Angel V Peterchev

Angel V Peterchev
Duke University Medical Center | DUMC · Department of Psychiatry and Behavioral Science

PhD

About

243
Publications
40,178
Reads
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7,448
Citations
Citations since 2016
147 Research Items
4690 Citations
201620172018201920202021202202004006008001,000
201620172018201920202021202202004006008001,000
201620172018201920202021202202004006008001,000
201620172018201920202021202202004006008001,000
Additional affiliations
January 2011 - present
Duke University
Position
  • Professor (Assistant)
January 2011 - present
Duke University
Position
  • Professor (Assistant)
August 1999 - May 2005
University of California, Berkeley
Position
  • Research Assistant

Publications

Publications (243)
Article
The temporal shape of a pulse in transcranial magnetic stimulation (TMS) influences which neuron populations are activated preferentially as well as the strength and even direction of neuromodulation effects. Furthermore, various pulse shapes differ in their efficiency, coil heating, sensory perception, and clicking sound. However, the available TMS...
Preprint
Objective. Transcranial magnetic stimulation (TMS) with monophasic pulses achieves greater changes in neuronal excitability but requires higher energy and generates more coil heating than TMS with biphasic pulses, and this limits the use of monophasic pulses in rapid-rate protocols. We sought to design a stimulation waveform that retains the charac...
Article
Full-text available
Precisely timed activation of genetically targeted cells is a powerful tool for the study of neural circuits and control of cell-based therapies. Magnetic control of cell activity, or ‘magnetogenetics’, using magnetic nanoparticle heating of temperature-sensitive ion channels enables remote, non-invasive activation of neurons for deep-tissue applic...
Article
Background: Motor-evoked potentials (MEP) are one of the most prominent responses to brain stimulation, such as supra-threshold transcranial magnetic stimulation (TMS) and electrical stimulation. Understanding of the neurophysiology and the determination of the lowest stimulation strength that evokes responses requires the detection of even smalle...
Article
Full-text available
Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design...
Preprint
Background Transcranial magnetic stimulation (TMS) can modulate neural activity by evoking action potentials in subpopulations of cortical neurons. The TMS-induced electric field (E-field) can be simulated in subject-specific head models derived from MR images, but the spatial distribution of the E-field alone does not predict the physiological res...
Preprint
Objective Temporal interference stimulation (TIS) was proposed as a non-invasive, focal, and steerable deep brain stimulation method. However, the mechanisms underlying experimentally-observed suprathreshold TIS effects are unknown, and prior simulation studies had limitations in the representations of the TIS electric field (E-field) and cerebral...
Article
Full-text available
Transcranial (electro)magnetic stimulation (TMS) is currently the method of choice to non-invasively induce neural activity in the human brain. A single transcranial stimulus induces a time-varying electric field in the brain that may evoke action potentials in cortical neurons. The spatial relationship between the locally induced electric field an...
Article
Objective: Persons with tetraplegia can use brain-machine interfaces to make visually guided reaches with robotic arms. Without somatosensory feedback, these movements will likely be slow and imprecise, like those of persons who retain movement but have lost proprioception. Intracortical microstimulation (ICMS) has promise for providing artificial...
Article
Objective: Transcranial magnetic stimulation (TMS) can modulate brain function via an electric field (E-field) induced in a brain region of interest (ROI). The ROI E-field can be computationally maximized and set to match a specific reference using individualized head models to find the optimal coil placement and stimulus intensity. However, the a...
Article
Objective: We present a combination of a power electronics system and magnetic nanoparticles that enable frequency-multiplexed magnetothermal-neurostimulation with rapid channel switching between three independent channels spanning a wide frequency range. Approach: The electronics system generates alternating magnetic field spanning 50 kHz to 5...
Article
This paper presents a novel transcranial magnetic stimulation (TMS) pulse generator with a wide range of pulse shape, amplitude, and width. Approach: The novel MM-TMS device is the first to use a modular multi-level circuit topology at full TMS energy levels. It consists of ten cascaded H-bridge modules, each implemented with insulated-gate bipol...
