Anindya Bose

Siksha O Anusandhan University | SOA · School of Pharmaceutical Sciences (SPS)

Triple-negative breast cancer (TNBC) holds just about 15% of all breast tumours and subtypes of breast cancer with distinct characteristics of negative expressions for the progesterone receptor, estrogen receptor, and human epidermal growth factor receptor 2. Unfortunately, treatment options for TNBCs are minimal. Most currently available therapies...

Background Limnophila rugosa (Scrophulariaceae) is a perennial aquatic plant used as a diuretic and digestive tonic as well as in the treatment of diarrhea, dysentery, dyspepsia and urinary ailments. Genus Limnophila has been reported as hepatoprotective. The present study was undertaken to evaluate the hepatoprotective activity of the ethanolic ex...

There are several bacteria called superbugs that are resistant to multiple antibiotics which can be life threatening specially for critically ill and hospitalized patients. This article provides up-to-date treatment strategies employed against some major superbugs, like methicillin-resistant Staphylococcus aureus, carbapenem-resistant Enterobacteri...

The present work demonstrates the eco-friendly green synthesis of Iron oxide nanoparticles from the aqueous extract of Triphala churna (TIONPs) using ferric chloride hexahydrate (FeCl3.6H2O) precursor in a single-step process. The formulated TIONPs were characterized by various instrumental techniques such as UV–Visible spectrophotometry (UV–Vis),...

In the current study, dually modified retrograded acetylated corn starch was prepared with improved physicochemical properties than its native form. The modified starch was utilized as a polymer for colonic targeted direct compressible tablets with budesonide as a model drug. In vitro release study showed the formulation exhibited pH dependent rele...

Kokilaksha Kashayam is a polyherbal Ayurvedic formulation prescribed for treating pain and inflammation. The scientific validation of the claimed pharmacological activities of this formulation has not been established yet. In the present work, the anti-inflammatory and Analgesic activity of freshly prepared in house Kokilaksha Kashayam as well as i...

A simple and sensitive liquid chromatographic method along with tandem mass detection has been developed for the determination of levodopa and carbidopa in mice plasma. Owing the hydrophilic nature of both the analytes, a hydrophilic interaction liquid chromatography (HILIC) setup was used for their separation by a Merck (Germany) HILIC column (4.6...

Capparis zeylanica (Capparaceae) is a climbing shrub, commonly known as ‘Asadua’ in Oriya language. Folkloric it is used as anti-inflammatory, anti-rheumatic, hepatitis and liver tonics. The present work aimed to investigate the hepatoprotective activity of Capparis zeylanica root. The ethanolic extract was subjected to GC-MS analysis and quantific...

Starch is a cheap and easily available excipient in pharmaceutical manufacturing. Although tablet formulated containing native starch have rapid disintegrating property, these products cannot be commercialized due to their poor mechanical strength. Physical modification like annealing can greatly rectify this limitation of starches. However, the pr...

Interpenetrating polymer network (IPN)-based bead formulations were exploited by cross-linking different hydrophilic polymers in different combinations and at different ratios. Polyvinyl alcohol, xanthan gum, guar gum, gellan gum, and sodium alginate (Na-alginate) were used in this work as hydrophilic polymers to enhance the solubility of diclofena...

The current work deals with the effect of hydrophilic polymer in a multi-component β-cyclodextrin (βCD) inclusion complex for enhancement of solubility and taste masking ability of linezolid (LZ). The phase solubility studies indicated the formation of 1:1 M stoichiometric ratio of LZ to βCD in all complexes in presence or absence of hydrophilic po...

Balarista, a classical ayurvedic formulation, is traditionally claimed for the treatment of rheumatoid arthritis (RA). The drawback behind this fermented product remains lack of its proper documentation and validation. In the present investigation, therefore, an in-house Balarista (IBF) formulation was prepared by using standard raw materials as me...

Amrtadi Churna is an Ayurvedic polyherbal formulation containing three herbs viz., Amalaki (Emblica officinalis), Gokshur (Tribulus terrestris) and Guduchi (Tinospora cordifolia). It is prescribed in India for immunomodulation and treating hyperacidity. The present work reports the acute and sub-acute toxicity assessment of Amrtadi Churna on experi...

