Angel Josabad Alonso-Castro

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Verified

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• PhD in Biochemistry
• Professor at University of Guanajuato

Ethnopharmacological relevance: Mexico has great biodiversity of fauna. The use of fauna with medicinal properties is a common practice since pre-Hispanic times. In the last decade, there has been an interest in ethnozoological studies in Mexico. Therefore, more studies are needed in order to gather information regarding the use of fauna with medi...

This review provides a summary of Mexican medicinal flora in terms of ethnobotanical, pharmacology, and chemistry of natural products related to anticancer activity. Bibliographic investigation was carried out by analyzing recognized books and peer-reviewed papers, consulting worldwide accepted scientific databases from the last five decades. Mexic...

ETHNOPHARMACOLOGICAL IMPORTANCE: Cecropia obtusifolia Bertol (Cecropiaceae) is a plant extensively used for the empirical treatment of type 2 diabetes in México. Although some of its hypoglycemic principles have been described, their mechanisms of action remain unclear. To investigate the anti-diabetic mechanisms of Cecropia obtusifolia aqueous ext...

The concentrations of Pb, Cd, Cr, Mn and Fe were evaluated in leaves, stem and root of the Scirpus americanus and Typha latifolia aquatic macrophytes, which were collected from Tanque Tenorio, an artificial lagoon highly polluted by municipal and industrial wastewater. Some S. americanus and T. latifolia plants were collected from four different si...

Some Magnolia (Magnoliaceae) species are used for the empirical treatment of diabetes mellitus, but the antidiabetic properties of Magnolia dealbata have not yet been experimentally validated. Here we report that an ethanolic extract of Magnolia dealbata seeds (MDE) and its active principles honokiol (HK) and magnolol (MG) induced the concentration...

This work assessed the antioxidant, antimicrobial, genotoxic, acute toxicity, antidiarrheal, antinociceptive, and anti‐inflammatory effects of an ethanolic extract from the Catasetum integerrimum pseudobulbs (CIE). The antidiarrheal activity of CIE (1–100 mg/kg p.o.) was assessed with castor oil‐related tests. The anti‐inflammatory activity was est...

Litchi (Litchi chinensis) peel has been used in traditional medicine to treat diarrhea and pain. However, these uses have not been scientifically validated. This study aimed to chemically characterize the litchi peel crude extract (CE) and evaluate its antidiarrheal and antinociceptive effects. CE showed no apparent toxicity in the acute toxicity t...

Background: Combining antinociceptive drugs with different mechanisms of action can reduce the doses and the adverse effects, with a possible increase in the antinociceptive effect. This work evaluated the antinociceptive effect of the combination of an ethanol extract of Justicia spicigera (JSE) with naproxen (NPX) or tramadol (TML) using the form...

The contamination of rivers by potentially toxic elements (PTEs) is a problem of global importance. The Valles River is Ciudad Valles’ (Central Mexico) main source of drinking water. During the four seasons of the year, water samples (n = 6), sediment samples (n = 6), and Phragmites australis plants (n = 10) were taken from three study sites select...

Background Montanoa grandiflora, a plant species native from Mexico to Central America, locally known as “Teresita” in Yucatán, México, is used to alleviate anxiety, rheumatism, and stomach issues. This study aims to investigate the anti-inflammatory properties of the methanol extract of Montanoa grandiflora leaves (MMG) in experimental models of i...

Background/Objectives: The antinociceptive and anti-inflammatory effects of a patent-pending ointment containing plant extracts from Eucalyptus globulus, Curcuma longa, Hamamelis virginiana, Echinacea purpurea, and Zingiber officinale were evaluated. Methods: Plant extracts were chemically characterized by gas chromatography–mass spectroscopy. The...

Some species of the Orchidaceae family are used in Mexican traditional medicine. However, there are no current and critical compilations of the medicinal uses and pharmacological effects of the members of the Orchidaceae family. This review provides a current, critical, and comprehensive analysis of the traditional medicinal uses, pharmacological r...

This article systematically reviews the advancements in processing litchi peel (Litchi chinensis), emphasizing drying, extraction, purification methods, and the potential of bioactive compounds obtained from litchi peel. This work also highlights the impact of various drying techniques on phytochemical profiles, focusing on how methods such as hot...

