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Anne-Sophie Vignion

Anne-Sophie Vignion

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54
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Publications

Publications (54)
Article
Full-text available
Glioblastomas (GBMs) are high-grade malignancies with a poor prognosis. The current standard of care for GBM is maximal surgical resection followed by radiotherapy and chemotherapy. Despite all these treatments, the overall survival is still limited, with a median of 15 months. For patients harboring inoperable GBM, due to the anatomical location o...
Article
Full-text available
Photodynamic therapy (PDT) appears to be a promising strategy in biomedical applications. However, the complexity of its parameters prevents wide acceptance. This work presents and characterizes a novel optical device based on knitted light-emitting fabrics and dedicated to in vitro PDT involving low irradiance over a long illumination period. Tech...
Article
Background : Interstitial photodynamic therapy (iPDT), inserting optical fibers inside brain tumors, has been proposed for more than 30 years. While a promising therapeutical option, it is still an experimental treatment, with different ways of application, depending on the team performing the technique. Objective : In this systematic review, we r...
Article
Full-text available
Surgical treatment is standard for the treatment of small breast cancers. Due to the pain and esthetic sequelae that can follow surgery, minimally invasive treatments are under investigation. Our aim was to conduct a dosimetry study of laser interstitial thermotherapy. Turkey tissue was used as an ex vivo model, and mammary glands from ewes were us...
Article
Full-text available
Background: Epithelial ovarian cancers (EOC) are usually diagnosed at an advanced stage and managed by complete macroscopic cytoreductive surgery (CRS) and systemic chemotherapy. Peritoneal recurrence occurs in 60% of patients and may be due to microscopic peritoneal metastases (mPM) which are neither eradicated by surgery nor controlled by system...
Article
Topical photodynamic therapy (PDT) is widely used to treat non melanoma skin cancers. It consists of topically applying on the skin lesions a cream containing a prodrug (5-aminolevulinic acid (5-ALA) or methyl aminolevulinate (MAL)) that is then metabolized to the photosensitizer protoporphyrin IX (PpIX). Light irradiation at PpIX excitation wavele...
Article
Full-text available
A homogeneous and reproducible fluence rate delivery during clinical PDT (PhotoDynamic Therapy) plays a determinant role in preventing under‐ or overtreatment. The development of a flexible light source able to generate uniform light on all its surface would considerably improve the homogeneity of light delivery. The integration of plastic optical...
Article
An actinic keratosis (AK) is an area (lesion) of sun‐damaged skin, mainly found on sun‐exposed parts of the body, particularly the forearms, backs of the hands, face, ears, bald scalp and the lower legs. Left untreated, there is a small risk that an AK could progress into a form of skin cancer called squamous cell carcinoma. One way of treating AK...
Article
光化性角化症 (AK) 是指主要在身体曝光部位(尤其是前臂、手背、面部、耳部、光头头皮和小腿)发现的晒伤皮肤区域。若未经治疗,AK 可能进展成为一种名为鳞状细胞癌的皮肤癌,但这一变化的风险较低。 治疗 AK 的一种方法称为光动力疗法 (PDT)。使用 PDT 治疗 AK 的常用或常规方案称为 C‐PDT。它需要在皮肤上涂抹感光的乳膏,该乳膏随后约 2.5 小时会被高强度红光激活。这会在皮肤上引发严重的炎症, 但只会破坏异常(而非正常)的皮肤组织。 C‐PDT 的主要缺陷是患者在治疗期间会经历疼痛。由于这种疼痛, 许多患者无法完成治疗。这项研究的作者来自法国和德国, 他们拟定了一项新 AK PDT 治疗方案, 称为 P‐PDT。 P‐PDT 涉及改良后的红光激活: 光强度已显著降低, 而且在分...
