Anne-Lise Pitel

Anne-Lise Pitel
Université de Caen Normandie | UNICAEN · UFR de Psychologie

PhD, Psychology

About

133
Publications
44,619
Reads
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2,626
Citations
Introduction
Alcohol Use Disorder and Korsakoff's syndrome, Neuropsychology and Neuroimaging, Age-alcohol interaction, Cognitive rehabilitation, Non-pharmacological interventions
Additional affiliations
September 2012 - present
Université de Caen Normandie
Position
  • Professor (Assistant)
January 2011 - August 2012
Unité Inserm U1077
Position
  • PostDoc Position
January 2011 - August 2012
French Institute of Health and Medical Research
Position
  • Junior Scientist

Publications

Publications (133)
Article
Introduction et but de l’étude Le trimethylamine-N-oxyde (TMAO) est une molécule issue du métabolisme par le microbiote intestinal de différents micronutriments tels que la bétaïne, la choline ou la carnitine. Des modèles expérimentaux murins semblent montrer que des concentrations élevées de cette molécule pourrait être responsable d’un vieillisse...
Preprint
Full-text available
Background. Health-related quality of life (HRQoL) is an important clinical outcome in Alcohol Use Disorder (AUD) and is considered as a relevant indicator of treatment success. While a better understanding of the factors affecting HRQoL would enable to adjust patients’ care to favour treatment outcome, the determinants of HRQoL in AUD remain uncle...
Article
The pathophysiological mechanisms behind amnesia are still unknown. Recent literature, through the study of patients with Alcohol Use Disorder with and without Korsakoff's syndrome, increasingly shows that physiological alterations to the thalamus have an important role in the development of amnesia. This review gives an overview of neuropsychologi...
Article
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Brain abnormalities observed in alcohol use disorder are highly heterogeneous in nature and severity, possibly because chronic alcohol consumption also affects peripheral organs leading to comorbidities that can result in exacerbated brain alterations. Despite numerous studies focusing on the effects of alcohol on the brain or liver, few studies ha...
Article
Full-text available
Objective To investigate, in Korsakoff patients (KS), cognitive and brain changes over months and up to 10 years after the diagnosis. Methods Two groups of 8 KS patients underwent neuropsychological, motor and neuroimaging investigations including structural MRI and ¹⁸ F-FDG-PET. The KS C group was examined early after the KS diagnosis (KS C -T1)...
Article
Substance use disorder develops from complex interactions between socio-environmental and neurobiological factors. A neurocognitive model of addiction, the triadic model, proposes that Alcohol Use Disorder (AUD) is the result of an imbalance between the reflective and the impulsive subcomponents along with a disruption of the regulatory subcomponen...
Article
Cognitive and brain alterations are common in alcohol use disorder and vary importantly from one patient to another. Sleep disturbances are also very frequent in these patients and remain largely neglected even though they can persist after drinking cessation. Sleep disturbances may be the consequence of specific brain alterations, resulting in cog...
Article
Full-text available
Background The aim of the present study was to determine whether the Brief Evaluation of Alcohol‐Related Neuropsychological Impairments (BEARNI), a screening tool developed to identify neuropsychological deficits in Alcohol Use Disorder (AUD) patients, can also be used as a relevant tool for the early identification of AUD patients at risk of devel...
Chapter
Histopathological alterations of the mamillary bodies are the most conspicuous and the most consistent neuropathological features of several disorders that occur after severe thiamine deficiency, such as Wernicke's encephalopathy and Korsakoff's syndrome. Moreover, they are among the few abnormalities that are visible to the naked eye in these diso...
Article
Full-text available
In alcohol use disorder, drinking cessation is frequently associated with an alcohol withdrawal syndrome. Early in abstinence (within the first two months after drinking cessation), when patients do not exhibit physical signs of alcohol withdrawal syndrome anymore (such as nausea, tremor or anxiety), studies report various brain, sleep and cognitiv...
Article
Background: Neuropsychological impairments found in recently detoxified patients with alcohol use disorder (AUD) can limit the benefit of psychosocial treatments and increase the risk of relapse. These neuropsychological deficits are reversible with abstinence. The aim of this retrospective clinical study was to investigate whether a short-term st...
Article
Full-text available
Alcohol abuse is a major public health problem worldwide causing a wide range of preventable morbidity and mortality. In this translational study, we show that heavy drinking (HD) (≥6 standard drinks/day) is independently associated to a worse outcome of ischemic stroke patients. To study the underlying mechanisms of this deleterious effect of HD,...
Article
Full-text available
Alcohol induced neurocognitive disorder: screening strategies and tools. Chronic and excessive alcohol consumption results in cognitive disorders partially reversible with abstinence. These heterogeneous cognitive impairments affect executive functions, episodic memory and social cognition. They may interfere with the motivational process to abando...
Poster
Alcohol Use Disorder (AUD) results in multiple social and cognitive problems with a poor health related quality of life (HRQoL). The association between HRQoL and cognition is well-known in various diseases (stroke, dementia...). While HRQoL is crucial to maintain abstinence, it remains little studied in AUD. Depression and anxiety also afect HRQoL...