Depressive and anxiety disorders constitute some of the most prevalent mental disorders around the world. For years, the development of new lead compounds for drug discovery in this field has been an area of great attention. Recently, a series of tetrahydrocarbazole derivatives have demonstrated important anxiolytic-like activity, associated with t...

Stanhopea tigrina Bateman ex Lindl. (Orchidaceae) is an orchid endemic to Mexico, known as “Calavera” or “calaverita”, in the Huasteca Potosina (central region of Mexico). This plant species is used for the folk treatment of mental disorders and urological kidney disorders, according to the ethnomedicinal information obtained in this study. Ethanol...

This systematic review and meta-analysis aimed to evaluate the analgesic efficacy and adverse effects of celecoxib after total knee arthroplasty. Keywords in the PubMed and Scopus databases were used to find article abstracts. Each included clinical trial was assessed using the Cochrane Collaboration risk of bias tool, and we extracted data on post...

For years, crop protection from pest attack, has been dominated by the use of synthetic insecticides. However, many of them can cause severe environmental problems and human health. In this context, the use of plant extracts constitutes an alternative to avoid this kind of contaminants. In this work, we investigated the chemical constituents and in...

Medicinal plants have been historically significant for treating common human diseases in Mexico. Although some ethnobotanical research exists, limited ethnomedicinal data has documented medicinal plants employed for eye health. This review focuses on ethnomedicinal information and preclinical and clinical studies regarding medicinal plants used in...

The aim of this systematic review and meta-analysis was to evaluate the analgesic effect of different doses of tapentadol immediate release (IR) and its adverse effects after a bunionectomy. Pubmed, Cochrane, Lilacs, Medline, and Imbiomed were used to identify abstracts of scientific publications related to the keywords of this systematic review (P...

Latin America is a multicultural region encompassing 43 countries, with 665 million inhabitants with a mean age of 31 years old, 84% of whom live in urban areas [...]

Argemone ochroleuca Sweet (Papaveraceae) is used in folk medicine as a sedative and hypnotic agent. This study aimed to evaluate the anxiolytic-like, sedative, antidepressant-like, and anticonvulsant activities of a dichloromethane extract of A. ochroleuca stems (AOE), chemically standardized using gas chromatography–mass spectrometry (GC–MS), and...

Background: Bacterial multi-resistance is a serious global problem that continues to worsen over time due to multiple factors. Among these factors, it is important to highlight the clinical misuse of antibiotics and the mechanisms that microorganisms have developed to protect themselves from these drugs. In this sense, Staphylococcus aureus (S. au...

Catasetum is a genus of the Orchidaceae family with approximately 170 species, some of which have been reported with medicinal properties in different countries of America. The species of this genus are mostly epiphytic plants and are one of the few genera in the Orchidaceae family that develops male and female flowers. Catasetum is distributed fro...

Neophytadiene (NPT) is a diterpene found in the methanolic extracts of Crataeva nurvala and Blumea lacera, plants reported with anxiolytic-like activity, sedative properties, and antidepressant-like actions; however, the contribution of neophytadiene to these effects is unknown. This study determined the neuropharmacological (anxiolytic-like, antid...

Metformin is the most widely known anti-hyperglycemic, officially acquired by the USA government in 1995 and in 2001 it became the most prescribed treatment for type II diabetes. But how did it become the must-use drug for this disease in such a short period of time? it all started with traditional medicine, by using a plant known as "goat's rue" f...

With the increase of nanotechnology applications in all the industries, the emission of engineering nanomaterials (ENMs) has increased in the environment. Understanding the relationship between ENMs and plants has become very important, mainly because plants are organisms involved in all environmental spheres. This fact makes them a potential route...

Senna septemtrionalis (Viv.) H.S. Irwin & Barneby, Fabaceae, is a shrub used for treating asthma, diarrhea, and sore throat. This work evaluated for the first time the vasorelaxant, tracheo-relaxant effect, spasmolytic, and antidiarrheal activity of a dichloromethane extract of the aerial parts of Senna septemtrionalis. The chemical characterizatio...

