Ankit Mathur

Bangalore Medical Services Trust · Transfusion Medicine

Antibodies against Rh (CEce) and Kidd (Jka and Jkb) system antigens are mostly implicated in delayed hemolytic transfusion reactions (DHTR), which is a potentially life-threatening complication observed in patients receiving chronic transfusions. Here, we are describing a case of Chido/Roger antibody which presented to our laboratory as DHTR. The c...

Background: Platelet additive solutions (PAS) are crystalloid nutrient media used in place of plasma for platelet storage. They replace 60%–70% of plasma in platelet components, so the amount of storage plasma can be decreased. Platelets in PAS have lower risk for allergic transfusion reactions with equivalent clinical efficacy for controlling blee...

Routinely, Immunohematology Reference Testing Center receives samples with blood group discrepancy, presence of allo/autoantibodies, positive direct antiglobulin test (DAT), etc. We are presenting a case in which we not only resolved blood group discrepancy but also identified multiple alloantibodies reacting at different phases. A tricenarian fema...

Introduction: Karnataka state has a total of 176 blood banks, with a total collection of around 650,000 units annually. From January 2014, all units under the Department of Health and Family Welfare services are tested at NAT Lab established at the Central facility and from September 2014, standalone Regional Blood Transfusion Centre was included i...

Purpose: To determine the corneal surfaces and lens contributions to ocular aberrations. Methods: There were 61 healthy participants with ages ranging from 20 to 55 years and refractions -8.25 diopters (D) to +3.25 D. Anterior and posterior corneal topographies were obtained with an Oculus Pentacam, and ocular aberrations were obtained with an i...

Background: It is well-known that alloimmunization to red blood cell antigens resulting from the genetic disparities between donor and recipient is one of the risks of blood transfusion. The antibody screening cells are used to detect unexpected antibodies. The risk of alloimmunization is higher in patients who have received multiple blood transfus...

To validate a simple partial coherence interferometry (PCI) based retinal shape method, estimates of retinal shape were determined in 60 young adults using off-axis PCI, with three stages of modeling using variants of the Le Grand model eye, and magnetic resonance imaging (MRI). Stage 1 and 2 involved a basic model eye without and with surface ray...

Straylight, lens yellowing and ocular aberrations were assessed in a group of people with type 1 diabetes and in an age matched control group. Most of the former had low levels of neuropathy. Relative to the control group, the type 1 diabetes group demonstrated greater straylight, greater lens yellowing, and differences in some higher-order aberrat...

This is a comprehensive study of a large range of biometric and optical parameters in people with type 1 diabetes. The parameters of 74 people with type 1 diabetes and an age matched control group were assessed. Most of the people with diabetes had low levels of neuropathy, retinopathy and nephropathy. Marginal or no significant differences were fo...

To investigate how distance visual acuity in the presence of defocus and astigmatism is affected by age and whether aberration properties of young and older eyes can explain any differences. Participants were 12 young adults (mean [±SD] age, 23 [±2] years) and 10 older adults (mean [±SD] age, 57 [±4] years). Cyclopleged right eyes were used with 4-...

Purpose: People with diabetes have accelerated age-related biometric ocular changes compared with people without diabetes. We determined the effect of type 1 diabetes on amplitude of accommodation. Methods: There were 43 participants (33 ± 8 years) with type 1 diabetes and 32 (34 ± 8 years) age-balanced controls. There was no significant differe...

Aim Comparison of new Luminex cross match method with classical method of leukocyte cross match i.e. complement dependent cytotoxicity. Material & method Total 60 living related renal transplant cases were included in the study. All samples were tested for CDC as well as Luminex DSA cross match using donor lysate. The kits used were Gen Probe (Gen...

Purpose: We investigated effects of pupil shifts, occurring with changes in luminance and accommodation stimuli, on refraction components and higher-order aberrations. Methods: Participants were young and older groups (n = 20; 22 ± 2 years; age range, 18-25 years; and n = 19, 49 ± 4 years, 45-58 years, respectively). Aberrations/refractions at 4...

