Ankit B. Patel

Ankit B. Patel
Brigham and Women's Hospital | BWH · Department of Medicine: Division of Renal Medicine

MD, PhD

About

41
Publications
4,752
Reads
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1,229
Citations
Additional affiliations
September 2007 - September 2012
Weill Cornell Medical College
Position
  • PhD Student
Education
July 2017 - June 2020
Brigham and Women's Hospital
Field of study
  • Nephrology
June 2014 - June 2017
Brigham and Women's Hospital
Field of study
  • Internal Medicine
September 2007 - September 2012
Weill Cornell Medical College
Field of study
  • Physiology and Biophysics

Publications

Publications (41)
Article
Background Endothelial cell injury is a common nidus of renal injury in patients and consistent with the high prevalence of acute kidney injury reported during the COVID-19 pandemic. This cell type expresses integrin α5 (ITGA5), which is essential to the Tie2 signaling pathway. The micro-RNA miR-218-5p is upregulated in endothelial progenitor cells...
Article
Full-text available
Background: Mathematical modelling may aid in understanding the complex interactions between injury and immune response in critical illness. Methods: We utilize a system biology model of COVID-19 to analyze the effect of altering baseline patient characteristics on the outcome of immunomodulatory therapies. We create example parameter sets meant...
Article
Full-text available
As predicting the trajectory of COVID-19 is challenging, machine learning models could assist physicians in identifying high-risk individuals. This study compares the performance of 18 machine learning algorithms for predicting ICU admission and mortality among COVID-19 patients. Using COVID-19 patient data from the Mass General Brigham (MGB) Healt...
Article
Novel 2019 coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) and coronavirus disease 2019 (COVID-19), the respiratory syndrome it causes, have shaken the world to its core by infecting and claiming the lives of many people since originating in December 2019 in Wuhan, China. World Health Organization and several states have...
Article
Sodium glucose cotransporter 2 inhibitors (SGLT2i) have revolutionized the treatment of heart failure and diabetic kidney disease. The DAPA-CKD trial by Heerspink et al. evaluated primary kidney outcomes with dapagliflozin in both diabetic and non-diabetic patients and identified kidney protection by SGLT2i independent of diabetes mellitus.
Article
Hemodynamic alterations, metabolic dysfunction, inflammation, and fibrosis are the main drivers of diabetic kidney disease (DKD) progression. Targeting inflammation and fibrosis as a driver, the FIDELIO-DKD (Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes) trial reported by Bakris et al. provides evidence of a new therape...
Article
Full-text available
Significance A distinctive feature of COVID-19 is its extreme heterogeneity—illness ranges from minimally symptomatic to life threatening. Heterogeneity results from a poorly understood combination of patient factors, viral dynamics, antiviral and immune modulating therapies, and dynamics of the innate and adaptive immune responses. In order to bet...
Preprint
Full-text available
As predicting the trajectory of COVID-19 disease is challenging, 28 machine learning models could assist physicians determine high-risk individuals. This study 29 compares the performance of 18 machine learning algorithms for predicting ICU admission and 30 mortality among COVID-19 patients. Using COVID-19 patient data from the Mass General 31 Brig...
Article
Full-text available
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pandemic and a public health emergency. The overwhelming rise in the number of cases has brought significant challenges to healthcare systems worldwide. Patients with end-stage kidney disease (ESKD) are highly vulnerable with the mu...
Article
Full-text available
Among patients with short bowel syndrome who commonly have kidney disease, kidney transplantation remains challenging. We describe the clinicopathologic course of a 59-year old man with short bowel syndrome secondary to Crohn's disease who underwent a deceased donor kidney transplant that was complicated by recurrent acute kidney allograft injury d...
Preprint
Full-text available
Understanding the underlying mechanisms of COVID-19 progression and the impact of various pharmaceutical interventions is crucial for the clinical management of the disease. We developed a comprehensive mathematical framework based on the known mechanisms of the SARS-CoV-2 virus infection, incorporating the renin-angiotensin system and ACE2, which...
Article
A 53-year-old woman with a history of chronic obstructive pulmonary disease, epilepsy, hypertension, and alcohol abuse presented after getting a burn injury on her lap from spilling boiled water. She reported 3 vodka drinks daily. Her medications included valproic acid, sertraline, isosorbide mononitrate, omeprazole, and loratadine. Her blood press...
Article
Full-text available
An increasing number of COVID-19 cases worldwide has overwhelmed the healthcare system. Physicians are struggling to allocate resources and to focus their attention on high-risk patients, partly because early identification of high-risk individuals is difficult. This can be attributed to the fact that COVID-19 is a novel disease and its pathogenesi...
Article
