Annette Fromm

Annette Fromm
Haukeland University Hospital · Department of Neurology

MD, PhD

About

52
Publications
4,420
Reads
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260
Citations
Additional affiliations
July 2015 - December 2018
Haukeland University Hospital
Position
  • PostDoc Position
September 2011 - November 2014
University of Bergen
Position
  • PhD cancidate
August 2010 - present
Haukeland University Hospital
Position
  • Neurologist

Publications

Publications (52)
Article
Full-text available
Objectives We studied the prevalence of vascular risk factors (RFs) among 385 ischaemic stroke patients ⩽60 years and 260 controls, and their association with atherosclerosis in seven vascular areas. Methods History of cardiovascular events (CVE), hypertension, diabetes mellitus (DM), dyslipidaemia, pack-years of smoking (PYS), alcohol, and physic...
Article
Background Tenecteplase is a modified tissue plasminogen activator with pharmacological and practical advantages over alteplase—which is currently the only approved thrombolytic drug for ischaemic stroke. The NOR-TEST trial showed that 0·4 mg/kg tenecteplase had an efficacy and safety profile similar to that of a standard dose (0·9 mg/kg) of altepl...
Article
Objectives We examined the association between obesity and early-onset cryptogenic ischemic stroke (CIS) and whether fat distribution or sex altered this association. Materials and Methods This prospective, multi-center, case-control study included 345 patients, aged 18-49 years, with first-ever, acute CIS. The control group included 345 age- and...
Article
Full-text available
Background and Objectives There is a worldwide increase in the incidence of stroke in young adults, with major regional and ethnic differences. Advancing knowledge of ethnic and regional variation in causes and outcomes will be beneficial in implementation of regional healthcare services. To study the global distribution of risk factors, causes and...
Article
Full-text available
Objectives We studied the prevalence of atherosclerosis among ischaemic stroke patients ≤60 years and controls at the time of the index stroke, and its association with occurrence of new cardiovascular events (CVEs) and mortality at a 5-year follow-up. Methods Prevalent atherosclerosis was assessed for 385 patients and 260 controls in seven vascul...
Article
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The impact of age and 24-h ambulatory blood pressure (ABPM) on arterial stiffness and carotid intima-media thickness (cIMT) in ischemic stroke patients younger than 60 years of age is poorly explored. A total of 385 acute ischemic stroke patients (aged 49.6±9.7 years, 68% men) were prospectively included and grouped in younger (15–44 years, n = 93...
Article
Full-text available
Background: Carotid artery atherosclerosis is a major risk factor for ischemic stroke. This risk is related to plaque vulnerability and is characterized by plaque morphology, intraplaque neovascularization, and cerebral microembolization. Advanced neurosonology can identify vulnerable plaques and aid in preventing subsequent stroke. We aimed to ass...
Article
Full-text available
Objectives We aimed to assess frequencies and radiological aspects of single- and multiterritory clinical manifestation among patients with acute cerebral infarcts in multiple arterial territories (MACI). Materials & methods We retrospectively reviewed admission records and diffusion-weighted magnetic resonance imaging of patients with MACI admitt...
Article
Rationale: Cerebrovascular diseases associated with pregnancy and postpartum period are uncommon; however, they can have an important impact on health of both women and foetus or newborn. Aims: To evaluate the frequency, characteristics and management of cerebrovascular events in pregnant/postpartum women, to clarify pathophysiological mechanism...
Article
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Introduction Worldwide, 2 million patients aged 18–50 years suffer a stroke each year, and this number is increasing. Knowledge about global distribution of risk factors and aetiologies, and information about prognosis and optimal secondary prevention in young stroke patients are limited. This limits evidence-based treatment and hampers the provisi...
Article
Background: Young and middle-aged ischemic stroke survivors have a high prevalence of hypertension, increased arterial stiffness and abnormal left ventricular (LV) geometry, which all are associated with the presence of LV diastolic dysfunction. However, the prevalence and covariates of diastolic dysfunction in these patients have not been reporte...
Article
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Background and purpose: Microembolic signals (MES) are detectable by transcranial Doppler monitoring and associated with increased risk of first or recurrent ischemic stroke. MES detection can also illuminate stroke etiology and the effect of prophylactic treatment. MES detection cannot accurately distinguish between stroke-related microemboli and...
Article