Preprint
The temporal shape of a pulse in transcranial magnetic stimulation (TMS) influences which neuron populations are activated preferentially as well as the strength and even direction of neuromodulation effects. Furthermore, various pulse shapes differ in their efficiency, coil heating, sensory perception, and clicking sound. However, the available TM...
Article
Objective Investigate the variability previously found with cortical stimulation and handheld transcranial magnetic stimulation (TMS) coils, criticized for its high potential of coil position fluctuations, bypassing the cortex using deep brain electrical stimulation (DBS) of the corticospinal tract with fixed electrodes where both latent variations...
Preprint
Transcranial magnetic stimulation (TMS) has become an important technique in both scientific and clinical practices, and yet our understanding of how the brain responds to TMS is still limited. Concurrent neuroimaging during TMS may bridge this gap, and emerging evidence suggests widespread that modulatory effects of TMS may be best captured throug...
Preprint
Background: Motor-evoked potentials (MEP) are one of the most prominent responses to brain stimulation, such as supra-threshold transcranial magnetic stimulation (TMS) and electrical stimulation. Understanding of the neurophysiology and the determination of the lowest stimulation strength that evokes responses requires the detection of even smaller...
Article
TMS has become a powerful tool to explore cortical function, and in parallel has proven promising in the development of therapies for various psychiatric and neurological disorders. Unfortunately, much of the inference of the direct effects of TMS has been assumed to be limited to the area a few centimeters beneath the scalp, though clearly more di...
Article
Full-text available
Introduction: High frequency repetitive transcranial magnetic stimulation applied to the motor cortex causes an increase in the amplitude of motor evoked potentials (MEPs) that persists after stimulation. Here, we focus on the aftereffects generated by high frequency controllable pulse TMS (cTMS) with different directions, intensities, and pulse du...
Preprint
Objective Persons with tetraplegia can use brain-machine interfaces to make visually guided reaches with robotic arms. Without somatosensory feedback, these movements will likely be slow and imprecise, like those of persons who retain movement but have lost proprioception. Intracortical microstimulation (ICMS) has promise for providing artificial s...
Article
Full-text available
Background Online repetitive transcranialmagnetic stimulation (rTMS) has been shown to modulate working memory (WM) performance in a site‐specific manner, with behavioral improvements due to stimulation of the dorsolateral prefrontal cortex (DLPFC), and impairment from stimulation to the lateral parietal cortex (LPC). Neurobehavioral studies have d...
Preprint
Objective: This article presents a novel transcranial magnetic stimulation (TMS) pulse generator with a wide range of pulse shape, amplitude, and width. Approach: Based on a modular multilevel TMS (MM-TMS) topology we had proposed previously, we realized the first such device operating at full TMS energy levels. It consists of ten cascaded H-bridge...
Preprint
Objective We present a power electronic system and magnetic nanoparticles for multiplexed magnetogenetic neurostimulation with three channels spanning a wide frequency range and rapid channel switching capability. This enables selective heating of magnetic nanoparticles with different coercivity using various frequency–amplitude combinations of the...
Article
Full-text available
Computational modeling and human studies suggest that transcranial alternating current stimulation (tACS) modulates alpha oscillations by entrainment. Yet, a direct examination of how tACS interacts with neuronal spiking activity that gives rise to the alpha oscillation in the thalamo-cortical system has been lacking. Here, we demonstrate how tACS...
Preprint
Transcranial magnetic stimulation (TMS) offers possibilities to modulate function in regions of interest (ROI) in the brain via an induced electric field (E-field). The ROI E-field can be maximized using individualized computational head modeling to find an optimal scalp coil placement. We present a TMS targeting and analysis pipeline (TAP) softwar...
Preprint
Full-text available
Precisely timed activation of genetically targeted cells is a powerful tool for studying neural circuits and controlling cell-based therapies. Magnetic control of cell activity or "magnetogenetics" using magnetic nanoparticle heating of temperature-sensitive ion channels enables remote, non-invasive activation of neurons for deep-tissue application...
