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3
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Introduction
Currently working on analyzing the epigenetic signatures of the small population of cells that survive/tolerate acute drug stress. In the long run, we would like to identify small molecule inhibitors to re-sensitize the drug-tolerant tumour cells.
Current institution
Additional affiliations
May 2015 - December 2015
May 2014 - July 2014
Education
August 2012 - May 2016
Publications
Publications (3)
Over the years, the landscape of cisplatin-based cancer treatment options has undergone continuous transitions. Currently, there is much debate over the optimum dose of cisplatin to be administered to cancer patients. In clinical practice, it can extend from repeated low sub-toxic doses to a few cycles of acute high drug doses. Herein, the molecula...
Traditional chemotherapy against cancer is often severely hampered by acquired resistance to the drug. Epigenetic alterations and other mechanisms like drug efflux, drug metabolism, and engagement of survival pathways are crucial in evading drug pressure. Herein, growing evidence suggests that a subpopulation of tumor cells can often tolerate drug...
Red/Near Infra-red-emissive organic molecules with AIE active and pH-sensitive core is high in-demand for real-world applications. We have designed and synthesized a far-red to NIR fluorogenic Donor-Acceptor (D-A) type probe 4-((4-(2-(3,3-dimethyl-3H-indole-2-yl)vinyl)phenyl)(phenyl)amino)benzaldehyde (TPA-SCY), that can undergo protonation with a...