Background and Purpose— Patients with acute cerebral infarcts in multiple arterial territories (MACI) represent a substantial portion of the stroke population. There are no data on short-term outcome and in-hospital complications in patients with MACI. We compared patients with MACI with patients having acute cerebral infarct(s) in a single arteria...
Article
Full-text available
Introduction: Norwegian Stroke in the Young Study (NOR-SYS) is a three-generation research program of young ischaemic stroke. In this study, we assessed ischaemic stroke incidence, education and work status among young stroke patients. Furthermore, we evaluated the participation of family members for future validated information on hereditary card...
Article
Full-text available
Background: The utility of incorporating both diffusion information and T2 relaxation times in the imaging work-up of stroke patients is being investigated in a number of clinical trials and scientific studies. However, these tissue characteristics are often determined both qualitatively and independent of each other. Purpose: To investigate the fe...
Article
Background: Hypertension is highly prevalent in ischemic stroke patients, but less is known about its impact on subclinical left ventricular (LV) dysfunction in such patients. Methods: Conventional and speckle tracking echocardiography was performed in 276 young (15-44 years) and middle-aged (45-60 years) ischemic stroke patients (mean age 50 ±...
Article
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Contrast-enhanced sonothrombolysis (CEST) seems to be a safe and promising treatment in acute ischemic stroke. It remains unknown if temporal bone features may influence the efficacy of CEST. We investigated the association between different temporal bone features on admission computed tomography (CT) scan and the outcome in acute ischemic stroke p...
Poster
Full-text available
Background and Aims: The etiology of multiple acute cerebral infarcts in more than one arterial territory (MACI) is in most cases associated with cardioembolism. However, the presence of cancer should always be considered as a possible underlying mechanism due to its procoagulant activity. We sought to investigate if MACI are more frequent in patie...
Article
Background: Abnormal left ventricular (LV) geometry types, like LV hypertrophy (LVH) and concentric remodelling, are independently associated with impaired prognosis in hypertension. Little is known about the prevalence and covariables of abnormal LV geometry types in younger ischemic stroke patients. Methods: We used clinical and echocardiograp...
Article
Purpose: Hypertension is the most important modifiable risk factor for stroke. Few data are available on control of hypertension in younger ischemic stroke survivors. Material and methods: We assessed clinic and ambulatory blood pressure (BP) measurements in 320 patients aged 15–60 years (mean 48 ± 10) included in the Norwegian Stroke in the Young...
Article
The treatment options for acute ischemic stroke are rapidly improving, and there is high awareness for community-onset stroke, pre-hospital pathways and streamline in-hospital management. However, the management of in-hospital stroke is often less well established, and stringent procedures are frequently missing. Higher rates of in-hospital complic...
Article
Full-text available
Background and purpose: Positive family history (FH+) of cardiovascular disease (CVD) is a risk factor for own CVD. We aimed to analyze the effect of different types of FH (stroke, coronary heart disease (CHD), peripheral artery disease (PAD) on carotid intima-media thickness (cIMT) in young and middle-aged ischemic stroke patients. Methods: Fir...
Conference Paper
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The European Master in Stroke Medicine (EMSM) is a postgraduate programme which covers all areas of cerebrovascular diseases and is provided by a faculty of leading European experts. The program is organized by the ESO and endorsed by the WSO. Currently on its fifth intake, the programme aims to establish evidence based knowledge standards of strok...
Article
Background: Masked hypertension (MHT) is characterized by normal clinic blood pressure (BP), but elevated ambulatory BP has been associated with a higher prevalence of cardiovascular organ damage. Methods: We assessed the prevalence and characteristics of MHT in 298 ischemic stroke patients aged 15-60 years. High-normal office BP was considered...
Article
Background: Ischemic stroke patients subtyped as of undetermined cause (SUC) usually outnumber those with determined cause subtypes. Etiological stroke classifications may lead to neglect of parallel, noncausative findings. Atherosclerosis progresses over decades and is associated with high morbidity and mortality in young stroke patients in long-...
Article
Abnormal night-time blood pressure (BP) reduction is associated with increased cardiovascular risk in hypertension. Little is known about the prevalence and covariates of night-time BP reduction in ischemic stroke patients. Clinic and ambulatory BP measurements were recorded in 268 stroke survivors aged 15-60 years. The degree of night-time dipping...
Article
Full-text available
