Angel Alonso

Angel Alonso
German Cancer Research Center | DKFZ · Research Program Infection and Cancer

41.47
 · 
PhD

About

158
Publications
5,060
Reads
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3,289
Citations
Introduction
Skills and Expertise
Cell Culture
PCR
Western Blot Analysis
Gene Expression
Cancer Biology
Immunofluorescence
DNA
Gel Electrophoresis
Cloning
Electrophoresis
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Research Experience
December 1974 - December 1975
Beatson Institute for Cancer Research
  • Glasgow, United Kingdom
Position
  • Post Doc
January 1973 - present
German Cancer Research Center
  • Heidelberg, Germany
Position
  • Prof. Dr.

Publications

Publications (158)
BetaHPV E6 and E7 colocalize with NuMa in dividing keratinocytes
Article
Full-text available
  • Jul 2019
Human papillomavirus type 8 E7 protein binds nuclear myosin 1c and downregulates the expression of pre-rRNA
Article
  • Jul 2017
A computational model of EGFR receptor trafficking
Conference Paper
Full-text available
  • Sep 2016
Gap Junctions
Chapter
  • Jan 2016
Bergner et al. CTO 2015
Data
  • Dec 2015
Individual and Complementary Effects of Human Papillomavirus Oncogenes on Epithelial Cell Proliferation and Differentiation
Article
Full-text available
  • Oct 2015
Mutation of Human Connexin43 Amino Acids S279/S282 Increases Protein Stability Upon Treatment with Epidermal Growth Factor
Article
Full-text available
  • Jan 2014
Gap Junctions
Chapter
  • Jan 2014
Multiparametric image analysis reveals role of Caveolin1 in endosomal progression rather than internalization of EGFR
Article
  • Apr 2012
Strain response in fibroblasts indicates a possible role of the Ca2+-dependent nuclear transcription factor NM1 in RNA synthesis
Article
  • Apr 2011
3D model-based quantification of EGF receptor internalization from three-channel 3D microscopic images.
Conference Paper
Full-text available
  • Jan 2011
E6 and E7 proteins from different beta-papillomaviruses types do not interfere in UVB-induced apoptosis of HaCaT keratinocytes
Article
  • Jan 2011
Human papillomavirus and p16 expression in inverted papillomas of the urinary bladder
Article
  • Jun 2010
Small intestinal mucosa expression of putative chaperone fls485
Article
Full-text available
  • Mar 2010
Mechano-transduction in periodontal ligament cells identifies activated states of MAP-kinases p42/44 and p38-stress kinase as a mechanism for MMP-13 expression
Article
Full-text available
  • Jan 2010
Expression of ADAM9 in CIN3 lesions and squamous cell carcinomas of the cervix
Article
  • Jun 2009
E6 and E7 from different beta-HPV do not interfere UVB-induced apoptosis in HaCaT cells
Conference Paper
  • Mar 2009
Tumor marker nucleoporin 88 kDa regulates nucleocytoplasmic transport of NF-κB
Article
  • Sep 2008
Generation of Novel, Secreted Epidermal Growth Factor Receptor (EGFR/ErbB1) Isoforms Via Metalloprotease-Dependent Ectodomain Shedding and Exosome Secretion
Article
  • Apr 2008
Leykauf K, Kabsch K, Gassler N, Gissmann L, Alonso A, Schenkel JExpression of the HPV11 E2 gene in transgenic mice does not result in alterations of the phenotypic pattern. Transgenic Res 17:1-8
Article
Full-text available
  • Mar 2008
The first hydrophobic region of the HPV16 E5 protein determines protein cellular location and facilitates anchorage-independent growth
Article
Full-text available
  • Feb 2008
Gap Junctions
Chapter
  • Jan 2008
Regulation of Enterocyte Apoptosis by Acyl-CoA Synthetase 5 Splicing
Article
  • Sep 2007
Phylogeny and evolution of papillomaviruses based on the E1 and E2 proteins
Article
Full-text available
  • Jul 2007
Defensin expression in HPV 5 or HPV 8 E6/E7 transduced human primary keratinocytes
Article
  • Jun 2007
Multiple Evolutionary Mechanisms Drive Papillomavirus Diversification
Article
Full-text available
  • May 2007
The E5 protein of the human papillomavirus type 16 down-regulates HLA-I surface expression in calnexin-expressing but not in calnexin-deficient cells
Article
Full-text available
  • Feb 2007
Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process
Article
Full-text available
  • Oct 2006
Phosphorylation of the gap junction protein Connexin43 in CIN III lesions and cervical carcinomas
Article
  • May 2006
Different papillomaviruses have different repertoires of transcription factor binding sites: Convergence and divergence in the upstream regulatory region
Article
Full-text available
  • Feb 2006
Papillomaviruses: Different genes have different histories
Article
  • Dec 2005
The phosphorylated form of connexin43 is up-regulated in breast hyperplasias and carcinomas and in their neoformed capillaries
Article
  • Jun 2005
The E5 protein of the human papillomavirus type 16 modulates composition and dynamics of membrane lipids in keratinocytes