Ceiba aesculifolia (Kunth) Britten & Baker f (Malvaceae) is used for the folk treatment of mood disorders. C. aesculifolia bark was extracted in ethanol, and the extract (CAE) was chemically standardized using gas chromatography–mass spectrometry (GC-MS). This study evaluated the effects of CAE (10–100 mg/kg p.o.) on anxiolytic-like activity, sedat...

Symptomatic irreversible pulpitis is a painful clinical condition with a broad inflammatory component. Dental anesthesia in these patients is affected by the inflammatory process, reporting a high incidence of anesthesia failure. The aim of this systematic review and meta-analytical evaluation was to determine the effect of pre-treatment with trama...

The aim of this in vitro study was to evaluate the interaction between ciprofloxacin and amoxicillin against beta‐lactamase‐producing Staphylococcus aureus (S. aureus). Concentration‐dependent curves for each individual drug were carried out to obtain the mean inhibitory concentration in the agar well diffusion assay. Then, different ratios of the...

Latin America is a multicultural region with ancient traditional medicine. There is extensive knowledge of the use of medicinal plants for wound healing in this region. Nevertheless, many of these medicinal plants lack pharmacological, toxicological, and chemical studies. This review focuses on the ethnomedicinal, phytochemical, and pharmacological...

Background: Pediatric self-medication is based on the subjective interpretation of symptoms in children by the mother or an adult, the decision to self-medicate is made by a third party. The objective of this work is to provide information on the factors and practices associated with the self-medication of children among parents in Mexico. Methods:...

The first enantioselective synthesis of a tetrahydrochromeno[2,3-b]carbazole derivative via trienamine catalysis is presented. This molecule reduced the anxiety-like behavior in mice. On the contrary, its enantiomer showed low activity, demonstrating the importance of the stereochemisty in the corresponding cycloadduct. On the other hand, both enan...

Inferior alveolar nerve block (IANB) has a high failure rate in subjects with symptomatic irreversible pulpitis (SIP). It has been suggested that drugs with anti-inflammatory activity could improve the efficacy of the anesthetic used for IANB. The aim of this study was to assess the effect of dexamethasone on the success of dental anesthesia in pat...

Iodine(III) reagents have attracted chemical relvance in organic synthesis by their use as safe, non-toxic, green and easy to handle reagents in different transformations. These characteristics make them important alternatives to procedures involving hazardous and harsh reaction conditions. Their versatility as oxidants has been exploited in the fu...

The purpose of this systematic review and meta-analysis was to assess the efficacy of methylprednisolone compared to other drugs to control postoperative complications following third molar surgery. PubMed and Google Scholar were used for article searching. Thereafter, the trials meeting the selection criteria and with high methodological quality,...

Tagetes parryi is a plant empirically used to treat gastrointestinal and inflammatory diseases, its essential oil (EOTP) was obtained from the aerial parts, and the composition was elucidated by GC-MS. The in vivo and in vitro anti-inflammatory activities and the antinociceptive activity of EOTP and (1S)-(-)-verbenone (VERB) were assessed. The majo...

Zygomycetes are ubiquitous saprophytes in natural environments which transform organic matter. Some zygomycetes of gender Mucor have attracted interest in health sector. Due to its ability as opportunistic microorganisms infecting immuno-compromised people and to the few available pharmacological treatments, the mucormycosis is receiving worldwide...

Ethnopharmacological relevance Laelia anceps and Cyrtopodium macrobulbon are two orchids used in Mexican traditional medicine for treating pain. Aim of the study The individual antinociceptive activity of ethanol extracts from the roots of Laelia anceps (LAE) and Cyrtopodium macrobulbon (CME) was evaluated, and their metabolomic profiles were comp...

Aims The aim of this study was to evaluate the analgesic effectiveness and adverse reactions of ketorolac in comparison with other drugs when administered postoperatively after third molar surgery. Methods PubMed and Google Scholar were utilized to search for articles comparing the efficacy and safety of ketorolac and other analgesic agents after...

Catasetum integerrimum is an orchid used in Mexican traditional medicine, which is overexploited due to its ornamental and medicinal properties. In this scenario, conservation strategies are mandatory to protect wild populations from this valuable orchid. The aim of the present study was to establish a micropropagation protocol by direct organogene...

