
Andrian MamoshinA.V. Vishnevsky National Medical Research Center of Surgery of the Russian Ministry of Healthcare · Department of abdominal surgery
Andrian Mamoshin
Doctor of Medicine
About
71
Publications
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Introduction
Publications
Publications (71)
The analysis of data from relevant domestic and foreign literature on the intraoperative determination of intestinal viability using modern diagnostic methods in various diseases of the abdominal cavity accompanied by impaired blood supply to the intestinal wall is presented in this work. The analysis is based on the concept of mesenteric ischemia...
Objectives
One of the widely used optical biopsy methods for monitoring cellular and tissue metabolism is time-resolved fluorescence. The use of this method in optical liver biopsy has a high potential for studying the shift in energy-type production from oxidative phosphorylation to glycolysis and changes in the antioxidant defense of malignant ce...
Timely detection and prognosis of liver failure play an important role in improving treatment outcomes for patients with biliary obstruction. The study describes the use of optical biopsy methods to determine the functional state of the liver in patients with obstructive jaundice syndrome during and after antegrade biliary decompression. Fluorescen...
This work reports a machine-learning-based approach to
interpret time-resolved fluorescence spectroscopy data acquired
during optical biopsy of the liver. The approach allowed to
differentiate between liver parenchyma and tumor with sensitivity
and specificity above 0.91 and 0.79, respectively, providing
differential diagnosis of liver cancer (prim...
Profound changes in the metabolism of cancer cells have been known for almost 100 years, and many aspects of these changes have continued to be actively studied and discussed. Differences in the results of various studies can be explained by the diversity of tumours, which have differing processes of energy metabolism, and by limitations in the met...
Background. Acute intestinal ischemia is a disease characterized by a violation of blood supply, which leads to hypoxia of intestinal
wall tissues and secondary pathological changes. One of the main factors determining the urgency of the problem of acute intestinal ischemia is the intraoperative determination of the viability of the intestinal wall...
Introduction. Diseases accompanied by a violation of the blood supply to the intestinal wall occupy one of the main places in urgent surgery of the abdominal organs. Intraoperative assessment of intestinal viability is one of the most difficult tasks and plays a leading role in determining the volume of surgical aid, predicting the course of the po...
Objectives:
Currently, one of the most pressing issues for surgeons in the treatment of obstructive jaundice is the ability to assess the functional state of the liver and to detect and determine the degree of liver failure in a timely manner with simple and objective techniques. In this regard, the use of fluorescence spectroscopy method can be c...
Aim. To evaluate the potential and effectiveness of antegrade X-ray surgical interventions as treatment choice to eliminate the cholecysto- and choledocholithiasis in the complicated cholelithiasis. Materials and methods. We carried out an analysis of the results of staged X-ray surgical treatment of 29 patients with cholecysto- and/or choledocholi...
There is a clinical report of successful oral intraluminal laser lithotripsy with subsequent lithoextraction of a large concretion of the common bile duct in a patient with choledocholithiasis and mechanical jaundice. For the intraluminar lithotripsy a tulium laser "Urolaz" was used with energy modes 0,025-0,05-0,1 J, up to a maximum of 0.5 J. The...
At the moment, percutaneous needle biopsy (PNB) remains the gold standard for diagnosing liver cancer. However, the relatively high probability of false-negative results can still be an issue with the method. The introduction of real-time feedback for the precise navigation of the biopsy tool is an up-and-coming technology to immensely reduce the m...
This work presents results of in vivo and in situ measurements of hepatocellular carcinoma by a developed optical biopsy system. Here, we describe the technical details of the implementation of fluorescence lifetime and diffuse reflectance measurements by the system, equipped with an original needle optical probe, compatible with the 17.5G biopsy n...
Herein, we develop an enhanced and automated methodology for detection of the tumour cells in fixed biopsy samples. Metamaterial formalism (MMF) approach allowing recognition of tumour areas in tissue samples is enhanced by providing an advanced technique to digitize mouse biopsy images. Thus, a colour-based segmentation technique based on the K-me...
A flexible fibre optical probe is implemented to record the parameters of the endogenous fluorescence during minimally invasive interventions in patients with cancers of hepatoduodenal area. Using machine learning techniques, the obtained spectra are classified to indicate cancerous or healthy tissue. For this, a set of different binary classifiers...
