Anil Kumar Srivastava

• CEO at Agricultural Scientists Recruitment Board

Pharmacokinetics and milk levels of ceftriaxone were studied in healthy and endometritic cows following single intravenous administration. The drug was detected up to 8 h of dosing in plasma of healthy and endometritic cows and the drug disposition followed three-compartment open model. The values of Vd area , AUC, t 1/2β ,C l B , MRT and P/C ratio...

The present study was outlined to determine the grades of non-specific bacterial infection in endometritic cattle by a rapid test under field condition. White side test was performed on estrual mucus to confirm endometritis. For this purpose, Forty eight crossbred cows with endometritis and eight healthy cows were selected based on history of repea...

Disease conditions are known to alter the pharmacokinetics of antibacterials in bovines. Ceftriaxone is effective for the treatment of bacterial endometritis particularly caused by Gram-negative pathogens. In this regard, the plasma pharmacokinetics and milk levels of ceftriaxone were studied in healthy and endometritic cows following single intram...

Disposition and urinary excretion of levofloxacin following a single intravenous administration of 4 mg/kg body mass were investigated in six febrile crossbred calves. The drug levels in plasma and urine were estimated by microbiological assay. Levofloxacin was rapidly distributed from the blood to the tissue compartment, as evidenced by the high v...

Paraoxonases (PON) are group of enzymes responsible for the metabolism of oxidized phospholipids, homocysteine thiolactone, pro-inflammatory molecules including platelet activating factor and other reactive oxygen species (ROS) that are responsible for initiation of atherosclerosis and other cardiovascular disorders. The PON gene is a member of a t...

The role of the gut microbiome in human health and disease with a particular emphasis on therapeutic use of probiotics under specific medical conditions was mainly highlighted in 1st Annual conference of Probiotic Association of India (PAi) and International Symposium on "Probiotics for Human Health - New Innovations and Emerging Trends" held on 27...

Dairy livestock have been domesticated for centuries and hence have had long history of close association with humans. Domesticated livestock have played a pivotal role in the development of human civilizations around the world and continues to be an integral part of human culture, society, and the local and global economy.The animal-source food (A...

Food Quality and Safety–A Growing Concern in Global Trade: With the rising liberalization of agro-industrial markets and thus the world-wide integration of food supply chains, the assurance of food quality and safety has become a major concern. Following serious and repeated incidents such as mad cow disease (Bovine Spongiform Encephalitis–BSE), Di...

: As part of a recent study on goats, alterations in enzymatic parameters were determined after oral administration for 30 days of 20 mg of NaF/kg bw/day to four healthy goats (Group 1) plus the same dose of NaF with 150 mg of aluminium sulphate/kg bw/day to another four healthy goats (Group 2). Significant decreases (p < 0.01) in acetylcholinester...

Pharmacokinetics and milk levels of ceftriaxone were studied in healthy and endometritic cows following single intravenous administration. The drug was detected up to 8 h of dosing in plasma of healthy and endometritic cows and the drug disposition followed three-compartment open model. The values of Vd(area), AUC, t(1/2beta), Cl(B), MRT and P/C ra...

Molybdenum toxicity produces a state of secondary hypocuprosis, resulting into alterations in normal hematological profile. In the present study, ammonium molybdate alone and with copper sulfate (II) pentahydrate (ameliorative agent) was administered orally for 30 consecutive days in healthy goats of group 1 and 2, respectively, to access the effec...

Pharmacokinetics and milk levels of ceftriaxone were studied in healthy and endometritic cows following single intravenous administration. The drug was detected up to 8 h of dosing in plasma of healthy and endometritic cows and the drug disposition followed three-compartment open model. The values of Vd area , AUC, t 1/2β ,C l B , MRT and P/C ratio...

Pharmacokinetics and milk levels of ceftriaxone were studied in healthy and endometritic cows following single intravenous administration. The drug was detected up to 8 h of dosing in plasma of healthy and endometritic cows and the drug disposition followed three-compartment open model. The values of Vd area , AUC, t 1/2β , Cl B , MRT and P/C ratio...

Our previous study suggested that toxicokinetic parameters of fluoride were significantly changed on the 30th day as compared with 1st day, after repeated oral administration of sodium fluoride alone for 30 days in goats. The purpose of this study was to investigate whether aluminum sulfate has ameliorative effect on the toxicokinetics of fluoride....

