Angeliki Melidou

Angeliki Melidou
Aristotle University of Thessaloniki | AUTH · Department of Microbiology II, Medical School

BSc in Biology, MSc in Human Reproductive Biology

About

125
Publications
4,259
Reads
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418
Citations
Citations since 2016
22 Research Items
181 Citations
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
Additional affiliations
April 2013 - present
Aristotle University of Thessaloniki
Position
  • Professor (Assistant)
March 2010 - April 2013
Aristotle University of Thessaloniki
Position
  • Lecturer
January 2004 - February 2010
Aristotle University of Thessaloniki
Position
  • Biologist, Lecturer (407)
Education
January 2005 - September 2008
Aristotle University of Thessaloniki
Field of study
  • Molecular Virology
September 2000 - September 2001
Imperial College London
Field of study
  • Human Reproductive Biology
September 1997 - June 2000
University of Bath
Field of study
  • Biology

Publications

Publications (125)
Article
Background: In the setting of the oral-gut-liver axis, microbiome dysbiosis has been associated with decompensated cirrhosis progression. However, little is known on salivary microbiome profiles in stable decompensated patients. Methods: We studied patients with stable decompensated cirrhosis (n =28) and matched healthy controls (n =26). There w...
Technical Report
Full-text available
This situation update for seasonal influenza uses epidemiological and virological data to assess the seasonal increase of influenza cases in relation to disease severity and impact on healthcare systems. It is designed to assist forward planning in Member States.
Article
The aim of the present study was to describe the genetic diversity of Mycobacterium tuberculosis (M.tuberculosis) strains circulating in the region of Northern Greece. A total of thirty-seven M. tuberculosis clinical isolates were analysed by the spoligotyping method. According to the results, six clusters comprising seventeen strains were detected...
Article
Full-text available
We use surveillance data to describe influenza A and B virus circulation over two consecutive seasons with excess all-cause mortality in Europe, especially in people aged 60 years and older. Influenza A(H3N2) virus dominated in 2016/17 and B/Yamagata in 2017/18. The latter season was prolonged with positivity rates above 50% among sentinel detectio...
Article
Full-text available
Background: The recent advent of high-throughput sequencing methods enabled the study of the composition of the upper respiratory tract (URT) microbial ecosystem and its relationship with health and disease in immense detail. The aim of the present study was the characterization of the human pharyngeal microbiome of healthy individuals in Greece....
Article
Respiratory syncytial virus (RSV) is one of the most important causes of viral lower respiratory tract illness in infants and children globally. It often causes severe and even fatal infections, particularly in children aged under 6 months, and RSV is considered responsible for one-third of deaths resulting from acute lower respiratory infection (A...
Article
Full-text available
During the European 2016/17 influenza season, A(H3N2) viruses have predominated and the majority clustered in genetic subclade 3C.2a1. Genetic analyses showed that circulating viruses have undergone considerable genetic diversification of the haemagglutinin gene from the current vaccine virus A/Hong Kong/4801/2014 (clade 3C.2a), but the antigenic d...
Technical Report
Full-text available
Since the notification of a novel reassortant influenza A(H7N9) virus on 31 March 2013, 1 548 laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus have been reported. This is the fifth winter season in the northern hemisphere with human cases caused by A(H7N9) infections. During this wave, the number of human cases has b...
Article
Background Influenza A(H3N2) viruses predominated during the influenza 2016/2017 season and showed extensive genetic diversification. A high vaccination failure rate was noticed during the 2016/17 season in Greece, especially among the elderly. Objectives The scope of the study was to investigate the genetic characteristics of A(H3N2) circulating...
Article
The aim of the present study was to determine the current status of measles immunity in northern Greece, in light of outbreaks in many European countries, while recently, there is an ongoing measles outbreak in our country, affecting mostly Northern Greece. For the 611 sera tested (collected during June 2014-January 2016, and age range 10 d. - 82 y...
Article
Measles is an infectious disease that still represents an existing health issue of concern in Europe. While the World Health Organization (WHO) target for the elimination of measles virus has been postponed until year 2020, in 2016 measles outbreaks were seen in a number of EU/EEA countries and an increase in the number of cases is still observed i...
