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Angela Zacharasiewicz

Angela Zacharasiewicz
Wiener Gesundheitsverbund

MD, Univ.Prof, MBA (Health Care Management)

About

106
Publications
14,494
Reads
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3,300
Citations
Introduction
Angela Zacharasiewicz works as a Consultant and leads the General Pediatric and Infectious Diseases Unit at a large Teaching Hospital. Research: Respiratory Medicine, Allergology, Public Health. Projects: 'Induced sputum in cystic fibrosis', Cough&Wheeze Monitoring, Effects of tobacco exposure. Member of various European Respiratory Society Task forces on Asthma Diagnosis, Non CF -Bronchiectasis, Chronic Cough and holds Chair Positions in 3 national/international specialist medical societies.
Education
September 2012 - November 2014
Vienna University of Economics and Business
Field of study
  • Master of Business Administration on Health Care Management, Executive Academy
February 2002 - February 2003
Dept. of Respiratory Paediatrics, Royal Brompton Hospital,
Field of study
  • Paediatric Research Fellow,
December 2001 - October 2006
Wilhelminenspital
Field of study

Publications

Publications (106)
Article
Bronchiectasis is being diagnosed increasingly in children and adolescents. Recurrent respiratory exacerbations are common in children and adolescents with this chronic pulmonary disorder. Respiratory exacerbations are associated with an impaired quality-of-life, poorer long-term clinical outcomes and substantial costs to the family and health syst...
Article
Full-text available
Chronic cough is a common symptom of many underlying respiratory and non-respiratory disorders and may be associated with less serious causes, such as gastroesophageal reflux and nasal diseases. Chronic cough in children differs from that in adults with respect to its etiologies and management since it can indicate a symptom of an underlying diseas...
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The Austrian Society of Pneumology (ASP) launched a first statement on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in May 2020, at a time when in Austria 285 people had died from this disease and vaccinations were not available. Lockdown and social distancing were the only available measures to prevent more infections and...
Article
Montelukast, a leukotriene receptor antagonist (LTRA) has been approved for use in Europe since 1998. Indications for use (from the age of 6 months) include mild to moderate asthma, seasonal allergic rhinitis with asthma, and the prevention of exercise-induced asthma episodes. The psychiatric side effects of montelukast have been known for the last...
Article
Background A hallmark of many respiratory conditions is the presence of nocturnal symptoms. Nevertheless, especially in children there is currently still a huge diagnostic gap in detecting nighttime symptoms, which leads to an underestimation of the frequency in clinical practise. Methods We evaluated the clinical applicability and determined the...
Article
These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella term that explains the exquisite sensitivity of patients to external stimuli such a cold air, perfumes, smoke and bleach. Thus, adults with chronic cough now have a firm physical e...
Article
Full-text available
The global burden of children and young people (CYP) with bronchiectasis is being recognised increasingly. They experience a poor quality-of-life and recurrent respiratory exacerbations requiring additional treatment, including hospitalisation. However, there are no published data on patient-driven clinical needs and/or research priorities for paed...
Article
Full-text available
Diagnosing asthma in children represents an important clinical challenge. There is no single gold standard test to confirm the diagnosis. Consequently, both over-, and under-diagnosis of asthma are frequent in children. A Task Force (TF) supported by the European Respiratory Society has developed these evidence-based clinical practice guidelines fo...
Article
Zusammenfassung Das vorliegende Addendum zur Leitlinie zur Diagnostik und Therapie von Patienten mit Asthma (2017) ergänzt wichtige neue Erkenntnisse zur Diagnostik und Therapie von Asthma sowie zu neu für die Therapie des Asthmas zugelassenen Medikamenten. Es werden sowohl für Kinder und Jugendliche als auch für Erwachsene mit Asthma die aktuellen...
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In Austria, newborns have been screened for cystic fibrosis (CF) by analyzing immunoreactive trypsinogen (IRT) from dried blood spots (DBS)s for nearly 20 years. Recently, pancreatitis-associated protein (PAP) analysis was introduced as a second-tier test with the aim of reducing recalls for second DBS cards while keeping sensitivity high. For 28 m...
Article
There is increasing awareness of bronchiectasis in children and adolescents, a chronic pulmonary disorder associated with poor quality-of-life for the child/adolescent and their parents, recurrent exacerbations and costs to the family and health systems. Optimal treatment improves clinical outcomes. Several national guidelines exist, but there are...