The toxicokinetics of fluoride was investigated in healthy cross breed goats after single and repeated oral administration of sodium fluoride (20 mg kg b.wt.) for 30 days. Serial blood samples at various predetermined time intervals were collected for plasma separation on days 1 and 30 of administration. The plasma fluoride levels were estimated by...

High affinity of the fluoride to the bone causes intoxication of bone marrow resulting into alterations in normal hematological profile. In present study sodium fluoride alone and with aluminium sulphate (ameliorative agent) was administered orally daily for 30 days in healthy goats of group 1 and 2 respectively to access the effect on the hematolo...

Sodium fluoride (NaF) alone or together with aluminium sulphate was administered to goats to determine the fluoride levels of milk and the effect of aluminium sulphate on the excretion of fluoride in goat milk. The increase in milk fluoride levels at various time intervals was reduced when aluminium sulphate was administered. On the basis of these...

Fluorosis or crippling disease is one of the existing environmental challenges for animal and human beings in most parts of the globe. In the present study, sodium fluoride alone and with aluminium sulphate (ameliorative agent) was administered orally daily for 30 days in healthy goats of group 1 and 2, respectively, to access the effect on the ele...

: Four healthy goats were administered 20 mg NaF/kg bw/day for 30 days. Oxidative stress occurring in the blood was indicated by a significant increase in catalase activity (p<0.01) and a decrease in superoxide dismutase (SOD) activity (p<0.05) along with a significant increase in lipid peroxidation (p<0.01). Concurrent administration of 150 mg Al...

Four healthy goats were administered 20 mg NaF/kg bw/day for 30 days. Oxidative stress occurring in the blood was indicated by a significant increase in catalase activity (p<0.01) and a decrease in superoxide dismutase (SOD) activity (p<0.05) along with a significant increase in lipid peroxidation (p<0.01). Concurrent administration of 150 mg Al 2(...

Plasma levels and disposition of paracetamol were determined in cross-bred calves after single intramuscular administration of 50 mg.kg -1 followed by intravenous injection of levofloxacin (4 mg.kg -1). The concentration of paracetamol in plasma was estimated spectrophotometrically. The minimum therapeutic plasma drug concentration was maintained u...

Fluoride toxicity is a serious health problem in many parts of the globe. In present study, sodium fluoride at 20 mg/kg alone and in conjunction with aluminum sulfate at 150 mg/kg was administered orally daily for 30 days in healthy goats of group 1 and 2, respectively, to access the alterations in the various biochemical parameters during subacute...

Sodium fluoride (NaF) alone or together with aluminium sulphate was administered to goats to determine the fluoride levels of milk and the effect of aluminium sulphate on the excretion of fluoride in goat milk. The increase in milk fluoride levels at various time intervals was reduced when aluminium sulphate was administered. On the basis of these...

Four healthy goats were administered 20 mg NaF/kg bw/day for 30 days. Oxidative stress occurring in the blood was indicated by a significant increase in catalase activity (p<0.01) and a decrease in superoxide dismutase (SOD) activity (p<0.05) along with a significant increase in lipid peroxidation (p<0.01). Concurrent administration of 150 mg Al2(S...

The effects of tramadol on electrocardiogram (ECG), mean electrical axis and respiratory rates were studied in adult kagani goats after intramuscular administration of tramadol at 1 mg/kg b.wt as a prelude to its clinical use as an analgesic in veterinary practice. The ECG was monitored by standard bipolar leads and discernible electrocardiographic...

The disposition kinetics and urinary excretion study of levofloxacin was conducted in 5 male cross-bred calves following its single intravenous administration (4mgkg(-1)) concurrently with meloxicam (0.5mgkg(-1)). Levofloxacin was estimated by microbiological assay. The drug levels above MIC(90) in plasma, were detected up to 10h. Disposition kinet...

2007. Phamacokinetics of tobramycin following a single intramuscular administration in Kaghani goats (Capra hircus). Bulg. J. Vet. Med., 10, No 2, 95−101. The pharmacokinetics and safety of tobramycin sulphate solution was studied in Kaghani goats (Capra hircus) following a single intramuscular administration at a dose rate of 3 mg/kg body weight....

Major proportion of intracellular calcium (Ca2+) is achieved through opening of calcium channels present in the plasma membrane which play an important role in regulating neuromuscular coordination and release of neurotransmitters from nerve terminals. Blockade of these calcium channels adversely affects contractile process and release of neurotran...