Article
Photodynamic therapy (PDT) using daylight as the photoactivating light source requires weather conditions and temperature to be suitable for effective treatment and for patients to stay comfortably outdoors. In order to get rid of such requirements, artificial white light sources have been proposed as photoactivating alternatives to daylight, parti...
Article
Full-text available
Background Topical photodynamic therapy (PDT) using methyl aminolevulinate is a non‐invasive treatment option suitable to treat clinical and subclinical actinic keratosis (AK) over a large area (field cancerization). The most widely used, conventional protocol in Europe includes illumination with a red‐light lamp. This illumination commonly causes...
Article
日光性角化病 (AK) 是指主要在身体曝光部位(尤其是手和前臂背侧、面部和耳部以及光头男性头皮)发现的晒伤皮肤区域。它们通常是无害的,但可能不美观或带来不便,一些日光性角化病有进展成为鳞状细胞癌(一种皮肤癌)的极轻微风险。有若干可能的治疗,包括光动力疗法 (PDT),在此方法中,首先在受影响的皮肤区域涂敷称为光敏剂的乳膏,然后使用一种特殊光线将其激活。此疗法可杀灭皮肤中的异常细胞。欧洲批准用于 AK PDT 的光敏剂需要在施用光敏剂后 3 小时通过红光激活(称为 C‐PDT)或在施用光敏剂后 30 分钟内通过日光激活(称为 D‐PDT)。C‐PDT 的主要不足是治疗中疼痛,而 D‐PDT 由于施用光敏剂和日光激活的间隔时间短,因此几乎无痛。遗憾的是,D‐PDT 需要良好的气候条件。因此,来自...
Article
Actinic keratoses (AKs) are areas of sun‐damaged skin found mainly on sun‐exposed parts of the body, particularly the backs of the hands and forearms, the face and ears, and the scalp in balding men. They are usually harmless although they can be unsightly or inconvenient, and there is a very small risk of some actinic keratoses progressing to a fo...
Article
Full-text available
Background: There is currently no therapy that prevents high-grade glioma recurrence. Thus, these primary brain tumors have unfavorable outcomes. Recently, 5-ALA photodynamic therapy (PDT) has been proposed to delay relapse and is highly expected to have potential synergistic effects with the current standard of care. However, PDT treatment delive...
Preprint
Full-text available
BACKGROUND Actinic keratosis (AK) is a common precancerous skin lesion caused by long-term sun exposure and usually develops on sun-exposed skin areas. Left untreated, AK may progress to squamous cell carcinoma. In order to prevent such risk, most clinicians routinely treat AK. Therapy options for AK include cryotherapy, topical treatments, curetta...
Article
Full-text available
Background: Actinic keratosis (AK) is a common early in situ skin carcinoma caused by long-term sun exposure and usually develops on sun-exposed skin areas. Left untreated, AK may progress to squamous cell carcinoma. To prevent such risk, most clinicians routinely treat AK. Therapy options for AK include cryotherapy, topical treatments, curettage,...
Article
Full-text available
Background Topical photodynamic therapy is an established treatment modality for various dermatological conditions, including actinic keratosis. In Europe, the approved protocols for photodynamic therapy of actinic keratosis involve irradiation with either an Aktilite CL 128 lamp or daylight, whereas irradiation with the Blu‐U illuminator is approv...
Article
Full-text available
Background: Topical photodynamic therapy (PDT) is an established treatment modality for various dermato-oncologic conditions. In Europe, initially requiring irradiation with red light, PDT of actinic keratosis (AK) can now also be carried out with exposure to daylight that has been clinically proven to be as effective as and less painful than red...
Article
Full-text available
Objective and Study Design Photodynamic therapy (PDT) is an emerging treatment modality for various diseases, especially for dermatological conditions. Although, the standard PDT protocol for the treatment of actinic keratoses in Europe has shown to be effective, treatment‐associated pain is often observed in patients. Different modifications to th...
