Ann-Louise Esserlind

• Medical Doctor, Ph.D
• Medical Doctor at University of Gothenburg

Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3...

Objective: To assess whether the polygenic risk score (PRS) for migraine is associated with acute and/or prophylactic migraine treatment response. Methods: We interviewed 2,219 unrelated patients at the Danish Headache Center using a semistructured interview to diagnose migraine and assess acute and prophylactic drug response. All patients were...

Complex traits, including migraine, often aggregate in families, but the underlying genetic architecture behind this is not well understood. The aggregation could be explained by rare, penetrant variants that segregate according to Mendelian inheritance or by the sufficient polygenic accumulation of common variants, each with an individually small...

Background: The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10- 8) due to multiple testing. Thus, the identified variants only explain a small fraction of the genetic risk. It is expected that hundreds of thousands of...

Gilles de la Tourette syndrome (GTS) is a neuropsychiatric disorder characterized by multiple motor and vocal tics. GTS is a complex disorder, with environmental factors and several genes involved. Although variations within a few genes such as AADAC, NRXN1, SLITRK1, HDC, and IMMP2L have been tentatively associated with GTS (in a small number of pa...

In the version of this article initially published online, the affiliations for Bertram Muller-Myhsok and Patricia Pozo-Rosich were incorrect or incomplete. These errors have been corrected for the print, PDF and HTML versions of this article.

Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus...

Objective Specific acute treatments of migraine are 5HT1B/D receptor agonists; triptans and ergotamine, but only two-thirds of patients respond well without side effects. No migraine-prophylactic drugs are specific to migraine. Prophylactic drugs are selected by time-consuming âtrial and error.†Personalized treatment is therefore much needed. The...

Background: Intravenous infusion of adenylate cyclase-activating polypeptide-38 (PACAP38) provokes migraine-like attacks in 65-70% of migraine sufferers. Whether aggregation of migraine in first-degree relatives contributes to this discrepancy in PACAP38-induced response is unknown. We hypothesized that genetic enrichment plays a role in triggerin...

Migraine is a debilitating neurological disorder affecting around 1 in 7 people worldwide, but its molecular mechanisms remain poorly understood. Some debate exists over whether migraine is a disease of vascular dysfunction, or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far iden...

Background and purpose: Over the last three decades mitochondrial dysfunction has been postulated to be a potential mechanism in migraine pathogenesis. The lifetime prevalence of migraine in persons carrying the 3243A>G mutation in mitochondrial DNA was investigated. Methods: In this cross-sectional study, 57 mDNA 3243A>G mutation carriers betwe...

The objective of the study was to follow up and to test whether 12 previously identified migraine-associated single nucleotide polymorphisms were associated as risk factors and/or modifying factors for severe migraine traits in a Danish clinic-based population. Semi-structured migraine interviews, blood sampling and genotyping were performed on 180...

Objective: Specific acute treatments of migraine are 5HT1B/D receptor agonists; triptans and ergotamine, but only two-thirds of patients respond well without side effects. No migraine-prophylactic drugs are specific to migraine. Prophylactic drugs are selected by time-consuming "trial and error." Personalized treatment is therefore much needed. Th...

Migraine with typical aura (MTA) and migraine without aura (MO) are common neurological disorders with complex inheritance. Recent efforts have identified 12 independent loci at which single nucleotide polymorphisms (SNPs) have shown to confer risk of migraine (Antilla V. Nat.Genet 2013). The objective of this study was to investigate whether these...

Background and purpose: Genetic factors contribute to the aetiology of the prevalent form of migraine without aura (MO) and migraine with typical aura (MTA). Due to the complex inheritance of MO and MTA, the genetic background is still not fully established. In a population-based genome-wide association study by Chasman et al. (Nat Genet 2011: 43:...

Migraine with and without aura (MA and MO, respectively) have a strong genetic basis. Different approaches using linkage-, candidate gene- and genome-wide association studies have been explored, yielding limited results. This may indicate that the genetic component in migraine is due to rare variants; capturing these will require more detailed sequ...

Although the genetics of familial hemiplegic migraine are being unraveled, this is not the case for the prevalent types of migraine. However, a recent genome wide association study (GWAS) reported an association of the single nucleotide polymorphism (SNP) rs1835740 and migraine. The aim of this study is to evaluate the association of clinical chara...

Manhattan plot for GWAS of permanent tooth eruption between age 6 and 14 years (analyzed as age-adjusted standard deviation scores averaged over multiple time points) in 5,104 women from the DNBC I study group. (TIF)

Descriptive statistics of study groups. a) Basic description of study groups, and b) detailed distribution of number of exams by study group. (DOC)

Primary tooth eruption analysis for the identified SNPs in the ALSPAC data. Results are presented for a) number of primary teeth erupted at age 15 months based on 6,609 individuals and b) time to eruption of first tooth based on 5,998 individuals. (DOC)

Height results for the four identified SNPs based on the GWAS meta-analysis with 183,727 individuals. (DOC)

Results for GWAS of permanent tooth eruption between age 6 and 14 years in 5,104 women from the DNBC for all variants previously reported for primary dentition [16]. (DOC)

Results from GWAS of permanent tooth eruption between age 6 and 14 years in 5,104 women from the DNBC for 19 variants previously reported with P<5×10−8 for breast cancer in Caucasians [19], [26]–[32]. (DOC)

Age at menarche results for the four identified SNPs based on the GWAS meta-analysis with 87,802 women. (DOC)

Kruskal-Wallis tests for data in Table 1. (DOC)

ALSPAC GWAS for primary dentition. (DOC)

Results for GWAS of permanent tooth eruption between age 6 and 14 years in 5,104 women from the DNBC for all 42 variants previously reported for age at menarche [33]. (DOC)

Breast cancer results for the four identified SNPs based on the recent British Breast Cancer GWAS. (DOC)

Quantile-quantile plot for GWAS of permanent tooth eruption between age 6 and 14 years (analyzed as age-adjusted standard deviation scores averaged over multiple time points) in 5,104 women from the DNBC I study group. (TIF)

Results from GWAS of permanent tooth eruption between age 6 and 14 years in 5,104 women from the DNBC for 180 variants previously reported for adult height [34]. (DOC)

The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score ave...

Fourteen children (median age 43 months, range 14-82 months; 7 girls and 7 boys) were treated for mangle injuries (one hot steam, and 13 cold roller presses) to the hand and forearm between 1996-2002 at the Department of Hand Surgery, Malmö, Sweden. All children had unilateral skin damage with avulsion or necrosis of skin in nine. Seven of the 14 h...