Ani Amar

Bar Ilan University | BIU · Faculty of Engineering

Computational methods and tools are a powerful complementary approach to experimental work for studying regulatory interactions in living cells and systems. We demonstrate the use of formal reasoning methods as applied to the Caenorhabditis elegans germ line, which is an accessible system for stem cell research. The dynamics of the underlying genet...

Computational methods and tools are a powerful complementary approach to experimental work for studying regulatory interactions in living cells and systems. We demonstrate the use of formal reasoning methods as applied to the Caenorhabditis elegans germ line, which is an accessible model system for stem cell research. The dynamics of the underlying...

Heart failure is characterized as any heart condition resulting from impairment of the heart’s ability to pump blood, with high prevalence in both aged and diseased hearts. Numerous population-based studies have shown that, in patients with impaired left ventricular systolic function, additional structural and functional cardiovascular abnormalitie...

Mechano-electric feedback affects the electrophysiological and mechanical function of the heart and the cellular, tissue, and organ properties. To determine the main factors that contribute to this effect, this study investigated the changes in the action potential characteristics of the ventricle during contraction. A model of stretch-activated ch...

Electrophysiological modifications in HF. (DOCX)

A biophysical detailed multiscale model of the myocardium is presented. The model was used to study the contribution of interrelated cellular mechanisms to global myocardial function. The multiscale model integrates cellular electrophysiology, excitation propagation dynamics and force development models into a geometrical fiber based model of the v...

The heart has been modeled as an anatomically arranged and oriented array of contracting fibers. The model was developed to study the interplay between cellular mechanisms and global myocardial function. Our modeling approach combines cellular electrophysiology, force development, and anatomical ventricle model into a multiscale model of cardiac co...

Diabetes mellitus is considered a chronic disease resulting from metabolic disorders, characterized by damage to the blood vessels, immune system, ect. The common symptoms of diabetes are related to high blood and urine glucose levels due to the failure of the pancreatic beta cells to produce insulin in order to control blood glucose level. Injecti...