Angela Mª. Villalba-Moreno

Hospital Universitario Virgen del Rocío | HUVR · Servicio de Farmacia

Objective The ‘LESS-CHRON criteria’ (List of Evidence-Based Deprescribing for Chronic Patients criteria) is a newly created tool with 27 criteria to guide deprescribing. It was developed using a Delphi methodology. Each criterion consists of drugs and their indications, conditions under which deprescribing would be considered, a health variable to...

Background: Anticholinergic and sedative drugs are associated with adverse events such as cognitive and functional impairment in elderly. The Drug Burden Index (DBI) is a measure of an individual's total exposure to anticholinergic and sedative drugs. Objetive: To evaluate the association between the total DBI and cognitive and functional impairme...

Background Clinical trials lead to the development of new drugs and new indications for existing ones. It is important to know the design of clinical trials to interpret and evaluate the results when applying them to clinical practice. Purpose To characterise the main design aspects of clinical trials (CT) managed in the pharmacy department of a t...

Background Anticholinergic drugs may increase the risk of cognitive and functional disorders in older patients. Anticholinergic exposure quantified by anticholinergic scales (AS) can detect patients with a high risk of adverse events. Purpose Design, development and validation of a tool that calculates the anticholinergic burden. Material and met...

Background There is great diversity in cooperation of pharmacy departments depending on the clinical areas of study and the investigational product (IP). Identifying the most common diseases in which clinical trials (CT) are conducted could allow the pharmacist to improve their clinical skills and provide quality pharmaceutical care (PC). Purpose...

Background Drugs with anticholinergic and sedative effects carry significant risks in older people. An increased incidence of falls, impaired physical function and cognitive decline has been attributed to the use of these drugs. Purpose To estimate the Risk of Anticholinergic Effects (RAE) in patients with several conditions based on their pharmaco...

Purpose The successful use of nadolol as an alternative to propranolol therapy in three cases of infantile hemangioma is reported. Summary Infantile hemangioma is a benign vascular neoplastic disorder that affects up to 10% of newborns and can lead to deformity or local complications in severe cases. Propranolol, administered alone or in combinati...

Purpose The successful use of nadolol as an alternative to propranolol therapy in three cases of infantile hemangioma is reported. Summary Infantile hemangioma is a benign vascular neoplastic disorder that affects up to 10% of newborns and can lead to deformity or local complications in severe cases. Propranolol, administered alone or in combinati...

Objective To analyze the impact of a multidisciplinary and decentralized safety committee in the pediatric management unit, and the joint implementation of a computing network application for reporting medication errors, monitoring the follow-up of the errors, and an analysis of the improvements introduced. Material and methods An observational, d...

Introduction: Lung cancer accounts for 20 % of cancer deaths in Spain. The most frequent subtype (87 %) is non-small cell lung cancer (NSCLC). Pemetrexed is a recently marketed drug added to NSCLC therapeutic arsenal. It seems to have become one of the most used options for the treatment of this condition over the last 3 years. Aim of the review:...

Background Clofarabine is a recently marketed drug used in paediatric patients with refractory acute lymphoblastic leukaemia (ALL) after at least two prior chemotherapy regimens. Its safety and effectiveness have not been evaluated in adults. Purpose To evaluate the effectiveness and safety of clofarabine in adult and paediatric patients in a terti...

Background Boceprevir has been linked with high rates of anaemia in patients with HCV infection. Anaemia management strategies (AMS) are strongly recommended in order to achieve therapeutic success. Purpose To describe AMS in HCV-infected patients who are on triple therapy that includes boceprevir. Materials and methods We conducted a retrospective...

To analyze the impact of a multidisciplinary and decentralized safety committee in the pediatric management unit, and the joint implementation of a computing network application for reporting medication errors, monitoring the follow-up of the errors, and an analysis of the improvements introduced. An observational, descriptive, cross-sectional, pre...

Background Drug dispensing errors are a common reason for medicines errors in hospitals, although they don’t usually reach the patient. Different situations contribute to their appearance, such as the availability of drugs from the same supplier, similarity in names, physical closeness, etc. Purpose To analyse the drugs most commonly involved in me...

Background Calcinosis is caused by accumulation of calcium salts in the tissues, with subcutaneous nodules, atrophy and ulceration over the affected area. Treatment with intravenous sodium thiosulfate has been used, since it inhibits the precipitation of calcium salts and dissolves calcium deposits. Recently, cases successfully treated with topical...

Background Vancomycin is an antibiotic against Gram positive bacteria. Vancomycin is useful in treating infections caused by foreign materials, such as catheters used in haemodialysis. It is eliminated mainly through the renal system, so any renal system alteration affects the concentration of vancomycin. Purpose To assess the effectiveness of vanc...

Background Axitinib is a new oral cytostatic VEGFR-1,-2 and -3 inhibitor, used in the treatment of renal cell carcinoma (RCC), available through an expanded access programme. Purpose To analyse the effectiveness and safety of axitinib treatment in patients with RCC in a tertiary hospital. Materials and methods A retrospective descriptive study of p...

Background Some autoimmune diseases can develop renal manifestations that are refractory to conventional drug treatment, making haemodialysis the only therapeutic alternative. Purpose To analyse the response rate to rituximab as third-line treatment in patients with renal manifestations secondary to autoimmune diseases. Materials and methods Retros...

Background Boceprevir has recently changed hepatitis C virus (HCV) treatment by greatly improving sustained virological response (SVR) rates. Purpose To identify predictive factors of SVR in HCV-infected patients receiving triple therapy including boceprevir. Materials and methods We conducted a retrospective observational study. Medical records of...

Background The principles of deprescribing (the process of tapering, withdrawing, discontinuing or stopping medicines) arise from appropriateness methods (Beers and STOPP criteria). They include reviewing all current medicines and identifying medicines to be withdrawn, substituted or reduced. Considering the high pill burden for patients with sever...

Objective: Study the physical and chemical stability of different concentrations gentamicin and heparin to lock catheter. Method: Study analytical of different concentrations of gentamicin with heparin. From commercial vials gentamicin 40 mg/ml and sodium heparin 5%, five samples were prepared with different concentrations of gentamicin (5, 4, 3, 2...

Background Crizotinib is a cytostatic oral ALK inhibitor, a newly-introduced oral cytostatic to treat non-small cell lung cancer (NSCLC) that has been accessible through an expanded use programme prior to marketing authorization. Purpose To analyse the effectiveness and safety of crizotinib treatment in patients with NSCLC in a tertiary hospital. M...

Background A communications system was designed after notification of two errors in two months, in intrathecal and intraventricular chemotherapy in paediatric oncohaematology: prescribing by protocol, consultation sheet standardised and computerised; transcription using the Farmis integrated system for chemotherapy and preparation centralised in th...

Background and objectiveThe Pharmacy and Therapeutics Committee (PTC) evaluates the requests for off-label uses with an abbreviated report format. The aim of this study is to perform a descriptive analysis of this activity and to study the rate of approvals.Material and MethodsA descriptive study was performed on the PTC reports in a tertiary hospi...