Angela Nnenna Ukwuani-Kwaja

• PhD
• Kebbi state university of science and technology, aliero. kebbi state, nigeria

Background and Objective: Venomous snakes pose severe health problems, especially for the rural dwellers in the tropical regions of developing countries, in Nigeria alone, snakebite injuries lead to 10,000 deaths annually and over 65% of the mortality cases result from the venomous viper species. This study aimed to assess the intraperitoneal letha...

Multidrug resistant (MDR) bacteria remain the greatest challenge in whole world. According to the report from WHO, MDR causes an estimated 700,000 deaths annually worldwide, and every country is potentially affected. If not properly addressed, the number could grow to 10 million per year by 2050. Different strategies, such as the use of nanoparticl...

Background and Objective: Snakebite and its envenomation is still a vital cause of mortality especially among rural dwellers in underdeveloped countries, this phenomenon is categorized under the first class of neglected public health problem by WHO. Black-necked spitting cobra (Naja nigricollis), is among the important species associated with snake...

The lelna people of Zuru, Kebbi State, North-western Nigeria, predominantly prefer the use of medicinal plants as viable treatments against different ailments, including trypanosomiasis, as the area is endowed with viable medicinal plants, despite a gradual decrease in the traditional knowledge of usage. This study seeks to document medicinal pla...

Diabetes mellitus is a metabolic disease characterized by high blood sugar that profoundly affects human health and economy. Although there are a plethora of antidiabetic drugs in the market, the efficacy shown by some medicinal plants sometimes outperforms that of synthetic drugs while being more affordable and less toxic. This study was conducted...

This study was undertaken to investigate the antimalarial activity of Indigofera tinctoria in Plasmodium berghei-infected rats. Phytochemical investigation was conducted using standard method to determine the presence of the bioactive compounds. The in vitro anti-malarial assay of Indigofera tinctoria was carried out in triplicates in 96 wells micr...

The herbal contraceptives used by the residents of Kebbi state were surveyed. Data on plants, parts of plants, and mode of preparation were collected from 400 respondents using questionnaires and oral interviews. Twenty medicinal plants were identified as herbal contraceptives used in Kebbi state. The most frequently mentioned plant was Momordica c...

Background and Objective: Bacterial infections particularly with the emergence of multidrug-resistant (MDR) bacterial strains have become an urgent threat to public health. Noble metal nanoparticles (NPs), such as Silver Nanoparticles (Ag-NPs) and Copper-Oxide Nanoparticles (CuO-NPs) have been shown to exhibit strong and sustainable antibacterial a...

Abstract Background: Sterculia setigera is one of the medicinal plants used traditionally to treat various diseases with the insertion of diabetes. Diabetes mellitus is a prolonged metabolic disorder recognized as a hyperglycemia. The present study aimed at investigating the antidiabetic activity of the methanol stem bark extract of Sterculia setig...

Introduction: For decades, viral diseases have been treated using medicinal plants and herbal practices in the northern part of Nigeria. Though scarcely investigated, these medicinal plants could serve as potential sources for novel antiviral drugs against emerging and remerging viral diseases. Therefore, this study is aimed at investigating the me...

Background: Diabetes is a metabolic disorder characterized by hyperglycemia due to the body’s inability to produce insulin or inaction of the produced insulin or a combination of both. One antidiabetic therapeutic approach is to reduce gastrointestinal glucose production and absorption through the inhibition of carbohydrate digesting enzymes suc...

Introduction: For decades, viral diseases have been treated using medicinal plants and herbal practices in the northern part of Nigeria. Though scarcely investigated, these medicinal plants could serve as potential sources for novel antiviral drugs against emerging and remerging viral diseases. Therefore, this study is aimed at investigating the me...

Piliostigma thonningii is used in many parts of West Africa including Kebbi State, Nigeria for management of wounds, chronic ulcer, gastric heart pain and headache. The present study was carried out to evaluate the wound healing effect of methanolic leaves and stem bark extract of P. thonningii in animal model. The wound healing effect was evaluate...

This research was designed to evaluate the antipyretic activity of K. senegalensis leaf extract with the view of isolating and identifying the active components. The K. senegalensis leaf was extracted using 90% methanol and further fractionated with hexane, ethylacetate, n-butanol and distilled water.The qualitative phytochemical screening was carr...

Modern therapeutic drugs are not generally acceptable, their accessibility are limited and also have more side effects hence there is need to search for safe natural alternatives from medicinal plants. This research was aimed at evaluating the toxicological effect of methanol stem bark extract of Vitex doniana in female albino rats. Vitex doniana s...