Abdominal cancer is a widely prevalent group of tumours with a high level of mortality if diagnosed at a late stage. Although the cancer death rates have in general declined over the past few decades, the mortality from tumours in the hepatoduodenal area has significantly increased in recent years. The broader use of minimal access surgery (MAS) fo...
The aspects of using optical instruments for minimally invasive interventions in abdominal surgery are considered. The results of clinical and preclinical trials of the application of the multimodal optical approaches in endoscopic instruments for the treatment and diagnosis of abdominal cancer are reviewed and discussed. A significant increase in...
This paper describes the experimental monitoring of pancreatic oxidative metabolism in laboratory mice that combines the methods of fluorescence and diffuse reflectance spectroscopy and laser speckle contrast imaging with a pancreatic ischemia model. The combined measurements show a close dependence of tissue metabolism on blood and oxygen supply....
The article demonstrates the diagnostic effectiveness of clinical, laboratory and instrumental methods for the differentiation of clinical and morphological forms of acute destructive pancreatitis. The importance of such promising methods as minimally invasive multi-frequency bioimpedancemetry of the pathological focus, the crystallographic study o...
The paper reviews various methods of performing esophageal-intestinal anastomoses with complete removal of the stomach (gastrectomy). The main methods of manual and stapler stitching of the esophagus with the jejunum are described. Special attention is paid to detailing of techniques for the most commonly performed esophageal-intestinal anastomoses...
Liver cancer remains one of the most widespread cancer types worldwide. The time spent on the diagnosis is one of crucial factors ensuring the effectiveness of treatment. As percutaneous needle biopsy remains the gold standard for liver diagnosis, it is necessary to develop new methods for improving this procedure. One of the most promising directi...
This paper presents the results of the experiments which were performed using the optical biopsy system specially developed for in vivo tissue classification during the percutaneous needle biopsy (PNB) of the liver. The proposed system includes an optical probe of small diameter acceptable for use in the PNB of the liver. The results of the feasibi...
A device for optical biopsy with a fluorescence spectroscopy channel and a fine-needle optical probe for use in fine-needle aspiration biopsy of liver tumors is described. To test the developed device, experimental measurements of the fluorescence of internal organs of a laboratory rat were carried out in vivo while exposing the tissue surface to m...
To determine optimal lighting conditions for contrast imaging of surgical objects, optical characteristics of biological tissues and spectral characteristics of smart light "LED light" source based on RGBW LED are compared. The spectral characteristics of tissues and organs have been investigated. Optimal lighting conditions for contrast imaging of...
The paper describes the results of experimental studies using custom developed optical biopsy system for diagnostics in vivo during the procedure of fine needle aspiration biopsy. Experimental studies were conducted in laboratory mice with inoculated hepatocellular carcinoma. The measurements were carried out using fluorescence spectroscopy and dif...
Laser speckle contrast imaging of the microcirculatory bed of the pancreas is performed, which allows its condition to be assessed and thereby is an additional valuable tool for making a diagnostic decision and dynamically monitoring the effectiveness of the treatment for pathology of the abdominal organs. Laparoscopic operations on the pancreas ar...
BACKGROUND: A new original laparoscopic operative technique was used to suture paraesophageal hernia (PEH) with the strips of mesh.
METHODS: The Mercilen (MercilenTM) mesh suture was used to close large hiatal hernia. The strips of mesh, instead of normal thread, were applied to close the gap between diaphragm's crura in four patients with hernia d...
Objective:
To analyze an effectiveness of laparoscopic surgery with simultaneous abdominoplasty in patients with superficial abdominal obesity.
Material and methods:
Laparoscopic abdominal, retroperitoneal and pelvic surgery with simultaneous abdominoplasty was performed in 25 patients with body mass index >40 kg/m2.
Results:
Surgery time and...
During surgery, it is important for the surgeon to determine the optimal lighting conditions for contrast imaging of the operated objects. The paper analyzes various parameters of a controlled colour-dynamic surgical lamp based on a powerful led when contrasting individual organs and tissues of model animals, as well as optical parameters of the or...
Inguinal hernioplasty is one of the most common surgical procedures, but the long-term results of operations leave much to be desired: there are recurrences of hernias, chronic pain syndrome, violation of testicular function in men. A modern review of the literature on the most common surgical methods of treatment of inguinal hernias is presented....