Article
Complete and homogeneous illumination of the target is necessary for the success of a photodynamic therapy (PDT) procedure. In most applications, light dosimetry is done using detectors placed at strategic locations of the target. In this study we propose a novel approach based on the combination of light distribution modeling with spatial localiza...
Article
Background: Glioblastoma is a high-grade cerebral tumor with local recurrence and poor outcome. Photodynamic therapy (PDT) is a localized treatment based on the light activation of a photosensitizer (PS) in the presence of oxygen, which results in the formation of cytotoxic species. The delivery of fractionated light may enhance treatment efficacy...
Article
Accurate tumor segmentation in [18F]-fluorodeoxyglucose positron emission tomography is crucial for tumor response assessment and target volume definition in radiation therapy. Evaluation of segmentation methods from clinical data without ground truth is usually based on physicians' manual delineations. In this context, the simultaneous truth and p...
Article
Full-text available
Photodynamic therapy (PDT) is an emerging treatment modality for various diseases, especially for cancer therapy. Although high efficacy is demonstrated for PDT using standardized protocols in nonhyperkeratotic actinic keratoses, alternative light doses expected to increase efficiency, to reduce adverse effects or to expand the use of PDT, are stil...
Article
Introduction There are many automated segmentation softwares in PET-CT, but none of them is used as gold standard. The aim of this study is to compare two segmentation softwares, one based on maximum intensity projection (MIP-based) and the second: PETVCAR®, to measure TLG in patients with metastatic melanoma treated by vemurafenib. Materials and...
Article
Full-text available
Objective: A general method was developed to analyze and describe tree-like structures needed for evaluation of complex morphology, such as the cerebral vascular tree. Clinical application of the method in neurosurgery includes planning of the surgeon's intraoperative gestures. Method: We have developed a 3D skeletonization method adapted to tub...
Article
Full-text available
Computer-assisted medical interventions and treatment planning have known an increasing interest and research activity in different fields and applications. However, before the routine deployment of these procedures becomes a reality, in vivo and in silico validations must be undertaken. This paper describes a platform containing multimodality medi...
Article
18F-fluorodeoxyglucose positron emission tomography (18FDG PET) is a nuclear medicine imaging technique of growing interest in oncology. In context of external radiotherapy, optimization of radiotherapy planning as well as objective patient monitoring require accurate tumor volume measurement. In this paper, a new, nearly automatic and operator-ind...
Article
[¹⁸F]-Fluorodeoxyglucose PET has become an essential technique in oncology. Accurate segmentation is important for treatment planning. With the increasing number of available methods, it will be useful to establish a reliable evaluation tool. Five methods for [F]-fluorodeoxyglucose PET image segmentation (MIP-based, Fuzzy C-means, Daisne, Nestle an...
Article
18F-fluorodeoxyglucose positron emission tomography (18FDG PET) has become an essential technique in oncology. Accurate segmentation and uptake quantification are crucial in order to enable objective follow-up, the optimization of radiotherapy planning, and therapeutic evaluation. We have designed and evaluated a new, nearly automatic and operator-...
Article
In this paper, the authors propose a short overview of image fusion techniques in nuclear medicine. First, the methodological concepts of image fusion are discussed. Then, a sample of applications in nuclear medicine is presented. These applications ranging from diagnosis to guided therapy and monitoring clearly exemplify the challenges of image fu...
Article
This work deals with positron emission tomography segmentation methods for tumor volume determination. We propose a state of art techniques based on fixed or adaptive threshold. Methods found in literature are analysed with an objective point of view on their methodology, advantages and limitations. Finally, a comparative study is presented.
Article
Objects: We present computer-assisted diagnosis (CAD) software designed to improve prostate cancer detection using perfusion MRI data. Methods: In addition to standard visualization features, this software allows for the 2D and multislice 2D contouring of suspicious areas based on a seeded region growing algorithm, and area labeling based on zon...