Article
Full-text available
Background Nocturnal cough and wheeze are important symptoms when diagnosing any respiratory disease in a child, but objective measurements of these symptoms are not performed. Methods The aim of our study was to analyze the use of an automated detection system to assess breath sounds objectively in comparison to cough and wheeze questionnaires an...
Article
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Background: Early reports suggest that most children infected with severe acute respiratory syndrome coronavirus 2 ("SARS-CoV-2") have mild symptoms. What is not known is whether children with chronic respiratory illnesses have exacerbations associated with SARS-CoV-2 virus.
Article
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Background Early reports suggest that most children infected with severe acute respiratory syndrome coronavirus 2 (“SARS-CoV-2”) have mild symptoms. What is not known is whether children with chronic respiratory illnesses have exacerbations associated with SARS-CoV-2 virus. Methods An expert panel created a survey, which was circulated twice (in A...
Article
In pediatrics, chronic cough is defined as daily extensive coughing over a period of more than 4 weeks. Prolonged subacute cough has a duration of 3–8 weeks. Coughing is a mechanism to clear the airways and the cough reflex is primarily for protection of the airway. Chronic cough is mostly caused by excessive secretions due to overload of the airwa...
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Full-text available
The coronavirus disease 2019 (COVID-19) pandemic is currently a challenge worldwide. In Austria, a crisis within the healthcare system has so far been prevented. The treatment of patients with community-acquired pneumonia (CAP), including SARS-CoV‑2 infections, should continue to be based on evidence-based CAP guidelines during the pandemic; howeve...
Article
Background To date, few data on paediatric COVID-19 have been published, and most reports originate from China. This study aimed to capture key data on children and adolescents with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across Europe to inform physicians and health-care service planning during the ongoing pandemic....
Article
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Zusammenfassung Die COVID-19-Pandemie stellt derzeit weltweit eine Herausforderung dar. In Österreich konnte eine Krise innerhalb des medizinischen Versorgungssystems bisher verhindert werden. Die Behandlung von Patienten mit ambulant erworbener Pneumonie („community acquired pneumonia“, CAP), inklusive durch SARS-CoV-2-Infektionen, sollte sich auc...
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Zusammenfassung Im Rahmen eines industrieunabhängigen Expertenkreises wurden die Empfehlungen zur Respiratory-Syncytial-Virus(RSV)-Prophylaxe mit Palivizumab der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde (ÖGKJ) von 2008 überarbeitet und im Delphi-Verfahren ein Update für das Jahr 2019 geschaffen. Frühgeborene (FG) ≤28 (+6 Tage)...
Article
Full-text available
These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella term that explains the exquisite sensitivity of patients to external stimuli such a cold air, perfumes, smoke and bleach. Thus adults with chronic cough now have a firm physical ex...
Article
Background: There is a lack of agreement among measures of asthma control in children. In Central Europe, body plethysmography is additionally used for asthma monitoring. However, its value is still unclear. Objectives: We investigated the possible additional value of body plethysmographic measures (specific resistance, RV/TLC) compared with spi...
Article
Full-text available
Background Tuberculosis (TB) has become a rare disease in developed countries. Austria is a low incidence country for TB with an incidence rate of 7.2/100,000 in 2016. The incidence of TB has shown a constant decline in Austria from 2008 (9.8/100,000) to 2015 (6.7/100,000) but recently stagnated in 2016 (7.2/100,000). In recent years migration to A...
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Full-text available
Asthma ist die häufigste chronische Erkrankung bei Kindern und Jugendlichen. Die Diagnose wird dann gestellt, wenn anamnestisch typische Symptome auftreten und eine variable Atemwegsobstruktion besteht; optimaler Weise kann die chronische Entzündung der Atemwege gezeigt werden und/oder auch eine bronchiale Hyperreagibilität nachgewiesen werden. Zus...
Poster
effects of hypertonic saline inhalation on the oxidation reduction status in children, adolescents and young adults with cystic fibrosis (CF)
Article
Full-text available
Objective Aim of this study was to analyze whether children with objectively measured second‐hand cigarette smoke (SHS) exposure suffer from a more severe course of disease when hospitalized with lower respiratory tract infection (LRTI) due to respiratory syncytial virus (RSV). Methods This prospective study was conducted at the Department of Pedi...