We term the visual field position from which the pupil appears most nearly circular as the pupillary circular axis (PCAx). The aim was to determine and compare the horizontal and vertical coordinates of the PCAx and optical axis from pupil shape and refraction information for only the horizontal meridian of the visual field. The PCAx was determined...

Purpose: Race appears to be associated with myopiogenesis, with East Asians showing high myopia prevalence. Considering structural variations in the eye, it is possible that retinal shapes are different between races. The purpose of this study was to quantify and compare retinal shapes between racial groups using peripheral refraction (PR) and peri...

Purpose: We investigated effects of luminance and accommodation stimuli on pupil size and pupil center location, and their implications for progressive addition lens wear. Methods: Participants were young and older adult groups (n = 20; 22 ± 2 years; age range, 18-25 years; and n = 19; 49 ± 4 years; age range, 45-58 years). A wave aberrometer in...

To design and manufacture lenses to correct peripheral refraction along the horizontal meridian and to determine whether these resulted in noticeable improvements in visual performance. Subjective refraction of a low myope was determined on the basis of best peripheral detection acuity along the horizontal visual field out to ±30° for both horizont...

The purpose of this study is to determine visual performance in water, including the influence of pupil size. The water environment was simulated by placing goggles filled with saline in front of the eyes with apertures placed at the front of the goggles. Correction factors were determined for the different magnification under this condition in ord...

Changes in pupil size and shape are relevant for peripheral imagery by affecting aberrations and how much light enters and/or exits the eye. The purpose of this study is to model the pattern of pupil shape across the complete horizontal visual field and to show how the pattern is influenced by refractive error. Right eyes of 30 participants were di...

Voluntary blood donation is not satisfactory all over India. In India, about 55% of donation is through voluntary non-remunerated blood donors (VNRBD). However, about one third already motivated blood donors are deferred due to stringent screening criteria, either temporarily or permanently. The temporarily deferred donors could be a good source of...

To investigate hyperopic shifts and the oblique (or 45-degree/135-degree) component of astigmatism at large angles in the horizontal visual field using the Hartmann-Shack technique. The adult participants consisted of 6 hypermetropes, 13 emmetropes and 11 myopes. Measurements were made with a modified COAS-HD Hartmann-Shack aberrometer across ±60 d...

A significant number of safe donations are removed from the blood supply, because of the reactive anti-HCV screening test results. This study aimed to assess if the HCV (Hepatitis C Virus) seropositive donors were confirmed positive or not. More than 68,000 blood donors' samples were routinely screened and 140 samples were found to be anti-HCV ELIS...

One of the responsibilities of blood center is to provide safety to blood donors. It is mandatory to screen a blood donor for hemoglobin (Hb) or hematocrit which should not be less than 12.5 g/dl or 38% Hct. Most commonly applied method for hemoglobin estimation is copper sulphate method, but this method has chances of false acceptance as well as f...

To investigate the effect of age on the contributions of the anterior cornea and internal components to ocular aberrations in the peripheral visual field. Ocular aberrations were measured in 10 young emmetropes and 7 older emmetropes using a modified commercial Hartmann-Shack aberrometer across 42° × 32° of central visual field. Anterior corneal ab...

  We provide an account of the relationships between eye shape, retinal shape and peripheral refraction.   We discuss how eye and retinal shapes may be described as conicoids, and we describe an axis and section reference system for determining shapes. Explanations are given of how patterns of retinal expansion during the development of myopia may...

Investigations of foveal aberrations assume circular pupils. However, the pupil becomes increasingly elliptical with increase in visual field eccentricity. We address this and other issues concerning peripheral aberration specification. One approach uses an elliptical pupil similar to the actual pupil shape, stretched along its minor axis to become...

