Anna Jurowska

• Doctor
• Jagiellonian University

In the text, the synthesis and characteristics of the novel ONS-type vanadium(V) complexes with thioanilide derivatives of amino acids are described. They have shown inhibition of human protein tyrosine phosphatases (PTP1B, LAR, SHP1 and SHP2) in the submicromolar range, as well as inhibition of non-tyrosine phosphatases (CDC25A and PPA2) similar t...

In the text, the synthesis and characteristics of the novel ONS-type vanadium (V) complexes with thioanilide derivatives of amino acids are described. They showed the inhibition of human protein tyrosine phosphatases (PTP1B, LAR, SHP1, and SHP2) in the submicromolar range, as well as the inhibition of non-tyrosine phosphatases (CDC25A and PPA2) sim...

The thermal decomposition of (XMebpyH)3(H3O)[W(CN)8]·3H2O (where XMebpy denotes 4Mebpy 4,4′-dimethyl-2,2′-bipyridine or 5Mebpy 5,5′-dimethyl-2,2′-bipyridine) in glycerol results in the coordination of XMebpy. Salts of the anion formula [W(CN)6(XMebpy)]²⁻ were isolated for PPh4⁺ and/or AsPh4⁺ cations as well as for K⁺, Rb⁺, and Cs⁺ ones. X-ray singl...

First metal-asisted diaminoacetylene molecule synthesis is achieved. Three salts of [W(CN) 6 (C 2 N 2 H 4 )] ²⁻ ion were isolated and characterized including single crystal structure determination. The formation of diaminoacetylene is described and discussed.

In the text, the synthesis and characteristics of the novel ONS-type vanadium(V) complexes with thioanilide derivatives of amino acids are described. They have shown inhibition of human protein tyrosine phosphatases (PTP1B, LAR, SHP1 and SHP2) in the submicromolar range, as well as inhibition of non-tyrosine phosphatases (CDC25A and PPA2) similar t...

The synthesis and characteristics of the novel ONS-type vanadium(V) complexes with thioanilidine derivatives of aminoacids have been described. They showed inhibition of human protein tyrosine phosphatases (PTP1B, LAR, SHP1 and SHP2) in the submicromolar range and as well as inhibition of non-tyrosine phosphatases (CDC25A and PPA2) similar to bis(m...

The detailed approach to the synthesis of [W(CN)6(bpy)]2-/- ion salts at different conditions as well as the by-products formed are described. Single crystal X-ray structures of isolated salts: (PPh4)2[W(CN)6(bpy)]·bpy·10H2O, [{Cd(bpy)(H2O)}{Mn(bpy)(H2O)}{W(CN)2(bpy)}2(μ-CN)8]·4H2O, (PPh4)3[W(CN)7(O2)]·0.2bpy, (H3O)2[W(CN)6(bpy)]·4MeOH, {(PPh4)2 [W...

The biological activity of the vanadium Schiff base complexes, which can be potentially used as insulin-mimetic compounds, was extensively studied in the last decade. Pharmacological data showed that these compounds produced a significant decrease in blood glucose level and improved liver and kidney function after two weeks of daily use. The vanadi...

Four dioxidovanadium(V) complexes with Schiff-base ligands based on 2-hydroxybenzhydrazide with four different substituted salicylaldehydes (5-chlorosalicylaldehyde, 3,5-dichlorosalicylaldehyde, 5-nitrosalicylaldehyde, 3-bromo-5-chlorosalicylaldehyde) were synthesized and described, by using V2O5 and triethylamine. The single crystal X-ray structur...

The synthesis of molecular materials with magnetic properties, in particular ferromagnetic properties, has been the subject of interest in coordination chemistry for decades. In the last three decades, research has accelerated, as it has emerged that creating bridging systems based on cyanido ligands is a good and relatively simple way to create co...

The synthesis and single X-ray crystal structures of Tl2[W(CN)6(bpy)]·H2O, Tl[W(CN)6(bpy)], Tl57[{Fe(CN)6}12{NO3}9]·9H2O, Tl4[W(CN)8] and Tl4[Mo(CN)8] are described. Salts crystalize in the monoclinic or trigonal (Fe) space group. For all complexes, the very unusual “side-on” coordination of Tl to C and N of cyanido ligands is observed and compared...

Five vanadium(IV) and (V) complexes, with Schiff base ligand, based on three vanadium precursors such as [VO(acac)2], VOSO4 and V2O5 were synthesized and characterized. Only the last vanadium substrate, in a very simple synthesis, with the addition of triethylamine, results in formation of the crystalline product for which crystal structure measure...

