Anna Michel

University Hospital Essen | UK Essen · Clinic for Neurosurgery

Purpose Breast cancer (BC) is the most frequently diagnosed tumor entity in women. Occurring at different time intervals (TI) after BC diagnosis, brain metastases (BM) are associated with poor prognosis. We aimed to identify the risk factors related to and the clinical impact of timing on overall survival (OS) after BM surgery. Methods We included...

Background: Brain metastases requiring surgical treatment determine the prognosis of patients with breast cancer. We aimed to develop the scores for the prediction of short (<6 months) and long (≥3 years) survival after BCBM surgery. Methods: Female patients with BCBM surgery between 2008 and 2019 were included. The new scores were constructed u...

Objective Occurrence of brain metastases BM is associated with poor prognosis in patients with breast cancer (BC). Magnetic resonance imaging (MRI) is the standard of care in the diagnosis of BM and determines further treatment strategy. The aim of the present study was to evaluate the association between the radiographic markers of BCBM on MRI wit...

Spinal epidural lipomatosis (SEL) is a rare condition caused by hypertrophic growth of epidural fat. The prevalence of SEL in the Western world is approximately 1 in 40 patients and is likely to increase due to current medical and socio-economic developments. Rarely, SEL can lead to rapid severe neurological deterioration. The pathophysiology, opti...

Objective Spinal cord ependymomas account for 3–6% of all central nervous system tumors and around 60% of all intramedullary tumors. The aim of this study was to analyze the neurological outcome after surgery and to determine prognostic factors for functional outcome. Patients and Methods Patients treated surgically due to a spinal cord ependymoma...

Purpose: Disturbances of electrolytes and renal function have been linked to the prognosis of critically ill patients and recently also of cancer patients. This study aimed to assess electrolyte and renal disorders in glioblastoma patients and evaluate their prognostic effect. Methods: Medical records of patients with newly diagnosed glioblastoma b...

Background Hormone and HER2/neu receptor status is prognostic and predictive in breast cancer (BC) and guides the choice of therapy. Due to receptor conversion, receptor conversion may differ in metastases compared to primary tumor. Objective The aim of the present study is to analyze the prognostic value of receptor status, receptor conversion an...

Background and Study Aims/Object Despite the relevance of molecular criteria for brain tumor diagnosis and prognosis, meningioma grading is still solely based on histologic features. Atypical meningiomas (AMs; WHO grade II) display a great histologic heterogeneity and individual courses of disease can differ significantly. This study aimed to ident...

Objective Gliosarcoma (GSC) is a rare histological variant of glioblastoma (GBM). Due to limited evidence regarding clinical, genetic and radiographic characteristics of GSC, this study aimed to analyze independent outcome predictors of GSC, and to address the differences between GSC and GBM concerning the baseline characteristics and patients’ sur...

Background Electrolyte disturbances and altered renal function have been linked to the prognosis of critically ill patients and recently also of cancer patients. Little is known about the prevalence and prognostic impact of electrolyte and renal disorders in patients with glioblastoma (GBM), the most frequent malignant primary brain tumor. This stu...

Objective: Glioblastoma is the most common malignant brain tumor in adults. The treatment consists of surgical reduction of the tumour mass, radiation and chemotherapy. A definitive cure cannot currently be achieved. In general, mean survival times range from a few months without treatment to around 15 months with combined radio-chemotherapy. Only...

Background Despite recent improvements in treatment of glioblastoma (GBM), some patients still show a short survival. Objective In this study, we sought to develop a new risk score for preoperative assessment of short-term survival (STS, < 6 months) in GBM patients. Methods All adult patients that underwent surgical resection of GBM between 2004...

Background: Glioblastoma (GBM) is the most common malignant brain tumor in adults and still carries a dismal prognosis. As several studies detected a connection between inflammation and GBM prognosis, we sought to explore possible associations between routinely investigated inflammatory parameters and GBM outcome. Patients and methods: Patients...

Introduction Glioblastoma multiforme (GBM) has a peak incidence in patients older than 65 years. The aim of the present study is to evaluate the impact of surgical strategy on short- and long-term outcomes of older GBM patients. Methods A total of 273 older patients (65–84 years) from 2006 to 2014 were operated in our neurosurgical center. The stu...

In this Letter, Dominic Grün and Sagar should have been listed as authors, with the affiliation Max Planck Institute of Immunobiology and Epigenetics (MPI-IE), Freiburg, Germany. These authors established the sequencing platform, supervised the sequencing and helped with bioinformatics (see ‘Author contributions’). This study was supported by the D...

Microglia have critical roles not only in neural development and homeostasis, but also in neurodegenerative and neuroinflammatory diseases of the central nervous system. These highly diverse and specialized functions may be executed by subsets of microglia that already exist in situ, or by specific subsets of microglia that develop from a homogeneo...

Hemangiopericytoma (HPC) is a highly vascularized mesenchymal tumor. Local recurrence and distant metastasis are common features of HPC. Considering the remarkable hyper-vasculature phenotype of HPC, we assumed that dysregulated angiogenic signaling pathways were involved in HPC. The key components of angiogenic signaling pathways including VEGF-VE...