Andrew Orton

Andrew Orton
University of Utah | UOU · Division of Radiation Oncology

Doctor of Medicine

About

36
Publications
832
Reads
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385
Citations
Citations since 2017
16 Research Items
336 Citations
20172018201920202021202220230204060
20172018201920202021202220230204060
20172018201920202021202220230204060
20172018201920202021202220230204060
Additional affiliations
July 2014 - June 2018
University of Utah
Position
  • Medical Doctor

Publications

Publications (36)
Article
Purpose: Prospective, randomized data does not exist to guide treatment in primary vaginal cancer (PVC). We evaluated the impact of brachytherapy on survival in women with PVC. Methods and materials: Women who received radiotherapy for PVC were identified using the Surveillance, Epidemiology, and End Result database. Two retrospective cohorts we...
Article
Purpose: We aimed to investigate the patterns-of-care and overall survival (OS) benefit of aCRT versus monotherapy (aMT), defined as either chemotherapy or radiation alone, utilizing a large national registry of patients. Patients and methods: Adult patients with stage III endometrial adenocarcinoma diagnosed from 2004-2013 were included. Logist...
Article
Previously, we reported that murine gammaherpesvirus-68 (M1-MHV-68) induces pulmonary artery (PA) neointimal lesions in S100A4-overexpressing, but not in wild-type (C57), mice. Lesions were associated with heightened lung elastase activity and PA elastin degradation. We now investigate a direct relationship between elastase and PA neointimal lesion...
Article
Efforts to understand and optimize separations employing compressible mobile phases have been limited by a lack of understanding of the mobile phase density gradient. Mobile phase compressibility leads to gradients in linear velocity and solute retention and affects separation speed and efficiency, especially in packed columns. Gas chromatography (...
Article
Objectives: In endometrial cancer, the appropriate sequence of adjuvant chemotherapy (aCT) and adjuvant radiation therapy (aRT) is unclear. We aim evaluated whether early chemotherapy is associated with improved overall survival (OS) and cancer-specific survival (CSS). Methods: Endometrial cancer patients that received aCT and aRT were selected...
Article
Background: The available literature to guide treatment decision making in esthesioneuroblastoma (ENB) is limited. Objective: To define treatment patterns and outcomes in ENB according to treatment modality using a large national cancer registry. Methods: This study is a retrospective cohort analysis of 931 patients with a diagnosis of ENB who...
Article
Purpose Although several feasibility studies have demonstrated the safety of adjuvant concurrent chemoradiotherapy (CRT) for locally advanced or incompletely resected non–small-cell lung cancer (NSCLC), it remains uncertain whether this approach is superior to sequential chemotherapy followed by postoperative radiotherapy (C→PORT). We sought to det...
Article
OBJECTIVE Anaplastic meningiomas represent 1%–2% of meningioma diagnoses and portend a poor prognosis. Limited information is available on practice patterns and optimal management. The purpose of this study was to define treatment patterns and outcomes by treatment modality using a large national cancer registry. METHODS The National Cancer Databa...
Article
Full-text available
Purpose The purpose is to evaluate the patterns of care and comparative effectiveness for cause-specific and overall survival of definitive local treatments versus conservatively managed men with a primary or secondary Gleason pattern of 5. Methods and materials Patients diagnosed from 2004 to 2012 with a primary or secondary Gleason pattern of 5 N...
Article
OBJECTIVE The authors compared presenting characteristics and survival for patients with gliosarcoma (GS) and glioblastoma (GBM). Additionally, they performed a survival analysis for patients who underwent GS treatments with the hypothesis that trimodality therapy (surgery followed by radiation and chemotherapy) would be superior to nontrimodality...
Article
Purpose/Objectives Esophageal stenting is often considered to relieve dysphagia in patients with locoregionally advanced esophageal cancer. We sought to determine effects of stenting on acute toxicities and oncologic outcomes in patients treated with chemoradiotherapy (CRT). Materials/Methods Patients treated with curative intent RT for locoregion...
Article
Full-text available
Objectives There is no consensus standard regarding the placement of the inferior field border in whole brain radiation therapy (WBRT) plans, with most providers choosing to cover the first versus (vs.) second cervical vertebrae (C1 vs. C2). We hypothesize that extending coverage to C2 may increase predicted rates of xerostomia. Methods Fifteen pa...
Article
Purpose To evaluate the survival benefit of adding vaginal brachytherapy (BT) to pelvic external beam radiation therapy (EBRT) in women with stage III endometrial cancer. Methods and Materials The National Cancer Data Base was used to identify patients with stage III endometrial cancer from 2004 to 2013. Only women who received adjuvant EBRT were...
Article
Full-text available
Background: “Abscopal response” refers to the spontaneous involution of untreated metastatic disease following local primary tumor-directed therapy. We report a case of an abscopal response of untreated lung metastasis in a man with pleomorphic sarcoma of the head and neck treated with hypofractionated radiotherapy. Methods: An inoperable pleomorph...
Article
Introduction: Our purpose was to determine the overall survival (OS) benefit of post-operative radiotherapy (PORT) in patients with advanced thymic malignancies and the associated predictors of PORT receipt. Methods: We queried the National Cancer Database (NCDB) for all stage II-III thymic malignancies. Trends in PORT usage over time were analy...
Article
Purpose: We aimed to evaluate if use of brachytherapy (BT) is associated with improved survival in patients with oral cavity cancer who do not receive surgery and to analyze patterns of care. Methods and materials: We queried the Surveillance, Epidemiology, and End Results database for patients who received radiation therapy for squamous cell ca...
Article
Cancer is a devastating disease which affects millions of people every year. There is a need for reliable markers which indicate more aggressive tumors. Thymidine kinase 1 (TK1) has been shown to have prognostic potential in the serum of cancer patients, correlating with disease stage and recurrence. Serum TK1 has been studied extensively, but rela...
Article
Density gradients in packed capillary columns operating under the extreme pressure drops typical for solvating gas chromatography were investigated by on-column spectroscopic measurements and compared to a theoretical model. Laser-induced fluorescence was used to follow the elution of various analytes, and Raman spectroscopy was used to measure the...
Article
To investigate how fluid compressibility affects efficiency in supercritical fluid separations, band dispersion along a packed capillary column was measured from on-column elution rate profiles obtained under solvating gas chromatography (SGC) conditions; this allowed efficiency to be determined with respect to position along the column. Theoretica...

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