Technical Report
Full-text available
Since the notification of a novel reassortant influenza A(H7N9) virus on 31 March 2013, 1 258 laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus have been reported. This is the fifth winter season in the northern hemisphere with human cases caused by A(H7N9) infections. During this wave, the number of human cases has b...
Technical Report
Full-text available
Most countries with high influenza activity have reported appreciable numbers of cases with severe outcomes. These case numbers place a high burden on hospitals. This updated risk assessment provides an overview of the current influenza situation in Europe.
Technical Report
Full-text available
This season, influenza viruses, mainly A(H3N2), began circulating early in the EU/EEA. It is too early to anticipate the intensity in primary care and severity in secondary care, but if A(H3N2) continues to predominate, there is a risk that people over 65 years of age will be the most severely affected, possibly putting some healthcare systems unde...
Article
Full-text available
Abstract. The ‘2nd Workshop on Paediatric Virology’, which took place on Saturday the 8th of October 2016 in Athens, Greece, provided an overview on recent views and advances on Paediatric Virology. Emphasis was given to HIV‑1 management in Greece, a country under continuous financial crisis, hepatitis B vaccination in Africa, treatment options for...
Article
Macrolides are widely used for the treatment of ureaplasma infections. The aim of this study was to investigate possible genetic resistance determinants in Ureaplasma parvum isolates with erythromycin elevated MICs. Nine U. parvumisolates (four isolates with MIC ≥ 8 μg/ml and five isolates with MIC ≤ 8 μg/ml) from urogenital specimens were studied...
Article
The 2014-2015 influenza season was marked by circulation of antigenically drifted A/H3N2 strains, raising the possibility of low seasonal influenza Vaccine Effectiveness (VE). We assessed VE against hospitalization with laboratory-confirmed influenza for the 2014-2015 season, using routine surveillance data. Non-sentinel swab samples from Greek hos...
Article
Full-text available
Tuberculosis (TB) remains one of the world’s deadliest diseases. Increasing rates of drug-resistant tuberculosis in Eastern Europe, Asia and sub-Saharan Africa now threaten to undermine the gains made by worldwide tuberculosis control efforts. The region of Macedonia in North Greece is an entrance gate of thousands of immigrants, moving mainly from...
Article
A premature female infant with intrauterine growth restriction, microcephaly, hepatosplenomegaly and cholestasis developed hyperthyroidism on the fifth day of life. The mother had also developed hyperthyroidism during pregnancy. Real-time polymerase chain reaction was positive for rubella virus in samples from both mother (blood) and neonate (blood...
Article
Genetic and antigenic characterization of 37 representative influenza A(H3N2) strains isolated in Greece during the 2011-12 winter season was performed to evaluate matching of the viruses with the seasonal influenza A/Perth/16/2009 vaccine strain. Haemagglutinin-gene sequence analysis revealed that all Greek strains clustered within the Victoria/20...
Article
Since its appearance, influenza A(H1N1)pdm09 caused considerable morbidity and mortality in Northern Greece. Genetic analysis of post-pandemic circulating strains scoped to investigate any correlation between genetic variations that emerged during viral evolution and severity of infection. Pharyngeal swabs/aspirates (n = 1,870) were examined with r...
Article
In 2013-2014 Greece experienced a resurgence of severe influenza cases, coincidental with a shift to H1N1pdm09 predominance. We sought to estimate Vaccine Effectiveness (VE) for this season using available surveillance data from hospitals (including both inpatients and outpatients). Swab samples were sent by hospital physicians to one of three labo...
Article
We identified the proportion of tetM-positive Ureaplasma spp. isolates phenotypically susceptible to tetracycline by real-time PCR.•The tetM determinant is detected in 35% of phenotypically susceptible to tetracycline Ureaplasma spp. Greek isolates.•The tetM gene was detected by a novel real-time PCR method especially designed for this study.•The u...
Article
The global community is constantly threatened by viral infectious diseases of the respiratory tract. Influenza is one of the most important causes of severe acute respiratory infections. Emerging viral pathogens also contribute to the high morbidity and mortality along with a huge economic impact. In September 2012, a new corona virus, MERS-CoV, ha...
Article