Introduction: Technology is a proven teaching aid, and online teaching has facilitated teaching across borders; however although technology has been proved to be an effective teaching aid, it cannot replace a teacher. There are many reports that discuss the constraints of only using online classes, as a result the use of both online and face to fac...

Introduction: Reactive oxygen species produced in our body may result in the pathogenesis of different degenerative diseases like atherosclerosis, carcinogenesis, neurodegenerative diseases, ageing etc. Antioxidant-rich foods can protect us by neutralizing these free radicals reducing. Objective: This study determined the total flavonoid and phenol...

Ketoprofen (KTF) is classified as a biopharmaceutics classification system (BCS) class II drug owing to low aqueous solubility. To improve the solubility and dissolution profile of pure ketoprofen its inclusion complexes with sulfobutylether7-beta-cyclodextrin (SBE7-β-CD) were prepared by kneading (KD) and freeze-drying (FD) technique. The effects...

GC–MS analysis of different fractions of in-house Balarista formulation (IBF) and marketed Balarista formulations (M1, M2, M3 and M4) confirmed the presence of various active metabolites. The database of National Institute of Standards and Technology (NIST) library was used to identify these compounds. This study revealed the presence of benzoic ac...

The objective of the present review is to evaluate the therapeutic potential of phytochemicals against arthritis, which is asymptomatic disorder of chronic joint inflammation followed by swelling and pain. Here, we discussed about the anti-arthritic activity of many phytomolecules such as Norisoboldine, Berberine, Triptolide, Hesperidin Hesperidin,...

Madhuyashti Ghrita, is an Ayurvedic medicated ghee preparation containing Yashtimadhu. It is used for treating external ulcers and wounds in vital points of the body. However, there is no quality monograph available for Madhuyashti Ghrita. Hence, the present work was carried out to characterize this Ghrita to confirm its identity, quality and purit...

Background and aim Balarista is a fermented ayurvedic liquid preparation recommended as a good therapy for the treatment of rheumatoid arthritis. In the present investigation, the anti-arthritic activity of in-house Balarista formulation and marketed M1, M2, M3 and M4 Balarista formulations at the dose of 2.31 ml/kg were studied on Complete Freund'...

The medical values of garlic, a traditionally used allium vegetable, were recognized as early as 3000 BC. Allicin, one of the major organosulfur compounds present in garlic, is associated with a wide variety of benificial activities like anticancer, anti-inflammatory, antiarthritic, antimicrobial, anti-diabetic, cholesterol-lowering, the potential...

‘Balarista’ is an important Ayurvedic arista formulation containing twelve crude drugs among which Sida cordifolia and Withania somnifera are the two major drugs. The Ayurvedic Formulary of India mentions various usages of Balarista, but it is mainly used in the treatment of rheumatoid arthritis. This study deals with the evaluation of pharmacognos...

New anti-ulcer substances are still vitally necessary for the people of countries such as India and South Africa to avoid high cost of the most prescribed marketed anti-ulcer drugs (proton-pump inhibitors). New candidate against gastric ulcer is also necessary to avoid the potential problem (enterochromaffin-like cell hyperplasia may be induced) as...

New antiulcer substances are still vitally necessary for the people of countries such as India and South Africa to avoid high cost of the most prescribed marketed anti-ulcer drugs (proton-pump inhibitors). New candidate against gastric ulcer is also necessary to avoid the potential problem (enterochromaffin-like cell hyperplasia may be induced) ass...

The design and synthesis of different prodrugs for nonsteroidal anti-inflammatory drugs (NSAIDs) have been given much attention by medicinal chemists in last decade, esters are one of them. This review will focus on NSAID ester prodrugs that have little to non-ulcerogenic activity. Majority of the efforts were given to design prodrugs of non-select...

The design and synthesis of different prodrugs for nonsteroidal anti-inflammatory drugs (NSAIDs) have been given much attention by medicinal chemists in last decade, esters are one of them. This review will focus on NSAID ester prodrugs that have little to non-ulcerogenic activity. Majority of the efforts were given to design prodrugs of non-select...

Background: Cholesterol is an essential component of cell membrane that is needed to maintain proper membrane permeability and fluidity; also required for synthesis of steroid hormones, vitamin D and bile acids. But cholesterol plays a major role in human heart health because high level of it increases risk of cardiovascular diseases, stroke, perip...

