
Angelina ZherebtsovaOrlov State University · Scientific-Educational Center of "Biomedical Engineering"
Angelina Zherebtsova
PhD
About
35
Publications
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336
Citations
Introduction
Additional affiliations
December 2016 - present
Publications
Publications (35)
This paper presents clinical results of wireless portable dynamic light scattering sensors that implement laser Doppler flowmetry signal processing. It has been verified that the technology can detect microvascular changes associated with diabetes and ageing in volunteers. Studies were conducted primarily on wrist skin. Wavelet continuous spectrum...
The rising interest in the development of new wearable electronic devices for mobile healthcare can be exemplified by great opportunities for the development of new methods for broader use of blood perfusion monitoring for the purposes of precision medicine. A fine analysis of capillary blood flow structure and its rhythmic oscillations in the time...
This study is devoted to the trials of wearable diagnostic system that implements the laser Doppler flowmetry technique to analyse the blood microcirculation. We do preliminary test with involvement of limited group of healthy volunteers of different age and in patients with type 2 diabetes. During the series of measurements, the microcirculation p...
Early diagnostics of microcirculation complications is an important area for biomedical photonics application. The blood perfusion measurements are capable of identification of particular markers for diagnostics of many pathological conditions of blood microcirculation in the skin. In this work, we apply the laser Doppler Flowmetry
method with the...
In this work, we applied a wearable distributed laser measuring system for the study of regional changes in blood microcirculation in healthy volunteers of different age and diabetic patients. It was found that age-related changes in blood microcirculation can be characterized by increased perfusion level in the fingers and decreased amplitudes of...
Presently, in the modern laser Doppler flowmetry (LDF) the distribution of blood perfusion and its changes along the Doppler shift frequencies are simply ignored and/or not properly addressed. Utilizing the registered power spectrum of photocurrent, we introduce an LDF signal processing approach suitable for expanding of diagnostic capabilities of...
Laser Doppler flowmetry (LDF) was used for detection of age-related changes in the blood microcirculation. TheLDF signal was simultaneously recorded from the 3rd fingers’ pads of both hands. Amplitudes of the blood flowoscillations and wavelet coherence of the signals were used for the data analysis. A statistical difference in thesynchronisation o...
Due to simplicity and ease of use, the laser Doppler flowmetry (LDF) has found applications in various areas of research related to non-invasive diagnosis of blood microcirculation. In fact, LDF still has a number of unsolved problems that limit its day-to-day use in clinical practice. Current report discusses the new approach for the LDF signal pr...
The introduction of optical non-invasive diagnostic methods into clinical practice can substantially advance in the detection of early microcirculatory disorders in patients with different diseases. This paper is devoted to the development and application of the optical non-invasive diagnostic approach for the detection and evaluation of the severi...
A novel non-invasive, wearable VCSEL-based system for multipoint in − vivo measurements of blood perfusion was introduced. The system operates on the basis of the laser Doppler flowmetry (LDF) method and allows for microcirculation studies. The sensors developed were used to analyse the skin blood flow synchronization in homologous regions of the c...
The possibilities and prospects of optical non-invasive diagnostic technologies for detecting and assessing the severity of microcirculatory and metabolic disorders in rheumatic diseases and diabetes mellitus were assessed. Experimental studies were conducted with the participation of 137 conditionally healthy volunteers and 147 patients with menti...
Laser Doppler
owmetry (LDF) is widely used to study blood microcirculation in the skin. However, during
tradition signal processing based on the integral estimations of the power spectrum of detector photocurrent,
the signi�cant part of the information about the skin blood
ow is lost. In this study, we propose to analyse the
distribution of the b...
Laser Doppler flowmetry (LDF), tissue reflectance oximetry (TRO) and pulse oximetry (PO) and cold pressor test (CPT)
were used to assess the microcirculation parameters and the activation of regulatory mechanisms. LDF and TRO samples
wavelet transform in the frequency bands 0.01-2 Hz was used to evaluate microvascular disturbances in rheumatic
dise...
