Angelo Poletti

Neurology, Pharmacy, Cancer Research



We study the molecular mechanisms at the basis of two forms of motor neuron diseases (MNDs): SBMA and ALS, both associated to the formation of neurotoxic mutant protein conformations. We recently found a protective effect of a small heat shock protein (HSPB8) in MNDs mediated by autophagy.
We are also studying prostate cancer and found an antiproliferative, antimetastatic action of the androgen metabolite 3beta-diol. This protective role is mediated by the estrogen receptor.

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