Annabelle Monnier

Annabelle Monnier
Université de Rennes 1 | UR1 · Institut Génétique et Développement de Rennes- UMR CNRS 6290

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48
Publications
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1,239
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Publications

Publications (48)
Article
Full-text available
Background Glioblastoma (GB) is a highly invasive primary brain tumor that nearly always systematically recurs at the site of resection despite aggressive radio-chemotherapy. Previously, we reported a gene expression signature related to tumor infiltration. Within this signature, the EMX2 gene encodes a homeodomain transcription factor that we foun...
Article
Full-text available
In order to understand mechanisms involved in osteoporosis observed during iron overload diseases, we analyzed the impact of iron on a human osteoblast-like cell line. Iron exposure decreases osteoblast phenotype. HHIPL-2 is an iron-modulated gene which could contribute to these alterations. Our results suggest osteoblast impairment in iron-related...
Article
Full-text available
Marine Synechococcus undergo a wide range of environmental stressors, especially high and variable irradiance, which may induce oxidative stress through the generation of reactive oxygen species (ROS). While light and ROS could act synergistically on the impairment of photosynthesis, inducing photodamage and inhibiting photosystem II repair, acclim...
Data
Cluster of genes involved in photoprotection, defence against oxidative stress and DNA repair around midday. BFC clusters from 2038 gene probes selected after PCA. Each colour corresponds to a biological process. Feature Number (Feat Num), BFC cluster number (BFC). Right: The main BFC profiles and coefficients are shown.
Data
Full-text available
Coregulation of genes involved in basic transcription machinery during the night. BFC clusters from 2038 gene probes selected after PCA. Each colour corresponds to a biological process. Feature Number (Feat Num), BFC cluster number (BFC). Stars indicate two probes corresponding to two Feature Numbers associated to a single gene in the final annotat...
Data
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Coregulation of genes involved in mitosis at dusk. Mitotic BFC clusters from 2038 gene probes selected after PCA. Each colour corresponds to a biological process. Feature Number (Feat Num), BFC cluster number (BFC). Right: The main BFC profiles and coefficients are shown. Note that clusters 71 and 49 as well as clusters 104 and 36 have nearly ident...
Data
Full-text available
List of TOP50 genes with highest amplitude. TOP50 genes ranked according to their amplitude as log2(ratio).
Data
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List of Top 50 genes with highest median expression. TOP50 genes ranked according to their median hybridization signal (absolute value).
Data
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Clusters of genes involved in protein synthesis including translation regulators, tRNA and amino acid biosynthesis around dawn. BFC clusters from 2038 gene probes selected after PCA. Each colour corresponds to a biological process. Feature Number (Feat Num), BFC cluster number (BFC). Right: The main BFC profiles are shown. Note that clusters 39 and...
Data
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Coregulation of DNA replication and DNA repair genes at the end of the light period. S Phase BFC Clusters from 2038 gene probes selected after PCA. Each colour corresponds to a biological process. Feature Number (Feat Num), BFC cluster number (BFC). Right: The main BFC profiles and coefficients are shown. Note that clusters 41, 64 and 87 as well as...
Data
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Transcriptional regulations of transcription factors. (A) Hierarchical clustering of 170 expressed transcription factors. (B) Transcription patterns of expression of CCAAT HAP3/HAP5 transcription factors.
Data
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Late night clusters of genes involved in chloroplast biogenesis, pigment biosynthesis, lipid biosynthesis and metabolism. BFC clusters from 2038 gene probes selected after PCA. Each colour corresponds to a biological process. Feature Number (Feat Num), BFC cluster number (BFC). Right: The main BFC profiles and coefficients are shown. Note that clus...
Data
Full-text available
Afternoon genes involved in Chlorophyll and Photosystem proteins biosynthesis. BFC clusters from 2038 gene probes selected after PCA. Each colour corresponds to a biological process. Feature Number (Feat Num), BFC cluster number (BFC). Stars indicate two probes corresponding to two Feature Numbers associated to a single gene in the final annotation...
Article
Full-text available
Picoeukaryotes represent an important, yet poorly characterized component of marine phytoplankton. The recent genome availability for two species of Ostreococcus and Micromonas has led to the emergence of picophytoplankton comparative genomics. Sequencing has revealed many unexpected features about genome structure and led to several hypotheses on...
Article