Heavy metal contamination represents a health risk due to occupational and environmental exposure, and their introduction into the food chain. Green technology and affordable to remediate sites contaminated with heavy metals is the phytoremediation. However, although phytoremediation represents a cheap and sustainable technology, it is very importa...

In recent decades, there has been an increase in anthropogenic activities such as industrialization, urbanization, energy generation, agricultural practices, and the burning of fossil fuels, which has resulted in an increase of heavy metals (HM) concentrations in soils and waters to amounts that are harmful to plants, animals, and humans. An altern...

This study evaluated the inhibitory effect of myristic acid (MA) on models of inflammation and nociception. The in vitro anti-inflammatory activities of MA were assessed on LPS-stimulated macrophages, membrane stabilization assay, and inhibition of protein denaturation, whereas the inhibitory activity of MA on in vivo inflammation was assessed on T...

El objetivo de este trabajo fue evaluar la calidad del agua de 11 manantiales del humedal natural “Ciénega Tamasopo”, los cuales son la principal fuente de agua disponible para uso humano entre la población alrededor de este humedal. Actualmente no existe información suficiente de los parámetros fisicoquímicos y biológicos de tales manantiales. El...

Background. The purpose of this meta-analysis was to assess the clinical efficacy of etoricoxib in comparison with traditional NSAIDs for postoperative pain after third molar surgery. Methods. The quality of studies found in PubMed and Google Scholar was evaluated with Cochrane Collaboration’s risk of bias tool. Data on total consumption of rescue...

Ethnopharmacological relevance Asclepias curassavica L. (Apocynaceae) is a perennial shrub used in the folk treatment of parasitism, pain, and inflammation. Aim of the study This work assessed the antiparasitic, anti-inflammatory, antinociceptive, and sedative effects of an ethanol extract from the aerial parts of Asclepias curassavica (ACE). Mat...

Objective This study aims to assess the prevalence of herbal medicine (HM) use and factors influencing HM usage including the identification of the main plants consumed by patients with type 2 diabetes mellitus (T2DM) in central-western Mexico. Design A total of 1862 patients with diabetes were surveyed in public and private hospitals in four stat...

Background The aim of this study was to assess the frequency of allopathic and complementary medicine use for preventing the infection with SARS-CoV-2 in Mexico. A descriptive and cross-sectional study was conducted using an online questionnaire among general adult population (n=16724) of the 32 Mexican states from March to November 2020. Methods...

En México, la contaminación por elementos potencialmente tóxicos en el suelo y el agua representa importantes problemas ecológicos y de salud. Las plantas capaces de crecer en terrenos antropogénicamente modificados reflejan su capacidad de adaptación a diversas condiciones ambientales. La mayoría de los estudios de fitorremediación se lleva a cabo...

The aim of this meta-analysis was to assess the analgesic efficacy and adverse effects of celecoxib compared to non-opioid drugs after third molar surgery. A search in PubMed and Google Scholar was performed to identify clinical trials, and then, the Cochrane Collaboration's toll for assessing risk of bias tool was used to evaluate the quality of a...

Objectives The aim of this meta-analysis was to assess the clinical efficacy and safety profile of ropivacaine in comparison with other dental anesthetics in different clinical conditions. Materials and methods This meta-analysis was registered in the National Institute for Health Research PROSPERO (ID: CRD42020205580). PubMed and Scholar Google w...

The purpose of this systematic review was to determine the analgesic efficacy and adverse effects of ibuprofen in comparison with other traditional non-opioid analgesics after third molar surgery. A total of 17 full texts were identified in PubMed and assessed using the Cochrane Collaboration’s risk of bias tool by two independent researchers. The...

Aim/Background The combination of drugs with different mechanisms of action could be more effective due to an enhanced synergistic activity. The pharmacological interactions between rutin and paracetamol, and rutin and non-steroidal anti-inflammatory drugs (NSAIDs), such as naproxen, ketorolac, and diclofenac were investigated using in vitro and in...

