between lung cancer mortality and exposure as PVC baggers in a cohort of workers involved in VCM production and polymerization in Porto Margher...
Article
The p-value has been widely criticized in the scientific literature for its naive use in classifying results as 'significant' and 'non significant'. Much has been written about it; for example, see the American Statistical Association position statement of march 2016. To date, few alternative measures have been suggested and few changes were observ...
Article
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Background: Asbestos exposure is a recognized risk factor for ovarian cancer and malignant mesothelioma. There are reports in the literature of geographical ecological associations between the occurrence of these two diseases. Our aim was to further explore this association by applying advanced Bayesian techniques to a large population (10 million...
Article
Background: We determined the relative contribution of decreased tumour thickness to the favourable trend in survival from cutaneous malignant melanoma (CMM) in Italy. Methods: Eleven local cancer registries covering a population of 8 056 608 (13.4% of the Italian population in 2010) provided the records of primary CMM cases registered between 2...
Article
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Numerous studies have been conducted worldwide to investigate if an association exists between meteorological factors and the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection incidence. Although research studies provide conflicting results, which can be partially explained by different methods used, some clear trends emerge on...
Article
Background Maternal exposure to air pollutants has been associated with pregnancy complications and adverse birth outcomes. Endothelial dysfunction, an imbalance in vascular function, during pregnancy is considered a key element in the development of pre-eclampsia. Environmental exposure to particulate matter (PM) during the first trimester of preg...
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In this paper, we will present an ongoing Citizen Science (CS) project in environmental epidemiology in five European countries focussing on the Italian pilot study conducted in the Serchio Valley (Tuscany). The area is rich in natural, cultural and historic significance, but it also suffers from environmental contamination from a variety of source...
Article
Currently, there are more and more requests for a characterization of the health profile by populations living in areas affected by several types of environmental contaminations, notably for the presence of previously unknown and accidentally discovered landfills. The aim of the present paper is to describe the mortality profile of the residents of...
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Undertaking citizen science research in Public Health involving human subjects poses significant challenges concerning the traditional process of ethical approval. It requires an extension of the ethics of protection of research subjects in order to include the empowerment of citizens as citizen scientists. This paper investigates these challenges...
Article
A suitable protocol for the collection, extraction, and characterization of a large quantity of a local and current fine particulate matter (PM2.5) was developed, to provide homogeneous PM2.5 amounts for use in in vitro and in vivo toxicological assays rather than a generic and obsolete standard reference material (SRM). PM2.5 samples were collecte...
Article
Politics is facing the need to make important decisions about anti-COVID-19 vaccination campaign in uncertain and changing contexts. With reference to the time frame between the administration of the first and second dose, the scientific evidence is still weak and comes from different contexts. New ways to collect and synthesize expert knowledge an...
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In a wide area among the provinces of Vicenza, Verona, and Padua (Veneto Region, Northern Italy), one of the larger known massive contamination of the environment by per- and polyfluoroalkyl substances (PFASs) occurred since the year 1965. The most important source of human exposure was through aquiferous and contaminated water supplies (the region...
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Background: Diagnosis of endometriosis and evaluation of incidence data are complex tasks because the disease is identified laparoscopically and confirmed histologically. Incidence estimates reported in literature are widely inconsistent, presumably reflecting geographical variability of risk and the difficulty of obtaining reliable data. Methods...
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Several citizen science (CS) initiatives have been adopted in environmental science to monitor air and noise pollution, and water quality related to civic concerns. Nevertheless, CS projects in environmental epidemiology remain scarce. This is because little attention has been paid to evaluate associations of environmental exposures with health eff...
Article
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Background: In the context of the COVID-19 pandemic, there is interest in assessing if per- and polyfluoroalkyl substances (PFAS) exposures are associated with any increased risk of COVID-19 or its severity, given the evidence of immunosuppression by some PFAS. The objective of this paper is to evaluate at the ecological level if a large area (Red...