Article
Full-text available
Background: In this study, we investigated (1) the effect of chronic and excessive alcohol consumption on whole blood (WB) and serum concentrations of thiamine and its metabolites after supplementation, and (2) the relationship between the perturbations of thiamine metabolism and neuropsychological abilities. Methods: WB and serum samples were coll...
Article
Full-text available
Background: Despite severe structural brain abnormalities within the fronto-cerebellar circuit (FCC), cerebellar metabolism studied with FDG-PET is relatively preserved in patients with alcohol use disorder (AUD). The compensatory role of the cerebellum has been explored mainly through fMRI examination of AUD patients with preserved level of perfo...
Article
The thalamus, a relay organ consisting of several nuclei, is shared between the frontocerebellar circuit and the Papez circuit, both particularly affected in alcohol use disorder. Shrinkage of the thalamus is known to be more severe in alcoholics with Korsakoff’s syndrome than in those without neurological complications (uncomplicated alcoholics)....
Article
Full-text available
Background Alcohol Use Disorder (AUD) patients without Korsakoff's syndrome (KS) report a variable self‐rated sleep quality. Their ability to accurately judge their sleep quality may be related to their alcohol‐related cognitive deficits and brain damage. KS patients, who present severe brain dysfunction, may be cognitively unable to judge their sl...
Chapter
Full-text available
Alcohol is a psychoactive substance consumed worldwide and directly responsible or at least contributing to the development of diseases such as alcohol use disorder (AUD), cirrhosis, fetal alcohol syndrome, cancer, and cardiovascular diseases. The past decades of research have revealed brain structural and functional abnormalities associated with m...
Article
Full-text available
The function of the human mediodorsal thalamic nucleus (MD) has so far eluded a clear definition in terms of specific cognitive processes and tasks. Although it was at first proposed to play a role in long-term memory, a set of recent studies in animals and humans has revealed a more complex, and broader, role in several cognitive functions. The MD...
Article
Full-text available
L’impact des troubles cognitifs liés à l’alcool sur les prises en charge addictologiques est de plus en plus considéré. La résistance aux changements observée chez certains patients peut être secondaire à des troubles neuropsychologiques. Ces derniers vont entraver l’engagement dans les soins en contrariant les modifications comportementales. Le re...
Article
Full-text available
Alcohol use disorder is a brain disease that can be modeled by an imbalance between three cerebral and cognitive systems. The reflective system, underpinned by the frontal cortex and corresponding to the executive functions, would be involved in the control of alcohol consumption. The impulsive system, underpinned by the amygdala-striatal complex,...
Article
Full-text available
After a traumatic brain injury (TBI), behavioral disorders can occur without major focal brain lesion and in this case, their pathophysiology remains unclear. The aim of this study is to examine whether TBI patients with behavioral disorders but without any focal damage, as observed from an initial clinical CT scan, present subtle volumetric altera...
Conference Paper
Objectif Le trouble de l’usage d’alcool (TUAL) est associé à des atteintes cérébrales et cognitives hétérogènes, ainsi que des troubles du sommeil fréquents. Le sommeil contribue à l’intégrité des structures cérébrales et au bon fonctionnement cognitif. Nous cherchons donc à mieux comprendre l’impact des troubles du sommeil sur les anomalies struct...
Article
Introduction: Decoding emotional information from faces and voices is crucial for efficient interpersonal communication. Emotional decoding deficits have been found in alcohol-dependence (ALC), particularly in crossmodal situations (with simultaneous stimulations from different modalities), but are still underexplored in Korsakoff syndrome (KS). T...
Article
Background Alcohol-dependence is related to large-scale cognitive impairments, particularly for executive functions (EF). These deficits persist even after long-term abstinence and have a major impact on patients’ everyday life and relapse risk. Earlier studies, based on multi-determined tasks, mostly focused on inhibition and did not offer a theor...
Article
Full-text available
Gray matter (GM) lobar atrophy and glucose hypometabolism are well-described hallmarks of frontotemporal lobar degeneration (FTLD), but the relationships between them are still poorly understood. In this study, we aimed to show the patterns of GM atrophy and hypometabolism in a sample of 15 patients with the behavioral variant of FTLD (bv-FTD), com...
Article
Background: Korsakoff syndrome (KS), most frequently resulting from alcohol dependence (ALC), is characterized by severe anterograde amnesia. It has been suggested that these deficits may extend to other memory components, and notably source memory deficits involved in the disorientation and temporal confusion frequently observed in KS. However, t...
Article
Full-text available
The effects of alcoholism on cognitive and motor functioning are heterogeneous. While the role of some factors (patterns of alcohol consumption, eating habits or associated liver disease) has been hypothesized, the origins of this heterogeneity remain difficult to establish. The goals of the present study were thus to identify the clinical and biol...
Chapter
Full-text available