The pharmacokinetics and urinary excretion following single intramuscular administration of levofloxacin at a dose of 4 mg/kg was investigated in seven male cross bred calves. Appreciable plasma concentration of levofloxacin (0.38+/-0.06 microgram/ml) was detected at 1 min after injection and the peak plasma level of 3.07+/-0.08 microgram/ml was ob...

The pharmacokinetics and dosage regimen of cefotaxime following its single subcutaneous administration (10 mg/kg) were investigated in buffalo calves. Plasma and urine samples were collected over 10 and 24 h post administration, respectively. Cefotaxime in plasma and urine was estimated by microbiological assay technique using E. coli as test organ...

Effects of repeated feeding of selenium, when given alone or along with reduced glutathione, on whole blood selenium levels, selenosis and glutathione peroxidase activity, was studied in buffalo calves. After feeding 2.5 mg/kg of BW sodium selenite, good correlation was found between the onset of selenosis and whole blood selenium concentrations. A...

The present study was planned to investigate the pharmacokinetics of ceftriaxone in experimentally induced febrile buffalo calves (n=5). The fever was induced by intravenous injection of E.coli lipopolysaccaride (1 microgram/kg). To study the pharmacokinetics, ceftriaxone was administered at the dose rate of 10 mg/kg body wt. in all animals. At 1 m...

The most important goal in chemotherapeutics is to achieve the desired beneficial effects of drugs with minimal adverse effects to the host cells. A rational approach to achieve this objective is to apply the principles of pharmacokinetics in therapy. Pharmacokinetic analysis of a drug describes its sojourn in the body through absorption and distri...

The paper describes the disposition of oxytetracycline in cows suffering from brucellosis. Five pregnant cows suffering from brucellosis as per their high titre weighing about 300 kg were administered oxytetracycline L A @ 20 mg/kg b. wt. deep intramuscular. The disposition kinetics determined by one compartment open model. The test organism used f...

The pharmacokinetics, urinary excretion and dosage regimen of cefotaxime after its single intravenous administration (10 mg.kg-1) was investigated in hepatic-dysfunctioned buffalo calves. Hepatic-dysfunction was induced by intramuscular administration of paracetamol (250 mg.kg-1 body weight on day 1, followed by two subsequent doses of 50 mg.kg-1 b...

Pharmacokinetics and dosage regimen for cefoperazone were investigated in buffalo calves following a single intramuscular dose of 15mg/kg. The absorption and elimination half lives were 0.8±0.393 and 5.65±0.30 hr respectively. Based on the pharmacokinetic parameters intramuscular dosage regimen for cefoperazone in buffalo calves would be 12 mg/kg f...

The disposition kinetics, urinary excretion and dosage regimen of meloxicam were investigated in crossbred calves following its single subcutaneous administration of 0.5 mg.kg -1. The peak plasma drug concentration was attained at 6 hr and the minimum therapeutic plasma concentration was maintained from 0.5 to 48 hr of administration. The absorptio...

The pharmacokinetic pattern of cefotaxime following its repeated dosing was studied in buffalo calves. Cefotaxime was given at a dose rate of 13 mg/kg, first by intravenous route (i.v.) followed by intramuscular (i.m.) administration, 8 hourly for 5 days. Plasma levels of cefotaxime equivalent at different pre-determined time intervals were estimat...

The present study was conducted on 18 anaemic dogs divided into 3 groups of 6 animals each. The group-1 (G1) was kept as control group. In the animals of group 2 (G2), blood transfusion was undertaken @ 15 ml kg-1 body weight (wt) with fresh blood collected from healthy donor dogs. In group 3 (G3), ringer's lactate was administered @ 15 ml kg-1 bod...

The effect of oxydemeton-methyl on lipid peroxidation (LPO) and antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) was studied in buffalo calves. Oxydemeton-methyl administration (1 and 2.5 mg/kg body weight/day for 21 days) enhanced LPO, which was dose dependent and levels continued to increase...

The present study was planned to investigate the subacute dermal toxicity of chlorpyrifos in buffalo calves following its daily dermal spray (0.25%) for 8 consecutive days. The animals exhibited mild to moderate toxic symptoms day 3 onwards and 1 animal died on day 7 of exposure. The surviving calves were apparently normal by day 9 post-treatment....