Allopolyploidy results from two events: the merger of divergent genomes and genome duplication. Both events have important functional consequences for the evolution and adaptation of newly formed allopolyploid species. In spite of the significant progress made in recent years, few studies have decoupled the effects of hybridization from genome dupl...
Article
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Although hepcidin expression was shown to be induced by the BMP/Smad signaling pathway, it is not yet known how iron regulates this pathway and what its exact molecular targets are. We therefore assessed genome-wide liver transcription profiles of mice of 2 genetic backgrounds fed iron-deficient, -balanced, or -enriched diets. Among 1419 transcript...
Article
Full-text available
Development of the sporophyte and gametophyte generations of the brown alga E. siliculosus involves two different patterns of early development, which begin with either a symmetric or an asymmetric division of the initial cell, respectively. A mutant, immediate upright (imm), was isolated that exhibited several characteristics typical of the gameto...
Article
The iron absorption by duodenal enterocytes is a key step of its homeostasis. But the control of this absorption is complex and cannot be fully explicated with present knowledge. In a global transcriptome approach, we identified 60 genes over-expressed in hemin (iron) overload in Caco-2 cells, an in vitro model of duodenal enterocytes. The challeng...
Article
Full-text available
Cell division often occurs at specific times of the day in animal and photosynthetic organisms. Studies in unicellular photosynthetic algae, such as Chlamydomonas or Euglena, have shown that the photoperiodic control of cell division is mediated through the circadian clock. However, the underlying mechanisms remain unknown. We have studied the mole...
Article
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The t(12;21)(p13;q22) translocation is found in 20 to 25% of cases of childhood B-lineage acute lymphoblastic leukemia (B-ALL). This rearrangement results in the fusion of ETV6 (TEL) and RUNX1 (AML1) genes and defines a relatively uniform category, although only some patients suffer very late relapse. TEL/AML1-positive patients are thus an interest...
Article
Full-text available
Regulation of iron absorption by duodenal enterocytes is essential for the maintenance of homeostasis by preventing iron deficiency or overload. Despite the identification of a number of genes implicated in iron absorption and its regulation, it is likely that further factors remain to be identified. For that purpose, we used a global transcriptomi...
Article
Full-text available
Iron absorption, distribution, use, and storage are thought to be tightly regulated since altered iron stores may lead to cellular damage and disease. HFE, the hereditary hemochromatosis gene product, is expressed in the crypts of the duodenum, but the molecular mechanism by which it contributes to the inhibition of iron absorption is still unknown...
Article
Excessive adiposity has become a major drawback in meat-type chicken production. However, few studies were conducted to analyze the liver expression of genes involved in pathways and mechanisms leading to adiposity. A previous study performed by differential display on RNAs extracted from chicken livers from lean and fat lines allowed us to isolate...
Data
GO terms associated with the Down cluster: Venn category, GO ID, Name, GOA Human annotation with evidence codes and genes, PubGene annotation with significant scores and genes.
Data
Full-text available
Up cluster. (A) Boxplots of the PQIs for the Evidence (GOA), Literature (PUB) and combination of both (GOAPUB). (B) Boxplots of the PQIs for the evidence and literature terms (GOAPUB), for the same set enriched with the associative relations (+Dep.) or a random term set of the same size (+Random).
Data
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Lung cluster. (A) Boxplots of the PQIs for the Evidence (GOA), Literature (PUB) and combination of both (GOAPUB). (B) Boxplots of the PQIs for the evidence and literature terms (GOAPUB), for the same set enriched with the associative relations (+Dep.) or a random term set of the same size (+Random).
Data
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Retina clusters. (A) Boxplots of the PQIs for the Evidence (GOA), Literature (PUB) and combination of both (GOAPUB). (B) Boxplots of the PQIs for the evidence and literature terms (GOAPUB), for the same set enriched with the associative relations (+Dep.) or a random term set of the same size (+Random).
Data
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Alzheimer's disease cluster. (A) Boxplots of the PQIs for the Evidence (GOA), Literature (PUB) and combination of both (GOAPUB). (B) Boxplots of the PQIs for the evidence and literature terms (GOAPUB), for the same set enriched with the associative relations (+Dep.) or a random term set of the same size (+Random).
Data
Full-text available
Glioblastomas clusters. (A) Boxplots of the PQIs for the Evidence (GOA), Literature (PUB) and combination of both (GOAPUB). (B) Boxplots of the PQIs for the evidence and literature terms (GOAPUB), for the same set enriched with the associative relations (+Dep.) or a random term set of the same size (+Random).
Data
Full-text available