The series of salts with 2,2’-H2bpy, 2,2’-Hbpy, 4,4’-H2bpy and dq²⁺ as cations (where bpy – bipyridine, dq - diquat) and, [Fe(CN)6]⁴⁻ as anions were synthesized and described. Three of them, with the [Fe(CN)5(NO)]²⁻ anion were structurally characterized, and the formulas of other salts were determined on the basis of elemental analysis and IR spect...

The series of salts with [W(CN)6(bpy)]²⁻ and protonated 2,2′-bpy (1), 4,4′-bpy (2), 4,4′-dimethyl-2,2′-bpy (4), 5,5′-dimethyl-2,2′-bpy (5), 6,6′-dimethyl-2,2′-bpy (6), and dq (3) as cations (where bpy - bipyridine, dq - diquat dication = 1,1′-ethylene-2,2′-bipyridylium ion) were synthesized and characterized. The single-crystal X-ray crystal struct...

The syntheses of five vanadium complexes with ONO donor Schiff bases (L) along with analyses of obtained compounds were described: two [VO(L)(phen)] (phen = 1,10-phenanthroline) with V(IV) and three [V(L)2] with V(III). Ligands were derived from phenylacetic hydrazide and four aldehydes: 3-bromo-5-chloro-salicylaldehyde, 4-(diethylamino)-salicylald...

The 10 ion-pairs of [W(CN)8]4- with substituted Hphen and Hnbpyn+ (where phen = 1,10-phenantroline, bpy = 2,2'-bipyridine, n = 1 or 2) were isolated and the spectroscopic properties of these salts are discussed. Three salts with dimethyl-substituted Hnbpyn+ cation were structurally characterized. In the structure of the salt with H2bpy, one of the...

Three complexes with the formula Na[W(CN)6(bpy)]·H2O (1), K[W(CN)6(bpy)] (2) and Rb[W(CN)6(bpy)] (3) have been synthesized and structurally characterized based on the X-ray analysis of single crystals, as well as described and compared with analogues in which the tungsten atom is in the fourth oxidation state. All salts crystallize in orthorhombic...

Twenty-four oxidovanadium(IV,V) complexes with tridentate Schiff base ligands based on 5-nitrosalicylaldehyde, 5-methoxysalicylaldehyde, or 5-sulfosalicylaldehyde and respective hydrazide were isolated, and characterized using physicochemical and spectroscopic methods. Three of them were structurally characterized by single-crystal X-ray structure...

The synthesis, properties, including single crystal structures and biological activity of 16 new vanadium complexes with tridentate ONO Schiff base ligands L based on 5-chloro- and 5-hydroxy-salicylaldehyde and selected hydrazides are presented. Several types of complexes were synthesized at different oxidation state of vanadium: [VO(L)(phen)] (whe...

We present a straightforward, fast, inexpensive, and environmentally friendly synthesis of 1,2,3,4,5-pentasubstituted derivatives of pyrrole, which were produced in one-pot reactions of 3-oxoanilides with hydrazides of carboxylic acids, catalyzed by 10 mol % VOSO4·H2O. The reactions were carried out in ethanol in contact with air as the oxidant. Th...

Two sodium salts with the [W(CN) 6 (bpy)] ²⁻ ion were synthesized and compared to Li ⁺ , K ⁺ , Rb ⁺ and Cs ⁺ structures. The comparison of molecular packing, inter- and intra-molecular interactions and cation properties is discussed.

The complexes of formula K2[W(CN)6(bpy)]·3H2O (1) and Rb2[W(CN)6(bpy)]·3.5H2O (2) were synthesized, structurally characterized, described and compared with lithium and cesium analogues. The salts crystalize in triclinic (P-1 for 1) or monoclinic (P21/n for 2) space groups. In these salts the layered structure are observed with weak hydrophobic bpy-...

The synthesis and single-crystal X-ray structure of the supramolecular complex {[Zn]1.5[Zn(H2O)][W(CN)5(OH)2][W(CN)5(OH)(H2O)]} (1) are reported. We found that photolysis of PPh4[W(CN)6(bpy)] in the presence of Zn(NO3)2 aq results in formation of a porous supramolecular network (channels with a volume of 44.1% of the unit cell volume) with all cyan...

