Angie BaroffioUniversity of Colorado | UCD · Graduate School
Angie Baroffio
Master of Science
About
16
Publications
869
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4
Citations
Citations since 2017
Introduction
Currently researching the role of IL-37 and the inflammasome in the tumor microenvironment of melanomas.
Additional affiliations
August 2017 - present
June 2015 - August 2017
January 2013 - January 2014
US EPA
Position
- Researcher
Education
August 2012 - May 2015
August 2008 - May 2012
August 2008 - May 2012
Publications
Publications (16)
The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). The clinical use of IFN-γ has been driven by the finding that its administration to patients with chronic granulomatous disease (CGD) results in decreased incidence and severity of infections....
Severe congenital neutropenia type 4 (SCN-4) is an autosomal recessive condition in which mutations in the G6PC3 gene encoding for the catalytic 3 subunit of glucose-6-phosphatase-β result in neutropenia, neutrophil dysfunction, and other syndromic features. We report a child with SCN-4 caused by compound heterozygous mutations in G6PC3, a previous...
Interferon-gamma (IFN-γ) is a cytokine with powerful immunoregulatory effects. Most of these have been documented within the adaptive immune system and less has been reported about its effects on neutrophil function. Furthermore, most neutrophil studies have evaluated the effect of IFN- γ on mature cells isolated from peripheral blood thus potentia...
BACKGROUND
Cannabinoids, including cannabidiol (CBD) and tetrahydrocannabinol (THC), are a class of compounds found in marijuana. Numerous studies in adults have examined cannabinoid use in management of cancer-related symptoms such as nausea, anorexia, and pain. Less is known about the use in the pediatric oncology population. Lay interest is also...
Introduction
Severe congenital neutropenia, type 4 results from a mutation in the G6PC3 gene. This gene encodes the enzyme glucose-6-phosphatase (G6Pase) which is ubiquitously expressed in endoplasmic reticulum and is responsible for the final step of gluconeogenesis and glycogenolysis. G6pc3-/- mouse models have demonstrated decreased neutrophil (...
Introduction: Most information about the immunoregulatory functions of INF-γ has focused on the interaction with the adaptive immune system and less is reported about neutrophil function. Furthermore, the majority of studies with neutrophils evaluate the effects of INF-γ on differentiated cells. The clinical use of IFN-γ has been driven by these da...
Most information about the immunoregulatory functions of INF-γ has focused on the interaction with the adaptive immune system and less is reported about neutrophil function. Furthermore, the majority of studies with neutrophils evaluate the effects of INF-γ on differentiated cells. The clinical use of IFN-γ has been driven by these data and the cli...
This study characterized the impact of treatment infrastructure and altered flow regimes on the occurrence and effects on fish of endocrine disrupting chemicals (EDCs) discharged by a wastewater treatment plant (WWTP) effluent. This site has been evaluated before and after two major upgrades in wastewater treatment infrastructure, which were implem...
This study characterized the impact of treatment infrastructure and altered flow regimes on the occurrence and effects on fish of endocrine disrupting chemicals (EDCs) discharged by a wastewater treatment plant (WWTP) effluent. This site has been evaluated before and after two major upgrades in wastewater treatment infrastructure, which were implem...
This study characterized the impact of treatment infrastructure and altered flow regimes on the occurrence and effects on fish of endocrine disrupting chemicals (EDCs) discharged by a wastewater treatment plant (WWTP) effluent. This site has been evaluated before and after two major upgrades in wastewater treatment infrastructure, which were implem...
This study characterized the impact of treatment infrastructure and altered flow regimes on on the occurrence and effects on fish of endocrine disrupting chemicals (EDCs) discharged by a wastewater treatment plant (WWTP) effluent. This site has been evaluated before and after two major upgrades in wastewater treatment infrastructure, which were imp...
Projects
Projects (5)
Recent advances in treating cancers with immune checkpoint
inhibitors have fueled the investigation of new therapeutic modalities. Alpha-1 Antitrypsin (AAT) is a serine protease inhibitor with
immunomodulatory effects shown to dampen proinflammatory
responses. Inflammation within the tumor microenvironment plays a crucial role in tumor development and progression. We hypothesize that AAT suppresses progression of melanoma by affecting tumor cells and immune cells in the tumor microenvironment.
We are looking to define the role of IL-37 in the inflammasome - specifically, how does IL-37 alter immune function in the tumor microenvironment of melanomas? We will look at IL-37 expression and immune modulation in various immune cell subpopulations, including T cells (especially T regs), dendritic cells, macrophages, myeloid-derived suppressor cells, etc.
Patients currently being treated for brain tumors are evaluated at baseline, and after 3 months of medical marijuana treatment for neutrophil function, including superoxide anion production and chemotaxis.