Article
Full-text available
  • Mar 2005
Characterization and Differentiation-dependent Regulation of Secreted Phospholipases A2 in Human Keratinocytes and in Healthy and Psoriatic Human Skin
Article
  • Feb 2005
Mucosal Human Papillomaviruses Encode Four Different E5 Proteins Whose Chemistry and Phylogeny Correlate with Malignant or Benign Growth
Article
Full-text available
  • Dec 2004
Auvinen E, Alonso A, Auvinen P.. Human papillomavirus type 16 E5 protein colocalizes with the antiapoptotic Bcl-2 protein. Arch Virol 149: 1745-1759
Article
Full-text available
  • Oct 2004
Activation of dendritic cells and induction of T cell responses by HPV 16 L1/E7 chimeric virus-like particles are enhanced by CpG ODN or sorbitol
Article
Full-text available
  • Sep 2004
Codon optimization of the human papillomavirus 11 (HPV 11) L1 gene leads to increased gene expression and formation of virus-like particles in mammalian epithelial cells
Article
  • Sep 2004
Identification of membrane proteins differentially expressed in human papillomavirus type 16 E5-transfected human keratinocytes by nanoelectrospray ionization mass spectrometry
Article
Full-text available
  • Jul 2004
Activation of phospholipase C-?1 in human keratinocytes by hyperosmolar shock without enzyme phosphorylation
Article
Full-text available
  • May 2004
Synthetic construct L1 major capsid protein gene, complete cds
Data
  • Feb 2004
The HPV-16 E5 protein inhibits TRAIL-and FasL-mediated apoptosis in human keratinocyte raft cultures
Article
Full-text available
  • Feb 2004
Multiple independent kinase cascades are targeted by hyperosmotic stress but only one activates stress kinase p38
Article
  • Feb 2004
Human papillomavirus type 16 E5 protein
Article
Full-text available
  • Jan 2004
Functional dissection of the mouse tyrosinase locus control region identifies a new putative boundary activity
Article
Full-text available
  • Nov 2003
The human papillomavirus HPV2a E5 protein localizes to the Golgi apparatus and modulates signal transduction
Article
  • Oct 2003
Analysis of Protein Tyrosine Phosphorylation by Nanoelectrospray Ionization High-Resolution Tandem Mass Spectrometry and Tyrosine-Targeted Product Ion Scanning
Article
  • Jul 2003
Characterisation of a phosphorylation-specific Connexin43 antibody and its use in the analysis of protein-protein associations
Conference Paper
  • Mar 2003
Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells
Article
Full-text available
  • Feb 2003
The Human Papillomavirus Type 16 E5 Protein Impairs TRAIL- and FasL-Mediated Apoptosis in HaCaT Cells by Different Mechanisms
Article
Full-text available
  • Jan 2003
Modelling of the human papillomavirus type 16 E5 protein
Article
  • Dec 2002
Hyperosmotic stress induces phosphorylation of cytosolic phospholipase A(2) in HaCaT cells by an epidermal growth factor receptor-mediated process
Article
  • Nov 2002
Stress kinase p38 mediates EGFR transactivation by hyperosmolar concentrations of sorbitol
Article
  • Sep 2002
Nup88 (karyoporin) in human malignant neoplasms and dysplasias: Correlations of immunostaining of tissue sections, cytologic smears, and immunoblot analysis
Article
  • Jun 2002
The human papillomavirus type 16 (HPV-16) E5 protein sensitizes human keratinocytes to apoptosis induced by osmotic stress
Article
  • Feb 2002
Topographic Changes of Focal Adhesion Components and Modulation of p125FAK Activation in Stretched Human Periodontal Ligament Fibroblasts
Article
Full-text available
  • Dec 2001
Hyperosmotic stress induces phosphorylation of cytosolic phospholipase A2 and increases intracellular calcium in human keratinocytes
Conference Paper
  • Jan 2001
A Novel, Nuclear Pore-Associated, Widely Distributed Molecule Overexpressed in Oncogenesis and Development
Article
  • Dec 2000
Connexin 43 expression is downregulated in raft cultures of human keratinocytes expressing the human papillomavirus type 16 E5 protein
Article
Full-text available
  • Sep 2000
Binding of human papillomavirus 16 E5 to the 16 kDa subunit c (proteolipid) of the vacuolar H+-ATPase can be dissociated from the E5-mediated epidermal growth factor receptor overactivation
Article
  • Sep 2000
HPV16 E5 modulates activation of the stress-induced kinase p38 and JNK in human keratinocytes
Conference Paper
  • Jul 2000
Modulation of the epidermal growth factor receptor by the human papillomavirus type 16 E5 protein in raft cultures of human keratinocytes
Article
  • Jul 2000
Induction of Cellular Genes Is Mediated by the Bel1 Transactivator in Foamy Virus-Infected Human Cells
Article
  • Jun 2000
Human papillomavirus type 16 E5 protein localizes to the Golgi apparatus but does not grossly affect cellular glycosylation
Article
Full-text available
  • Feb 2000