The aim of the present research work was to explore the impact of ibuprofen-captisol® (sulfobutylether sodium salt of β-CD) inclusion complexes on in vitro dissolution performance. Phase solubility studies of ibuprofen using the carrier captisol® had generated AL-type profiles which indicated the formation of 1:1 stoichiometric inclusion complexes....

The present invetigation was carried out to characterise the Ayurvedic preparation, Amrtadi churna, a polyherbal formulation comprising of three ingredients, on the basis of the pharmacognostic, physicochemical, pharmaceutical, microbiological, toxicological, spectroscopic and chromatographic parameters to confirm its identity, quality and purity....

Background: Samasharkara Churna, a polyherbal Ayurvedic formulation, is prescribed for treating various conditions such as asthma and cough. Literature review suggested that characterization parameters of Samasharkara Churna are not reported. Objective: To report characteristic parameters of Samasharkara Churna to conform its identity, quality a...

The present study was undertaken for characterization of the steady state and non steady state corneal permeation kinetics of diclofenac potassium (DCP) using statistical moment theory. Hydrogel films containing DCP in a hydroxypropyl methylcellulose (HPMC) matrix were prepared by a casting method, and the steady state and non-steady state corneal...

A series of new 7-heterocyclic substituted-4-methylquinolin derivatives were synthesized. Different derivatives were synthesized using unique techniques. Purity of synthesized compound was checked by TLC and structures were elucidated by their IR, 1H NMR and Mass data. The synthesized compounds were screened for anti-microbial and anti-tubercular a...

The antioxidant activity, total phenolic content (TPC) and total flavonoid content (TFC) of four natural spices namely fennel fruits (Foeneculum vulgare), fenugreek seeds (Trigonella foenum-graecum), coriander seeds (Coriandrum sativum Linn.) and black pepper fruits (Piper nigrum) were investigated. In antioxidant assay, DPPH (2,2-diphenyl-1-picryl...

Objective: Standardization of any herbal formulation is essential in order to assess the quality, purity, safety, and efficacy of drugs based on the analysis of their active properties. Testing of Ayurvedic preparations using scientific methodologies adds to quality and authenticity of the product. Methods: This article reports standardization para...

HPTLC screening of raw materials vs. Samasharkara Churna at 254 nm after derivatization.

Organoleptic properties of raw materials and Samasharkara Churna.

HPTLC screening of raw materials vs. Samasharkara Churna at 254 nm before derivatization.

HPTLC screening of raw materials vs. Samasharkara Churna at 366 nm before derivatization.

HPTLC screening of raw materials vs. Samasharkara Churna at 366 nm after derivatization.

HPTLC screening of raw materials vs. Samasharkara Churna at 540 nm after derivatization.

To study efficacy of Boerhavia diffusa L. extract (Punarnava capsule) to treat hyperkalemia , 30 patients were selected and categorized in 3 groups according to mild ,moderate and severe hyperkalemia status with 10 patients in each group. Punarnava capsule containing 250 mg of Boerhavia diffusa L. extract from Himalaya drugs were prescribed to trea...

Drug discovery process develops faster due to more advances in computational techniques. The protein ligand interaction well predicted due to the in-silico approach study. The present investigation focused towards the development of lead structure for treatment of hepatic disorders. An increase in serum acid hydrolase, including β-glucuronidase has...

Objective: The present study deals with evaluation of hepatoprotective effect against paracetamol induced hepatitis in rats and in-vitro antioxidant activity of aerial parts of ethanolic extract (70%) of Phyllanthus reticulates. Methods: Alteration in the levels of biochemical markers of hepatic damage like AST, ALT, ALP and total Bilirubin were te...

In the survey of 34 patients of clubfoot, 20 were unilateral cases and 14 were bilateral. The ratio of unilateral: bilateral was 1.42:1. As per Kawashima and Uhth off classification, with this stucy 36 feet (75%) to be flexible and 12 feet (25%) to be rigid out of total 48 feet considered. The rigid foot was relatively smaller as compared to the...

