Ane Orchard

Ane Orchard
University of the Witwatersrand | wits · Department of Pharmacy and Pharmacology

PhD

About

20
Publications
6,753
Reads
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311
Citations
Citations since 2017
19 Research Items
311 Citations
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2017201820192020202120222023020406080

Publications

Publications (20)
Article
Full-text available
Essential oil compounds have been identified as alternative antimicrobials; however, their use is limited due to their toxicity on human lymphocytes, skin, and reproduction. Carrier oils can reduce the toxicity of essential oils, which raises the question as to whether such activity would extend to the essential oil compounds. Thus, this study aime...
Article
Full-text available
Background: Vaccination falls within the scope of practice of a pharmacist and the coronavirus disease 2019 pandemic has seen an increase in pharmacies providing vaccination services. These vaccines are not without risk of allergic reactions and anaphylaxis. The available guidelines for the management of anaphylaxis include the administration of in...
Article
Ethnopharmacological relevance African traditional medicine is one of the oldest and most diverse practices for treating ailments and numerous natural products have been recommended for gastric ulcer treatment. Helicobacter pylori is the main causative organism implicated in several diseases, most notably in causing inflammation and the onset of ga...
Article
Ophthalmic infections are common and can cause substantial loss of eyesight. It is estimated that nearly 45% of the South African population has suffered from partial or total loss of eyesight with a substantial portion of this being due to infections. However, in approximately 80% of cases, this loss of eyesight could have been easily prevented or...
Article
The challenge of premature non-communicable diseases (NCDs) deaths in developing countries has been attributed to late diagnosis due to limited access to preventive and primary care. Foremost in addressing this challenge is the need to develop healthcare models with low costs but guaranteeing access of healthcare. Such a need is pressing, as the in...
Article
Background and purpose Cancer is on the rise both globally and in South Africa, with an estimated 70% increase in incidence in Sub-Saharan Africa by 2030. While oncology pharmacy is a highly specialized field of practice, there is currently no formal certification for oncology pharmacists in South Africa. Educational activity and setting To standa...
Article
Acne is a skin condition arising from excess sebum production and microbial overgrowth within the pilosebaceous unit. Several commercial essential oils have shown promising activity against acne-related pathogens. Due to their volatility and thermal instability, the formulation of essential oils into commercial products remains a pharmaceutical cha...
Article
Full-text available
Elevated blood pressure (BP) is a growing burden worldwide, leading to over 10 million deaths each year. May Measurement Month (MMM) is a global initiative of the International Society of Hypertension (ISH) aimed at raising awareness of high BP and acting as a temporary solution to the lack of screening programmes worldwide. As part of MMM, screeni...
Article
Full-text available
Patients with severe hypercholesterolaemia have a high lifetime risk for developing cardiovascular disease. These patients are traditionally treated with high-intensity statins and ezetimibe. Some patients are refractory to treatment and cannot achieve a desirable reduction in low-density lipoprotein cholesterol (LDL-C). LDL apheresis or lipoprotei...
Article
Full-text available
Wounds are a common medical infliction. With the increase in microbial resistance and a shift of interest towards complementary medicines, essential oils have been shown to be beneficial in suppressing microbial growth. However, in practice, essential oils are more often diluted into a base due to the risk of topical adverse effects, such as dermat...
Article
Full-text available
The topical use of essential oils requires dilution into a carrier oil; however, scientific evidence regarding the antimicrobial efficacy and cytotoxicity when a carrier oil is combined with an essential oil is lacking. This study sets out to determine the antimicrobial activity and cytotoxicity of 23 essential oils combined with six known carrier...
Article
Essential oils are amongst the most popular natural products recommended for the treatment of topical fungal infections. This study investigated the antifungal activity of 128 essential oil combinations against fungal pathogen reference strains using the broth microdilution technique to determine the minimum inhibitory concentration (MIC). The esse...
Article
Cover Picture. Essential oil combinations were investigated against pathogens most frequently found in wounds. From this study, the importance of scientific validation is emphasised, especially considering that the recommended aroma‐therapeutic combinations did not always result in the predicted efficacy. Furthermore, only a slight variation in ant...
Article
This study aimed to determine the antimicrobial activity of 247 essential oil combinations against the reference strains of wound pathogens. Essential oil combinations were investigated for antimicrobial activity against five pathogens relevant to wounds. The minimum inhibitory concentration (MIC) assay was used and the fractional inhibitory concen...
Article
Foot odour (bromodosis) is an embarrassing and perplexing condition mostly caused by bacteria of the Brevibacterium species. Essential oils are a credible option as an affordable treatment of odour and contribute towards antimicrobial efficacy. Therefore, this study sets out to investigate the antimicrobial activity of essential oil combinations ag...
Article
Objective The study investigated the efficacy of commercial essential oil combinations against the two pathogens responsible for acne with the aim to identify synergy and favourable oils to possibly use in a blend. Methods and materials Antimicrobial activity was assessed using the minimum inhibitory concentration (MIC) assay against Staphylococcu...
Article
Full-text available
Essential oils are one of the most notorious natural products used for medical purposes. Combined with their popular use in dermatology, their availability, and the development of antimicrobial resistance, commercial essential oils are often an option for therapy. At least 90 essential oils can be identified as being recommended for dermatological...
Article
This study reports on the inhibitory concentration of 59 commercial essential oils recommended for dermatological conditions, and identifies putative compounds responsible for antimicrobial activity. Essential oils were investigated for antimicrobial activity using minimum inhibitory concentration assays (MICs). Ten essential oils were identified a...

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Projects

Project (1)
Project
Investigating antimicrobial activity of essential oils against dermatological pathogens individually and in combination. Identifying putative biomarkers responsible for antimicrobial activity. Analysing the identified putative biomarkers as potential antimicrobials.