Andrey Ivankin

Andrey Ivankin
Illinois Institute of Technology | IIT

About

30
Publications
1,696
Reads
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991
Citations
Citations since 2017
1 Research Item
461 Citations
2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080
Introduction
Skills and Expertise

Publications

Publications (30)
Article
Full-text available
The peptidomimetic approach has emerged as a powerful tool for overcoming the inherent limitations of natural antimicrobial peptides, where the therapeutic potential can be improved by increasing selectivity and bioavailability. Restraining conformational flexibility of a molecule may reduce the entropy loss upon its binding to the membrane. Experi...
Article
Nucleosomes are the fundamental repeating units of chromatin, and dynamic regulation of their positioning along DNA governs gene accessibility in eukaryotes. Although epigenetic factors have been shown to influence nucleosome structure and dynamics, the impact of DNA methylation on nucleosome packaging remains controversial. Further, all measuremen...
Article
In recent years, nanopores have emerged as exceptionally promising single-molecule sensors due to their ability to detect biomolecules at sub-femtomole levels in a label-free manner. Development of a high-throughput nanopore-based biosensor requires multiplexing of nanopore measurements. Electrical detection, however, poses a challenge, as each nan...
Article
Herein we report a novel approach for fast, label-free probing of DNA-histone interactions in individual nucleosomes. We use solid-state nanopores to unravel individual DNA/histone complexes for the first time, and find that the unraveling time depends on the applied electrophoretic force, and our results are in line with previous studies that empl...
Conference Paper
Full-text available
In this investigation, three complimentary experimental techniques including atomic force microscopy (AFM), X-ray reflectivity (XR), and epiflourescence microscopy (EFM) were employed to determine the mechanism of action of the antimicrobial cyclic peptoid ML2-6 on model mammalian and bacteria membrane systems. Mammalian and bacterial membranes wer...
Conference Paper
Full-text available
Non-natural oligomeric mimics of antimicrobial peptides (AMPs) can be designed to display chemical moieties analogous to the active side chains of natural peptides, while their abiotic backbone provides protection from proteolytic degradation. N-substituted glycine oligomers (peptoids) are an outstanding example of potential anti-infectious agents...
Article
Membrane-activity of the glycoprotein 41 membrane-proximal external region (MPER) is required for HIV-1 membrane fusion. Consequently, its inhibition results in viral neutralization by the antibody 4E10. Previous studies suggested that MPER might act during fusion by locally perturbing the viral membrane, i.e., following a mechanism similar to that...
Article
Full-text available
Biomembranes undergo extensive shape changes as they perform vital cellular functions. The mechanisms by which lipids and proteins control membrane curvature remain unclear. We use x-ray reflectivity, grazing incidence x-ray diffraction, and epifluorescence microscopy to study binding of HIV-1 glycoprotein gp41’s membrane-bending domain to DPPC/cho...
Conference Paper
Full-text available
Synthetic compounds mimicking the structure of natural antimicrobial peptides (AMPs) have a great promise as potential anti-infectious agents due to their stability towards enzymatic degradation, high antibiotic efficiency, and broad adjustability of physicochemical properties. Recently we have demonstrated that antimicrobial activity of AMP synthe...
Article
Electron microscopy structural determinations suggest that the membrane-proximal external region (MPER) of glycoprotein 41 (gp41) may associate with the HIV-1 membrane interface. It is further proposed that MPER-induced disruption and/or deformation of the lipid bilayer ensue during viral fusion. However, it is predicted that the cholesterol conten...
Poster
Full-text available
The high toxicity of most anticancer chemotherapeutic drugs and their deacti- vation by multidrug resistant phenotypes motivated an extensive search for drugs with new modes of action. Host defense peptides (HDPs) represent a promising class of natural-source drugs with a distinct mode of action, de- creased likelihood of resistance development, an...
Article
A link between structural flexibility of biomimetic antimicrobials and their ability to penetrate into the hydrophobic core and disrupt the integrity of bacterial lipid model membranes has been established using liquid surface X-ray scattering techniques. Results indicate that the modes of interaction of flexible and conformationally restrained ant...
Article
Full-text available
Oligomers of acylated lysines (OAKs) are synthetic mimics of host defense peptides (HDPs) with promising antimicrobial properties. Here we challenged the OAK concept for its ability to generate both systemically efficient and economically viable lead compounds for fighting multidrug-resistant bacteria. We describe the design and characterization of...
Article
Full-text available
We report a structural study of cholesterol-DPPC (1,2-dipalmitoyl-sn-glycero-3-phophocholine) monolayers using x-ray reflectivity and grazing incidence x-ray diffraction. Reflectivity reveals that the vertical position of cholesterol relative to phospholipids strongly depends on its mole fraction (chi(CHOL)). Moreover, we find that at a broad range...
Article
Non-natural mimics of antimicrobial peptides (AMPs) are excellent candidates for anti-infectious agents due to their stability towards enzymatic degradation and broad adjustability of physicochemical properties. Conformationally flexible acyl-lysine oligomers (OAKs) and restrained arylamide foldamers have demonstrated capability to be fine-tuned to...
Article
Recently, antimicrobial peptides (AMPs) have emerged as a promising anticancer remedy. Negative charge of the bacterial membranes gives some measure for selectivity of cationic AMPs, since mammalian cell membranes are largely zwitterionic. Accumulating evidence indicates that lipid composition of the cancer cell membranes is different from a health...
Article
This work investigates the discrimination of lipid monolayers by the ovine antimicrobial peptide SMAP-29 and compares it to that of the human LL-37 peptide. Fluid phospholipid monolayers were formed in a Langmuir trough and subsequently studied with the X-ray scattering techniques of X-ray reflectivity and grazing incidence X-ray diffraction. Any c...
Article
Full-text available
We investigated the potency, selectivity, and mode of action of the oligo-acyl-lysine (OAK) NC(12)-2 beta(12), which was recently suggested to represent the shortest OAK sequence that retains nonhemolytic antibacterial properties. A growth inhibition assay against a panel of 48 bacterial strains confirmed that NC(12)-2 beta(12) exerted potent activ...
Article
Full-text available
Antimicrobial peptides (AMPs) and their mimics are emerging as promising antibiotic agents. We present a library of “ampetoids” (antimicrobial peptoid oligomers) with helical structures and biomimetic sequences, several members of which have low-micromolar antimicrobial activities, similar to cationic AMPs like pexiganan. Broad-spectrum activity ag...

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Projects

Project (1)
Project
Elucidate physicochemical characteristics of peptoid-based AMP mimics essential for their lipid membrane activity