The syntheses of 16 vanadium(IV and V) complexes with ONO tridentate Schiff base ligands are described. The vanadium(IV) compounds were synthesized with 1,10-phenantroline as a co-ligand. In the case of five complexes of vanadium(V), the solvent molecule in form of ethanol or ethoxy ligand fill the coordination sphere of V(V) to six. In the crystal...

Four dendrimeric hexa- or nona-dentate Schiff base ligands based on triazine structure and several lithium and vanadium(IV) complexes with these ligands were synthesized and characterized by elemental analysis, ¹H NMR and IR spectra. The synthetic methods are described, and we paid special attention to the need to use a co-ligand (in case of vanadi...

The synthesis, spectral and structural description of two salts of formula {[Li][Li(H2O)(µ-CN)3]}([W(CN)3(bpy)] (1) and {Li}{[Li(µ-CN)¬2[Li(µ-CN)3]µ-Cl}[W(CN)(bpy)]·2H2O (2) were described. The structural investigation shows the influence of the size and charge of Li+ on the nature of the CN-/Li+ interaction and thus on the structure of the compoun...

Schiff base ligands based on 5-bromosalicylaldehyde and 4-tertbutylbenzhydrazide or benzhydrazide were used in syntheses of eight vanadium complexes with VOSO4(aq), [VO(acac)2] and [V(acac)3] in ethanolic solution. In selected syntheses 1,10-phenanthroline (phen), 2,2’-bipyridine (bpy) or 2,5-pyridinedicarboxylic acid (dpy) were used as co-ligands...

Seventeen complexes of vanadium (III-V) with hydrazido-hydrazone Schiff bases, formed from 5-bromosalicylaldehyde and different hydrazides, are described and characterized by elemental analysis, IR, UV-Vis (in solution and as reflectance spectra) and EPR spectroscopy, cyclic voltammetry and thermogravimetric measurements. The nonoxido complexes sho...

The synthesis and physicochemical properties of three new complexes of vanadium at +5, +4 and +3 oxidation state are described and discussed. The octahedral surrounding of vanadium for V(III) complexes of [V(L1)(HL1)] general formula is filled with two ONO tridentate ligand L, for V(IV) one ONO ligand L, oxido ligand and 1,10-phenanthroline (phen)...

The synthesis and physicochemical properties of vanadium(III,IV,V) complexes with Schiff base ligands based on 3,5-dibromo-4-methoxy-salicylaldehyde and phenylacetic hydrazide (H2L1), 5-chlorosalicylaldehyde and 4-hydroxybenzhydrazide (H2L2) and 5-chlorosalicylaldehyde and 2-hydroxybenzhydrazide (H2L3) were presented. The formulas of the complexes...

The synthesis and physicochemical properties of new vanadium(IV) complex of formula [VO(L)(phen)] is described. The L denotes ONO tridentate Schiff base derived from 2,3-dihydroxybenzaldehyde and phenylacetic hydrazide, while phen = 1,10-phenanthroline used as a co-ligand to stabilize the V(IV) oxidation state. The single crystal X-Ray crystal stru...

Nine new vanadium complexes, with tridentate Schiff base ligand based on 3,5-di-tert-butyl-2-hydroxybenzaldehyde and different hydrazides, are described and characterized. The X-ray crystal structure of complex 8 shows distorted octahedral geometry of vanadium, with ONO ligand in equatorial position. The tridentate Schiff base ligand forms six memb...

The oxidovanadium(V) Schiff base complex of formula [VO(L)(EtO)(EtOH)] (where H2L = Schiff base ligand derived from 5-methoxysalicylaldehyde and phenylacetic hydrazide) was synthesized and described. Complex crystalizes in triclinic P-1 space group. Octahedral geometry of the vanadium(V) centre is filed with oxido, ONO L2- ligand and two solvent mo...

Four complexes of V(IV/V) of octahedral geometry, with tridentate ONO Schiff base ligand, oxido and bidentate (maltol, 1,10-phenantroline or 2,2′-bipyridine) co-ligands are described. The Schiff bases were formed from 3,5-di-tert-butyl-2-hydroxybenzaldehyde and hydrazides (benzhydrazide, 2-hydroxybenzhydrazide and phenylacetic hydrazide). The X-ray...

The reaction of tetrazole ligand derived from 5-amino-2-cyanopyridine with K3Na[Mo(CN)4O2]⋅6H2O in water–ethanol solution results in isolation of a new complex of formulae: (PPh4)2[Mo(CN)3O(apdt)]·2.5H2O (1) (apdt = 6-(1H-tetrazol-5-yl)-pyridin-3-amine). The complex was characterized by elemental analysis, single crystal X-ray structure measurement...