Article
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Hypertensive disorders are common complications during pregnancy (HDP) with substantial public health impact. Acute and chronic particulate matter (PM) exposure during pregnancy increases the risk of HDP, although the underlying molecular mechanisms remain unclear. Extracellular vesicles (EVs) may be the ideal candidates for mediating the effects o...
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Despite a 15-year long effort to define the “safety” of fish intake during pregnancy, there remains still uncertainty on this important public health issue. The evaluation of the toxic effects of contaminants, particularly mercury (Hg) in fish-eating populations is complicated by the fact that sea-food is also rich in beneficial nutrients, such as...
Article
Background Respond to alarms for possible cancer cluster is a public health problem, but the management of these alarms is difficult and sometime conflictual. Methods We reviewed the guidelines on the management of disease clusters developed in various countries and the approaches used in previous disease cluster episodes in Tuscany. Statistical a...
Article
Background: the first confirmed cases of COVID-19 in WHO European Region was reported at the end of January 2020 and, from that moment, the epidemic has been speeding up and rapidly spreading across Europe. The health, social, and economic consequences of the pandemic are difficult to evaluate, since there are many scientific uncertainties and unk...
Article
Background: since the beginning of the COVID-19 pandemic, the importance of developing a serological test has emerged and a debate on test accuracy and reliability become an issue widely discussed in the media. The importance of communication during this pandemic has been strongly underlined by public health experts, epidemiologists, media expert,...
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Objective Thirty-four geothermal power plants for the production of electricity are currently active in the geothermal areas in Tuscany. The present study aimed to investigate the association between short-term exposure to hydrogen sulfide (H2S) and acute health outcomes.Methods This study used individual data on non-accidental, cardiovascular and...
Preprint
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Pandemias pós-normais amazonialatitude.com/2020/05/15/pandemias-pos-normais/ Condução da crise do Covid-19 evidencia necessidade de uma nova abordagem científica [RESUMO] Ao abordar as pandemias em contextos locais, a ciência nunca pareceu tão necessária e útil e, ao mesmo tempo, limitada e impotente. O contrato existente entre a ciência e a soci...
Article
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Introduction Measuring and mapping the occurrence of malignant mesothelioma (MM) is a useful means to monitor the impact of past asbestos exposure and possibly identify previously unknown sources of asbestos exposure. Objective Our goal is to decompose the observed spatial pattern of incidence of MM in the Lombardy region (Italy) in gender-specifi...
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Nell'affrontare le pandemie, la scienza non è mai apparsa più necessaria e utile, anche se al contempo limitata e impotente. L'attuale patto tra scienza e socie-tà sta cadendo a pezzi. È necessaria urgentemente una nuova alleanza per affrontare i giorni a venire. https://www.recentiprogressi.it/articoli.php?archivio=yes&vol_id=3347&id=33181 In ad...
Preprint
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Face aux pandémies passées et actuelle, notre besoin et l’utilité de la science s’affirment comme jamais, alors même que nos connaissances et capacités paraissent si insuffisantes. Le « contrat » entre science et société a besoin d’être renouvelé. Une nouvelle entente sur les rôles et les bons usages de la science devient prioritaire afin d’anticip...
Preprint
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Para enfrentar la pandemia, la ciencia nunca ha parecido más necesaria y útil, y a la vez más limitada e impotente. El contrato existente entre la ciencia y la so-ciedad se está desmoronando. Se necesita con urgencia un nuevo acuerdo para navegar el futuro próximo. Autores: David Waltner-Toews, Annibale Biggeri, Bruna De Marchi, Silvio Funtowicz,...
Preprint
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In addressing the local pandemics science has never seemed more needed and useful, while at the same time limited and powerless. The existing contract between science and society is falling apart. A new covenant is urgently needed to navigate the days ahead. Co-authors: © David Waltner-Toews, Annibale Biggeri, Bruna De Marchi, Silvio Funtowicz, Mar...
Article
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INTRODUCTION: Describing and monitoring socioeconomic inequalities in health are the prerequisite for planning equity policies. In Italy, some cities have integrated personal information from the municipal registries with Census data and with data from healthcare information systems to set up Longitudinal Metropolitan Studies (LMS). Under the coor...