Influenza is continuously strongly connected to public health and therefore scientific research targets the responsible microorganisms as well as the relevant human immunity mechanisms. The recent 2009 pandemic is used as a research model in order to study the characteristics of the immune response to influenza viruses. Initially, TLR7 acts as an i...
Article
High genetic instability is the main characteristic of the influenza virus. Its surface glycoproteins, hemagglutinin (HA), and neuraminidase (NA) are the external viral antigens [Webster et al., 1992]. A continuous process of antigenic drift occurs extensively in the HA and causes the emergence of new virus variants. HA is essential in the early...
Article
Aim: This study attends to determine the prevalence and the antimicrobial susceptibility of Ureaplasma urealyticum in asymptomatic women in Northern Greece. Materials-methods: A total of 347 cervical smears were divided into 5 groups according to age. Samples were cultured, Ureaplasma urealyticum isolation was confirmed by the detection of the u...
Article
Following the influenza pandemic in 2009, the influenza virus continues to threaten public health with its yearly epidemics. This is a review of the laboratory influenza surveillance in northern Greece, during 2012-2013. Starting from the 40th week of 2012 until the 20th week of 2013, 309 clinical samples were examined. All the three influenza A(H1...
Article
Objectives: Influenza viruses constitute one of the most common pathogens that cause acute respiratory disease in children. The aim of this study is to present the contribution of influenza viruses to influenza-like illness (ILI) in children (aged<10 years old) in Northern Greece during six influenza seasons (2004-2010). Materials and methods: 1...
Article
Since the pandemic in 2009, the two following post pandemic influenza seasons have been associated with increased morbidity and mortality rates in Northern Greece. The scope of this short report is to provide relevant epidemiological information, an evaluation of the efficacy of the seasonal vaccine and antiviral drugs. Molecular analysis revealed...
Article
Influenza viruses, respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are the most common pathogens that cause acute respiratory disease in children. The aim of this study is to present the contribution of the above three pathogens to influenza-like illness (ILI) in children (aged <6 years old) during 2-year (2008-2010) influenza se...
Article
Full-text available
Resistance to oseltamivir was observed to influenza A pandemic (H1N1) 2009 virus strains, isolated from two patients in North Greece. Investigations showed resistant viruses with the neuraminidase (NA) 275Y genotypes. Pandemic A (H1N1) 2009 virus should be closely monitored for emergence of resistant variants.
Article
Full-text available
Although elimination of measles virus (MV) by 2010 was a revised target, a new epidemic has been ongoing in Greece and other European countries. The purpose of this study was the molecular and phylogenetic analysis of the Greek MV circulating strain. Twenty-four MV strains isolated from clinical samples during the 2010 outbreak were genotyped and s...
Article
Full-text available
Background. Parvovirus B19 infects children and adults, often causing erythema infectiosum, polyarthritis, but also aplastic crisis in patients with chronic haemolytic anaemia, rash, fever and fetal hydrops or fetal death. This study aims at the detection of acute parvovirus B19 infections during 2006-2009 in northern Greece on epidemiological and...
Article
Full-text available
During April 2009 a novel A(H1N1) influenza virus emerged in Mexico and since then spread worldwide. On 11th June 2009, the World Health Organization declared an ongoing pandemic, caused by the novel influenza virus. Greece had set up an enhanced surveillance system for pandemic H1N1 2009 by 30th April 2009. During the period of study in Northern G...
Article
In April 2009 a novel influenza A (H1N1) virus emerged in Mexico and was spread rapidly throughout the world. The World Health Organization announced the pandemic on the 11th of June and advised all countries to closely monitor affected individuals and circulating viral strains. The aim of this study is to present the molecular analysis of the circ...
Article
The objectives of this research is molecular and phylogenetic analysis of pandemic influenza A(H1N1) 2009 strains that circulated in northern Greece, focusing on severe or fatal infections, identification of sequence variations in relation with the severity of the illness and comparison of circulating viruses with the vaccine strain. A total of 159...
Article
An association has been proposed between atherosclerosis and several organisms. We investigated 50 carotid atherosclerotic plaques by real-time polymerase chain reaction for human bocavirus (HBoV). HBoV DNA was not detected in any of the specimens. Future studies are warranted to prove or disprove the role of infectious pathogens, including HBoV, i...