The reaction of vanadyl sulfate, VOSO4·H2O, with Schiff base ligand based on 2-hydroxybenzhydrazide and 5-bromosalicylaldehyde, with addition of 1,10-phenantroline as co-ligand, in ethanolic solution results in isolation of oxovanadium(IV) complex [VO(phen)L]·H2O (1). The complex was characterized by elemental analysis, single crystal X-ray structu...

The reactions of tetrazole ligand derived from 2-cyanopyridine with K3Na[Mo(CN)4O2]·6H2O and K3Na[W(CN)4O2]·6H2O in water-ethanol solution result in isolation of two new complexes with the following formulae: (PPh4)2[Mo(CN)3O(pdt)]·2H2O (1) (Hpdt = 5-(2-pyridil)-1H-tetrazole) and (PPh4)2[W(CN)3O(pdt)]·3H2O (2). The complexes were characterized by e...

Metal-based drugs, also called "metallopharmaceuticals" or "metallodrugs", are examples of sophisticated compounds that have been used in inorganic medicinal chemistry as therapeutic agents for a long time. Few of them have shown substantially promising results and many of them have been used in different phases of clinical trials. The Mo-based met...

Mnemonic devices are specific ways, which during coding new information apply known elements for improving subsequent access to that information in the memory. Consequently, not much is known about techniques for optimizing recall performance with mnemonic devices or the suitability of using mnemonic devices in educational applications. Moreover, i...

Wstęp Współczesnym trendem panującym na uczelniach wyższych – zwłaszcza w odniesieniu do przedmiotów przyrodniczych i ścisłych - jest powszechne stosowanie prezentacji multimedialnych na wszelkich typach zajęć – wykładach, seminariach, konwersatoriach, ćwiczeniach jak również na zajęciach laboratoryjnych. W dobie łatwych i ogólnodostępnych źródeł r...

The concept of oxidation state (or oxidation number) and related issues have always been difficult for students. In addition, there are misunderstandings and obscurities, which can cause improper balancing of the chemical equations (mostly in organic reactions). In particular, these problems are related to determination of the oxidation state of ni...

The reaction of N-substituted alcohols (2-aminoethanol, 3-amino-1-propanol and 2-hydroxyethylhydrazine) with K3Na[Mo(CN)(4)O-2]center dot 6H(2)O in water-ethanol solution results in isolation of three new complexes of formulae: (PPh4)(2)[Mo(CN)(4)O-2(amet)]center dot 3H(2)O (1), (amet = 2-aminoethanol), (PPh4)(2)[Mo(CN)(4)O(ampro)]center dot 3H(2)O...

Mnemonic devices can be defined as learning strategies which can often enhance the learning and later recall of information. On the other hand, mnemonic systems are special techniques or strategies consciously used to improve memory, it helps employ information already stored in long term memory to make memorization an easier task. There is no doub...

A series of W(IV) complexes with 2-aminoethanol and 5-bromo-, 5-chloro-, 5-methoxy-, 3,5 -dichloro-substituted salicylaldehydes is described. The complexes were isolated and characterized by elemental analysis, IR and UV-Vis spectroscopy as well as cyclic voltammetry. The single crystal X-ray analysis of salt (PPh4)(2)[W(CN)(3)O(metsal)]center dot...

The reaction of Schiff bases formed in reaction of 2-(aminomethyl)pyridine and aliphatic ketones (acetone, dihexyl ketone, 2- and 4-heptanone) or 2-acetylpyridine and 2-aminoethanol with K3Na[Mo(CN)(4)O-2]center dot 6H(2)O in water-ethanol solution results in isolation of two new complexes of formulae: (PPh4)[Mo(CN)(3)O(ampy)]center dot 2H(2)O (1)...

The reaction of K3Na[Mo(CN)(4)O-2]center dot 6H(2)O with 2,3-dicyanopyrazine or 2-pyridinecarbonitrile in aqueous media results in isolation of two new compounds of formulae (PPh4)(2)[Mo(CN)(3)O(pzac)]center dot 2H(2)O (Hpzac = 3-carbamoyl-2-pyrazinecarboxylic acid) and (PPh4)(2)[Mo(CN)(3)O(pynccn)]center dot 3H(2)O center dot EtOH (Hpynccn = 2-pyr...