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Publications (11)
Much of the sensory-motor processing in the human brain is lateralized to either hemisphere, with the corpus callosum integrating these distinct processes into a seemingly unified conscious experience. The corpus callosum is thought to be topographically organized, with different subregions along its anterior-to-posterior axis involved in integrati...
The dynamic integration of the lateralized and specialized capacities of the two cerebral hemispheres constitutes a hallmark feature of human brain function. This inter-hemispheric exchange of information is thought to critically depend upon the corpus callosum. Classical anatomical descriptions of callosal organization outline a topographic gradie...
Two-thirds of published patients with anti-leucine rich, glioma inactivated 1 (LGI1) encephalitis develop hippocampal sclerosis (HS). It is likely that this contributes to residual cognitive long-term deficits and the risk of epilepsy. Almost all patients harbor anti-LGI1-immunoglobulin G-(IgG-) subclass 4, which is considered a “benign”, non-destr...
Background and objectives:
Patients with ongoing seizures are usually not allowed to drive. The prognosis for seizure freedom is favorable in patients with autoimmune encephalitis (AIE) with antibodies against NMDA receptor (NMDAR), leucine-rich glioma-inactivated 1 (LGI1), contactin-associated protein-like 2 (CASPR2), and the gamma-aminobutyric-a...
Objective
Benchmarking has been proposed to reflect surgical quality and represents the highest standard reference values for desirable results. We sought to determine benchmark outcomes in patients after surgery for drug‐resistant mesial temporal lobe epilepsy (MTLE).
Methods
This retrospective multicenter study included patients who underwent MT...
Autoantibodies against contactin-associated protein 2 (Caspr2) not only induce limbic autoimmune encephalitis but are also associated with pain conditions. Here, we analyzed clinical data on pain in a large cohort of patients included into the German Network for Research in Autoimmune Encephalitis. Out of 102 patients in our cohort, pain was a freq...
Seizures resulting from cerebral autoimmunity are either acutely symptomatic in the context of autoimmune encephalitis (AIE) with neural surface antibodies, or they are indicative of an enduring predisposition to seizures, that is, epilepsy. Here, we propose a practical definition for autoimmune encephalitis‐associated epilepsy (AEAE): Seizures ass...
Corpus callosotomy is a palliative therapy option in patients with drop attacks or therapy-resistant bilateral tonic-clonic seizures (BTCS), particularly in Lennox Gastaut syndrome (LGS), if curative epilepsy surgery is not possible. This is the case in bilateral or multifocal lesions, pathologies near to eloquent areas or in non-lesional epilepsie...
Background:
Clinicians have questioned whether any disorder involving seizures and neural antibodies should be called "(auto)immune epilepsy." The concept of "acute symptomatic seizures" may be more applicable in cases with antibodies against neural cell surface antigens. We aimed at determining the probability of achieving seizure-freedom, the us...
Für das lokalbegrentze Prostatakarzinoms gelten aktuell Brachytherapie und radikale Prostatektomie als anerkannte Therapie-Methoden. Welche Therapie-Methode letztendlich gewählt wird, unterliegt der Entscheidung des Patienten und des behandelnden Arztes. Ein wichtiges Entscheidungskriterium ist die Häufigkeit von posttherapeutischen hantraktbezogen...
