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Publications (27)
Scope
This multi‐omic study investigates the bidirectional interactions between gut microbiota and silymarin metabolism, highlighting the differential effects across various age groups. Silymarin, the extract from Silybum marianum (milk thistle), is commonly used for its hepatoprotective effects.
Methods and results
An in vitro fermentation colon...
Scope This multi-omic study investigates the bidirectional interactions between gut microbiota and silymarin metabolism, highlighting the differential effects across various age groups. Silymarin, the extract from Silybum marianum (milk thistle), is commonly used for its hepatoprotective effects. Methods and results An in vitro fermentation colon m...
Recently, neglected and underutilized species (NUS) have deservedly come to the forefront of scientific interest because they can contribute to the human nutrition, due to the content of bioactive substances such as antioxidants. Despite the great diversity and rich tradition in the use of Philippine NUS, the nutritional properties of many edible p...
Recently, neglected and underutilized species (NUS) have deservedly come to the forefront of scientific interest because they can contribute to the human nutrition, due to the content of bio-active substances such as antioxidants. Despite the great diversity and rich tradition in use of Philippine NUS, the nutritional properties of many edible plan...
f silymarin components, particularly isosilybin B, which was associated with higher abundance of Faecalibacterium and Erysipelotrichaceae UCG-003. Conclusion This study provides insights into microbiome functionality in metabolizing dietary flavonolignans, highlighting implications for age-specific nutritional strategies and advancing our understan...
f silymarin components, particularly isosilybin B, which was associated with higher abundance of Faecalibacterium and Erysipelotrichaceae UCG-003. Conclusion This study provides insights into microbiome functionality in metabolizing dietary flavonolignans, highlighting implications for age-specific nutritional strategies and advancing our understan...
Background
Exclusive enteral nutrition (EEN) is an effective treatment for active Crohn’s disease (CD). This study explored the immunostimulatory potential of a cell-free fecal filtrate and related this with changes in the fecal microbiota and metabolites in children with active CD undertaking treatment with EEN.
Methods
Production of tumor necros...
Diarrhoea remains an important public health concern, particularly in developing countries, and has become difficult to treat because of antibacterial resistance. The development of synergistic antimicrobial agents appears to be a promising alternative treatment against diarrhoeic infections. In this study, the combined effect of tetracycline toget...
Five putrescine and spermidine derivatives (1–5) together with five rotenoids (6–10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 ± 1.9% for AChE and 90.0 ± 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not...
This study investigates how the dietary supplement silymarin interacts with gut microbiota, with a focus on aging populations. Using advanced techniques such as next-generation sequencing, NMR and LC-MS, we analysed the dual impact of the gut microbiome on silymarin metabolism and the effect of silymarin on the microbiome’s structure and function....
This study investigates how the dietary supplement silymarin, interacts with gut microbiota, with a focus on aging populations. Using advanced techniques such as next-generation sequencing, NMR, and LC-MS, we analyzed the dual impact of the gut microbiome on silymarin metabolism and the effect of silymarin on the microbiome's structure and function...
Background
Predicting response to exclusive enteral nutrition (EEN) in active Crohn’s disease (CD) could lead to therapy personalization and pretreatment optimization.
Objectives
This study aimed to explore the ability of pretreatment parameters to predict fecal calprotectin (FCal) levels at EEN completion in a prospective study in children with C...
Background and aims:
Treatment by anti-TNFα antibodies (anti-TNF) changes the dysbiotic faecal bacteriome in Crohn's disease (CD). However, it is not known whether these changes are due to decreasing mucosal inflammatory activity or whether similar bacteriome reactions might be observed in gut-healthy subjects. Therefore, we explored changes in fa...
Introduction
Coeliac disease is a lifelong immune-mediated enteropathy manifested as gluten intolerance in individuals carrying specific human leukocyte antigen (HLA) molecules. Other factors than genetics and gluten intake, however, may play a role in triggering the disease. The gut internal environment is thought to be one of these potential cont...
BACKGROUND
The ultraviolet‐B (UV‐B) radiation can alter grape metabolism during berry development, but little is known on the effect of postharvest UV‐B exposure. In this study, we evaluated the effect of postharvest UV‐B exposure on berry primary and secondary metabolites in four grapevine varieties (Aleatico, Moscato bianco, Sangiovese, and Verme...
The presence of pharmaceuticals in the environment is a matter of great concern. They are consistently found in the environment, raising concerns regarding human exposure through dietary intake. In this study, we observed the effect of the application of carbamazepine at 0.1, 1, 10, and 1000 μg per kg of soil contamination levels to assess stress m...
Background
Predicting response to treatment with exclusive enteral nutrition (EEN) in paediatric Crohn’s disease (CD) can lead to more personalised, cost-effective, and efficacious therapy. We explored the ability of pre-treatment clinical and multi-omics parameters to predict faecal calprotectin (FCal) levels at EEN completion.
Methods
In 37 chil...
Background
Treatment by anti-TNFα antibodies (aTNFα) is known to change the dysbiotic faecal bacteriome in Crohn's disease (CD). However, whether the change is caused by aTNFα itself or by improving the gut inflammation status is unknown. Therefore, we aimed to identify and compare bacterial taxa and faecal metabolite changes upon aTNFα between chi...
Although some underutilized tropical fruits and vegetables have been found to be rich in antioxidants and micronutrients, the phytochemical and nutritional properties of most of them are still not fully explored. The objective of the present study was to evaluate 22 neglected fruits/vegetables consumed in Cambodia for their antioxidant activity (DP...
Aims/hypothesis:
We previously detected indications that beta cell function is protected by gluten-free diet (GFD) introduced shortly after the onset of childhood type 1 diabetes. The present aim was to assess whether GFD was associated with changes in the gut bacteriome composition and in its functional capacity, and whether such changes mediated...
Within the group of higher fungi, edible medicinal mushrooms have a long history of being used as food and in folk medicine. These species contain biologically active substances with many potential beneficial effects on human health. The Pleurotus genus is representative of medicinal mushrooms because Pleurotus ostreatus is one of the most commonly...
Powdery mildew is a common disease affecting the commercial production of gerbera flowers (Gerbera hybrida, Asteraceae). Some varieties show a certain degree of resistance to it. Our objective was to identify biomarkers of resistance to powdery mildew using an ¹H nuclear magnetic resonance spectroscopy and chemometrics approach in a complex, fully...
Fig trees (Ficus carica L.) are commonly grown in the Mediterranean area, where salinity is an increasing problem in coastal areas. Young, fruiting plants of cv. Dottato were subjected to moderate salt stress (100 mM NaCl added to irrigation water) for 48 days before fruit sampling. To clarify the effect of salinity stress, we investigated changes...
A set of 917 wines of Czech origin were analysed using nuclear magnetic resonance spectroscopy (NMR) with the aim of building and evaluating multivariate statistical models and machine learning methods for the classification of 6 types based on colour and residual sugar content, 13 wine grape varieties and 4 locations based on ¹H NMR spectra. The p...