Article
Objective The incidence of vulvar squamous cell carcinoma has increased for decades in most Western countries – a trend virtually restricted to women aged <50 or 60 years. In southern Europe, conversely, the trends have been insufficiently studied. This article reports a study from Italy. Method Thirty-eight local cancer registries, currently cove...
Article
Multicenter prospective observational study of people with acute traumatic spinal cord injury (TSCI) admitted to rehabilitation. To update epidemiological characteristics of a TSCI Italian population and verify the impact of patient characteristics at admission on two outcomes: functional gain (SCIM III) and discharge destination. Thirty-one SCI ce...
Article
Background: Sporadic Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disease caused by prions that is randomly distributed in all countries, with an overall yearly mortality rate of about 1-2 cases per million people. On a few occasions, however, sporadic CJD occurred with higher than expected rates, but further investigations failed t...
Article
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Background When communicating risks to the general population, the format of the epidemiological results may affect individual reactions. In environmental epidemiology, no study has compared the use of different statistical formats in communicating results to the population. The aim of this paper is to investigate whether the degree of concern expr...
Article
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To determine the acute effects on respiratory function of children exposed to sulphur dioxide (SO₂), we conducted two population-based longitudinal investigations near a major oil refinery. We enrolled 233 children, age 8⁻14, in Sarroch (Italy). The first study entailed five monthly spirometric visits (Panel 5). In a subgroup, children positive for...
Article
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Background Few studies, based on a limited number of patients using non-uniform therapeutic protocols, have analyzed Methicillin-resistant Staphylococcus aureus (MRSA) eradication. Methods In a randomized multicenter trial conducted on patients with new-onset MRSA infection we evaluated the efficacy of an early eradication treatment (arm A) compar...
Data
Variation BMI at 6 months in both arms. (XLSX)
Data
Arm B. Days in hospital and treatments. (XLS)
Data
Trial study protocol (original language). (PDF)
Data
Arm A. Days in hospital and treatments. (XLS)
Data
Variation in FEV1 at 6 months in both arms. (XLSX)
Article
Background In 1976 in Manfredonia (Italy), arsenic was released into the atmosphere due to an accident in a petrochemical plant. We aimed to analyze the mortality of workers involved in the factory for the site cleaning activities. Methods The cohort consisted of 1467 workers grouped into contract, fertilizer, and plastic workers. The outcome of i...
Article
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The different and seemingly unrelated practices of Information and Communication Technologies (ICT) used to collect and share personal and scientific data within networked communities, and the organized storage of human genetic samples and information-namely biobanking-have merged with another recent epistemic and social phenomenon, namely scientis...
Article
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Purpose The Italian Network of Longitudinal Metropolitan Studies (IN-LiMeS) is a system of integrated data on health outcomes, demographic and socioeconomic information, and represents a powerful tool to study health inequalities. Participants IN-LiMeS is a multicentre and multipurpose pool of metropolitan population cohorts enrolled in nine Itali...
Conference Paper
Introduction The association of gene expressions with exposure to ambient particulate matter (PM) concentrations is still mainly explorative. We took advantage of a study designed to evaluate the short-term association between PM exposure in working environment and biological molecular targets to assess the correlation between PM10 exposure and gen...
Article
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The outcome of stroke patients is complex and multidimensional. We evaluated the impact of acute-phase variables, including clinical state, complications, resource use and interventions, on 6-month survival after first-ever stroke, taking into account baseline conditions exerting a possible effect on outcome. As part of a National Research Program,...
Data
Antiplatelet therapy and early mobilisation in acute phase as predictors of 6-month mortality after stroke by NIHSS class of severity. Cox regression analysis adjusted for demographics, pre-stroke function, baseline diseases and risk factors, and other acute-phase variables. Total sample. (DOCX)
Article
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Aims: We aimed to improve the retention in treatment and therapeutic outcome of methadone maintenance treatment (MMT) patients by adjusting the oral methadone dose in order to reach a "target" plasma R-methadone level (80-250 ng/mL). Methods: A multicenter randomized controlled trial was organized. Results: The intention-to-treat statistical a...
