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Anneliese Synnot

Anneliese Synnot
La Trobe University and Monash University, Melbourne, Australia

About

96
Publications
35,866
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4,851
Citations
Additional affiliations
September 2015 - present
Monash University (Australia)
Position
  • Research Associate
October 2010 - present
La Trobe University
Position
  • Research Associate

Publications

Publications (96)
Article
Full-text available
Background Guideline developers are encouraged to engage patients, carers and their representatives (‘consumers’) from diverse backgrounds in guideline development to produce more widely applicable guidelines. However, consumers from diverse backgrounds are infrequently included in guidelines and there is scant research to support guideline develop...
Article
Introduction The incidence of traumatic brain injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in ol...
Article
Knowledge user consultation is often limited or omitted in the conduct of scoping reviews. Not including knowledge users within the conduct and reporting of scoping reviews could be due to a lack of guidance or understanding about what consultation requires and the subsequent benefits. Knowledge user engagement in evidence synthesis, including cons...
Chapter
Systematic reviewsSystematic reviews are difficult to keep up to date, but failure to do so leads to poor review currency and accuracy. “Living systematic reviewSystematic reviews” (LSR) is an approach that aims to continually update a review, incorporating relevant new evidence as it becomes available. LSRs may be particularly important in fields...
Article
Full-text available
Background: Health researchers and funders are increasingly consulting with stakeholders to set their research agendas but these activities are rarely evaluated. The Cochrane Consumers and Communication Group (CCCG) conducted a priority-setting project for systematic reviews in partnership with stakeholders (consumers/patients, health professional...
Article
Full-text available
Background: Stakeholder engagement has become widely accepted as a necessary component of guideline development and implementation. While frameworks for developing guidelines express the need for those potentially affected by guideline recommendations to be involved in their development, there is a lack of consensus on how this should be done in p...
Article
Full-text available
Background: Research priority setting with stakeholders can help direct the limited resources for health research toward priority areas of need. Ensuring transparency of the priority setting process can strengthen legitimacy and credibility for influencing the research agenda. This study aims to develop a reporting guideline for priority setting o...
Preprint
Full-text available
Background Research priority setting with stakeholders can help direct the limited resources for health research toward priority areas of need. Ensuring transparency of the priority setting process can strengthen legitimacy and credibility for influencing the research agenda. This study aims to develop a reporting guideline for priority setting of...
Article
Full-text available
Background: Living systematic reviews (LSRs) offer an approach to keeping high-quality evidence synthesis continually up to date, so the most recent, relevant and reliable evidence can be used to inform policy and practice, resulting in improved quality of care and patient health outcomes. However, they require modifications to authoring and edito...
Preprint
Background Research priority setting with stakeholders can help direct the limited resources for health research toward priority areas of need. Ensuring transparency of the priority setting process can strengthen legitimacy and credibility for influencing the research agenda. This study aims to develop a reporting guideline for priority setting of...
Preprint
Background Research priority setting with stakeholders can help direct the limited resources for health research toward priority areas of need. Ensuring transparency of the priority setting process can strengthen legitimacy and credibility for influencing the research agenda. This study aims to develop a reporting guideline for priority setting of...
Article
The mortality of traumatic brain injury (TBI) has been largely static despite advances in monitoring and imaging techniques. Substantial variance exists in outcome, not fully accounted for by baseline characteristics or injury severity, and genetic factors likely play a role in this variance. The aims of this systematic review were to examine the e...
Article
Full-text available
Stakeholder engagement is increasingly common in health research, with protocols for engaging multiple stakeholder groups becoming normative in patient-centered outcomes research. Previous work has focused on identifying relevant stakeholder groups with whom to work and on working with stakeholders in evidence implementation. This paper draws on th...
Article
Full-text available
Background There is increasing recognition that it is good practice to involve stakeholders (meaning patients, the public, health professionals and others) in systematic reviews, but limited evidence about how best to do this. We aimed to document the evidence-base relating to stakeholder involvement in systematic reviews and to use this evidence t...
Article
Full-text available
Objectives Involvement of patients, health professionals, the public and others (defined as ‘stakeholders’) is beneficial to the quality, relevance and impact of research and may enhance the usefulness and uptake of systematic reviews. However, there is a lack of evidence and resources to guide the authors of systematic reviews in how they can acti...
Article
Background: There is increasing recognition that it is good practice to involve stakeholders (meaning patients, the public, health professionals, and others) in systematic reviews, but limited evidence about how best to do this. We aimed to document the evidence-base relating to stakeholder involvement in systematic reviews, and to use this evidenc...
Conference Paper
Full-text available
Background: Involvement of patients, health professionals, the public and others (stakeholders) is beneficial to the quality, relevance and impact of research and may enhance the usefulness and uptake of systematic reviews. However there is a lack of evidence and resources to guide the authors of systematic reviews in how they can actively involve...
Conference Paper
Full-text available