While correcting the aberrations of the eye produces large increases in retinal image contrast, the corresponding improvement factors in the contrast sensitivity function have been little explored and results are controversial. We measured the CSF of 4 subjects with and without correcting monochromatic aberrations. Monochromatic CSF measurements we...

Dear Sir, The prevalence of red blood cell (RBC) alloantibodies among general, hospital-based patients typically has averaged approximately 1% in various studies. The presence of irregular antibodies in healthy voluntary blood donors is uncommon. Anti-M is a fairly common, naturally occurring antibody. Most anti-M are not active at 37 oC and gener...

To determine how high- and low-contrast visual acuities are affected by blur caused by crossed cylinder lenses. Crossed cylinder lenses of power 0 (no added lens), +0.12 diopter sphere (DS)/-0.25 diopter cylinder (DC), +0.25 DS/-0.50 DC and +0.37/-0.75 DC were placed over the correcting lenses of the right eyes of eight subjects. Negative cylinder...

Voluntary non-remunerated repeat blood donors are perceived to be safer than the first time blood donors. This study was planned for follow-up of previous hepatitis C virus (HCV) test results of anti-HCV enzyme-linked immunosorbent assay (ELISA) reactive repeat blood donors. The aim was to suggest a protocol for re-entry of the blood donors who are...

Hemolysis may occur in a red blood cell (RBC) unit during blood collection, transportation, preservation and or different stages of handling in the blood bank. Visual detection of hemolysis of a unit is possible usually by observing the color of the supernatant plasma. It is a good practice to observe the color of the plasma just before issue to av...

To investigate the influence of keratoconus on peripheral ocular aberrations. Aberrations in seven mild and five moderate keratoconics were determined over a 42° horizontal × 32° vertical visual field, with a modified aberrometer. Control data were obtained from an emmetropic group. Most aberrations in the keratoconics showed field dependence, pred...

To measure the effect of spherical intraocular lens (IOL) implantation and conventional myopic laser in situ keratomileusis (LASIK) on peripheral ocular aberrations. Visual and Ophthalmic Optics Laboratory, School of Optometry, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia. Peripheral ab...

On-axis monochromatic higher-order aberrations increase with age. Few studies have been made of peripheral refraction along the horizontal meridian of older eyes, and none of their off-axis higher-order aberrations. We measured wave aberrations over the central 42°x32° visual field for a 5mm pupil in 10 young and 7 older emmetropes. Patterns of per...

Changes in peripheral aberrations, particularly higher order aberrations, as a function of accommodation have received little attention. Wavefront aberrations were measured for the right eyes of 9 young adult emmetropes at 38 field positions in the central 42 x 32 degrees of the visual field. Subjects accommodated monocularly to targets at vergence...

We measured wave aberrations over the central 42 degrees x 32 degrees visual field for a 5-mm pupil for groups of 10 emmetropic (mean spherical equivalent = 0.11 +/- 0.50 D) and 9 myopic (MSE = -3.67 +/- 1.91 D) young adults. Relative peripheral refractive errors over the measured field were generally myopic in both groups. Mean values of C(4)(0) w...

To investigate the effect of orthokeratology on peripheral aberrations in two myopic volunteers. The subjects wore reverse geometry orthokeratology lenses overnight and were monitored for 2 weeks of wear. They underwent corneal topography, peripheral refraction (out to +/-34 degrees along the horizontal visual field) and peripheral aberration measu...

Refraction may be affected by the forces of lids and extraocular muscles when eye direction and head direction are not aligned (oblique viewing) which might potentially influence past findings on peripheral refraction of the eye. We investigated the effect of oblique viewing on axial and peripheral refraction. In a first experiment, cycloplegic axi...

We modified a commercial Hartmann–Shack aberrometer and used it to measure ocular aberrations twice at each of 38 points across the central 42 ° horizontal × 32 ° vertical visual fields of five young emmetropic subjects. Some Zernike aberration coefficients show coefficient field distributions that were similar to the field dependence predicted by...