Ann-Marie Shorrocks

Ann-Marie Shorrocks
University of Oxford | OX · Weatherall Institute of Molecular Medicine

Doctor of Philosophy

About

4
Publications
1,370
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246
Citations
Introduction
Education
September 2022 - June 2026
University of Oxford
Field of study
  • Graduate Entry Medicine
September 2017 - February 2022
University of Oxford
Field of study
  • Oncology
September 2012 - June 2016
University of Cambridge
Field of study
  • Natural Sciences: Biochemistry

Publications

Publications (4)
Article
Full-text available
The accurate repair of DNA double-strand breaks (DSBs), highly toxic DNA lesions, is crucial for genome integrity and is tightly regulated during the cell cycle. In mitosis, cells inactivate DSB repair in favor of a tethering mechanism that stabilizes broken chromosomes until they are repaired in the subsequent cell cycle phases. How this is achiev...
Article
Full-text available
The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1 and RMI2 to form the BTR complex, which dissolves double Holliday junctions to produce non-crossover homologous recombination (HR) products. BLM also promotes DNA-end resection, restart of stalled replication forks, and processing of ultra-fine DNA bridges in mitosis. H...
Article
Full-text available
Induction of DNA double-strand breaks (DSBs) in ribosomal DNA (rDNA) repeats is associated with ATM-dependent repression of ribosomal RNA synthesis and large-scale reorganization of nucleolar architecture, but the signaling events that regulate these responses are largely elusive. Here we show that the nucleolar response to rDNA breaks is dependent...
Article
Full-text available
In mitosis, cells inactivate DNA double-strand break (DSB) repair pathways to preserve genome stability. However, some early signaling events still occur, such as recruitment of the scaffold protein MDC1 to phosphorylated histone H2AX at DSBs. Yet, it remains unclear whether these events are important for maintaining genome stability during mitosis...

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