Objective: Nymphaea alba is a medicinal plant used in tropical regions for its genital, gastrointestinal and bronchial activities. In the present study, the probable effect of the ethanol extract of the rhizome on rat uterus in the presence of standard antagonists like salbutamol and atropine and a uterine stimulant like oxytocin were examined. Met...

Ethanol extract of the of rhizome of Nymphaea alba, at graded doses was investigated for the central depressant activity of the ethanol extract of rhizome. The behavioral effect of the extract (75, 150 and 300 mg/kg) was evaluated using diazepam induced sleep test, hole-board test, beam walking assay, staircase test, open field test and elevated pl...

Ethanol extract of the of rhizome of Nymphaea alba, at graded doses was investigated for anti-diarrhoeal activity in term of reduction in the rate of defecation in castor oil induced diarrhoea and anti-inflammatory activity in term of reduction in inflammation of rat paw. To understand the mechanism of its anti-diarrhoeal activity, its effect was f...

Prolonged timelines and large expenses associated with clinical trials have prompted a new focus on improving the operational efficiency of clinical trials by use of Clinical Trial Management Systems (CTMS) in order to improve managerial control in trial conduct. However, current CTMS systems are not able to meet the expectations due to various sho...

The central nervous system (CNS) depres-sant activity of the ethanol extract (200 and 400 mg/kg) and its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma was investigated in various models. The tested extract and its fractions showed significant (P<0.01) anxiolytic, anticonvulsant activity (in treating petit mal epilepsy) witho...

Nymphaea alba is rich in phytoconstituents that posses pharmacological actions. But any scientific literature about its antioxidant and analgesic actions using its rhizome part is not documented. So the objective of the present research is focused to evaluate the analgesic activity and antioxidant potential by different models of scavenging propert...

Lead Zirconate Titanate [Pb(Zr,Ti)O3, PZT] thin films have been extensively studied due to their possible applications in ferroelectric and piezoelectric devices. This work deals with the synthesis and characterization of ultra thin PZT films of thickness ∼100 nm deposited on Si/SiO2/TiO2/Pt(111) by RF Magnetron Sputtering under optimized depositio...

Two simple, precise and accurate visible spectrophotometric methods were developed for the estimation of Aceclofenac in bulk drug and in pharmaceutical formulations. The proposed methods were indirect and based on determination of aceclofenac after its reaction with either (p-dimethylaminocinnamaldehyde or 3-Methyl-2-benzothiazolinone hydrazine hyd...

PZT thin films of thickness (320–1040) nm were synthesized on Si/SiO2/Ti/Pt multilayered substrates by radio frequency magnetron sputtering. The influence of plasma pressure in the range of (0.24–4.9) Pa, during deposition, on the structural, electrical and ferroelectric properties of the PZT films was systematically studied. X-ray diffraction (XRD...

Ethanolic extract and its fraction of the aerial part of Mollugo pentaphylla L. were investigated for their anthelmintic activity against Pheritima posthuma and Ascardia galli. The study involves the determination of paralysis time and death time of the worms in the different doses of the extracts (12.5, 25 and 50 mg/kg). The extracts and its fract...

Schiff bases of isatin with aminothiazole, its N-mannich bases and Spiro isatin derivatives were synthesized. Their chemical structures were confirmed by Infrared, 1H-Nuclear Magnetic Resonance data and elemental analysis. Antimicrobial evaluation was performed by the agar diffusion method against four pathogenic bacteria and two pathogenic fungi....

The ethanolic extract of the plant Pistia stratiotes (Araceae) was investigated for activity against Indian earthworms Pheretima posthuma and nematode Ascardi galli. Various concentrations (10, 20, 50 mg/ml) of ethanolic extract were tested, which involved determination of time of paralysis and time of death of the worms. It was compared with Piper...

Objective: To study the in vitro antioxidant activity of the ethanolic extract of leaves of Cajanus cajan Linn. Materials and methods: The antioxidant activity, reducing power, nitric oxide scavenging activity, superoxide radical scavenging activity, anti lipid peroxidation activity and total phenolics of the ethanolic extract of Cajanus cajan were...

The stems of Tinospora tomentosa Miers. are used in Indian system of medicine. The present study deals with the preliminary qualitative phytochemical investigation and acute toxicity study on various extracts of the plant. The acute toxicity was studied in mice and rats in terms of 24 h LD50 of the methanol and aqueous extracts. These extracts were...

