Anna-Kaisa Tuomaala

Helsinki University Central Hospital | HUCH · Children’s Castle Hospital

Aims This study investigates the influence of the automated insulin delivery system (AID) on glycaemic control in children and adolescents with type 1 diabetes (T1D) who do not reach optimal glycaemic control with traditional treatment options. Materials and Methods All the patients aged 7 to 16 years with T1D who initiated the AID system between...

Aims To investigate whether the positive effects on glycaemic outcomes of 3‐month automated insulin delivery (AID) achieved in 2‐ to 6‐year‐old children endure over an extended duration and how AID treatment affects time in tight range (TITR), defined as 3.9–7.8 mmol/L. Research Design and Methods We analysed 18 months of follow‐up data from a non...

Introduction Intrauterine conditions and accelerating early growth are associated with childhood obesity. It is unknown, whether fetal programming affects the early growth and could alterations in the maternal-fetal metabolome be the mediating mechanism. Therefore, we aimed to assess the associations between maternal and cord blood metabolite profi...

Objective The safety and impact of the advanced hybrid closed-loop (AHCL) system on glycemic outcome in 2-6-year-old children with type 1 diabetes and the diabetes distress of caregivers were evaluated. Research Design and Methods This was an open-label prospective study (n=35) with historical controls matched by treatment unit, diabetes duration,...

Introduction Intrauterine conditions and accelerating early growth are associated with childhood obesity. It is unknown, whether fetal programming affects the early growth and could alterations in the maternal-fetal metabolome be the mediating mechanism. Therefore, we aimed to assess the associations between maternal and cord blood metabolome and o...

Background Between March 18 th and May 13 th 2020, the COVID-19 pandemic outbreak in Finland resulted in the closure of schools and the limitation of daycare (i.e. lockdown). Social distancing changed the daily routines of children with type 1 diabetes (T1D). Healthcare professionals were forced to adapt to the pandemic by replacing physical outpat...

Background: The hybrid close-loop system (HCL) is a rapidly emerging treatment method for type 1 diabetes (T1D), but the long-term effectiveness of the system remains unclear. This study investigates the influence of the HCL on glycemic control in children and adolescents with T1D in a real-life setting during the first year on HCL. Methods: Thi...

A multicenter randomized controlled pilot trial investigated whether motivational interviewing (MI) by diabetes physicians improves glycemic control and variability in the context of follow-up for adolescent patients with poorly controlled type 1 diabetes. Patients (n = 47) aged 12 to 15.9 years who showed poor glycemic control (HbA1c >75 mmol/mol/...

Context: Early growth associates with childhood adiposity, but the influence of lifestyle remains unknown. Objective: To investigate the association of growth profiles from high-risk pregnancies with adiposity at 5 years of age, taking into account lifestyle and several antenatal/postnatal exposures. Design: Prospective cohort study. Patients...

Introduction We studied if motivational interviewing (MI) added to standard educational care (SEC) improves vascular health in adolescents with poorly controlled type 1 diabetes. Research design and methods 47 adolescents with type 1 diabetes of at least 2 years duration and hemoglobin A1c >75 mmol/mol (>9.0%) on two visits were randomized to MI+S...

Diabeettinen ketoasidoosi on hätätilanne, joka pahimmillaan johtaa henkeä uhkaavaan kuivumiseen ja metaboliseen asidoosiin. Ketoasidoosin aiheuttaa insuliininpuutos yhdistyneenä vastavaikuttajahormonien määrän lisääntymiseen. Hoidon kulmakiviä ovat insuliini-infuusio ja oikeanlainen nestehoito, joiden tavoitteena on korjata kuivuminen, asidoosi ja...

About 500,000 people suffer from diabetes in Finland, a number which is predicted to increase within the next decades. At the moment, diabetes can neither be prevented nor cured. Diabetes is associated with microvascular (kidney, eye and peripheral nerves) and macrovascular complications (coronary heart disease, stroke). These complications affect...