Conference Paper
Fractal geometry may be an efficient tool for texture analysis in medical imaging. However its application is primarily restricted to 2D cases and at the only use of an approximation method of the fractal dimension (FD). Recently, multifractal analysis has showed interesting results in this field. This study focuses on the use of an optimized set o...
Article
Many algorithms exist for 3D reconstruction of data from freehand 2D ultrasound slices. These methods are based on interpolation techniques to fill the voxels from the pixels. For quantification purposes, segmentation is involved to delineate the structure of interest. However, speckle and partial volume effect errors can affect quantification. Thi...
Article
Full-text available
Accurate localization and contouring of prostate are crucial issues in prostate cancer diagnosis and/or therapies. Although several semi-automatic and automatic segmentation methods have been proposed, manual expert correction remains necessary. We introduce a new method for automatic 3D segmentation of the prostate gland from magnetic resonance im...
Article
In radiotherapy planning, target volumes and organs at risk delineation are a tedious and time-consuming task. In this paper we address a method to assist the radiologist in this task. We developed a 3D deformable model for prostate segmentation and used a seeded region growing algorithm for bladder and rectum delineation on MR images. Evaluation o...
Conference Paper
This paper introduces an original method for automatic 3D segmentation of the prostate gland from Magnetic Resonance Imaging data. A statistical geometric model is used as a priori knowledge. Prostate boundaries are then optimized by a Bayesian classification based on Markov fields modelling. We compared the accuracy of this algorithm, free from an...
Article
A new automatic method for tumor volume segmentation on PET images has been developed. The method introduced in this paper is based on previous works in MRA segmentation and involves both fuzzy set and possibility theories. Visual results prove the method efficiency which is confirmed by obtained Jaccard index.
Article
One of the imaging modalities used for the diagnosis of epilepsy is SPECT (Single-Photon Emission Computed Tomography). Ictal and interictal images are registered to MR images (SISCOM (Substracted Ictal Spect COregistred to MR) to delineate the sources. However, in some cases and for many reasons, the used method does not lead to precise delimitati...
Article
Full-text available
A new improving method to compute Spearman rank correlation test has been developed. This method is based on the use of a response to stimulation delay referred by many authors. Visual results tend to prove the method efficiency which is confirmed by obtained overlap rates; moreover this method can easily be adapted in a clinical context.
Article
In this work we present a method to automatic 3D segmentation of prostate on MR images and volume reconstruction by fuzzy sets fusion algorithm. The segmentation is model based method and the reconstruction takes into account the slice thickness to reduce the partial volume effect.
Article
In this paper, we introduce an approach for selective segmentation of vascular structure which has been applied for intracranial vessels. Based on MIP and fuzzy set principles, this approach brings good results while segmentation is achieved rapidly. The added value of this approach is a minimal user interaction and the taking into account of the v...
Article
Full-text available
Nous proposons une nouvelle approche pour calculer le Z-Score et le test de Student pour l'IRM fonctionnelle d'activation cérébrale. Cette approche intègre dans le calcul le décalage temporel qui existe entre le maximum de la réponse et la stimulation et qui a été introduit par de nombreux auteurs. Les résultats obtenus démontrent l'efficacité de l...
Article
Full-text available
A new approach to compute z-score and Student's test in functional MRI has been developed. This approach tends to involve standard z-score and Student's test computation. This approach is based on the delay of the response compared to the stimulation introduced by many authors. The results obtained prove the methods efficiency; moreover these metho...
Article
The goal of 3D conformal radiotherapy (CRT) is to conform the high dose region to the target volume while sparing surrounding normal tissue. Knowledge about the mobility of organs relative to the bony anatomy and to the reference position is of great importance when daily positioning patient. In this work we present a method to monitor patient setu...

Projects

Project (1)
Project
This project is a PhD and starts in October 2019 for 3 years. The aim of the project is to develop a device to illuminate homogeneously and reproductively the peritoneal cavity in order to destroy all metastasis with photodynamic therapy.