Acute Lymphocyte Leukemias (ALL) clusters. (A) Boxplots of the PQIs for the Evidence (GOA), Literature (PUB) and combination of both (GOA-PUB). (B) Boxplots of the PQIs for the evidence and literature terms (GOAPUB), for the same set enriched with the associative relations (+Dep.) or a random term set of the same size (+Random).
Data
Full-text available
Circadian cluster. (A) Boxplots of the PQIs for the Evidence (GOA), Literature (PUB) and combination of both (GOAPUB). (B) Boxplots of the PQIs for the evidence and literature terms (GOAPUB), for the same set enriched with the associative relations (+Dep.) or a random term set of the same size (+Random).
Data
Full-text available
Enriched GO Process terms (p < = 0.05) associated with at least 4 genes in the glioGBM cluster. Color: red = terms found in GOA and PubGene, green = terms only found in GOA, blue = terms only found in PubGene. Shape: rectangle = significantly enriched annotated terms (p < = 0.05) ; ellipse = non-significantly enri-ched annotated terms (p > 0.05).
Data
Full-text available
Enriched GO Process terms associated with at least 4 genes in the bcr-abl cluster. Color: red = terms found in GOA and PubGene, green = terms only found in GOA, blue = terms only found in PubGene. Shape: rectangle = significantly enriched annotated terms (p < = 0.05) ; ellipse = non-significantly enriched annotated terms (p > 0.05).
Data
LocusLink IDs, symbols, aliases and names of the down regulated genes.
Article
Full-text available
Large-scale genomic studies based on transcriptome technologies provide clusters of genes that need to be functionally annotated. The Gene Ontology (GO) implements a controlled vocabulary organised into three hierarchies: cellular components, molecular functions and biological processes. This terminology allows a coherent and consistent description...
Article
Complete clinical expression of the HFE1 hemochromatosis is very likely modulated by genes linked to duodenal iron absorption, whose level is conditioned by unknown processes taking place during enterocyte differentiation. We carried out a transcriptomic study on CaCo-2 cells used as a model of enterocyte differentiation in vitro. Of the 720 genes...
Article
Eukaryotic elongation factor 1 (eEF1) is a translational multimolecular complex reported in higher eukaryotes to be a target of CDK1/cyclin B, the universal regulator of M phase, but whose role in the cell cycle remains to be determined. A specific polyclonal antibody was produced and used to characterize the delta subunit of sea urchin elongation...
Article
Protein synthesis was analysed following fertilisation in sea urchin. Fluctuations in the accumulation of neo-synthesised proteins were observed during the first cell cycles. Accurate translation analyses were performed from lysates prepared from early embryos. The lysates readily translated endogenous pre-initiated mRNAs allowing the determination...
Article
Full-text available
Eukaryotic elongation factor 1 (eEF-1) contains the guanine nucleotide exchange factor eEF-1B that loads the G protein eEF-1A with GTP after each cycle of elongation during protein synthesis. Two features of eEF-1B have not yet been elucidated: (i) the presence of the unique valyl-tRNA synthetase; (ii) the significance of target sites for the cell...
Article
Protein synthesis is composed of three phases: initiation, elongation and termination. The eEF elongation factor-1 contains two elements: G protein, eEF-1A and a complex macromolecular exchange GDP / GTP, eEF-1B. In higher animals, eEF-1B consists of four subunits eEF-1βγδ and Vanyl-tRNA synthetase (Val-RS). We cloned and sequenced both 2 and 2.7 k...
Article
The molecular evolution of two components of elongation factor-1 (EF-1), EF-1beta and EF-1delta was analysed using the distance matrix, the maximum parsimony and the maximum likelihood methods, after careful alignment of protein and cDNA sequences. The topology of the phylogenetic trees obtained supports monophyly of plant EF-1beta and EF-1beta' se...
Article
The molecular evolution of two components of elongation factor-1 (EF-1), EF-1β and EF-1δ was analysed using the distance matrix, the maximum parsimony and the maximum likelihood methods, after careful alignment of protein and cDNA sequences. The topology of the phylogenetic trees obtained supports monophyly of plant EF-1β and EF-1β′ sequences, and...
Article
A probe for Sphaerechinus granularis EF-1α mRNA was generated and sequenced, and further used for comparative developmental analysis of gene expressions of two components of elongation factor-1, EF-1α and EF-1δ. EF-1α mRNA, detected as a single 2.7 kb transcript decreased 6 h after fertilization and dramatically increased 20 h post-fertilization at...
Article
Elongation factor-1 delta gene expression was analyzed during sea urchin development. EF-1 delta mRNA is present as a single 2.7-kb transcript in unfertilized eggs and in rapidly dividing cleavage stage embryos. It decreases rapidly 6 h after fertilization and then reappears at the gastrula stage as two transcripts of 2.7 and 2.0 kb. cDNA clones en...

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Projects

Projects (2)
Archived project
Cyclin/CDK Characteriozation and cell cycle/circiadian Clock link in the smallest photosynthetic eukaryote
Project
molecular genetics of HFE-Hemochromatosis