Cuphea aequipetala Cav (Lythraceae) is an herb used in folk treatment for pain and inflammation. The aim of this study was to evaluate the antinociceptive and anti-inflammatory actions of an ethanol extract from the leaves and stem of Cuphea aequipetala (CAE). The antinociceptive actions of CAE (10–200 mg/kg p.o.) were assessed with the acetic acid...

Ethnopharmacological relevance There are plant species used in the Mexican traditional medicine for the empirical treatment of anxiety and depression. Aim of the study This work assessed the prevalence of self-medication with medicinal plants and the prevalence of the concomitant use of prescribed psychiatric drugs and medicinal plants for treatin...

Background Drugs used for the treatment of diseases associated with chronic inflammation, such as cancer and rheumatoid arthritis have the potential to cause undesirable side-effects, which might result in patients ending treatment prematurely. However, plants are a viable option for the treatment of inflammatory diseases. In this study, we assesse...

Medicinal plants are an indispensable resource. However, many medicinal plants are disappearing at an accelerated rate. This chapter shows evidence on the diversity and mass extraction of medicinal plants around the world. The information emphasizes that conservation strategies must be considered for the sustainable use of medicinal plants. Biotech...

Medicinal plants contain bioactive components with beneficial effects for human health. Many plant extracts and active compounds are hydrophobic, and their pharmacological actions can be reduced due their difficulty to be dissolved in the cytoplasmic membrane of cells. Encapsulation of plant extracts and bioactive compounds is a useful strategy to...

Many studies describe different pharmacological effects of flavonoids on experimental animals and humans. Nevertheless, few ones are confirming the safety of these compounds for therapeutic purposes. This study aimed to investigate the preclinical safety of naringenin, naringin, hesperidin, and quercetin by in vivo, in vitro, and in silico approach...

The purpose of this study was to evaluate the antinociceptive interaction between dexketoprofen and tapentadol in three different dose ratios, as well as the ulcerogenic activity of this combination. Dose–response curves were carried out for dexketoprofen, tapentadol, and dexketoprofen–tapentadol combinations in the acetic acid‐induced writhing tes...

Mansoa hymenaea (DC.) A.H. Gentry is used in traditional medicine to treat pain, arthritis, and rheumatoid disease. It has also been demonstrated that species belonging to the Mansoa genus exert cytotoxic activity. Despite this data, biological properties and phytochemistry of M. hymenaea remain poorly understood. Therefore, we determined the metab...

Aim of the study: This work assessed the diuretic, antinociceptive, and anti-inflammatory actions of an ethanol extract from the leaves and stems of Eryngium carlinae (ECE). These ethnomedicinal properties of ECE were scientifically validated using in vitro and in vivo assays. Materials and methods: The antinociceptive and diuretic actions of EC...

Background Fibroblast Growth Factor 21 (FGF21) serum levels are associated with insulin resistance and metabolic syndrome in HIV patients. Objective To quantify FGF21 levels in HIV patients using antiretroviral therapy (ART) and to analyze a possible association between serum FGF21 levels and lipid profile, levels of pro-inflammatory cytokines, an...

Recalcitrant pollutants mainly come from industrial processes such as mineral extraction, metal casting and coating, discharge of effluents, and nuclear fuel generation. These pollutants are introduced into food chain resulting in their accumulation in human body. Even at low concentration they pose serious health effects. A low-cost biotechnologic...

Introduction Bidens odorata Cav (Asteraceae) is a medicinal plant employed for the treatment of pain, anxiety, and depression. This study aimed to evaluate some neuropharmacological effects of an ethanol extract of B. odorata (BOE) and assess its antinociceptive interaction with naproxen and paracetamol. Materials and methods The following neuroph...

The 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay is a valid and commonly test used to measure the total antioxidant capacity in natural extracts. The results of this assay are frequently expressed as IC50 values. Nevertheless, the reported IC50 value is influenced by the concentration of the DPPH solution used in the methodology....

Senna septemtrionalis (Viv.) H.S. Irwin & Barneby (Fabaceae) is a medicinal plant used as a folk remedy for inflammation and pain. The objective of this study was to evaluate the anti-inflammatory and antinociceptive actions of an ethanol extract of Senna septemtrionalis aerial parts (SSE). The in vitro anti-inflammatory effects of SSE were assesse...

