Anna Hubatová-Vacková

University of Chemistry and Technology, Prague | VSCHT · Department of Environmental Chemistry

Nilotinib is a selective tyrosine-kinase inhibitor approved for the treatment of chronic myeloid leukemia. It is poorly soluble in aqueous media and has a low oral bioavailability. Nilotinib encapsulation into yeast glucan particles (GPs) was investigated in this work as a means of increasing bioavailability. The amorphization of nilotinib in GPs r...

The food industry represents a vast environmental burden to our planet. Most animal products are known to have greater environmental impacts than alternative plant-based sources of nutrition. One of the most consumed animal products are eggs, represented in most dietary habits both as a primary ingredient and processed. In the European Union (EU),...

The particle size (PS) and encapsulation efficiency (EE%) of drug-loaded nanoparticles (NPs) may inhibit their cellular uptake and lead to possible leakage of the drug into the systemic circulation at the tumor site. In this work, ultra-high paclitaxel-loaded poly(lactide-co-glycolide) NPs (PTX-PLGA-NPs) with ultra-small sizes were prepared and opt...

Microfluidics allows to accurately control the synthesis of microparticles for specific applications, where size and morphology play an important role. In this work, we introduce microfluidic chip design with dedicated extraction and gelation sections allowing to prepare hydrogel particles in size range of a red blood cell. The influence of the ext...

Microfluidic devices, allowing superior control over the spatial and temporal distribution of chemical substances and high process reproducibility, are nowadays essential in various research areas and industrial fields where the traditional “macroscopic” approach was no longer able to keep up with the increasing demands of high-end applications. In...