Subjects with alcohol use disorder (AUD) frequently present memory disorders affecting selective components of memory (episodic memory, working memory, semantic memory and procedural memory) even in absence of neurological complication. These mnemonic deficits are at least partially reversible with abstinence, but even after a few weeks of sobriety...
Research
Full-text available
We are currently recruiting a research engineer having a background in Medical Physics. The expected starting date is January the 23rd 2017, for a contract of fixed duration of 18 months. Job Description The Inserm U1077 research unit in Caen, France, is a laboratory specialized in the neuropsychological and neuroimaging investigation of memory. An...
Article
La conscience de soi est sous-tendue par des fonctions cognitives supérieures pouvant être affaiblies par un trouble de l’usage de l’alcool (TUAL), notamment chez les personnes âgées, plus vulnérables aux effets toxiques du produit. Les troubles cognitifs et comportementaux induits par la consommation chronique et excessive d’alcool, aujourd’hui cl...
Research
Full-text available
Proposition de thèse CIFRE sur une problématique transversale: les nouvelles technologies et la neuropsychologie de la vie quotidienne
Article
Les troubles cognitifs liés à l'alcool sont une conséquence de l'exposition du cerveau à une alcoolisation régulière et/ou excessive d'alcool, en lien avec des altérations cérébrales structurales et fonctionnelles, notamment sur deux circuits : le circuit de Papez (CP) et le circuit frontocérébelleux (CFC). Ces atteintes sont hétérogènes, elles con...
Article
Full-text available
This perspective aims at underlining the usefulness of event-related potentials (ERP) to better understand the brain correlates of Korsakoff’s syndrome (KS), a neuropsychiatric disease characterized by severe memory impairment and most frequently resulting as a neurological complication of alcohol-dependence (AD). While ERP have been broadly used i...
Article
Full-text available
Alcohol-related cognitive impairments are largely underestimated in clinical practice, even though they could limit the benefit of alcohol treatment and hamper the patient's ability to remain abstinent or to respect his/her therapeutic contract. These neuropsychological deficits can impact the management of patients well before the development of t...
Research
Full-text available
Introduction : Les études de neuropsychologie et de neuroimagerie ont permis de préciser les atteintes cognitives et cérébrales des patients alcoolo-dépendants récemment sevrés (AD). D’autres travaux ont souligné la présence très fréquente de troubles du sommeil chez les AD, pouvant être un facteur de risque de rechute (Brower et al., 2001). En pra...
Article
Full-text available
Background: Alcohol-related neuropsychological impairments mainly affect episodic memory, working memory, and visuospatial abilities, as well as executive and motor functioning. These impairments can prevent alcoholic patients (ALs) early in abstinence from benefiting fully from treatment and reduce their ability to remain abstinent. A neuropsychol...
Article
Full-text available
Alcoholism is associated with widespread brain structural abnormalities affecting mainly the frontocerebellar and the Papez’s circuits. Brain glucose metabolism has received limited attention, and few studies used regions of interest approach and showed reduced global brain metabolism predominantly in the frontal and parietal lobes. Even though the...
Article
Full-text available
Les déficits neuropsychologiques consécutifs à l'alcoolodépendance affectent principalement la mémoire épisodique, la mémoire de travail et les capacités visuospatiales, ainsi que les fonctions exécutives et motrices. Ces déficits peuvent réduire le bénéfice des ateliers psychothérapeutiques et entraver le maintien de l'abstinence des patients alco...
Article
Introduction L'impulsivite, souvent decrite comme elevee chez les patients alcoolo-dependants (AD), est un concept complexe qui jouerait un role important dans le developpement de l'AD [1] et augmenterait les risques de rechutes [2]. L'impulsivite est consideree, selon les auteurs, comme un facteur de vulnerabilite psychopathologique ou comme une c...
Article
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Les troubles du sommeil et l'alcoolo-dependance (AD) sont deux comorbidites frequemment associees dans les pathologies psychiatriques, telles que l'anxiete, la depression, les troubles bipolaires ou la schizophrenie [1]. Depuis plusieurs annees, les etudes conduites dans l'AD ont permis de mieux preciser les atteintes cognitives et cerebrales de ce...
Article
Full-text available
Introduction Traumatic brain injury (TBI) frequently leads to cognitive and behavioural disorders interfering with everyday life and work, despite the absence of focal lesions on clinical images acquired after injury. The aim of this study is to use magnetic resonance imaging (MRI) to examine whether volumetric alterations measured voxel by voxel i...
Article
Full-text available
Measurement of synaptic activity by Positron Emission Tomography (PET) and its relation to cognitive functions such as episodic memory, working memory and executive functions in healthy humans and patients with neurocognitive disorders have been well documented. In this review, we introduce the concept of PET imaging that allows the observation of...
Article
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Alcohol consumption patterns and recognition of health outcomes related to hazardous drinking vary widely internationally, raising the question whether these national differences are reflected in brain damage observed in alcoholism. This retrospective analysis assessed variability of alcoholism's effects on brain cerebrospinal fluid (CSF) and white...