Background: There is increasing recognition that it is good practice to involve patients, health professionals, the public and others (stakeholders) in systematic reviews, but limited evidence about how best to do this. Objectives: We aimed to document the evidence-base relating to stakeholder involvement in systematic reviews, and to use this evi...
Article
Full-text available
Objective To appraise the currency, completeness and quality of evidence from systematic reviews (SRs) of acute management of moderate to severe traumatic brain injury (TBI). Methods We conducted comprehensive searches to March 2016 for published, English-language SRs and RCTs of acute management of moderate to severe TBI. Systematic reviews and R...
Data
(Itemised systematic review quality assessment scores). (DOCX)
Data
(Key excluded systematic reviews, with reasons). (DOCX)
Article
This paper describes the people, activities and methods of consumer engagement in a complex research project, and reflects on the influence this had on the research and people involved, and enablers and challenges of engagement. The 2.5-year Integrating and Deriving Evidence Experiences and Preferences (IN-DEEP) study was conducted to develop onlin...
Article
There is a growing literature on the impact of genetic variation on outcome in traumatic brain injury (TBI). Whereas a substantial proportion of these publications have focused on the apolipoprotein E (APOE) gene, several have explored the influence of other polymorphisms. We undertook a systematic review of the impact of single-nucleotide polymorp...
Article
There is a growing literature on the impact of genetic variation on outcome in traumatic brain injury (TBI). While a substantial proportion of these publications have focused on the Apolipoprotein E (APOE) gene, several have explored the influence of other polymorphisms. We undertook a systematic review of the impact of single nucleotide polymorphi...
Article
Full-text available
Objective To identify research priorities of consumers and other stakeholders to inform Cochrane Reviews in ‘health communication and participation’ (including such concepts as patient experience, shared decision-making and health literacy). Setting International. Participants We included anyone with an interest in health communication and partic...
Article
Objective: Inappropriate use of pain medication has serious consequences for older populations. Experts in the field have noted an increase in opioid prescriptions, and opioid-related hospitalisations and deaths among this vulnerable population. In the pursuit of educating pharmacists, physicians, allied healthcare professionals, researchers, acad...
Article
Full-text available
Background and Aims In earlier work, we identified that people affected by multiple sclerosis (MS) can have difficulty finding online treatment information that is up to date, trustworthy, understandable, and applicable to personal circumstances, but does not provoke confusion or negative emotional consequences. The objective was to develop online...
Article
Full-text available
A concerted effort to tackle the global health problem posed by traumatic brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insufficiently recognised, proportions. Worldwide, more than 50 million people have a TBI each year, and it is estimated that about half the world’s population will have one or more TBIs over th...
Article
A concerted effort to tackle the global health problem posed by traumatic brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insufficiently recognised, proportions. Worldwide, more than 50 million people have a TBI each year, and it is estimated that about half the world's population will have one or more TBIs over th...
Article
Background: Skeletal muscle spasticity is a major physical complication resulting from traumatic brain injury (TBI), which can lead to muscle contracture, joint stiffness, reduced range of movement, broken skin and pain. Treatments for spasticity include a range of pharmacological and non-pharmacological interventions, often used in combination. M...
Article
A concerted e ort to tackle the global health problem posed by traumatic brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insu ciently recognised, proportions. Worldwide, more than 50 million people have a TBI each year, and it is estimated that about half the world’s population will have one or more TBIs over their...
Article
Accurate diagnosis of traumatic brain injury (TBI) is critical to effective management and intervention, but can be challenging in patients with mild TBI. A substantial number of studies have reported the use of circulating biomarkers as signatures for TBI, capable of improving diagnostic accuracy and clinical decision-making beyond current practic...
Article
Full-text available
Background: Anticoagulation may improve survival in patients with cancer through a speculated anti-tumour effect, in addition to the antithrombotic effect, although may increase the risk of bleeding. Objectives: To evaluate the efficacy and safety of parenteral anticoagulants in ambulatory patients with cancer who, typically, are undergoing chem...
Article
A living systematic review (LSR) should keep the review current as new research evidence emerges. Any meta-analyses included in the review will also need updating as new material is identified. If the aim of the review is solely to present the best current evidence standard meta-analysis may be sufficient, provided reviewers are aware that results...
Article
Full-text available
Background: No definitive evidence exists on how intracranial hypertension should be treated in patients with traumatic brain injury (TBI). It is therefore likely that centers and practitioners individually balance potential benefits and risks of different intracranial pressure (ICP) management strategies, resulting in practice variation. The aim...
Article
Systematic reviews are difficult to keep up to date, but failure to do so leads to a decay in review currency, accuracy and utility. We are developing a novel approach to systematic review updating we term 'living systematic review' (LSR): systematic reviews which are continually updated, incorporating relevant new evidence as it becomes available....
Article
Full-text available
New approaches to evidence synthesis, which utilise human effort and machine automation in mutually reinforcing ways, can enhance the feasibility and sustainability of living systematic reviews. Human effort is a scarce and valuable resource, required when automation is impossible or undesirable, and includes contributions from online communities (...
Article
