Angela Davey

The University of Manchester · Centre for Radiotherapy Related Research

Background and purpose: Quantitative tumour shape features extracted from radiotherapy planning scans have shown potential as prognostic markers. In this study, we investigated if sphericity of the gross tumour volume (GTV) on planning computed tomography (CT) is an independent predictor of overall survival (OS) in lung cancer patients treated wit...

Purpose Early stage lung cancer patients undergoing stereotactic ablative radiotherapy receive four‐dimensional computed tomography (4D‐CT) for treatment planning. Often, an internal gross target volume (iGTV), which approximates the motion envelope of a tumour over the breathing cycle, is delineated without defining a gross tumour volume (GTV). Ho...

Purpose: 4D-CT is routine imaging for lung cancer patients treated with stereotactic body radiotherapy. No studies have investigated optimal 4D phase selection for radiomics. We aim to determine how phase data should be used to identify prognostic biomarkers for distant failure, and test whether stability assessment is required. A phase selection a...

AIMS Children receiving radiotherapy for head and neck tumours, such as Head and Neck Rhabdomyosarcoma (HN- RMS), often experience facial asymmetry later in life. Here, we present a convolutional neural network (CNN) that will enable the automatic detection of facial anatomical landmarks on MR images taken during follow-up examinations. This model...

Purpose For patients receiving lung stereotactic ablative radiotherapy (SABR), evidence suggests that high peritumor density predicts an increased risk of microscopic disease (MDE) and local-regional failure, but only if there is low or heterogenous incidental dose surrounding the tumor (GTV). A data-mining method ( Cox-per-radius ) has been develo...

Purpose: To develop a machine learning (ML) model based on radiomic features (RF) extracted from whole prostate gland magnetic resonance imaging (MRI) for prediction of tumour hypoxia pre-radiotherapy. Material and methods: Consecutive patients with high-grade prostate cancer and pre-treatment MRI treated with radiotherapy between 01/12/2007 and...

Objectives Children receiving radiotherapy for head and neck tumours can experience severe late dento-facial effects. However, recommendations for delineation and dose assessment to dento-facial structures are lacking. We report on a survey aiming to better understand current practice and establish areas for development. Methods An online survey w...

Background and purpose Twitter presence in academia has been linked to greater research impact which influences career progression. The purpose of this study was to analyse Twitter activity of the radiotherapy community around ESTRO congresses with a focus on gender-related and geographic trends. Materials and methods Tweets, re-tweets and replies...

Introduction: Heart dose has emerged as an independent predictor of overall survival in patients with NSCLC treated with radiotherapy. Several studies have identified the base of the heart as a region of enhanced dose sensitivity and a potential target for cardiac sparing. We present a dosimetric analysis of overall survival in the multicenter, ra...

PurposeLower dose outside the planned treatment area in lung stereotactic radiotherapy has been linked to increased risk of distant metastasis (DM) possibly due to underdosage of microscopic disease (MDE). Independently, tumour density on pretreatment computed tomography (CT) has been linked to risk of MDE. No studies have investigated the interact...