Angel O Custodio

Angel O Custodio
University of Puerto Rico at Aguadilla | UPRAG · Department of Natural Science

PhD

About

12
Publications
1,478
Reads
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914
Citations
Additional affiliations
May 2005 - December 2005
Boston Children's Hospital
Position
  • Research Assistant
Education
December 2005 - December 2007
New England Culinary Institute, Vermont, United States
Field of study
  • Culinary Arts
September 1998 - June 2005
Harvard University
Field of study
  • Genetics
August 1994 - May 1998

Publications

Publications (12)
Poster
Full-text available
Background & Objectives: Cocoyam corm flour is a good source of dietary fiber (15.4% insoluble and 2.8% soluble fiber) and starch (content 60.5%), of which 85.04% was analyzed as amylopectin. Also, it has potential for the development of ready-to-eat food products including expanded snacks by extrusion. We determined the effect of extrusion paramet...
Conference Paper
Full-text available
Actualmente el cormo de la yautía es descartado a pesar de que tiene un alto contenido de almidón. Sin embargo los almidones nativos no poseen las propiedades funcionales ideales para la formulación de alimentos. El objetivo de este trabajo fue extraer el almidón del cormo de la yautía del cultivar Nazareno y modificarlo mediante métodos físicos (e...
Conference Paper
Full-text available
La harina del cormo de yautía del cultivar Nazareno posee un gran potencial como ingrediente para el desarrollo de productos alimenticios, debido a su valor nutricional y a sus propiedades fisicoquímicas y funcionales. El objetivo de este trabajo fue caracterizar los parámetros de calidad y de textura de una pasta elaborada con una mezcla de 50% de...
Article
Full-text available
We undertook a quantitative trait locus (QTL) analysis in mice to identify modifier genes that might influence the severity of human iron disorders. We identified a strong QTL on mouse chromosome 9 that differentially affected macrophage iron burden in C57BL/10J and SWR/J mice. A C57BL/10J missense allele of an evolutionarily conserved gene, Mon1a,...
Article
Full-text available
Solute carrier family 11, member 2 (SLC11A2) is the only transmembrane iron transporter known to be involved in cellular iron uptake. It is widely expressed and has been postulated to play important roles in intestinal iron absorption, erythroid iron utilization, hepatic iron accumulation, placental iron transfer, and other processes. Previous stud...
Article
Divalent metal transporter 1 (DMT1) was shown to be important for iron metabolism through studies of the mk/mk mouse, which carries a spontaneous mutation (G185R) resulting in defective intestinal iron absorption and anemia. To further investigate the importance of this transporter in vivo, we inactivated the DMT1 gene through targeted deletion of...
Article
Full-text available
Inflammation influences iron balance in the whole organism. A common clinical manifestation of these changes is anemia of chronic disease (ACD; also called anemia of inflammation). Inflammation reduces duodenal iron absorption and increases macrophage iron retention, resulting in low serum iron concentrations (hyposideremia). Despite the protection...
Article
Full-text available
Individuals with hereditary hemochromatosis suffer from systemic iron overload due to duodenal hyperabsorption. Most cases arise from a founder mutation in HFE (845G-->A; ref. 2) that results in the amino-acid substitution C282Y and prevents the association of HFE with beta2-microglobulin. Mice homozygous with respect to a null allele of Hfe (Hfe-/...
Article
"July 2005." Thesis (Ph.D., Division of Medical Sciences (Genetics))--Harvard University, 2005. Includes bibliographical references (leaf 139).

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