Anibal Bueno Amorós

Anibal Bueno Amorós
University of Malaga | UMA · Department of Biochemistry and Molecular Biology

Molecular Systems Biology PhD

About

15
Publications
3,277
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152
Citations

Publications

Publications (15)
Article
Full-text available
Copy number variations (CNVs) are genomic structural variations (deletions, duplications, or translocations) that represent the 4.8–9.5% of human genome variation in healthy individuals. In some cases, CNVs can also lead to disease, being the etiology of many known rare genetic/genomic disorders. Despite the last advances in genomic sequencing and...
Article
Full-text available
Biocomputational network approaches are being successfully applied to predict and extract previously unknown information of novel molecular components of biological systems. In the present work, we have used this approach to predict new potential targets of anti-angiogenic therapies. For experimental validation of predictions, we made use of two in...
Conference Paper
Full-text available
Recent advances in sequencing technologies allow researchers to investigate diseases resulting of genomic variation. This allows us to further develop the concept of precision medicine and determine the best treatment for each patient. We have focused on developing tools for studying genomic loci associated to pathological traits from the perspecti...
Article
Full-text available
RAS proteins are the founding members of the RAS superfamily of GTPases. They are involved in key signaling pathways regulating essential cellular functions such as cell growth and differentiation. As a result, their deregulation by inactivating mutations often results in aberrant cell proliferation and cancer. With the exception of the relatively...
Article
Full-text available
Background Network medicine is a promising new discipline that combines systems biology approaches and network science to understand the complexity of pathological phenotypes. Given the growing availability of personalized genomic and phenotypic profiles, network models offer a robust integrative framework for the analysis of "omics" data, allowing...
Article
Full-text available
The complete collection of evolutionary histories of all genes in a genome, also known as phylome, constitutes a valuable source of information. The reconstruction of phylomes has been previously prevented by large demands of time and computer power, but is now feasible thanks to recent developments in computers and algorithms. To provide a publicl...
Conference Paper
Full-text available
Diagnosis is an important process in patient care. A suitable diagnosis helps a physician determine a precise treatment. Physicians also have a tendency to seek collaboration from other colleagues and expert systems for better confidence in their decision. The sources of knowledge can be both human in the form of medical specialist, and artificial...

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