The study of disposition kinetics of gentamicin following single intramuscular administration (3 mg/kg) in buffaloes suffering from clinical mastitis revealed that the drug was detectable in plasma and milk upto 12 and 24 h, respectively. The minimum therapeutic concentration of gentamicin achieved in milk is probably effective against a few organi...

Cefuroxime was administered @ 10 μg.kg -1 to buffalo calves by intramuscular route. The absorption half-life, elimination half-life, AUC and T/P ratio of drug was 0.12 ± 0.04 hr, 1.56 ± 0.21 hr, 19.9 ± 2.14 μg.ml- 1 × hr and 1.25 ± 0.24 μg.ml- 1 × hr 2, respectively. About 86.3% of the administered dose of cefuroxime was recovered in urine within 2...

Pharmacokinetics of ceftizoxime (10 mg kg -1) following intravenous administration in normal and febrile cow calves was described by two compartment open model. Levels of ceftizoxime were low in febrile calves as compared to normal calves. The values of AUC, Vd (area), Vd (ss) and total body clearance varied significantly between normal and febrile...

The disposition kinetics, urinary excretion and a dosage regimen for ciprofloxacin after a single intravenous administration of 5 mg/kg was investigated in 5 healthy buffalo calves. The disposition kinetics were best fitted to a three-compartment open model. After 1 min, the concentration of ciprofloxacin in plasma was 8.50 +/- 0.39 microg/ml and t...

The plasma levels, disposition kinetics and a dosage regimen for pralidoxime (2-PAM) were investigated in male buffalo calves following single intramuscular administration (15 or 30 mg/kg). The effects of 2-PAM on various blood enzymes were also determined. The absorption half-life, elimination half-life, apparent volume of distribution and total b...

The disposition kinetics of enrofloxacin following single intramuscular administration was investigated in buffaloes suffering from clinical mastitis. Following administration in plasma and milk the drug attained its peak concentration at 1 hr and 6 hr. The MIC of enrofloxacin in plasma and milk was maintained up to 24 hr. The absorption half-life,...

In the present study, the pharmacokinetics of 2-pyridine aldoxime (2-PAM, 30 mg/kg, i.v.) alone and in conjunction with atropine (0.3 mg/kg; 1/4 i.v., 3/4 i.m.) was investigated in 10 Bubalus bubalis intoxicated with a single oral lethal dose of fenitrothion (435 mg/kg). Based on the kinetic parameters, an appropriate dosage regimen of 2-PAM in B....

The therapeutic efficacy of 2-pyridine aldoxime methochloride and diacetylmonoxime (DAM) alone and in combination with atropine was determined in oral fenitrothion toxicity in buffalo calves. DAM alone and in combination with atropine constitute the most effective therapy of fenitrothion poisoning. As compared to 2-pyridine aldoxime methochloride,...

Objective: To compare the pharmacokinetics and dosage regimen of cefuroxime in healthy and febrile cow calves. Methods: Cefuroxime was administered at the dose rate of 10 mg/kg body weight in healthy and febrile cow calves. Fever was induced by intravenous administration of E. coli endotoxin at the dose of 1 μg/kg body weight. Cefuroxime was estima...

The effect of iv diacetylmonoxime (DAM) alone or in combination with atropine was determined on blood enzymatic activities in fenitrothion-exposed buffalo calves. Fenitrothion given po at 435 mg/kg bw produced pronounced inhibition of blood acetylcholinesterase (AChE) and elevation in serum aspartate and alanine aminotransferases, acid and alkaline...

The disposition kinetics and dosage regimen of diminazene was investigated in crossbred cow calves. The drug was administered in a single dose of 3.5 mg.kg-1 by intravenous route. The pharmacokinetic behaviour was determined by using two compartment open model. Distribution half life, elimination half life, apparent volume of distribution and total...

The disposition kinetics and urinary excretion of pefloxacin after a single intravenous administration of 5 mg/kg were investigated in crossbred calves and an appropriate dosage regimen was calculated. At 1 min after injection, the concentration of pefloxacin in the plasma was 18.95±0.892 μg/ml, which declined to 0.13±0.02 μg/ml at 10 h. The peflox...

The pharmacokinetics, urinary excretion and dosage regimen of diminazene were investigated in crossbred male calves following a single intramuscular dose (3.5 mg x kg-1). Following intramuscular administration, the pharmacokinetics of diminazene was described with a one-compartment open model. The absorption rate constant and absorption half-life w...