This work describes the neuropharmacological (sedative, anxiolytic, antidepressant, and anticonvulsant) actions of Gardenin A (GA) (0.1–25 mg/kg p.o.), a flavonoid found in medicinal plants. The sedative effects of GA were assessed with the pentobarbital‐induced sleep test. The anxiolytic actions of GA were evaluated with the elevated plus‐maze, th...

Enantioselective synthesis of tetrahydrocarbazoles via trienamine catalysis and their anxiolytic-like activity. https://doi.org/10.1016/j.bmcl.2020.127063 Bioorganic & Medicinal Chemistry Letters 30 (2020) 127063

The first study about the anxiolytic activity of two chiral tetrahydrocarbazoles is presented. This new chiral compounds were prepared through an organocatalytic strategy via trienamine activation. The in situ ortho-quinodimethane species, formed by the condensation of the N-protected 2-methylindole acrylaldehyde with a sterically hindred diarylsil...

In Mexico, the contamination by potentially toxic metals in soil and water represents substantial ecological and health problems. Plants capable to grow on anthropogenically modified grounds reflect their ability of adaptation to diverse environmental conditions. Most of phytoremediation studies are carried out under laboratory conditions, and only...

Multidrug resistance (MDR) is a great concern worldwide. There is a great need to develop new drugs with the potential to attack target cells that show MDR phenotype. The purpose of this study was to assess the reversing effect of new N-alkyl-3,4-diarylmaleimides on Bacillus subtilis resistant to rhodamine 6G as an indicator of its activity as modu...

Laelia anceps subsp. anceps is a species of the Orchidaceae family that presents high rates of illegal extraction and trade in several states of the Mexican Republic, and also requires specific nutritional conditions due to its development and distribution characteristics. Therefore, the aim of the present investigation was to establish an in vitro...

The aim was to evaluate the diuretic and neuropharmacological actions of d‐pinitol and describe a possible mechanism of action. The diuretic effects of d‐pinitol were evaluated using mice placed in metabolic cages. The sedative, anxiolytic‐like, antidepressant‐like, and anticonvulsant effects of 1–100 mg/kg d‐pinitol were assessed. The possible mec...

Salvia tiliifolia is used in folk medicine as a relaxant agent and for the treatment of diarrhea and neurodegenerative diseases. Tilifodiolide (TFD) is a diterpene obtained from this plant. The purpose of this work was to evaluate the antidiarrheal, vasorelaxant, and neuropharmacological actions of TFD. These effects were selected based on the folk...

Background Fibroblast growth factor 21 (FGF21) is considered an important regulator of lipid and glucose metabolism. However, the role of FGF21 in macronutrient intake and metabolic disease, particularly in pediatric population, still needs further clarification. This study aimed to evaluate the association of rs11665896 in the FGF21 gene with meta...

Gymnosperma glutinosum (Spreng) Less (Asteraceae) is a shrub used in traditional medicine for the treatment of inflammatory and renal diseases. The ent‐dihydrotucumanoic acid (DTA) is a diterpene obtained from G. glutinosum. This study evaluated the antioxidant, genotoxic, and diuretic properties of DTA, as well as its in vitro and in vivo anti‐inf...

Nowadays, consumers, food industries, and researchers have a great interest in evaluating the total antioxidant value of foodstuffs and plasma samples. The 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation scavenging assay is one of the most common antioxidant evaluations. However, this assay shows a great variability in...

Ethnopharmacological relevance: Mexico ranks second in the world for obesity prevalence. In Mexico, obese and overweight subjects commonly seek alternative treatments for weight-loss, including the use of herbal products. Aim of the study: The main objective of this study was to evaluate the prevalence of self-medication with herbal products for we...

Organometallic and coordination nickel, palladium and platinum complexes, neutral and cationic, with general formula [M(κ ³ -SacNac)X] and [M(κ ³ -SacNac)L′][BPh 4 ] (where M = Ni, Pd and Pt, X = Me, Cl, 1–6; M = Ni, X = N 3 , SMe, 7–8; M = Pd, X = I, 13; M = Ni and Pd, L′ = PPh 3 , 9–10; M = Ni and Pt, X = PMe 3 , dmso, 11–12) containing a new Sac...