Background: Coronavirus disease 2019 (COVID-19) is a rapidly expanding global health crisis. A disintegrin and metalloproteinase 17 (ADAM17), an ectodomain sheddase, is a key component of ACE2 modulation and plays a complex role in inflammation and immunosurveillance. Areas of uncertainty: Much remains unknown regarding the immunopathogenesis of...
Article
Data sharing: The data obtained as part of this study are available from the corresponding author upon reasonable request. Objectives As schools plan for re-opening, understanding the potential role children play in the coronavirus infectious disease 2019 (COVID-19) pandemic and the factors that drive severe illness in children is critical. Study...
Conference Paper
Full-text available
Emerging retrospective analyses show that cancer patients are more likely to develop severe COVID-19. The causes for these worse outcomes are unclear, but data suggest that cancer therapies, which can suppress the immune system, are not responsible for increased COVID-19 severity. An alternative hypothesis is that common molecular pathways are alte...
Article
Recent studies have shown impressive cardiovascular health benefits in individuals treated with SGLT2 inhibitors (SGLT2i) regardless of diabetic status. The underlying mechanisms driving these benefits are not well understood. Recently in Circulation, Griffin et al. (2020) reported the first human study investigating the diuretic effect of empaglif...
Article
Renal replacement therapy (RRT) can be used to support patient’s kidney function in cases of acute kidney injury (AKI). However, timing, modality, and dosing of RRT continue to remain in question. Recent studies have begun to provide data to help guide clinicians on when to initiate RRT, what form of RRT to use ranging from continuous venovenous he...
Article
Diabetic kidney disease (DKD), the most common cause of end-stage kidney disease (ESKD), has significant morbidity and mortality, particularly from cardiovascular complications. The CREDENCE (canagliflozin and renal events in diabetes with established nephropathy clinical evaluation) trial reported by Perkovic and collaborators has led to an emerge...
Article
Ischemia due to hypoperfusion is one of the most common forms of acute kidney injury. We hypothesized that kidney hypoxia initiates the up-regulation of miR-218 expression in endothelial progenitor cell (EPC) to guide endocapillary repair. Murine renal artery-derived endothelial progenitor cell (CD34+/CD105-) showed down-regulation of mmu-miR-218-5...
Article
Full-text available
Background: Interest in nephrology careers is declining, possibly due to perceptions of the field and/or training aspects. Understanding practices of medical schools successfully instilling nephrology interest could inform efforts to attract leading candidates to the specialty. Methods: The American Society of Nephrology Workforce Committee's Be...
Article
Full-text available
The Kidney Tutored Research and Education for Kidney Students (TREKS) Program is a product of the American Society of Nephrology (ASN) Workforce Committee that seeks to connect medical and graduate students to nephrology. This program starts with a weeklong camp-like course introducing participants to renal physiology through classic and modern exp...
Article
Full-text available
Intracellular [Na(+)] ([Na(+)]i) modulates the activity of the epithelial Na channel (ENaC) to help prevent cell swelling and regulate epithelial Na(+) transport, but the underlying mechanisms remain unclear. We show here that short-term (60-80 min) incubation of ENaC-expressing oocytes in high Na(+) results in a 75% decrease in channel activity. W...
Article
Full-text available
A medical student perspective on the role of core competencies in undergraduate medical education in light of medical education reform associated with recent Flexner II.
Article
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The epithelial Na(+) channel (ENaC) is tightly regulated by sodium intake in order to maintain whole-body sodium homeostasis. In addition, ENaC is inhibited by high levels of intracellular Na(+) [Na(+)]i , presumably to prevent cell Na(+) overload and swelling. However it is not clear if this regulation is relevant in vivo. We show here that in rat...
Article
Full-text available
Epithelial Na Channels (ENaC) are responsible for the apical entry of Na(+) in a number of different epithelia including the renal connecting tubule and cortical collecting duct. Proteolytic cleavage of γ-ENaC by serine proteases, including trypsin, furin, elastase, and prostasin, has been shown to increase channel activity. Here, we investigate th...
Article
Full-text available
Epithelial Na(+) channels (ENaC) form a highly regulated pathway for the reabsorption of Na(+) from urine. This regulation can take place at a number of different levels, including synthesis of channel protein, trafficking of the protein between the surface and internal membranes, proteolytic cleavage and channel gating. This article reviews the ro...
Article
Full-text available
The mechanism of action of Tenebrio molitor antidiuretic factor 'a' (Tenmo ADFa) was explored in isolated Malpighian tubules of Aedes aegypti. In the Ramsay assay of fluid secretion, Tenmo ADFa (10(-9) mol l(-1)) significantly inhibited the rate of fluid secretion from 0.94 nl min(-1) to 0.44 nl min(-1) without significant effects on the concentrat...

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