Article
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Objectives This study aimed to (i) describe mesothelioma incidence in the Italian national priority contaminated sites (NPCS) on the basis of data available from the Italian National Mesothelioma Registry (ReNaM) and (ii) profile NPCS using Bayesian rank analysis. Methods Incident cases of mesothelioma and standardized incidence ratios (SIR) were e...
Conference Paper
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Fragestellung: Am 26.9.1976 passierte ein Unfall in einer Chemischen Fabrik in Manfredonia, wo Caprolactam (Plastik) und Urea (Düngemittel) produziert wurden. Mehr als 12 Tonnen von Arsen Verbindungen wurden in die Atmosphäre freigesetzt. Sowohl die Fabrik als auch die Umgebung wurden kontaminiert. Wir untersuchen die langfristigen Auswirkungen vo...
Conference Paper
Background On September 26th 1976 an accident occurred in a chemical plant located in Manfredonia (Apulia region, Italy) where Caprolactam (plastic) and Urea (fertilisers) were produced. More than 12 tons of arsenic compounds, used in the production of Urea, were released in the atmosphere, contaminating the plant and surrounding areas. Our study i...
Article
Introduction: Exposure to particulate matter with diameter ≤10 μm (PM10) entails well documented adverse effects on human health. In the last decade, concentration of PM10 in Lombardy (10 million inhabitants), Italy, has been gradually decreasing. We evaluated how the mortality burden due to PM10 varied in that same period. Methods: We focused o...
Article
The objective of the study is to analyze the variation of adverse events (AEs) according to the different structure of hospitals. The study is a multicenter, retrospective study. It involves 4 teaching hospitals (THs) and 32 community hospitals, distributed in 12 local trusts (LTs), of the Tuscany Regional Healthcare Service (RHS). A random sample...
Article
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Introduction: This paper reports the experience of a participatory project in environmental epidemiology, formally initiated in 2015 and still underway, in Manfredonia, southern Italy. We provide some background information and justification for our choice of a participatory model of investigation, and summarize the antecedents to our involvement,...
Article
Participatory approaches to environmental research and decision-making require that all social stakeholders are involved from the onset of the debate. In such a setting, communication among different expertise is crucial, but language and technicalities may represent a barrier. In the clinical setting, decisions regarding treatment preferences may...
Article
Objectives: To quantify the contribution of each individual month to the annual mortality burden attributable to particulate matter (PM) in 2015 in Milan, Italy, after authorities and media considered December 2015 as an outlying month carrying an exceptional population exposure to PM. Study design: We used routinely available daily time series...
Article
OBJECTIVES: to evaluate the health status of the residents in the Manfredonia municipality (Apulia Region, Southern Italy) in the period 1970-2013. DESIGN: ecological study on general and cause-specific mortality by gender, age-class, calendar period, and birth cohort. SETTINGS AND PARTICIPANTS: demographic and mortality data came from the Italian...
Article
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Objectives: Surgery for vascular anomalies can occasionally fail to relieve symptoms, especially when severe tracheobronchial malacia persists. We studied outcomes in children who underwent airway stenting for severe post-surgical airway malacia and tested known clinical and surgical prognostic factors. Methods: Among 257 children evaluated for...
Conference Paper
ntroduction On 26th September 1976 an accident in a petrochemical plant in Manfredonia (Province of Foggia, Apulia Region, Southern Italy) resulted in a release of several tons of arsenic compounds. A population of about 57,000 inhabitants was exposed. The accident followed by two months that of Seveso and both contributed to the European Directive...
Article
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OBJECTIVES: to evaluate the health status of the residents in the Manfredonia municipality (Apulia Region, Southern Italy) in the period 1970-2013. DESIGN: ecological study on general and cause-specific mortality by gender, age-class, calendar period, and birth cohort. SETTINGS AND PARTICIPANTS: demographic and mortality data came from the Italian...