Anna-Marie FingerUniversity of California, San Francisco | UCSF · Department of Anatomy
Anna-Marie Finger
Phd
About
13
Publications
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Introduction
I have been performing laboratory research in Germany and the US for about 10 years. I am a molecular biologist by training, have worked in chronobiology the past few years, and recently moved into cancer field. I always felt curios about understanding mechanisms driving human disease. While I thought I could satisfy my curiosity by becoming a doctor, I quickly realized that I was longing for a deeper and more mechanistic understanding of disease development and progression. Therefore, I trans
Additional affiliations
October 2016 - present
Education
October 2016 - February 2020
October 2014 - August 2016
January 2012 - May 2014
Publications
Publications (13)
The circadian clock, a fundamental biological regulator, governs essential cellular processes in health and disease. Circadian-based therapeutic strategies are increasingly gaining recognition as promising avenues. Aligning drug administration with the circadian rhythm can enhance treatment efficacy and minimize side effects. Yet, uncovering the op...
Single-cell circadian oscillators exchange extracellular information to sustain coherent circadian rhythms at the tissue level. Within cells, the circadian clock and the cell cycle couple, yet the mechanisms governing this interplay remain poorly elucidated. Here, we study the role of extracellular circadian communication in the intracellular coord...
The circadian clock, a fundamental biological regulator, governs essential cellular processes in health and disease. Circadian-based therapeutic strategies are increasingly gaining recognition as promising avenues. Aligning drug administration with the circadian rhythm can enhance treatment efficacy and minimize side effects. Yet, uncovering the op...
A defining property of circadian clocks is temperature compensation, characterized by the resilience of their near 24-hour free-running periods against changes in environmental temperature within the physiological range. While temperature compensation is evolutionary conserved across different taxa of life and has been studied within many model org...
Circadian clocks can be found in nearly all eukaryotic organisms, as well as certain bacterial strains, including commensal microbiota. Exploring intercellular coupling among cell-autonomous circadian oscillators is crucial for understanding how cellular ensembles generate and sustain coherent circadian rhythms on the tissue level, and thus, rhythm...
The circadian clock is an evolutionarily highly conserved endogenous timing program that structures physiology and behavior according to the time of day. Disruption of circadian rhythms is associated with many common pathologies. The emerging field of circadian medicine aims to exploit the mechanisms of circadian physiology and clock–disease intera...
A defining property of circadian clocks is temperature compensation, characterized by the resilience of circadian free-running periods against changes in environmental temperature. As an underlying mechanism, the balance or critical reaction hypothesis have been proposed. While the former supposes a temperature-dependent balancing of reactions with...
Coupling between cell-autonomous circadian oscillators is crucial to prevent desynchronization of cellular networks and disruption of circadian tissue functions. While neuronal oscillators within the mammalian central clock, the suprachiasmatic nucleus, couple intercellularly, coupling among peripheral oscillators is controversial and the molecular...
The circadian system of mammals is hierarchically organized. The suprachiasmatic nucleus (SCN) in the hypothalamus is considered the master circadian clock adapting to environmental light-dark cycles and synchronizing subsidiary oscillators in peripheral organs. While being an attractive concept, this has never been convincingly shown in vivo. New...
RNA interference (RNAi) allows for the selective downregulation of gene expression by neutralizing targeted mRNA molecules and has frequently been used in high-throughput screening endeavors. Here, we describe a protocol for the highly parallel RNAi-mediated downregulation of gene expression in order to search for components involved in circadian r...
Zirkadiane Uhren sind Zell-autonome Oszillatoren. Aus diesem Grund ist deren interzelluläre Kopplung essentiell, um die Synchronität zirkadianer Oszillatornetzwerke zu erhalten und die Störung zirkadianer Gewebsfunktionen zu verhindern. Neuronale Oszillatoren des Nucleus suprachiasmaticus (SCN), der Schrittmacher-Uhr im Zentralnervensystem der Säug...
The circadian system is composed of coupled endogenous oscillators that allow living beings, including humans, to anticipate and adapt to daily changes in their environment. In mammals, circadian clocks form a hierarchically organized network with a “master clock” located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which ensures entra...
Humans and other mammalian species possess an endogenous circadian clock system that has evolved in adaptation to periodically reoccurring environmental changes and drives rhythmic biological functions, as well as behavioral outputs with an approximately 24‐hour period. In mammals body clocks are hierarchically organized, encompassing a so‐called p...
