Andrew J Swarts

Andrew J Swarts
University of the Witwatersrand | wits · School of Chemistry

PhD

About

20
Publications
2,471
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215
Citations
Citations since 2016
15 Research Items
190 Citations
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
Introduction
Current research interests are directed toward the development of benign and user-friendly catalysts for transformation of organic compounds, with a particular emphasis on oxidation reactions.

Publications

Publications (20)
Article
A series of novel cationic ruthenium half-sandwich complexes, bearing 1-substituted-4-pyridyl-1H-1,2,3-triazole ligands, were synthesized and fully characterized by a range of analytical techniques. The complexes were found to be efficient catalyst precursors for transfer hydrogenation reactions using ketones as substrates. We demonstrated that the...
Article
Oxidative transformations involve the conversion of organic substrates, through various processes to obtain oxygenates such as alcohols, phenolic and carbonyl compounds which can be used in the pharmaceutical and chemistry industries. Inspired by nature, particularly copper-based enzymes, these reactions include, but are not exclusive to, the radic...
Article
Herein we report the selective transfer hydrogenation (TH) of nitriles to secondary (2°) amines with simple Ni(II)-catalysts using ammonia borane (AB) as a source of hydrogen (H2). A bis(pyrazolylmethyl)pyridine (L1) or ethylenediamine (L4) ligated Ni(II) pre-catalyst, created in situ, could hydrogenate several aromatic- and aliphatic nitriles in f...
Article
Herein a series of novel bis(pyrazol-1-ylmethyl)pyridine-ligated Cu(I) complexes, C1–C4, bearing different donating groups [[H(C1), Me(C2), t-Bu(C3), Ph(C4)])] on the pyrazole rings, were synthesized and investigated as pre-catalysts in chemical and electrocatalytic water oxidation reactions. Ligands, 2,6-bis((1H-pyrazol-1-yl)methyl)pyridine (L1),...
Article
Herein we report the first Ni(II)-catalysed transfer hydrogenation of quinolines using ammonia borane (AB) as hydrogen (H2) source. An in situ generated Ni(II)-bis(pyrazolyl)pyridine pre-catalyst could hydrogenate quinoline and its derivatives in excellent yields of up to 90% at 25 °C in 30 minutes. Spectroscopic studies revealed that a Ni(II)-hydr...
Article
Full-text available
A series of neutral as well as cationic palladium methyl complexes bearing 1‐substituted‐4‐pyridyl‐1H‐1,2,3‐triazole ligands were prepared and fully characterized by a range of analytical techniques. Conventional and 2D NMR spectroscopy as well as single‐crystal X‐ray diffraction analysis unambiguously determined the molecular structure of the comp...
Article
A catalyst system comprising of pyrazolylpyridineamine/Cu(I)/CsOH is reported. for the hydroxylation of aryl iodides and bromides with moderate to outstanding yields, without the use of an inert atmosphere. A comprehensive parameter optimisation study established optimum component concentrations: [Cu(MeCN)4]BF4 and 2-(1H-pyrazol-1-yl)-N-(pyridine-2...
Article
Full-text available
The oxidation of alcohols to the corresponding carbonyl products is an important organic transformation and the products are used in a variety of applications. The development of catalytic methods for selective alcohol oxidation have garnered significant attention in an attempt to find a more sustainable method without any limitations. Copper, in c...
Article
We report the preparation and characterisation of a series of novel non-heme N4-tetradentate Mn(OTf)2 complexes of the type, [(L)MnOTf2], where L = R,R and S,S enantiomers of BPMCN, its 6-methyl and 6-bromo derivatives as well as the novel ligand BMIMCN (BPMCN = N,N’-dimethyl-N,N’-bis(2-pyridylmethyl)-(R,R/S,S)-1,2-diaminocyclohexane, BMIMCN = N,N’...
Article
A series of novel cationic palladacycle complexes bearing benzylidene-2,6-diisopropylphenylamine derivatives as ligands and with the general formula [Pd(MeCN)(L)(R-C6H3)CH=N{2,6-iPr2-C6H3}][B(3,5-(CF3)2-C6H3)] (R = H, Cl, Br, F, OMe and L = 1,3,5-triaza-7-phosphaadamantane (PTA), tricyclohexylphosphine (PCy3) and triphenylphosphine (PPh3) were prep...
Article
Full-text available
A range of mono- and bimetallic AumCun nanoparticles (NPs), with varying metal compositions, was prepared by using a third-generation diaminobutane poly(propylene imine) (G3 DAB-PPI) dendrimer, modified with alkyl chains, as a stabilizer. It was found that the length of the peripheral alkyl chain, (M1 (C15), M2 (C11), and M3 (C5)), had a direct inf...
Article
Herein a bis(pyridyl)-N-alkylamine/CuI/TEMPO/NMI catalyst system is reported for aerobic oxidation of a variety of primary alcohols to the corresponding aldehydes using readily available reagents, at room temperature and ambient air as the oxidant. ESI-MS analysis of the reaction showed the formation of a [(L1)(NMI)CuII-OOH]+ species, which is a ke...
Article
A series of mononuclear (C1–C4) and dendritic G1 (DC1–DC4) and G2 (DC5–DC8) cationic CuI iminopyridine complexes of the general formula [Cu{(R-C5H3N)CH=N(nPr)-κ2-N,N}2][BF4] (C1: R = 6-Me; C2: R = H; C3: R = 6-Br; C4: R = C4H3) and [DAB-Gx-PPI-(Cu{(R-C5H3N)-κ2-N,N}y)z][BF4]n [DAB: 1,4-diaminobutane; PPI: poly(propyleneimine); for G1: x = 1, y = 4,...
Article
Full-text available
A series of N-alkyl 2,2'-dipyridylamine ligands of general formula (2-C5H3NR)2NR', (): R = H, R' = Me; (): R = H, R' = benzyl; (): R = H, R' = methylcyclohexyl; (): R = H, R' = neopentyl; (): R = Me, R' = Me) were prepared by a modified method involving base-mediated N-alkylation with the respective alkyl halide. Reaction of the ligands, , with NiC...
Article
A series of novel neutral and cationic methylpalladium complexes bearing N-alkyl-2,2′-dipyridylaldiminato ligands were prepared and characterized. In the presence of ethylene, the cationic complexes were active as dimerization catalysts, producing a mixture of 1- and 2-butenes. A Pd–ethyl π-ethylene species was identified as the catalyst resting st...
Article
Full-text available
Malignant melanoma is an aggressive skin cancer and it is reported to be the most treatment-resistant human cancer. Here we describe the anti-tumour activity of a novel binuclear palladacycle complex (AJ-5) in vertical growth phase (ME1402) and metastatic (WM1158) melanoma cell lines. We show that compared to normal control cell lines, AJ-5 is more...
Article
Full-text available
ENGLISH ABSTRACT: Compounds benzylidene-2,6-diisopropylphenylamine (L1), 2-chlorobenzylidene-2,6-diisopropylphenylamine (L2), 2-bromobenzylidene- 2,6-diispropylphenylamine (L3) and 4-methylbenzylidene-2,6-diisopropylphenylamine (L4) were prepared by Schiff base condensation of 2,6-diisopropylaniline and the respective aldehydes in a 1:1 molar ratio...

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