The Human Papillomavirus Type 16 E5 Protein Modulates ERK1/2 and p38 MAP Kinase Activation by an EGFR-Independent Process in Stressed Human Keratinocytes
Article
Full-text available
  • Feb 2000
Induction of Cellular Genes Is Mediated by the Bel1 Transactivator in Foamy Virus-Infected Human Cells
Article
  • Jan 2000
The human papillomavirus type 16 E5 protein modulates phospholipase C-??-1 activity and phosphatidyl inositol turnover in mouse fibroblasts
Article
  • Dec 1999
The nuclear pore complex protein Nup88 is overexpressed in tumor cells
Article
Full-text available
  • Dec 1999
EGFR Family-Mediated Signal Transduction in the Human Keratinocyte Cell Line HaCaT
Article
  • Dec 1999
The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z‐protein in cells of the bulge region
Article
  • Aug 1999
The Human Papillomavirus Type 11 Upstream Regulatory Region Triggers Hair-Follicle-Specific Gene Expression in Transgenic Mice
Article
Full-text available
  • Jul 1999
The effect of proteolytic enzymes on skin hair follices of trangenic mice expressing the lac z-protein in cells of the bulge region
Article
  • Jan 1999
The Human Papillomavirus Type 16 E5-Protein Modulates Ligand-Dependent Activation of the EGF Receptor Family in the Human Epithelial Cell Line HaCaT
Article
  • Jun 1998
Human papillomavirus type 33 DNA and E6-E7 transcripts in late passages of the UT-DEC-1 vaginal keratinocyte cell line
Article
  • Mar 1998
Human papillomavirus type 16 E5 protein (Review)
Article
  • Dec 1997
Enhancement of EGF- and PMA-mediated MAP kinase activation in cells expressing the human papillomavirus type 16 E5 protein
Article
Full-text available
  • Oct 1997
P146 The effect of proteolytic enzymes of mouse skin hair follicles
Article
  • Sep 1997
Keratin intermediate filament dynamics in cell heterokaryons reveals diverse behaviour of different keratins
Article
Full-text available
  • Jun 1997
Promoter of the gene encoding the bovine catalytic subunit of cAMP-dependent protein kinase isoform Cβ2
Article
  • Jan 1997
Instability of chromosome 6 microsatellite repeats in human cervical tumors carrying papillomavirus sequences
Article
  • Dec 1996
Influence of human papillomavirus type 16 gene expression on in vitro differentiation of the human teratocarcinoma cell line 2102Ep
Article
  • Jun 1996
Genomic Cloning and Characterization of the Nonoccupied Allele Corresponding to the Integration Site of Human Papillomavirus Type 16 DNA in the Cervical Cancer Cell Line SiHa
Article
  • Apr 1996
Human papillomavirus type 16 DNA for integration site of deleted allele
Data
  • Jan 1996
Thyroid hormone receptors bind to the promoter of the mouse histone H1(0) gene and modulate its transcription
Article
Full-text available
  • Jan 1996
Human papillomavirus type 16 E5 protein affects cell-cell communication in an epithelial cell line
Article
Full-text available
  • Aug 1995
Papillomavirus capsid binding and uptake by cells from different tissues and species
Article
Full-text available
  • Mar 1995
The Promoter of the H1° Histone Gene contains a DNA Element bound by Retinoic Acid Receptors
Article
  • Oct 1994
Specific expression in adult mice and post-implantation embryos of a transgene carrying the histone H1° regulatory region
Article
  • Jan 1994
Basal level transcription of the histone H10 gene is mediated by a 80 bp promoter fragment
Article
Full-text available
  • Mar 1993
Genomic rearrangements of retroviral vectors carrying two genes in F9 EC cells
Article
Full-text available
  • Mar 1993
Multiple cis-acting elements of the proximal promoter region are required for basal level transcription of the H1(0) histone gene
Article
  • Dec 1992
Transcription of BPV-1 genes in transfected F9 cells
Article
  • Oct 1992
The F9-EC cell line as a model for the analysis of differentiation[J]
Article
Full-text available
  • Jan 1992
Zellkulturen als Modelle für die Analyse der Genexpression während der Entwicklung und Differenzierung. In: Krebsforschung heute: Berichte aus dem Deutschen Krebsforschungszentrum
Chapter
  • Jan 1992
Cell Differentiation and Carcinogenesis
Chapter
  • Jan 1992
Differentiation-specific gene expression from the H10 histone promoter in ES-cells
Article
  • Jul 1991
Differentiation of EC cells in vitro by the Fluorescent dye Hoechst 33342
Article
  • Feb 1990
Detection of genomic alterations in carcinogen-induced mouse liver tumors by DNA fingerprint analysis
Article
  • Jan 1990
Cloning and characterization of the mouse histone H1° promoter region
Article
  • Oct 1989
Expression of mouse histone H1° promoter sequences following microinjection into Xenopus oocytes and developing embryos
Article
Full-text available
  • Oct 1989

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Projects

Project (1)
HPV-E7 binding proteins
Project
Identification of cellular proteins binding to low-risk HPV E7 protein