The paper describes the methodology and technical implementation of a multimodal approach for optical diagnostics in hepatopancreatobiliary organs focal and diffuse neoplasms. Fine needle aspiration biopsy technique and following cytological examination show its effectiveness and safety but its performing takes several days. However, the problem of...
Diagnosis and treatment of acute destructive pancreatitis is one of the most urgent problems of abdominal surgery. To
obtain additional diagnostic information about the microcirculation state and metabolic processes, various imaging
techniques are widely used during surgical interventions. One of the most perspective techniques for in vivo
microcir...
The paper describes the experiment at pancreas ischemia model carried out by combining the methods of fluorescence spectroscopy and laser speckle contrast imaging in laboratory mice. The measurement was performed before and after ischemia to evaluate the relationship between the changes of blood flow and metabolic activity. The results showed high...
Fine needle aspiration biopsy technique and following histological examination show its effectiveness and safety but its performing takes several time. However, the problem of real-time analysis of pathological changes in tissues remains relevant. We demonstrate optical fine-needle biopsy method, combining a fine needle (17.5G) and a fiber-optic pr...
The paper presents the results of experimental measurements of endogenous fluorescence and blood perfusion in patients with pathology of the organs of hepatopancreatoduodenal area in vivo. A custom setup combining channels for fluorescence spectroscopy (excitation wavelengths of 365 nm and 450 nm) and laser Doppler flowmetry (1064 nm) with fibre op...
The recent development of the instrumental methods for two-and three-dimensional imaging allows one to upgrade minimally invasive surgical methods for the abdominal organs to a new level. This type of surgical interventions makes possible to achieve recovery with minimal trauma, reducing the incidence of complications, effectively maintaining and r...
The patient with neoplasm of major duodenal papilla combined with choledocholithiasis is described. Obstructive jaundice is one of manifestations complicating the course of these diseases. Complex approach to current diagnostic and therapeutic minimally invasive technologies is demonstrated. It is also presented literature review.
Determination of optimal lighting conditions for
contrast imaging of operated objects is important for the
surgeon. In this paper, we consider various parameters of a
controlled color-dynamic surgical light based on a powerful
LED when contrasting individual organs and tissues of model
animals. The obtained results will allow to develop a library o...
The work is devoted to review the various methods and approaches currently used within the framework of the concept of optical «biopsy» in the study of blood perfusion and metabolism of human organs tissues. The purpose of the review was to study the features and areas of application of these methods and to assess further application possibilities...
At present, minimally invasive interventions become more widespread for treating hepatopancreatoduodenal area pathologies. However, new methods and approaches are necessary for obtaining more diagnostic information in real time. Several methods within the framework of “optical biopsy” concept are considered. The features and areas of application of...
The use of liposomal nanoparticles with an incorporated active substance is an innovative and promising approach to diagnostics and therapy. The application of liposomal nanoparticle-based drugs allows for targeted localized delivery, overcomes the natural barriers within the body effectively, and minimizes possible side effects. Liposomes are able...
The studies were carried out on groups of clinically healthy mice line of outbred CD-1 stock. The model animals were divided into 2 groups and received experimental liposomal formulations. Using the method of fluorescence spectroscopy, we investigated the effectiveness of penetration into the circulatory system of fluorescently stained liposomes wi...
In the article the modern controlled miniinvasive techniques of acute destructive pancreatitis diagnostic and treatment and its complications are discussed. Perspective miniinvasive techniques as many-frequent bioimpedancemetry and crystallography are described. Different controlled miniinvasive interventions were used in the particular sequence in...
The purpose of this research is the use 5 stages of standardized methodology of compression elastography based on a preliminary assessment of gray-scale images, qualitative and semi-quantitative elastography. The authors give comparative characteristics of diagnostic efficiency and reproducibility standard data and propose the elastography in 3419...
In the article the modern controlled miniinvasive techniques of acute destructive pancreatitis diagnostic and treatment and its complications are discussed. Perspective miniinvasive techniques as many-frequent bioimpedancometry and crystallography are described. Different controlled mini- invasive interventions were used in the particular sequence...
The article describes the experience of puncture aspiration biopsy in 136 patients (110 males and 26 females at the age of 19-74) with suspected destructive pancreatitis in one-day inpatient conditions, followed by microscopic and microbiological tests. In order to increase the diagnostic accuracy when detecting necrotic zones, 49 patients were exa...