Article
Zusammenfassung Die vorliegende Leitlinie ist eine Neufassung und Aktualisierung der Leitlinie zur Diagnostik und Therapie von Patienten mit Asthma, welche die bisher für den deutschen Sprachraum gültige Version aus dem Jahr 2006 ablöst. Die Fülle an neuen Erkenntnissen zur Pathophysiologie und zu den Phänotypen von Asthma und das erweiterte Spektr...
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Values: Zapletal 86.6% (SD 20.6), GLI 79.9% (SD 20.3) and 32% (n = 497/1543) were misclassified as normal when using Zapletal. Despite showing no overall differences in FEV1 and forced vital capacity (FVC) between concomitant Pseudomonas detection (PA+) in n = 938 and Pseudomonas negative (PA-) (n = 2781) using either reference PA+ resulted in low...
Article
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Registry data for patients with cystic fibrosis (CF) are increasingly used to evaluate the natural history, for benchmarking of therapy and in order to identify eligible patients for clinical studies. So far, no data on frequency and clinical status of CF patients have been available for Austria on a national level. We collected data of CF patients...
Presentation
Full-text available
Diskussion in der Gesellschaft der Ärzte in Wien zum Thema Cannabiskonsum und Auswirkungen auf Intelligenz und Psyche
Article
Kindlicher chronischer Husten ist definiert als Husten täglich über mehr als vier Wochen. Bei einer Dauer von drei bis acht Wochen kann man auch von prolongiertem subakutem Husten sprechen. Chronischer Husten kann sich als Symptom einer Grunderkrankung darstellen und unterschiedlichste Ursachen haben. Diese müssen diagnostiziert und dann adäquat be...
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Maternal smoking in pregnancy (MSP) is a large modifiable risk factor for pregnancy related mortality and morbidity and also the most important known modifiable risk factor for asthma. This review summarises the effects of MSP throughout infancy, childhood and adolescence with regards to asthma (development and severity). Firstly, the direct damage...
Article
Full-text available
Background Lung function measurements are more and more being carried out in toddlers and preschool children. Special requirements must be fulfilled with respect to equipment and appropriate age-related application. Objective This article presents the current consensus on application and interpretation of lung function measurements in toddlers and...
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This statement was written by a group of pulmonologists and pediatric pulmonologists belonging to the corresponding professional associations ÖGP (Austrian Society for Pulmonology) and ÖGKJ (Austrian Society for pediatric and adolescent medicine) to provide a concise overview of the latest updates in the 2015 GINA Guidelines and to include aspects...
Presentation
Full-text available
Round Table Discussion with Politicians, Health Care Professionals and Health Care Economists
Article
Background and objective: Neutrophilic inflammation has been implicated in non-eosinophilic asthma (NEA) in adults, but little is known about NEA in children/adolescents. We assessed clinical and inflammatory characteristics of NEA in adolescent asthma. Methods: Airway inflammation, sputum endotoxin, airway hyper-reactivity, atopy and lung funct...
Article
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Rationale: The ABCA3 gene encodes a lipid transporter in type II pneumocytes critical for survival and normal respiratory function. The frequent ABCA3 variant R288K increases the risk for neonatal respiratory distress syndrome among term and late preterm neonates, but its role in children's interstitial lung disease has not been studied in detail....
Article
Full-text available
Maternal smoking in pregnancy (MSP) is a large modifiable risk factor for pregnancy related mortality and morbidity and also the most important known modifiable risk factor for asthma. This review summarises the effects of MSP throughout infancy, childhood and adolescence with regards to asthma (development and severity). Firstly, the direct damage...
Article
Background: The new lung function reference values of the global lung initiative (GLI) are recommended by most health societies. The aim of this study was to analyze FEV1- and FEV1/FVC-values from a German and Austrian patient group applying old and new reference values. Results: A total of 215 Caucasian children (aged 5-17 years) were included....
Article
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Background Bronchial provocation tests play an important role in the diagnostics and therapy monitoring of children and adolescents with obstructive airway diseases. Corresponding recommendations were published by the working group on lung function of the Society of Pediatric Pneumology in this journal in 1999. Aim The recommendations have been rev...