Background: Sickle cell disease is a genetic disorder in which an individual inherits the sickle cell allele from both parents. The modern disease modifying therapies are quite expensive and often come with side effects, hence, there is need to search for natural alternatives from medicinal plants. This research was aimed at evaluating the antisick...

Pain is the most common reason for physician consultation in most developed countries but treatment is becoming complex because of the side effects of analgesic pharmaceutical drugs. This has lead to an increase in the used of medicinal plants for pain and pain related conditions. Previous studies have demonstrated that Crateva adansonii stem-bark...

Piliostigma thonningii is used in many parts of West Africa including Kebbi State, Nigeria for management of wounds, chronic ulcer, gastric heart pain and headache. The present study was carried out to evaluate the wound healing effect of methanolic leaves and stem bark extract of P. thonningii in animal model. The wound healing effect was evaluate...

F. platyphylla is a tree that is native throughout the tropics with a few extending into the semi-warm temperate zone. In Nigeria, it is predominant in the Northern regions of the country. Acute oral toxicity (LD50) was determined using five (5) rats and monitored for fourteen while twenty five (25) rats were used for the subchronic toxicity studie...

Aims: The acceptability and accessibility of modern contraceptive drugs are limited especially in northern Nigeria. These contraceptives also have numerous side effects hence there is need to search for safe natural alternatives from medicinal plants. This research was aimed at evaluating the contraceptive effect of stem bark methanol extract of Vi...

Peptic ulcer is a common disease of the gastrointestinal tract often self-treated in Nigeria, particularly among the rural population with various forms of herbal remedies. Aim: The ethno-botanical survey conducted was aimed at collecting and identifying medicinal plants used and sold for the treatment of peptic ulcer in Gwandu emirate, Kebbi State...

Contraception is the deliberate use of artificial methods or other techniques to prevent pregnancy as a consequence of sexual intercourse. This research was aimed at studying the contraceptive effect of methanol leaves extract of Dalbergia saxatilis on female albino rats. Standard laboratory methods were used to test for the presence of the followi...

Combretum collinum root extract has been recognized long ago as traditional medicinal plant in curing several diseases among the indigenous people of Alela-land (Zuru), Kebbi State, Nigeria. This research work was carried out to evaluate the toxicological effects of Combretum collinum methanol root extract (CCME) in albino rats. Acute toxicity was...

Kebbi state is endowed with medicinal plants that have been used by different tribes especially the Hausa-Fulani, Dakarkari and Gungawa to treat different ailments such as cancer for decades. Therefore, this study is aimed at documenting the medicinal plants used for treating cancer in Kebbi state. Demographic data, personal information of willing...

Abstract Introduction The southwestern and northcentral parts of Nigeria are highly endowed with medicinal plants that have been used for decades to cancer. However, the herbal recipes and traditional medicinal practices used in treating cancer have been scarcely investigated and documented. New uninvestigated plants could serve as potential source...

Aim: To evaluate the antidiarrhoea effect of hydromethanolic leave extract of I. asarifolia (HLEIA) on castor oil-induced diarrhea. Place and Duration of Study: Department of Biochemistry, Faculty of Life sciences, Kebbi State University of Science and Technology, Aliero, Kebbi state, Nigeria. P.M.B.1144. Kebbi State. Nigeria, between February 2015...

Citrullus lanatus is widely distributed in Africa where majority of people consume its fruits while discarding its seeds. Apart from its nutritional benefit, traditionally, its seeds are used in the treatment of various ailment including ulcer. This study aims at evaluating the antiulcer property of Citrullus lanatus seed in animal models. The anti...

Abstract: Pennisetum pedicellatum is an aggressive weed, used for treatment of wounds, pain related condition, eye and parasitic infections among the traditional healers in Kebbi State, Nigeria. This study was undertaken to validate the analgesic and wound healing effect of P. pedicellatum using tail flick method and excision wound models respectiv...

Ficus polita leaves have been used in traditional medicines to increase physical strength, work productivity and longevity, resistance to high altitude sickness, fatigue, depression, anaemia, gastrointestinal ailments, infections and nervous system disorders. The objective of this study was to evaluate the analgesic activities of hydromethanolic ex...

Alterations in serum lipid profile following administration of the Datura metel aqueous root extract in female albino Wister rats were evaluated. Doses of 50, 100 and 200mg/kg body weight were administered orally for 28 days. Serum lipid profile was determined using standard methods of analysis. The result shows some behavioral changes in the rats...

Acacia nilotica is used in traditional formulation in Nigeria for the treatment of infectious diseases. The susceptibility of bacteria strains against Acacia nilotica leaves extracts was determined using the disk diffusion method. The result showed A. nilotica leaves to possess antibacterial activity against S. typhi, P. aerugonisa, E. coli and S....