To minimisethe influence of blood content on the fluorescence measurements in vivo, a fibre optical probe combining fluorescence and diffuse reflectance measurements was developed. For the inverse solution of the blood content recovery,a set of neural networkstrained by the Monte Carlo generated learning set was used.An approach of fluorescence mea...
Laser Doppler flowmetry (LDF) is a method widely used in diagnosis of microcirculation diseases. It is well known that information about frequency distribution of Doppler spectrum of the laser radiation scattered by moving red blood cells (RBC) usually disappears after signal processing procedure. Photocurrent’s spectrum distribution contains valua...
The paper shows the possibility of assessing the functional state of microcirculatory-tissue systems of patients with diabetes mellitus by laser Doppler flowmetry (LDF), diffuse reflectance spectroscopy (DRS) and fluorescence spectroscopy (FS) methods. A review of the existing non-invasive optical technologies used to assess the state of microcircu...
According to the International Diabetes Federation, the challenge of early stage diagnosis and treatment effectiveness monitoring in diabetes is currently one of the highest priorities in modern healthcare. The potential of combined measurements of skin fluorescence and blood perfusion by the laser Doppler flowmetry method in diagnostics of low lim...
The article suggests a method and a device for diagnostics of the functional state of peripheral vessels of the upper limbs, which provide identification of angiospastic disorders with a lower probability of false-negative result, allowing thereby the quality of diagnostics to be improved. The suggested approach is based on combined application of...
The use of liposomal nanoparticles with an incorporated active substance is an innovative and promising approach to diagnostics and therapy. The application of liposomal nanoparticle-based drugs allows for targeted localized delivery, overcomes the natural barriers within the body effectively, and minimizes possible side effects. Liposomes are able...
We introduce a noninvasive diagnostic approach for functional monitoring of blood microflows in capil-laries and thermoregulatory vessels within the skin. The measuring system is based on the combined use of laser Doppler flowmetry and skin contact thermometry. The obtained results suggest that monitoring of blood microcir-culation during the occlu...
Immunoinflammatory reactions affecting the state of the microvasculature play the key role in the genesis of rheumatic diseases. Therefore, it is important to develop new methods for the early detection of microcirculatory disorders. The purpose of this study was to assess the possibilities of diffuse reflectance spectroscopy used to identify micro...
This article presents the results of the study of the pressure applied on optical diagnostic probes as a significant factor affecting the results of measurements. During stepwise increasing and decreasing of local pressure on skin we conducted measurements using the methods of laser Doppler flowmetry and fluorescence spectroscopy. It was found out...
The studies were carried out on groups of clinically healthy mice line of outbred CD-1 stock. The model animals were divided into 2 groups and received experimental liposomal formulations. Using the method of fluorescence spectroscopy, we investigated the effectiveness of penetration into the circulatory system of fluorescently stained liposomes wi...
Optical techniques are one of the most promising non-invasive technologies for the diagnosis of medical conditions. This work is devoted to the current state of the optical non-invasive diagnostics (OND), especially about instrumentation as well as methodological and metrological provision for this technology. In some details Laser Doppler Flowmetr...
This study examines the effect of blood absorption on the endogenous fluorescence signal intensity of biological tissues. Experimental studies were conducted to identify these effects. To register the fluorescence intensity, the fluorescence spectroscopy method was employed. The intensity of the blood flow was measured by laser Doppler flowmetry.
W...
Vasospastic disorders are a common class of rheumatic disease. These include syndromes such as vegetative dystonia, Raynaud's syndrome, vibration disease and rheumatoid arthritis among others. The aim of this work is to develop an original method of diagnosing the functional state of peripheral vessels of the fingers, based on the simultaneous reco...
Skin blood microcirculation and the metabolism activity of tissue were examined on the patients with type 2 diabetes. Laser Doppler flowmetry (LDF) with 1064 nm laser light source and fluorescence spectroscopy (FS) with excitation light of 365 nm and 450 nm have been used to monitor the blood perfusion and the content of coenzymes NADH and FAD. Con...
The main problems of metrological assurance for laser Doppler flowmetry (LDF) devices that inhibit the further development of this diagnostic technology are discussed. The proposed method and device for monitoring the metrological status of LDF devices, characterized by the use of the principle of signal playback of Doppler shift based on probing t...