The disposition kinetics and dosage regimen of enrofloxacin were investigated in breeding buffalo bulls following a single intramuscular administration of 5 mg/kg. The absorption half-life, half-life of the terminal phase, apparent volume of distribution and total body clearance were 0.262+0.099 h, 1.97+/-0.23 h, 0.61+/-0.13 L/kg and 210.2+/-18.6 m...

The effect of endotoxin-induced fever on the pharmacokinetics and dosage regimen of cefuroxime was investigated in buffalo calves following a single intravenous dose of 10 mg/kg body weight. The fever was induced by intravenous administration of E. coli endotoxin at a dose of 1 microg/kg body weight. The distribution and elimination half-lives were...

Disposition kinetics and urinary excretion of ceftriaxone were investigated in healthy crossbred calves after its single intravenous administration (10 mg kg-1). Based on kinetic parameters, an appropriate dosage regimen of ceftriaxone in calves was calculated. The peak plasma level of ceftriaxone at 1 min was 84.0 +/- 1.55 micrograms ml-1 which de...

Enrofloxacin, a broad spectrum flouroquinolone antibiotic, is routinely used to treat bacterial infectins. In our earlier communication, we have reported the levels of enrofloxacin in seminal plasma of buffalo bulls at various time intervals (3,7,10,14, 17,20,24 days) after its repeated parenteral administration. Further, enrofloxacin was reported...

In clinical conditions where bacterial infections are manifested with fever and pain, paracetamol is commonly employed with antibiotics. It is frequently used with cefuroxime, a second generation cephalosporin having high anti bacterial activity, in the treatment of several bacterial infections caused by Gram + ve and Gram-ve microorganisms (Mandel...

The pharmacokinetics and dosage regimen of oxytetracycline were determined in healthy and febrile cross-bred calves following its single intravenous administration (10 mg kg-1). Fever was induced by a single intravenous injection of E. coli endotoxin (1 microgram kg-1 i.v.). The elimination half-life (t1/2 beta) and the apparent volume of distribut...

The disposition kinetics, urinary excretion and dosage regimen of amikacin after a single intravenous administration of 10 mg/kg was investigated in six cross-bred bovine calves. At 1 min, the concentration of amikacin in the plasma was 116.9 +/- 3.16 micrograms/ml and the minimum therapeutic concentration was maintained for 8 h. The elimination ha...

Plasma levels. pharmacokinetics. urinary excretion and dosage regimen of cephaloridine (10 mg/kg. iv) were determined in febrile crossbred calves. Fever was induced with single intravenous injection of E. coli endotoxin (1 μg/kg). The elimination half-life and apparent volume of distribution were 3.77 ± 0.50 hr and 0.97 ± 0.16 litre/kg respectively...

Disposition kinetics and dosage regimen of amikacin were investigated in experimentally induced febrile male cow calves. Fever was induced with E. coli endotoxin (1 μg.kg, i/v) and after induction of fever, amikacin was administered (10 mg/kg, i/v). At 1 min, the peak plasma level of amikacin was 133.6 ± 1.96 μg/ml and the minimum therapeutic conce...

The pharmacokinetics, protein binding and dosage regimen of sulphadimethoxine were investigated in buffalo calves following a single intravenous dose of 100 mg/kg. The distribution of half-life (t1/2 α), elimination half-life (t1/2 β) and Vd were 0.13 ± 0.02 hr, 32.4±2.91 hr and 2.28±0.33 L. kg4 respectively. Total body clearance which represents t...

The pharmacokinetics of cephalexin was investigated in male calves following a single intravenous (i.v.) and subcutaneous (s.c.) administration (10 mg/kg). The distribution rate constant and distribution half-life were 3.34 +/- 1.22 h-1 and 0.32 +/- 0.08 h, respectively. The values of elimination half-lives following i.v. and s.c. administration we...

The disposition kinetics and dosage regimen of cefotaxime were investigated in cross-bred calves following a single intravenous administration of cefotaxime (10 mg/kg). The elimination rate constant and elimination half-life were 0.273 +/- 0.060 h-1 and 3.48 +/- 1.17 h, respectively. The apparent volume of distribution (Vd area) and total plasma cl...

