Andrey Ponomarenko- M.D., Ph.D.
- Professor (Associate) at Odessa National Medical University
Andrey Ponomarenko
- M.D., Ph.D.
- Professor (Associate) at Odessa National Medical University
About
38
Publications
4,381
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149
Citations
Introduction
Accomplishments: 1) Identification of molecular, genetic and biophysical features of influenza virus that influence virus immunogenicity and virus predisposition to form either acute, or chronic/persistent infection; 2) Elaboration of a Screening Test for early identification of cancer-prone persons using flow cytometry/ immunogram; 3) Identification of the mechanism of some adverse reactions in animals subjected to autologous stem cell transplantation. Awarded 12 travel and educational grants.
Current institution
Additional affiliations
May 2011 - June 2011
Position
- Invited Lecturer
Description
- The role of Electromagnetic interactions in Influenza infection: Clinical, Diagnostic and Epidemiological aspects
Publications
Publications (38)
Recent studies demonstrate distinct changes in gene expression in cells exposed to a weak magnetic field (MF). Mechanisms of this phenomenon are not understood yet. We propose that proteins of the Cryptochrome family (CRY) are "epigenetic sensors" of the MF fluctuations, i.e., magnetic field-sensitive part of the epigenetic controlling mechanism. I...
We introduce a hypothesis that both: afferent and efferent neural pathways involve additional mechanism of signal transduction in form of a hydro-ionic waves in brain and body tissues, being induced by proteins and protein interactions and having properties similar to musical patterns, namely: rhythm, meaningful frequencies and presumably, consonan...
Since 1957 when Burnet’s Clonal selection Theory of Immune response was proposed a significant progress in molecular biology and genetics was achieved. Thus, it is time for reconsideration of possible mechanisms of immunity. It is obvious that an instructive immunological mechanism based on molecular recognition would be much more practical in comp...
Trends in excess winter mortality (EWM) were investigated from the winter of 1900/01 to 2019/20. During the 1918–1919 Spanish flu epidemic a maximum EWM of 100% was observed in both Denmark and the USA, and 131% in Sweden. During the Spanish flu epidemic in the USA 70% of excess winter deaths were coded to influenza. EWM steadily declined from the...
Pathogen interference is the ability of one pathogen to alter the course and clinical outcomes of infection by another. With up to 3000 species of human pathogens the potential combinations are vast. These combinations operate within further immune complexity induced by infection with multiple persistent pathogens, and by the role which the human m...
All vaccines exhibit specific and nonspecific effects. Specific effects are shown by the efficacy against the target pathogen, while nonspecific effects can be detected by the change in all-cause mortality. The real-world non-COVID-19 all-cause mortality (NCACM) data for the population of England between January 2021 and May 2023 was assessed. All...
Since 2020, COVID-19 has caused serious mortality around the world. Given the ambiguity in establishing COVID-19 as the direct cause of death, we first investigate the effects of age and sex on all-cause mortality during 2020 and 2021 in England and Wales. Since infectious agents have their own unique age profile for death, we use a 9-year time ser...
A recent study has suggested that the age profiles for deaths due to COVID-19 variants differs between variants and shows male/female specificity. This study implies that age/sex dependency is common among human pathogens. The often-reported higher susceptibility to infections among the young and elderly is true in general but does not apply to ind...
All vaccines exhibit both specific and non-specific effects. The specific effects are measured by the efficacy against the target pathogen, while the non-specific effects can be detected by the change in all-cause mortality. All-cause mortality data (gender, age band, vaccination history, month of death) between January 2021 and May 2022 was compil...
This study investigates the effects of age and sex on reported COVID-19 deaths and upon all-cause mortality during 2020, 2021 and 2022 to reveal the detail of the age-specificity of SARS-CoV-2 variants. The widely reported higher deaths in males was confirmed for most ages above 43 years in both 2020 and 2021. During 2020 (+ COVID but no vaccinatio...
Unexpected outcomes are usually associated with interventions in complex systems. Excess winter mortality (EWM) is a measure of the net effect of all competing forces operating each winter, including influenza(s) and non-influenza pathogens. In this study over 2400 data points from 97 countries are used to look at the net effect of influenza vaccin...
Trends in excess winter mortality (EWM) were investigated from the winter of 1900/01 to 2019/20. During the 1918-1919 Spanish flu epidemic a maximum EWM of 100% was observed in both Denmark and the USA. During the Spanish flu epidemic in the USA 70% of excess winter deaths were coded to influenza. EWM steadily declined from the Spanish flu peak to...
Trends in excess winter mortality (EWM) were investigated from the winter of 1900/01 to 2019/20. During the 1918-1919 Spanish flu epidemic a maximum EWM of 100% was observed in both Denmark and the USA. During the Spanish flu epidemic in the USA 70% of excess winter deaths were coded to influenza. EWM steadily declined from the Spanish flu peak to...
It was shown that photobiomodulation therapy (PBM) has anti-inflammatory and pain relief effects. M. Pelletier et al. demonstrated that PBM also have delayed effects comprising restoration of tissue alterations (healing, rejuvenation) and hair growth. Different research implies activation of mitochondrial functions, stimulation of ATP synthesis and...
