Andrew D Wiese

Baylor College of Medicine | BCM · Department of Psychiatry & Behavioral Sciences

Detection of neural signatures related to pathological behavioral states could enable adaptive deep brain stimulation (DBS), a potential strategy for improving efficacy of DBS for neurological and psychiatric disorders. This approach requires identifying neural biomarkers of relevant behavioral states, a task best performed in ecologically valid en...

Until recently, psychotherapies, including exposure and response prevention (ERP) for obsessive-compulsive disorder (OCD), have primarily been delivered in-person. The COVID-19 pandemic required OCD providers delivering ERP to quickly transition to telehealth services. While evidence supports telehealth ERP delivery, limited research has examined O...

Intolerance of uncertainty (IU) is a transdiagnostic construct referring to the aversive interpretation of contexts characterized by uncertainty. Indeed, there is a growing body of research examining individual differences in IU and how these are associated with emotional anticipation and reactivity during periods of certainty and uncertainty, howe...

Excoriation disorder (ED) is characterized by the presence of compulsive skin-picking behaviors and resulting distress/impairment. First-line psychotherapeutic for ED is habit reversal training (HRT). This intervention is designed develop awareness and skills to better tolerate urges to engage in picking behaviors and replace with more benign behav...

Background Little research has examined telehealth delivery of habit reversal training (HRT) for body focused repetitive behaviors (BFRBs; i.e., trichotillomania and excoriation disorder) and no known studies have directly compared these two modalities relative to one another. The present study examines providers and their perceptions of in-person...

Pediatric obsessive-compulsive disorder (OCD) can be debilitating and chronic unless treated early with efficacious intervention. The past several decades of intervention research have identified cognitive-behavioral therapy (CBT) with exposure and response/ritual prevention (ERP) as the first-line, evidence-based psychological intervention for ped...

Purpose: Examine the concurrent validity of specific Anxiety Disorders Section of the Anxiety Disorder Interview Schedule for DSM-IV-Autism Spectrum Addendum (ADIS-ASA)-Parent Interview in a sample of 167 autistic youth who met diagnostic criteria for an anxiety-related disorder (Mage = 9.91; 78.4% male; 82% non-Hispanic; 77.67% White). Methods: Co...

The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) is one of the most commonly used instruments for assessing and quantifying the presence and severity of obsessive-compulsive disorder (OCD) symptoms. Both the interview and self-report (SR) version of the original Y-BOCS have demonstrated good psychometrics, however, areas for revision were noted r...

Purpose: Examine the concurrent validity of specific Anxiety Disorders Section of the Anxiety Disorder Interview Schedule for DSM-IV-Autism Spectrum Addendum (ADIS-ASA)-Parent Interview in a sample of 167 autistic youth who met diagnostic criteria for an anxiety-related disorder (Mage = 9.91; 78.4% male; 82% non-Hispanic; 77.67% White). Methods: Co...

Purpose: The aim of this qualitative study was to investigate resilience among adults with Osteogenesis Imperfecta (OI). Materials and methods: Semi-structured interviews were conducted with 15 adults with OI. Transcripts were coded and subsequently abstracted, yielding themes specific to resilience and coping. Interview guides covered broad top...

Research specific to obsessive-compulsive disorder (OCD) among individuals of Hispanic and Latin American (H/L) ancestry is limited, as are culturally-relevant assessment and treatment recommendations. The present paper discusses the implications of underrepresentation of H/L populations in OCD research and emphasizes the need to consider issues re...

Cognitive behavioral therapy (CBT) is an effective treatment for a variety of psychiatric disorders. However, historic underrepresentation, misapplication of techniques, and neglected consideration for the unique experiences of marginalized groups – including racial, ethnic, sexual, and gender minorities – has led to mistrust of mental health treat...

Osteogenesis imperfecta (OI) is a genetic disorder characterized by bone fragility and fractures, short stature, dental abnormalities, hearing loss, scoliosis, and chronic pain. Despite a growing literature on the functional outcomes of OI, limited research has explicitly examined the psychosocial outcomes of pain within OI. Adults with OI (N = 15)...

Obsessive‐compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long‐sought risk...