Preprint
Full-text available
Precisely timed activation of genetically targeted cells is a powerful tool for studying neural circuits and controlling cell-based therapies. Magnetic control of cell activity or “magnetogenetics” using magnetic nanoparticle heating of temperature-sensitive ion channels enables remote, non-invasive activation of neurons for deep-tissue application...
Article
Transcranial magnetic stimulators are used for clinical diagnostic and therapeutic applications as well as in support of research. Consequently, a number of stimulator types and design variations have been developed to serve these purposes each having unique design requirements. Key design elements and performance trade-offs are discussed for conve...
Article
Many different types of TMS coils have been proposed and implemented, but all share certain common features. The induced electric field is always maximum in the superficial parts of the brain, nearest the coil, and attenuates toward the center of the head. Power requirements are high. Design tradeoffs are present between specific coil features incl...
Article
Full-text available
Background Transcranial electrical stimulation at an appropriate dose may demonstrate intracranial effects, including neuronal stimulation and cerebral blood flow responses. Objective We performed in vivo experiments on mouse cortex using transcranial alternating current [AC] stimulation to assess whether cerebral blood flow can be reliably altere...
Chapter
Transcranial stimulation induces or modulates neural activity in the brain through basic physical and biophysical processes. Transcranial electrical stimulation and transcranial magnetic stimulation impose an exogenous electric field in the brain that is determined by the stimulation device and the geometric and electric parameters of the head. The...
Article
This work aims to reduce the acoustic noise level of transcranial magnetic stimulation (TMS) coils. TMS requires high currents (several thousand amperes) to be pulsed through the coil, which generates a loud acoustic impulse whose peak sound pressure level (SPL) can exceed 130 dB(Z). This sound poses a risk to hearing and elicits unwanted neural ac...
Article
Full-text available
Background During transcranial magnetic stimulation (TMS) a coil placed on the scalp is used to non-invasively modulate activity of targeted brain networks via a magnetically induced electric field (E-field). Ideally, the E-field induced during TMS is concentrated on a targeted cortical region of interest (ROI). Determination of the coil position a...
Article
Full-text available
Objective: Compulsive behaviors are a core feature of obsessive-compulsive spectrum disorders but appear across a broad spectrum of psychological conditions. It is thought that compulsions reflect a failure to override habitual behaviors "stamped in" through repeated practice and short-term distress reduction. Animal models suggest a possible caus...
Article
Full-text available
This article is based on a consensus conference, promoted and supported by the International Federation of Clinical Neurophysiology (IFCN), which took place in Siena (Italy) in October 2018. The meeting intended to update the ten-year-old safety guidelines for the application of transcranial magnetic stimulation (TMS) in research and clinical setti...
Chapter
Transcranial magnetic stimulation (TMS) is a noninvasive method for focal brain stimulation, with applications in research, diagnostics, and treatment. In basic research, TMS can help establish a causal link between a brain circuit and a behavior. Clinically, repetitive TMS can alter the long-term excitability of specific brain regions to treat psy...
Article
Despite the widespread use of transcranial magnetic stimulation (TMS) in research and clinical care, the dose–response relations and neurophysiological correlates of modulatory effects remain relatively unexplored. To fill this gap, we studied modulation of visual processing as a function of TMS parameters. Our approach combined electroencephalogra...
Article
The brain is an inherently dynamic system, and much work has focused on the ability to modify neural activity through both local perturbations and changes in the function of global network ensembles. Network controllability is a recent concept in network neuroscience that purports to predict the influence of individual cortical sites on global netw...
Preprint
Objective: This work aims to reduce the acoustic noise level of transcranial magnetic stimulation (TMS) coils. TMS requires high currents (several thousand amperes) to be pulsed through the coil, which generates a loud acoustic impulse whose peak sound pressure level (SPL) can exceed 130 dB(Z). This sound poses a risk to hearing and elicits unwante...
