• Home
  • Anna Głobińska
Anna Głobińska

Anna Głobińska
Allergy (Wiley) · Swiss Institute of Allergy and Asthma Research (SIAF)

PhD
Graphics Editor of Allergy (Wiley)

About

36
Publications
11,944
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
2,151
Citations
Additional affiliations
September 2014 - present
Swiss Institute of Allergy and Asthma Research
Position
  • Research Associate
October 2011 - March 2018
University of Lodz
Position
  • PhD Student

Publications

Publications (36)
Article
Full-text available
Background Antigen‐specific memory B cells play a key role in the induction of desensitization and remission to food allergens in oral immunotherapy and in the development of natural tolerance (NT). Here, we characterized milk allergen Bos d 9‐specific B cells in oral allergen‐specific immunotherapy (OIT) and in children spontaneously outgrowing co...
Article
Background: Human bocaviruses (HBoVs) have been demonstrated in respiratory and gastrointestinal infections; however, the immune response to them has not been studied in detail. In this study, we investigated the B cell immune responses to HBoV1 and HBoV2, representing two different species of bocaviruses in humans. Methods: We analyzed the effe...
Article
Full-text available
Within the gastrointestinal tract, histamine is present at relatively high concentrations, especially during inflammatory processes. Histamine is a biogenic amine with numerous effects on many cell types, mediated by the activation of its four different histamine receptors (H1–H4Rs). It is produced and released by immune cells as mast cells and bas...
Preprint
Full-text available
Antigen-specific memory B cells play a key role in the induction of immune tolerance to food allergens and clinical healing. Here, we characterized the role of allergen-specific B cells in immune tolerance induced by oral allergen-specific immunotherapy (OIT) and natural tolerance that developed in children who spontaneously outgrew cow’s milk alle...
Article
Full-text available
Marek L. Kowalski was a dedicated scientist and clinician, dynamic leader and organizer, as well as committed educator and mentor for many students, researchers and doctors. His discoveries in human immunology, his empirical and implementation works made a significant contribution to modern medical knowledge and practice in the field of pathogenesi...
Article
Full-text available
In this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and prevention, mechanisms, diagnosis, and treatment of asthma. Many risk and protective factors and molecular mechanisms are involved in the development of asthma. Emerging concepts and challen...
Article
Full-text available
Background Despite the efficacy of allergen-specific immunotherapy (AIT), the role of trained immunity and tolerance in this process has not been elucidated. Objective Here, we have performed a comprehensive longitudinal analysis of the systemic innate immune cell repertoire during the course of AIT. Methods Patients with allergy received standar...
Article
Full-text available
B cells contribute to immune responses through the production of immunoglobulins, antigen presentation, and cytokine production. Several B cell subsets with distinct functions and polarized cytokine profiles have been reported. In this study, we used transcriptomics analysis of immortalized B cell clones to identify an IgG4 ⁺ B cell subset with a u...
Article
Full-text available
Introduction: Respiratory pathogens are thought to be involved in the pathogenesis and exacerbations of asthma at all ages; however, little is known about the airway microbiome in the elderly. Aim of the study: To identify respiratory pathogens in the induced sputum (IS) of elderly asthmatics, and to determine the association between pathogens a...
Article
Full-text available
Oral tolerance can develop after frequent exposure to food allergens. Upon ingestion, food is digested into small protein fragments in the gastrointestinal tract. Small food particles are later absorbed into the human body. Interestingly, some of these ingested food proteins can cause allergic immune responses, which can lead to food allergy. So fa...
Article
Objective The aim of this review is to provide an overview of the current knowledge on the mechanisms of allergen immunotherapy based on the recent publications and clinical trials. Data sources PubMed literature review. Study selections In this review, we focus on diverse mechanisms of AIT and provide an insight into alternative routes of administ...
Article
Objective: The aim of this review is to provide an overview of the current knowledge on the mechanisms of allergen immunotherapy based on the recent publications and clinical trials. Data sources: PubMed literature review. Study selections: In this review, we focus on diverse mechanisms of AIT and provide an insight into alternative routes of...
Article
Full-text available
Purpose: In order to gain an insight into determinants of reported variability in immune responses to respiratory viruses in human bronchial epithelial cells (HBECs) from asthmatics, the responses of HBEC to viral infections were evaluated in HBECs from phenotypically heterogeneous groups of asthmatics and in healthy controls. Methods: HBECs wer...
Article
Full-text available
Purpose of review: During the past few decades, modified allergens have been developed for use in allergen-specific immunotherapy (AIT) with the aim to improve efficacy and reduce adverse effects. This review aims to provide an overview of the different types of modified allergens, their mechanism of action and their potential for improving AIT....
