Anne-Laure Hemonnot-Girard

Anne-Laure Hemonnot-Girard
Institut de Génomique Fonctionnelle, | Igf · Department of Neuroscience

PhD
Open for any opportunity !

About

15
Publications
1,931
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186
Citations
Additional affiliations
January 2017 - July 2017
Institut de Génomique Fonctionnelle,
Position
  • Intern
July 2016 - August 2016
The University of Edinburgh
Position
  • Intern
January 2016 - July 2016
Institut de Génomique Fonctionnelle,
Position
  • Intern
Education
September 2015 - June 2017
Université de Montpellier
Field of study
  • Health Biology - Neurosciences
September 2013 - June 2015
Université de Montpellier
Field of study
  • Animal Physiology - Neurosciences
September 2009 - July 2011
Lycée Théodore Aubanel
Field of study
  • Sciences

Publications

Publications (15)
Article
Full-text available
Ependymal cells reside in the adult spinal cord and display stem cell properties in vitro. They proliferate after spinal cord injury and produce neurons in lower vertebrates but predominantly astrocytes in mammals. The mechanisms underlying this glial-biased differentiation remain ill-defined. We addressed this issue by generating a molecular resou...
Preprint
Full-text available
Background: Research in recent years firmly established that microglial cells play an important role in the pathogenesis of Alzheimer's disease (AD). In parallel, a series of studies showed that, under both homeostatic and pathological conditions, microglia are a heterogeneous cell population. In AD, amyloid-b (Ab) plaque-associated microglia (PAM)...
Preprint
Full-text available
Background: Research in recent years firmly established that microglial cells play an important role in the pathogenesis of Alzheimer's disease (AD). In parallel, a series of studies showed that, under both homeostatic and pathological conditions, microglia are a heterogeneous cell population. In AD, amyloid-b (Ab) plaque-associated microglia (PAM)...
Article
Full-text available
Shank3 monogenic mutations lead to autism spectrum disorders (ASD). Shank3 is part of the glutamate receptosome that physically links ionotropic NMDA receptors to metabotropic mGlu5 receptors through interactions with scaffolding proteins PSD95–GKAP–Shank3–Homer. A main physiological function of the glutamate receptosome is to control NMDA synaptic...
Thesis
La maladie d’Alzheimer (MA), première cause de démence chez les personnes âgées, est une maladie neurodégénérative pour laquelle il n'existe toujours pas de stratégie thérapeutique efficace. Singulièrement, une grande partie des facteurs de risques des formes sporadiques de la MA sont associés à des gènes microgliaux. Les microglies sont les cellul...
Preprint
Ependymal cells reside in the adult spinal cord around the central canal and have stem cell properties in vitro. They rapidly activate and proliferate after spinal cord injury, constituting a source of new cells. They produce neurons and glial cells in lower vertebrates but they mainly generate glial cells in mammals. The mechanisms underlying thei...
Article
Full-text available
L’exécution des fonctions cérébrales requiert des interactions optimales entre les neurones et les différents types de cellules gliales (astrocytes, microglies et oligodendrocytes). Le domaine de la gliobiologie, qui s’intéresse aux cellules gliales, est en pleine expansion. Les innovations techniques permettent désormais d’aborder des questions bi...
Preprint
Full-text available
Shank3 monogenic mutations lead to Autism Spectrum Disorders (ASD). Shank3 is part of the glutamate receptosome that physically links ionotropic NMDA receptors to metabotropic mGlu5 receptors through interactions with scaffolding proteins PSD95-GKAP-Shank3-Homer. A main physiological function of the glutamate receptosome is to control NMDA synaptic...
Article
Microglia, the resident immune cells of the brain, have recently emerged as key players in Alzheimer Disease (AD) pathogenesis, but their roles in AD remain largely elusive and require further investigation. Microglia functions are readily altered when isolated from their brain environment, and microglia reporter mice thus represent valuable tools...
Article
Full-text available
Neuronal hippocampal cultures are simple and valuable models for studying neuronal function. While embryonic cultures are widely used for different applications, mouse postnatal cultures are still challenging, lack reproducibility and/or exhibit inappropriate neuronal activity. Yet, postnatal cultures have major advantages such as allowing genotypi...
Article
Full-text available
Microglia are the resident macrophages of the central nervous system. They play key roles in brain development, and physiology during life and aging. Equipped with a variety of molecular sensors and through the various functions they can fulfill, they are critically involved in maintaining the brain’s homeostasis. In Alzheimer disease (AD), microgl...
Article
Network hyperexcitability is a feature of Alzheimer’s disease (AD) as well as numerous transgenic mouse models of AD. While hyperexcitability in AD patients and AD animal models share certain features, the mechanistic overlap remains to be established. We aimed to identify features of network hyperexcitability in AD models that can be related to ep...
Article
Full-text available
Network hyperexcitability is a feature of Alzheimer’ disease (AD) as well as numerous transgenic mouse models of AD. While hyperexcitability in AD patients and AD animal models share certain features, the mechanistic overlap remains to be established. We aimed to identify features of network hyperexcitability in AD models that can be related to epi...
Article
Full-text available
A growing number of tools now allow live recordings of various signaling pathways and protein-protein interaction dynamics in time and space by ratiometric measurements, such as Bioluminescence Resonance Energy Transfer (BRET) Imaging. Accurate and reproducible analysis of ratiometric measurements has thus become mandatory to interpret quantitative...

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Projects

Projects (2)
Project
Decipher the microglial role in Alzheimer's disease progression