Preprint
Full-text available
Despite the widespread use of transcranial magnetic stimulation (TMS) in research and clinical care, the underlying mechanisms-of-actions that mediate modulatory effects remain poorly understood. To fill this gap, we studied dose-response functions of TMS for modulation of visual processing. Our approach combined electroencephalography (EEG) with a...
Preprint
Background During transcranial magnetic stimulation (TMS) a coil placed on the scalp is used to non-invasively modulate activity of targeted brain networks via a magnetically induced electric field (E-field). Ideally, the E-field induced during TMS is concentrated on a targeted cortical region of interest (ROI). Objective To improve the accuracy o...
Article
Full-text available
This paper proposes a novel bipolar-type dc system suitable for both distribution and transmission systems based on Modular Multilevel Series/Parallel Converters. The system features decoupled operations of each pole of the bipolar system, being able to operate in both asymmetrical and regenerative modes. This enables two independent dc systems by...
Article
Split-battery converters based on cascaded H-bridges (CHBs) are gaining popularity due to their excellent physical modularity. During operation, however, the batteries experience substantial current ripple. Conventional ripple-current reduction methods rely on bulky passive components or complicated control. This article presents modulation and com...
Article
The perception of visual motion is dependent on a set of occipitotemporal regions that are readily accessible to neuromodulation. The current study tested if paired-pulse Transcranial Magnetic Stimulation (ppTMS) could modulate motion perception by stimulating the occipital cortex as participants viewed near-threshold motion dot stimuli. In this sh...
Article
Full-text available
Neuroimaging evidence suggests that the aging brain relies on a more distributed set of cortical regions than younger adults in order to maintain successful levels of performance during demanding cognitive tasks. However, it remains unclear how task demands give rise to this age-related expansion in cortical networks. To investigate this issue, fun...
Article
Full-text available
The process of manipulating information within working memory is central to many cognitive functions, but also declines rapidly in old age. Improving this process could markedly enhance the health-span in older adults. The current pre-registered, randomized and placebo-controlled study tested the potential of online repetitive transcranial magnetic...
Article
Full-text available
Background Accurate data on the sound emitted by transcranial magnetic stimulation (TMS) coils is lacking. Methods We recorded the sound waveforms of seven coils with high bandwidth. We estimated the neural stimulation strength by measuring the induced electric field and applying a strength–duration model to account for different waveforms. Resul...
Article
Cascaded multilevel converters have been gaining popularity in static compensators (STATCOMs) owing to their excellent modularity, output quality, and fault tolerance. However, cascaded multilevel converters require a large number of galvanically isolated voltage sensors and complex communication systems in order to balance the module dc-link volta...
Article
This erratum provides the link to the software implementation of the algorithm and the examples presented in [1] , which was omitted by mistake in the published version of the manuscript. The algorithm was implemented in Matlab and is available online on Code Ocean [2] .
Preprint
The brain is an inherently dynamic system, and much work has focused on the ability to modify neural activity through both local perturbations and changes in the function of global network ensembles. Network controllability is a recent concept in network science that purports to predict the influence of individual cortical sites on global network s...
Article
Background: Computational simulations of the E-field induced by transcranial magnetic stimulation (TMS) are increasingly used to understand its mechanisms and to inform its administration. However, characterization of the accuracy of the simulation methods and the factors that affect it is lacking. Objective: To ensure the accuracy of TMS E-fiel...
Article
Background: Transcranial magnetic stimulation (TMS) enables non-invasive modulation of brain activity with both clinical and research applications, but fundamental questions remain about the neural types and elements TMS activates and how stimulation parameters affect the neural response. Objective: To develop a multi-scale computational model t...
Preprint
Full-text available
The perception of visual motion is dependent on a set of occipitotemporal regions which are readily accessible to neuromodulation. Previous studies using paired-pulse Transcranial Magnetic Stimulation (ppTMS) have provided evidence of the capacity of this type of protocols to modulate cognitive processes. To test whether such cortical modulation ca...