Family history (FH) is a risk factor for cardiovascular disease, especially coronary artery disease (CAD). The impact on risk of stroke is less clear. This study investigated young and middle-aged ischemic stroke patients' knowledge on FH of stroke, CAD, and peripheral artery disease (PAD) with a special regard to sex differences. From September 20...
Article
Full-text available
Family history (FH) is used as a marker for inherited risk. Using FH for this purpose requires the FH to reflect true disease in the family. The aim was to analyse the concordance between young and middle-aged ischaemic stroke patients' reported FH of cardiovascular disease (CVD) with their parents' own reports. Ischaemic stroke patients aged 15-60...
Article
Full-text available
Objective: Our aim was to compare the clinical characteristics including risk factors, comorbidities, short-term outcome and long-term mortality in acute ischemic stroke patients with or without diabetes mellitus. Methods: This study includes all consecutive patients with acute ischemic stroke admitted to the Stroke Unit, Department of Neurology, H...
Article
Full-text available
Age dependency of acute ischaemic stroke aetiology and vascular risk factors have not been adequately evaluated in stroke patients in Norway. Aims of this study were to evaluate how stroke subtypes and vascular risk factors vary with age in a western Norway stroke population. Patients aged 15-100 years consecutively admitted to our neurovascular ce...
Article
Lack of nightly blood pressure (BP) reduction is associated with increased cardiovascular risk. The aim of this study was to assess the association of nightly BP reduction with arterial stiffness in young and middle-aged ischemic stroke patients.(Figure is included in full-text article.) DESIGN AND METHOD:: Clinic and ambulatory BP measurements wer...
Article
Full-text available
Ischemic stroke survivors have high risk of cardiovascular morbidity and mortality even at young age, suggesting that early arterial aging is common among such patients. We measured aortic stiffness by carotid-femoral pulse wave velocity (PWV) in 205 patients (69% men) aged 15-60 years with acute ischemic stroke in the prospective Norwegian Stroke...
Article
Full-text available
Vascular morbidity and mortality due to cardiovascular disease (CVD) are high after ischemic stroke at a young age. Data on carotid intima-media thickness (cIMT) as marker of atherosclerosis are scarce for young stroke populations. In this prospective case-control study, we examined cIMT, the burden of vascular risk factors (RF) and their associati...
Article
Full-text available
Ultrasound contrast agents (UCA) salvage a considerable number of transcranial Doppler (TCD) exams which would have failed because of poor bone window. UCA bolus injection causes an undesirable increase in measured blood flow velocity (BFV). The effect of UCA continuous infusion on measured BFV has not been investigated, and some in vitro experimen...
Article
Background: Individual assessment of rupture risk of cerebral aneurysms is challenging, and increased knowledge of predictors for aneurysm rupture is needed. Smoking and hypertension are shared risk factors for atherosclerotic disease and cerebral aneurysms, and patients with atherosclerosis have an increased prevalence of intracranial aneurysms....
Article
Full-text available
Background: Ischemic stroke in young adults is a major health problem being associated with a higher vascular morbidity and mortality compared to controls, and a stroke recurrence rate of 25% during the first decade. The assumed cause of infarction and the detected risk factors determine the early- and long-term treatment. However, for many patien...
Article
Mild cognitive impairment (MCI) is a subtle memory disorder not matching criteria for dementia. There is evidence for vascular comorbidity in several types of dementia. We hypothesized that neurovascular workup would detect a high degree of vascular disease in patients with MCI. In cooperation with our memory clinic, patients with amnestic MCI were...
Article
Full-text available
To assess the frequency of females and males aged ≤ 30 years with cerebral infarction in two different time periods. All patients aged ≤ 30 years with arterial cerebral infarction in 1988-1997 and 2006-2010 admitted to Haukeland University Hospital in Bergen, Norway, were included. Risk factors and etiology were assessed. Between 1988 and 1997, 16...
Article
Full-text available
Introduction. Young adults are likely to differ from old patients concerning cerebral infarction. Methods. We compared characteristics of patients aged under and above 50 years, admitted to the Department of Neurology with cerebral infarction between 2006 and 2009, based on prospective registration. Investigation followed one common protocol for bo...
Article
Full-text available
Die vorliegende Arbeit befasst sich mit der durchflusszytometrischen Analyse der Aktivität von Thrombozyten innerhalb eines gesunden Probandenkollektivs. Sie soll die Frage klären, inwiefern eine Grundaktivierung der thrombozytären Gerinnung auch bei Personen ohne wesentliche Risikofaktoren, wie z.B. hämodynamisch relevante Karotisstenosen, vorlieg...

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Projects

Projects (2)
Project
Norwegian Stroke in the Young Study