The pharmacokinetics, penetration into erythrocytes and plasma protein binding of cefotaxime were investigated in cross-bred calves. Following a single intramuscular dose of cefotaxime (10 mg/kg), the absorption half-life and elimination half-life were 0.13 +/- 0.03 h and 2.97 +/- 0.72 h, respectively. The apparent volume of distribution and total...

The disposition kinetics and appropriate dosage regimen for kanamycin were investigated in buffalo calves following a single intravenous dose of 10 mg/kg body weight. The distribution and elimination half-lives were 0.12 +/- 0.01 h and 1.94 +/- 0.11 h, respectively. The apparent volume of distribution and total body clearance were 0.2 +/- 0.01 L/kg...

The effects of administration of 2,3-butanedione monoxime (2,3-BM) or atropine alone and in combination were determined on the blood enzymatic activities of dichlorvos-exposed buffalo calves. Dichlorvos given po at 160 mg/kg body weight produced pronounced inhibition of erythrocyte acetylcholinesterase (AChE) and elevation in serum aminotransferase...

The disposition kinetics and dosage regimen of sulfapyridine were studied in buffalo calves following a single intravenous dose of 100 mg/kg. Distribution half-life (t1/2 alpha) elimination half-life (t1/2 beta) and Vd (area) was 0.181 +/- 0.008 h, 13.4 +/- 0.52 h and 0.59 +/- 0.03 L kg-1, respectively. Total body clearance, which represents the su...

Cephalexin was administered im to cow calves at a dose rate of 10 mg/kg bw. After im administration, the disposition kinetics of cephalexin followed a 1-compartment open model. The values of elimination half-life, volume of distribution and total body clearance were 2.00 +/- 0.13 h, 0.32 +/- 0.02 l/kg and 1.899 +/- 0.199 ml/kg/min, respectively. 58...

Alterations in circulating esterases induced by dichlorvos and their reversibility were investigated in male buffalo calves. Changes in blood glucose and total plasma proteins were also monitored. Animals received 4 or 8 mg dichlorvos/kg/day po for 28 consecutive d. Dichlorvos caused dose- and time- dependent significant (P less than 0.01) inactiva...

Disposition kinetics and dosage regimen of sulphamethazine were investigated in sheep following single intravenous administration (100 mg/kg). The distribution and elimination half-lives were 0.15 +/- 0.04 and 4.5 +/- 0.3 h, respectively. The volume of distribution and total body clearance were calculated to be 0.6 +/- 0.1 l/kg and 90 +/- 13 ml/kg/...

Dichlorvos was applied as spray at 1 and 2% concentrations daily for a period of 28 and 21 consecutive days, respectively to buffalo calves. Animals sprayed with 1% dichlorvos displayed mild to moderate clinical signs of toxicosis during the 4th week of exposure. The higher concentration (2%) produced clinical signs of poisoning after 12-16 applica...

After a single intravenous administration (100 mg/kg) of sulfadiadine to calves, the distribution half-life, elimination half-life and volume of distribution were 0.353 +/- 0.071 h, 11.2 +/- 0.79 h and 0.55 +/- 0.08 l/kg, respectively. Total body clearance and tissue/plasma ratio were calculated to be 34.8 +/- 4.6 ml.kg-1.1-1 and 1.34 +/- 0.38, res...

The disposition kinetics and dosage regimen of cephaloridine were investigated in calves following a single intravenous dose of 10 mg.kg-1. The distribution half-life and elimination half-life were 0.16 +/- 0.02 and 1.96 +/- 0.16 h, respectively. The apparent volume of distribution was 0.64 +/- 0.06 l.kg-1 and total body clearance which represents...

2-Pyridine aldoxime methochloride (2-PAM), an acetylcholinesterase (AChE) reactivator, is widely used in the treatment of organophos-phate intoxication in man and animals (Taylor, 1980; Hatch, 1982). Among other factors, the therapeutic efficacy of AChE reactivators is dependent on the use of a suitable dosage regimen, so that during the course of...

The disposition and dosage regimen of cephaloridine were investigated in healthy calves following a single intramuscular administration of 10 mg/kg. The absorption halflife, elimination halflife, apparent volume of distribution and total body clearance were 0.107 +/- 0.025 h, 2.08 +/- 0.14 h, 0.70 +/- 0.07 L kg-1 and 235.8 +/- 21.9 ml kg-1 h-1, res...