The invitro anti-inflammatory activity of various solvent fractions of Parkia biglobosa fruit bark was investigated using human red blood cell membrane stabilization, heat-induced hemolysis and protein denaturation methods. All the extracts of P. biglobosa fruit bark showed a concentration dependent increase in anti-inflammatory activity. The anti-...

The anti-hypertensive activity of aqueous calyx extract of Hibiscus sabdariffa on salt induce hypertensive albino rats was investigated for 28 days using the non invasive method. The extract and drug treated groups showed a significant (P < 0.01) reduction in diastolic and systolic blood pressure when compared to the normotensive and hypertensive r...

The effects of Sarcostemma viminale leaves extract on the haematological, toxicological and histopathological indices were evaluated in rats. The extracts at a single dose of 5000 mg/kg did not produce any behavioural sign of toxicity or mortality in any of the animals tested during 14 days observation period and as such, LD 50 of this plant was es...

The present investigation was carried out to evaluate the in vitro anti-inflammatory potential of Capsicum chinense. Hydromethanolic extracts of leave, seed, and fruits of Capsicum chinense (Red pepper) was assessed for its in vitro anti-inflammatory activity using heat and hypotonic solution induced membrane stabilization activity and protein dena...

In Nigeria, many plant products are used for their analgesic and anti inflammatory effects and their efficacy is traditionally acclaimed. Grewia crenata is an example of such plant with analgesic and anti-inflammatory claim amongst the traditional bone setters in northern-west Nigeria. Powdered Grewia crenata leaves (GCL) was sequentially extracted...

The research work was conducted to investigate the phytochemical constituents and analgesic activities of Tamarindus indica linn stem bark fractions. The fractions (hexane 13.6%, ethyl acetate 12.1%, methanol 7.9% and water 6.7%) were obtained using sequential fractionation. The analgesic activity of T. indica stem bark fractions at dose of 200 mg/...

The effect of hydromethanolic leaves extract of Grewia crenata was evaluated for 90 days in albino rats. Control group received distilled water orally 5 ml/kg/day. The extract was orally given to four treatment groups at the doses of 150, 300, 600, and 900 mg/kg/day for 90days (3 months). Changes in the body weights and organ weights were not signi...

The analgesic activity of the hydromethanolic extracts of Grewia crenata, Striga hermontheca and Gongronema latifolium were evaluated in mice using the mechanical method (Hot plate method) and chemical method (Acetic acid induced writhing). The hydromethanolic extracts of all the plants showed significant (P<0.05) analgesic activity compared to the...

The acute and sub-chronic oral toxicity studies of hydro-methanolic extracts of Grewia crenata leaves were evaluated in rats. The extract at a single dose of 5000 mg/kg did not produce treatment related signs of toxicity or mortality in any of the animals tested during 14 days observation period. Therefore, LD 50 of this plant was estimated to be m...

Aim: The objective of this study was to investigate the aqueous leaves extract of Vitex doniana properties against experimental diarrhoea induced by castor oil in albino rats. The aqueous leaves extract of Vitex doniana (100, 200, and 400 mg/kg body weight) was administered orally to three groups of rats (five animals per group) in order to evaluat...

Preparations of Grewia crenata, Striga hermontheca and Gongronema latifolium have been used in traditional medicine for treatment of pain for many years and their efficacies are widely acclaimed among the Hausa communities of northern Nigeria. The aim of the study was to assess the activity of hydromethanolic extract of these plants in baker's yeas...

The acute oral toxicity studies of the pulp extract of Tamarindus indica at 3000mg/kg and 5000mg/kg body weight of resulted in no mortality. This suggests that the LD50 is greater than 5000mg/kg body weight and can be classified as practically non-toxic and considered safe by the recommendations of World Health Organization (WHO) and Organization f...

The pulp extract of Tamarindus indica is used by traditional herbalists as a purgative, drug vehicle and antiobesity agent. The effect of 28 days administration of Tamarindus indica pulp extract on the body weight and lipid profile of the rat was evaluated. There was a significant increase in the weight of the control compared to the treated which...

The phytochemical analysis and antibacterial activity of aqueous pulp extract of Tamarindus indica were studied. The aqueous pulp extract of this plant was obtained using hot water extraction method. The antibacterial activity of aqueous pulp extract of this plant was carried out against four bacteria; Escherichia coli, Staphylococcus aureus, Pseud...

The effects of graded doses of Tamarindus indica pulp extract on the haematological, toxicological and histopathological indices in rats were evaluated. Hematological parameter was determined using micro-hematocrit method and Neubauer hemocytometer counting chamber. The haematological parameters. (PCV, WBC, Lymphocytes and Monocytes) of the treated...