This file represents an example of the "Protein music" created by the method described in Conference presentation Ponomarenko et al. "Perception, Feelings and Neuroregulatory signals as Music-Like Patterns Embodied in Ionic Waves Induced by Proteins" RAD-2017 Conference, Budva, Montenegro, June 2017.
Andrey Ponomarenko*, Alfredo Pereira Jr.**, Vict...
We hypothesize that in case of transformation of a molecular biological signal into neural signal, the generated neural signal could possess rhythmic pattern specific to that of inducing bio-molecule. For example, rhythmicity of positively/negatively charged amino acids in a polypeptide signaling molecule (cytokine, hormone, etc.) could predetermin...
The magnetic field effects on the growth of bacterial populations.
Andrey Ponomarenko (1), Claude Gaudeau de Gerlicz (2), Xavier d'Hérouville (2), Valentina Pushkina (3), Leonid Godlevsky (1)
(1) Odessa National Medical University, Odessa, Ukraine: aponom@hotmail.com
(2) Bioespas International laboratory Tours, France: Bioespas.international@gmail...
For scientific progress it is very important to realize the correct hierarchy of life-keeping and life-regulatory structures and forces. We tried to trace evolution of our conceptualization in the field, which was strictly followed the progress in our general scientific knowledge and accessible methodology. Let’s depict this evolution of our unders...
There are growing evidence supporting the role of electromagnetic fields and interactions in biological processes. In this paper we're trying to theoretically substantiate the feasibility and necessity of the "Theory of Electromagnetic Biological Regulation and Signaling" (TEBRS) development. To support the idea we attempted to describe and systema...
We performed a comparative study of lymphocytes subsets in blood of patients with gynecological tumors, pre-tumor diseases and in healthy volunteers. Flow cytometry method and set of 8 labeled monoclonal antibodies have been used. 140 persons have been examined in total. 72 percents of gynecological patients had abnormal contents of some lymphocyte...
Results: We used flow cytometry to monitor contents of some cell populations in peripheral blood of Gynecological Clinic patients and healthy volunteers. Among other peculiarities we have noted a direct correlation between contents of CD34+ progenitor cells and CD4+ CD25+ T-regs in blood of studied persons (r= +.58, p=0,005, n=84).
Discussion: Ther...
Zaporozhan V.N., Kholodkova E.L., Pihteev D.M., Ponomarenko A.I. Experimental study of some methodological approaches implemented in regeneration medicine // Transplantology (Ukraine) 2005. -V.8, №1.- P.10-20 _______ ________ _________ ________
Data of experimental studies performed by authors and dedicated to investigation of the influence of allo...
Method of immunoselection which allowed to model changeability of influenza virus and purposely change biological properties of virus strains, including their immunogenicity was elaborated. Comparative study of influenza virus strain-variants with heightened (High) and decreased (Low) immunogenicity created by the immunoselection method was conduct...
Localization of revealed amino acid substitutions in hemagglutinin of High-immunogenic (2/I-A/Victoria/35/72/50, red) and Low-immunogenic (5/II-A/Victoria/35/72/50, green) strain variants obtained by original method of immunoselection from initial influenza vaccine strain A/Victoria/35/72/50. (the original HA model taken from Wilson I.A, et al., 19...
Forecasting of biological properties of circulating or vaccine strains of influenza virus (I. V. ) is the problem of great importance. For its elaboration the comparative study of 2 groups of I. V. strains of A(H1N1) and A(H3N2) serotypes was carried out. Viruses inside each group possessed similar antigenic structure but differed by biological pro...
Localization of revealed amino acid substitutions in hemagglutinin of High-immunogenic (2/I-A/Victoria/35/72/50, red) and Low-immunogenic (5/II-A/Victoria/35/72/50, green) strain variants obtained by original method of immunoselection from initial influenza vaccine strain A/Victoria/35/72/50. (the original HA model taken from Wilson I.A, et al., 19...
Method of immunoselection which allowed to model changeability of influenza virus and purposely change biological properties of virus strains, including their immunogenicity was elaborated. Comparative study of influenza virus strain-variants with heightened (High) and decreased (Low) immunogenicity created by the immunoselection method was conduct...
Questions
Question (1)
There is a common rule that any significant influenza epidemics (pandemic especially) must have a certain period of the virus preadaptation when the future epidemic/pandemic strain has hidden/slow circulation in a susceptible population (in case of influenza pandemics - in humans). This period is absolutely necessary for such a complex reassortant (mixture of genes that the 2009 pandemic strain had): several genes from avian flu, several- from swine flu, rest - from human flu). Such a scratchy (complicated) construction should be adapted for efficient replication in human epitelial cells to increase its replication activity and virulence... And during these several months of preadaptation this NEW virus reassortant, its field isolates should be detected in any part of the world by a comprehensive World influenza Surveillance system (WHO, CDC, National epidemiological services, etc.). Have anybody seen any papers, reports describing preliminary (pre-pandemic) detection and evaluation of the pandemic-like HINI "swine" flu reassortants ?