Article
Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a clinical tolerance-inducing and immune tolerance-inducing therapy for allergic diseases and represents a potentially curative method of treatment. AIT functions through multiple mechanisms including early desensitization of basophils and mast cells, regulating T-cell a...
Article
Introduction: Innate lymphoid cells (ILCs) represent a diverse family of cells of the innate immune system, which play an important role in regulation of tissue homeostasis, immunity and inflammation. Emerging evidence has highlighted the importance of ILCs in both protective immunity to respiratory infections and their pathological roles in the lu...
Article
Background Respiratory syncytial virus (RSV) is an important risk factor of asthma development and is responsible for severe respiratory tract infections. However, the influence of RSV infection on barrier function of bronchial epithelial cells in vitro and in vivo is still unclear. Objective The aim of this study was to analyze the role of RSV in...
Article
Immune tolerance to both self-antigens and innocuous non–self-antigens is essential to protect the host against chronic inflammatory diseases and tissue damage. A wide range of cell types and suppressive molecules are involved in induction and maintenance of tolerance. In addition to their key function in the production of immunoglobulins, B cells...
Article
The aim of this study was to assess the immune response to parainfluenza virus type 3 (PIV3), rhinovirus 1B (RV1B) and intracellular Toll-like receptors (TLR) agonists in nasal epithelial cells (NECs) from patients with allergic rhinitis and healthy controls. NECs were obtained from eight patients with allergic rhinitis (AR) and 11 non-atopic healt...
Article
Full-text available
There have been extensive developments on cellular and molecular mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections during the last few years. Better understanding the functions, reciprocal regulation, and counterbalance of subsets of immune and inflammatory cell...
Article
Background: Tight junctions (TJs) form a barrier on the apical side of neighboring epithelial cells in the bronchial mucosa. Changes in their integrity might play a role in asthma pathogenesis by enabling the paracellular influx of allergens, toxins, and microbes to the submucosal tissue. Objective: The regulation of bronchial epithelial TJs by...
Article
Introduction. Model of primary bronchial epithelial cells culture has been used to study the innate response to viral infections in patients with bronchial asthma. Aim. The aim of the study was to evaluate the effectiveness of bronchial epithelial cell culture and the influence of parainfluenza virus type 3 (PIV- 3) on cell morphology. Materials an...
Article
Full-text available
Streszczenie Nanotechnologia jest niezwykle dynamicznie rozwijającą się wielodyscyplinarną dziedziną nauki, opartą na wykorzystywaniu właściwości struktur, których całkowita wielkość mieści się w przedziale 1-1000 nm. Wywodząca się z nanotechnologii nanomedycyna wykorzystuje możliwości, jakie stwarza zastosowanie nanostruktur do opracowywania nowyc...
Article
Nanotechnology is a fast growing multidisciplinary area of science based on the use of the properties of structures with overall size within the range 1-1000 nm. Nanomedicine has been derived from nanotechnology and uses the opportunities of nanostructures to develop new therapeutic strategies and diagnostic methods. Broadly defined nanostructures,...
Article
MicroRNAs (miRNAs) are small ssRNA molecules, which are involved in gene expression regulation at the post-transcriptional level. Their biological functions include modulation of both innate and adaptive immune response. miRNAs participate in the maintenance of the airway epithelial barrier and are also implicated in the modulation of antiviral def...
Article
Full-text available
The lysine connection with phosphatidylglycerol (PG) alters the M. tuberculosis (Mtb) surface charge, and consequently it may decrease the bacterial vulnerability to antimicrobial action of the immune cells. The aim of the study was to assess the significance of PG lysinylation in the Mtb interactions with mononuclear phagocytes. Both the Mtb strai...
Article
Interferon alfa jest cytokiną zaangażowaną w odpowiedź immunologiczną na infekcje wirusowe. Oprócz właściwości przeciwwirusowych, IFN-α posiada właściwości immunomodulacyjne oraz przeciwnowotworowe. Obecnie, IFN-α znajduje zastosowanie w leczeniu przewlekłego zapalenia wątroby typu C. Wcześniej podejmowane były liczne próby wykorzystania interferon...
Article
Interferon alpha belongs to type I family of interferons which are involved in immune response to viral infections. In addition to antiviral properties, IFN-α shows an immunomodulatory and antitumoural activity.Nowadays, IFN-α therapy is applied in chronic hepatitis C infections. Attempts were made to evaluate the clinical applications of interfero...
Article
Innate immune response to viruses is triggered by recognition of viral components by pattern recognition receptors (PRRs), which include Tolllike and RIG-I-like receptors: two major receptor systems for detecting RNA viruses. In addition to TLRs and RLRs there are also NOD-like receptors, but their contribution to antiviral response remains controv...

Network

Cited By