Article
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Hintergrund Ein Konsensuspapier zu Evaluation und Therapie des chronischen Hustens bei Kindern und Jugendlichen ist kürzlich in deutscher Sprache publiziert worden. Hier wird eine Zusammenfassung dieses ersten Konsensuspapiers der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde und der Österreichischen Gesellschaft für Pneumologie prä...
Article
Full-text available
Background: Currently no consensus guidelines on the evaluation and therapy of chronic cough in children have been published in German. Aim of this study was therefore, after a literature search on all relevant publications and guidelines concerning chronic cough in children, to publish a Statement of the Austrian Society of Pediatrics and The Aus...
Article
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Fragestellung Schäden des Passivrauchens auf die kindliche Gesundheit sind schon seit den 1960er Jahren be-kannt, 1992 wurde Passivrauchen von der "US Environmental Pro-tection Agency" als Kanzerogen der Klasse A bezeichnet. Kinder sind durch ihre altersbedingte Gebundenheit an ihre Bezugsper-sonen besonders von Passivrauch betroffen, und 40 % der...
Article
Detrimental effects of smoking in pregnancy have been recognized over half a century ago, with symmetrical growth retardation being described first [28]. The detrimental effects have now been systemically evaluated and summarized. This is a summary of the statement supported by five Austrian medical societies (Austrian Society of Pediatrics and Ado...
Article
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Einleitung [1–8]Epidemiologie und PathogeneseHäufigste letale autosomal rezessive Erkrankung der KaukasierIm Jahr 2000 Geborene haben voraussichtlich Lebenserwartung von durchschnittlich > 50 JahrenUrsächlich sind Mutationen im CFTR GenMehr als 1900 Mutationen F508del ist die häufigste MutationSechs verschiedene MutationsklassenDie Mukoviszidose, a...
Chapter
Lungenfunktionsdiagnostik beinhaltet eine Vielzahl von Messmethoden, mit denen jeweils bestimmte Qualitten der Lungen in verschiedenen Altersgruppen überwiegend nichtinvasiv untersucht werden können.
Article
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Es wird versucht, in möglichst prägnanter Form die wesentlichen Schadwirkungen durch Tabakrauchexposition auf die Gesundheit von Kindern und Jugendlichen zu beschreiben, Präventionsstrategien vorzuschlagen, um diese vor den Auswirkungen des Tabakrauchs zu schützen, und die wichtige Rolle des Pädiaters hierbei hervorzuheben. Passivrauchexposition, „...
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Background and methods. We handed out the standardised ISAAC (International Study of Asthma and Allergies in Childhood) questionnaire to 13,414 parents of school beginners aged 5–7 in 1996 and 1997 in Vienna, Austria. Results. Despite the existence of wheezing symptoms (1996: 8.2% (n=385) – 1997: 6.9% (n=603)) only one third of the symptomatic chil...
Article
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Over more than 50 years, the nocuous effects of smoking in pregnancy on the fetus are well known. In the first years of science the focus was primarily on restricted fetal growth while in more recent years over 10.000 studies investigated the incomparably big sum of detrimental effects for the unborn's health. In this statement we want to present t...
Article
Ciclesonide is a novel inhaled corticosteroid for the treatment of asthma, and it is important to measure the onset of effect of this therapy on airway hyperresponsiveness (AHR), exhaled nitric oxide (NO), and levels of eosinophils in induced sputum. In a randomized, double-blind, crossover study, 21 patients with mild asthma inhaled ciclesonide 32...
Article
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Management of asthma is currently based on symptoms (in children, usually a second-hand report from parents) and lung function measurements. Inhaled steroids, targeted at controlling airway inflammation, are the mainstay of asthma management. Due to possible side effects they should be used at the lowest possible doses while asthma is adequately co...
Article
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Dithiothreitol (DTT) is commonly used to liquefy induced sputum samples before assessment of cytology, but causes reduction of disulfide bonds and denaturation of proteins. To process sputum supernatants containing DTT to enable quantification of cytokines and chemokines. A standard solution of 22 pooled chemokines and cytokines was incubated with...
Article
Conventional asthma management aimed at controlling the underlying airway inflammation is classically based on symptoms and lung function. More recently, various non invasive markers of airway inflammation have become available. The ideal measurement method should be safe, non-invasive, easy to perform, reproducible and accurate. Fractional exhaled...