Ankita Sarkar

Ankita Sarkar
Cornell University | CU · Weill Institute for Cell and Molecular Biology

PhD

About

20
Publications
4,213
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185
Citations
Citations since 2016
17 Research Items
180 Citations
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060

Publications

Publications (20)
Article
Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder with no cure and few treatments. AD causes profound cognitive deficits and memory impairments. Accumulation of the peptide amyloid beta plaque is one of the characteristics of the disease. To understand the progression of Alzheimer’s disease, studies often rely on ectopic express...
Article
Full-text available
To understand the progression of Alzheimer's disease, studies often rely on ectopic expression of amyloid-beta 42 (Aβ42) throughout an entire tissue. Uniform ectopic expression of Aβ42 may obscure cell-cell interactions that contribute to the progression of the disease. We developed a two-clone system to study the signaling cross talk between GFP-l...
Article
Full-text available
Amyotrophic Lateral Sclerosis (ALS), a late-onset neurodegenerative disorder characterized by the loss of motor neurons in the central nervous system, has no known cure to-date. Disease causing mutations in human Fused in Sarcoma (FUS) leads to aggressive and juvenile onset of ALS. FUS is a well-conserved protein across different species, which pla...
Chapter
Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder that predominantly affects people aged over 65 years. AD is marked by cognitive deficits and memory problems that worsen with age and ultimately results in death. Pathology of AD includes aggregation of the amyloid beta peptide into extracellular plaques and the presence of hyper...
Article
Full-text available
Alzheimer's disease (AD), a fatal progressive neurodegenerative disorder, also results from accumulation of amyloid-beta 42 (Aβ42) plaques. These Aβ42 plaques trigger oxidative stress, abnormal signaling, which results in neuronal death by unknown mechanism(s). We misexpress high levels of human Aβ42 in the differentiating retinal neurons of the Dr...
Article
Full-text available
The ability to express a gene of interest in a spatio-temporal manner using Gal4-UAS system has allowed the use of Drosophila model to study various biological phenomenon. During Drosophila eye development, a synchronous wave of differentiation called Morphogenetic furrow (MF) initiates at the posterior margin resulting in differentiation of retina...
Data
Study of expression pattern of GMR lines carrying enhancer of dpp using GFP reporter in the developing eye imaginal disc. These GMR enhancer lines are carrying CRE sequences of dpp- gene (Table 1). Expression of (A) GMR18B08>GFP, (B) GMR18D08>GFP, (C) GMR19D09>GFP, (D) GMR16G02>GFP, (E) GMR17E04>GFP, (F) GMR17G08>GFP, (G) GMR19B04>GFP, (H) GMR19C03...
Data
Study of expression pattern of GMR lines carrying enhancer of dpp using GFP reporter in the developing leg imaginal disc. Expression of (A) GMR18B08>GFP, (B) GMR18D08>GFP, (C) GMR19D09>GFP, (D) GMR16G02>GFP, (E) GMR17E04>GFP, (F) GMR17G08>GFP, (G) GMR19B04>GFP, (H) GMR19C03>GFP in (A-H) leg imaginal disc. None of these lines exhibit GFP reporter ex...
Data
Study of expression pattern of GMR lines carrying enhancer of dpp using GFP reporter in the developing wing imaginal disc. Expression of (A) GMR18B08>GFP, (B) GMR18D08>GFP, (C) GMR19D09>GFP, (D) GMR16G02>GFP, (E) GMR17E04>GFP, (F) GMR17G08>GFP, (G) GMR19B04>GFP, (H) GMR19C03>GFP in (A-H) wing imaginal disc. None of these lines exhibit GFP reporter...
Data
Gain-of-function phenotype of reaper (rpr) using dpp-CRM lines exhibits ventral eye loss. (A, B)dpp>rpr, (C,D) GMR18D08>rpr, (E,F) GMR17E04>rpr. Note that dpp>rpr results in highly reduced eye as seen in (A) the eye imaginal disc and (B) the adult eye. (C, D) GMR18D08>rpr results in the reduced (C) eye imaginal disc and (D) the adult eye with prefe...
Data
Study of expression pattern of GMR lines carrying enhancer of dpp using GFP reporter in the developing haltere imaginal disc. Expression of (A) GMR18B08>GFP, (B) GMR18D08>GFP, (C) GMR19D09>GFP, (D) GMR16G02>GFP, (E) GMR17E04>GFP, (F) GMR17G08>GFP, (G) GMR19B04>GFP, (H) GMR19C03>GFP in (A-H) haltere imaginal disc. None of these lines exhibit GFP rep...
Data
Study of expression pattern of GMR lines carrying enhancer of dpp using GFP reporter in the developing third instar larval brain. Expression of (A) GMR18B08>GFP, (B) GMR18D08>GFP, (C) GMR19D09>GFP, (D) GMR16G02>GFP, (E) GMR17E04>GFP, (F) GMR17G08>GFP, (G) GMR19B04>GFP, (H) GMR19C03>GFP in (A-H) larval brain. Only GMR18B08 and GMR17E04 exhibits robu...
Article
Full-text available
We have developed an undergraduate laboratory to allow detection and localization of proteins in the compound eye of Drosophila melanogaster, a.k.a fruit fly. This lab was a part of the undergraduate curriculum of the cell biology laboratory course aimed to demonstrate the use of Western Blotting technique to study protein localization in the adult...
Article
Full-text available
In all multicellular organisms, the fundamental processes of cell proliferation and cell death are crucial for growth regulation during organogenesis. Strict regulation of cell death is important to maintain tissue homeostasis by affecting processes like regulation of cell number, and elimination of unwanted/unfit cells. The developing Drosophila e...
Article
Full-text available
Alzheimer's disease (AD), a fatal progressive neurodegenerative disorder, has no cure to date. One of the causes of AD is the accumulation of amyloid-beta 42 (Aβ42) plaques, which result in the onset of neurodegeneration. It is not known how these plaques trigger the onset of neurodegeneration. There are several animal models developed to (i) study...
Article
Full-text available
Background: The progressive neurodegenerative disorder Alzheimer's disease (AD) manifests as loss of cognitive functions, and finally leads to death of the affected individual. AD may result from accumulation of amyloid plaques. These amyloid plaques comprising of amyloid-beta 42 (Aβ42) polypeptides results from the improper cleavage of amyloid pr...
Article
The evolutionarily conserved Hippo signaling pathway is known to regulate cell proliferation and maintain tissue homeostasis during development. We found that activation of Yorkie (Yki), the effector of the Hippo signaling pathway, causes separable effects on growth and differentiation of the Drosophila eye. We present evidence supporting a role fo...

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