Background: Producing high-quality, relevant systematic reviews and keeping them up to date is challenging. Cochrane is a leading provider of systematic reviews in health. For Cochrane to continue to contribute to improvements in heath, Cochrane Reviews must be rigorous, reliable and up to date. We aimed to explore existing models of Cochrane Revie...
Article
Objective: This systematic review aimed to determine the effect of prehospital notification systems for major trauma patients on overall (< 30 days) and early (< 24 hours) mortality, hospital reception and trauma team presence (or equivalent) on arrival, time to critical interventions and length of hospital stay. Methods: Experimental and observ...
Article
Full-text available
Plain English Summary Researchers are expected to actively involve stakeholders (including patients, the public, health professionals, and others) in their research. Although researchers increasingly recognise that this is good practice, there is limited practical guidance about how to involve stakeholders. Systematic reviews are a research method...
Article
BACKGROUND: The Glasgow Coma Scale (GCS) characterizes patients with diminished consciousness. In a recent systematic review, we found overall adequate reliability across different clinical settings, but reliability estimates varied considerably between studies, and methodological quality of studies was overall poor. Identifying and understanding f...
Article
Full-text available
Background Concussion is common in the sporting arena and is often challenging to diagnose. The development of wearable head impact measurement systems has enabled measurement of head kinematics in contact sports. Objectives The objective of this systematic review was to determine the characteristics of head kinematics measured by an accelerometer...
Article
Although major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) are prevalent after traumatic brain injury (TBI), little is known about which patients are at risk for developing them. The authors systematically reviewed the literature on predictors and multivariable models for MDD and PTSD after TBI. The authors included 26 observ...
Article
Background: Barriers to access and long-term complications remain a challenge in transplantation. Further advancements may be achieved through research priority setting with patient engagement to strengthen its relevance. We evaluated research priority setting in solid organ transplantation and described stakeholder priorities. Methods: Database...
Article
Full-text available
Knowledge translation resources that summarise and disseminate systematic review findings can support evidence into policy and practice. Since 2007, we have produced Evidence Bulletins; brief, web-based summaries of Cochrane Reviews published by Cochrane Consumers and Communication. Evidence Bulletins are designed for health decision makers employe...
Article
Full-text available
The update search identified 6 new included studies (see Table 2). Two new papers reported incidence rates, which were derived from data obtained in Sweden (5) and Poland (4). These newly reported incidence rates were similar to those found in the original review; ranging from 126 to 230 per 100,000 population per year (see Table 3). Mortality rate...
Article
Traumatic Brain Injury (TBI) results frequently triggers in failure a disruption of cerebral autoregulation. The cerebral perfusion pressure (CPP) at which autoregulation is optimal (“CPPopt”) varies between individuals, and can be calculated based on fluctuations between arterial blood pressure and intracranial pressure. This review assesses the e...
Technical Report
Full-text available
Cochrane review summary: In this Cochrane systematic review, Anneliese Synnot and colleagues sought to answer: Does audiovisual presentation of information for informed consent for participation in clinical trials improve outcomes related to the informed consent process? What is audiovisual presentation of information for informed consent? Informed...
Article
Full-text available
Background People with multiple sclerosis (MS) are increasingly using the Internet in the daily management of their condition. They search for high-quality information in plain language, from independent sources, based on reliable and up-to-date evidence. The Integrating and Deriving Evidence, Experiences and Preferences (IN-DEEP) project in Italy...
Technical Report
Full-text available
Cochrane review summary In this Cochrane systematic review, Jessica Kaufman and colleagues sought to answer: Do face to face education interventions targeting parents about early childhood vaccinations change vaccination rates, knowledge and attitudes towards vaccinations and vaccine-preventable diseases? What are face to face information and educa...
Technical Report
Full-text available
This Evidence Bulletin summarises a Cochrane systematic review. In a systematic review the researchers aim to locate, quality appraise and synthesise all of the available evidence related to a specific research question. Cochrane review authors adopt rigorous methods to minimise bias as a way of producing reliable findings with the ultimate goal of...
Article
Full-text available
Background: Children with disability engage in less physical activity compared to their typically developing peers. Our aim was to explore the barriers and facilitators to participation in physical activity for this group. Methods: Ten focus groups, involving 63 participants (23 children with disability, 20 parents of children with disability an...
Article
Moderate to severe traumatic brain injury (TBI) remains a major global challenge, with rising incidence, unchanging mortality and lifelong impairments. State-of-the-science reviews are important for research planning and clinical decision support. This review aimed to identify randomised controlled trials (RCTs) evaluating interventions for acute m...
Article
Background: A growing literature describes the participation of children with disability, but less is known about the effect of disability type, severity and environmental factors on participation. Aim: To investigate the extent, context, experience and preferences for participation in out-of-school activities among children with disability in V...
Article
Introduction: The Glasgow Coma Scale (GCS) provides a structured method for assessment of the level of consciousness. Its derived sum score is applied in research and adopted in intensive care unit scoring systems. Controversy exists on the reliability of the GCS. The aim of this systematic review was to summarize evidence on the reliability of th...