Diabetes mellitus is a metabolic disorder affecting carbohydrate, fat and protein metabolism that affects nearly 10% of the population every year. The treatment of diabetes mellitus has been confined to use of oral hypoglycemic agents and insulin, the former being reported to possess serious side effects. This leads to increasing demand for herbal...

In analogy with Piezoelectric Wafer Active Sensors (PWAS), Lead Zirconate Titanate (PZT) thin films also seem to be promising for Structural Health Monitoring (SHM) due to a number of reasons. Firstly, PZT thin films with well oriented domains show enhanced piezoelectric response. Secondly, PWAS requires comparatively large voltage leading to a dem...

The study was aimed at evaluating the antioxidant and free radical scavenging activities of ethanolic extract and its fractions of Cleome rutidosperma. The antioxidant activity, reducing power, total phenolic content, total flavonoid content, superoxide anion scavenging activity, nitric oxide anion scavenging activity, in vitro antilipid peroxidati...

Oral administration of the ethanolic extract (200 and 400 mg/kg, p.o) and its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma produced significant analgesic activity,in acetic acid-induced writhing and tail immersion tests, antiinflammatory effect against carrageenin induced inflarnmation and adjuvant induced polyarthritis and...

The ethyl acetate fraction (EAF) and n-butanol fraction (NBF) of ethanolic extract of Bacopa monnieri aerial parts were screened for hepatoprotective activity and in vivo antioxidant activity on ethanol-induced hepatotoxic rats. Ethyl acetate fraction was found to be more potent even though both the fractions were endowed with significant hepatopro...

Bacopa monnieri is being used in the traditional system of medicine for a variety of ailments. In the present study, the ethanolic extract of Bacopa monnieri aerial parts has been studied for its wound healing activity using various models in rats. Significant increase in wound contraction and skin breaking strength were observed in the excision an...

Crude aqueous extract of Cleome rutidosperma was investigated for diuretic and antibacterial activity. The diuretic activity was tested in rats at 400 and 600 mg/kg, orally and compared with furosemide (20 mg/kg, intraperitoneally) as the standard. The antibacterial activity was assessed by disc diffusion method against Bacillus subtilis , Bacillus...

The ethyl acetate and n-butanol fractions of ethanol extract of Bacopa monnieri Linn. aerial parts were screened for antibacterial and antifungal activities by both zone of inhibition study and determination of minimum inhibitory concentration (MIC). The ethyl acetate fraction was found to be more potent than the n-butanol fraction, though both of...

The ethanolic extract of Bacopa monnieri Linn. aerial parts were studied for its hepatoprotective effect on CCl4-induced hepatotoxic rats. The extract was found to decrease significantly CCl4-induced elevation of SGOT, SGPT, ALP, bilirubin and total cholesterol. But, it increased HDL-cholesterol level and liver weight with respect to CCl4 toxic rat...

Cited By (since 1996):9, Export Date: 18 October 2014

Objective: To study the antimicrobial activity of the ethanolic extract and its various fractions of Cleome rutidosperma DC. Materials and methods: Minimum inhibitory concentration of the extract was performed by broth dilution method against both for the bacterial and fungal strains. Results: The results of MIC study revealed the antimicrobial act...

The ethyl acetate, the n-butanolic and the aqueous fractions of the ethanolic extract of Bacopa monnieri were evaluated separately for anthelmintic activity on adult Indian earthworms, Pheretima posthuma, the n-butanolic fraction being more potent. The activities are comparable with the reference drug piperazine citrate and albendazole respectively...

Objective: To study the antimicrobial activity of the ethanolic extract of aerial parts of Bacopa monnieri Linn. Materials and methods: Minimum inhibitory concentration of the extract was performed by broth dilution method and the zone of inhibition was studied by agar disc diffusion method at concentrations of 2, 5 and 10 mg/ml in DMSO. Ciprofloxa...

The ethanolic (50% v/v) extract of the leaves of Tagetes erecta Linn.(Family – Asteraceae) was screened for wound-healing activity on adult albinorats by Excision wound model and Incision wound model respectively. Thestudies on excision wound model reveals significant wound healing activity ofthe extract, which is comparable with the reference cont...