Osteogenesis imperfecta (OI) is a pleiotropic, heritable connective tissue disorder associated with a wide range of health implications, including frequent bone fracture. While progress has been made to understand the spectrum of these physical health implications, the impact of OI on psychosocial well-being, as well as protective factors that buff...

Obsessive-compulsive disorder (OCD) affects 1–2% of children and is associated with functional impairment and diminished quality of life. Several treatments are efficacious: cognitive behavioral therapy (CBT) with exposure and response prevention, serotonin reuptake inhibitor (SRI) monotherapy, and combined treatment (SRI + CBT). Expert clinician-i...

The past four decades have yielded a robust body of evidence supporting the efficacy and effectiveness of cognitive-behavioral therapy (CBT) as a gold-standard treatment for obsessive-compulsive disorder (OCD) across the lifespan. Exposure and response prevention (E/RP) has been identified as a key component of this approach. Despite robust researc...

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk...

Background: Obsessive-compulsive disorder (OCD) is a neuropsychiatric condition featuring patterns of obsessions, compulsions, and avoidant behaviors that are often time consuming and distressing to affected individuals. Cognitive-behavioral therapy (CBT) with exposure and response prevention and/or serotonin reuptake inhibitors are first-line tre...

Obsessive-compulsive disorder (OCD) is characterized by the presence of debilitating obsessions and compulsions. Cognitive and behavioral models of OCD provide a strong theoretic and empirical foundation for informing effective psychotherapeutic treatment. Cognitive-behavioral therapy (CBT) for OCD, which includes a deliberate emphasis on exposure...

Behavioral intervention technology (BIT) is one avenue for extending the reach of evidence-based pediatric mental health. We developed Anchors Away: Anxiety at Bay, a family-friendly stand-alone mobile health app for children ages 6 to 11 that delivers CBT strategies tailored to mental health struggles typical for youth. This study assessed the acc...

Public health crises, including the ongoing COVID-19 pandemic, have wide reaching implications on mental health, and have resulted in unique OCD presentations specific to respective crises. The distribution of highly efficacious and effective vaccines for COVID-19 present a crossroads for the COVID-19-specific OCD presentation, including the potent...

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by distressing thoughts, images, or impulses that nearly always present with compensatory behaviors (ie, compulsions, avoidance) that are completed to neutralize distress. OCD is associated with lower quality of life and functional impairment. The recommended gold standa...

Purpose of Review This systematic review evaluated the impact of the COVID-19 pandemic on obsessive–compulsive symptoms. Recent Findings Most studies showed that obsessive–compulsive symptoms worsened during the early stages of the pandemic, particularly for individuals with contamination-related obsessive–compulsive disorder (OCD), though other s...

This commentary outlines assessment and treatment of patients with OCD during the era of COVID-19. The ongoing COVID-19 pandemic has required providers to make important considerations in treatment, including how usual risk is defined, as well as the use of personal protective equipment and telehealth services. These considerations have allowed pro...

Misophonia is a condition characterized by marked distress following the perception of innocuous sounds and is often accompanied by behavioral avoidance. This presentation is currently absent from the Diagnostic and Statistical Manual of Mental Disorders, as it remains poorly understood and understudied. Despite these limitations, there have been r...

Background: While cognitive behavioral therapy (CBT) is the first-line intervention for pediatric anxiety, significant barriers remain in accessing credible self-help CBT resources for prevention. Family-based mobile health (mHealth) interventions are a promising alternative to traditional self-help methods in preventing anxiety and other common pe...

Laboratory measures have played an integral role in diagnosing pathology; however, compared to traditional medicine, psychiatric medicine has lagged behind in using such measures. A growing body of literature has begun to examine the viability and development of different laboratory measures in order to diagnose psychopathologies. The present revie...

Introduction • Obsessive-compulsive disorder (OCD) has been associated with a number of symptoms, however, with heterogeneity of OCD presentations, it is difficult to suggest these associations are ubiquitous across all OCD presentations. • The advent of the Dimensional Obsessive-Compulsive Scale (DOCS; Abramowitz et al., 2010) has allowed research...

Introduction • A recent publication identified Item-15 from the Penn State Worry Questionnaire (PSWQ; "I worry all the time") as a useful predictor of problematic worry in a college sample, with scores of 4 or greater suggestive of problematic worry (Schroder, Clark & Moser, 2017). • Previous research has shown that worry is common across anxiety d...