Andrew Nicholson

Andrew Nicholson
McMaster University | McMaster · Department of Psychiatry and Behavioural Neurosciences

PhD Neuroscience

About

45
Publications
18,889
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1,020
Citations
Additional affiliations
March 2019 - August 2020
University of Vienna
Position
  • PostDoc Position
January 2017 - March 2019
The University of Western Ontario
Position
  • PostDoc Position

Publications

Publications (45)
Article
Full-text available
Background: Systemic oppression, particularly towards sexual minorities, continues to be deeply rooted in the bedrock of many societies globally. Experiences with minority stressors (e.g. discrimination, hate-crimes, internalized homonegativity, rejection sensitivity, and microaggressions or everyday indignities) have been consistently linked to a...
Article
Full-text available
Background: While many elaborated treatment protocols focus on post-traumatic stress symptoms, a large number of refugees suffer from a range of mental health problems. Thus, brief and transdiagnostic psychological interventions may be helpful first interventions for help-seeking refugees and asylum seekers in a stepped-care approach. Critically,...
Article
Borderline personality disorder (BPD) is a mental health condition characterized by emotion dysregulation, interpersonal impairment, and high suicidality. Dialectical behaviour therapy (DBT) is the most widely studied psychotherapeutic treatment for BPD. To date, the vast majority of DBT research has focused on cisgender women, with a notable lack...
Article
Full-text available
Background Intrinsic connectivity networks, including the default mode network (DMN), are frequently disrupted in individuals with posttraumatic stress disorder (PTSD). The posterior cingulate cortex (PCC) is the main hub of the posterior DMN, where the therapeutic regulation of this region with real-time fMRI neurofeedback (NFB) has yet to be expl...
Article
Full-text available
Neurofeedback allows for the self-regulation of brain circuits implicated in specific maladaptive behaviors, leading to persistent changes in brain activity and connectivity. Positive-social emotion regulation neurofeedback enhances emotion regulation capabilities, which is critical for reducing the severity of various psychiatric disorders. Traini...
Article
Full-text available
LAY SUMMARY In 2015, the Canadian Armed Forces (CAF) implemented Operation HONOUR to eliminate sexual misconduct (SM) in the military. Sexual assault, inappropriate sexual behaviours, sexual harassment, and gender discrimination are all types of SM. Experiencing SM can result in depression, substance abuse, physical health problems, and even posttr...
Article
Full-text available
The COVID-19 pandemic along with the restrictions that were introduced within Europe starting in spring 2020 allows for the identification of predictors for relationship quality during unstable and stressful times. The present study began as strict measures were enforced in response to the rising spread of the COVID-19 virus within Austria, Poland,...
Presentation
Full-text available
Close relationships have always been critical to successfully manage crises and build a sense of security, where attachment patterns have been proposed to exert a particularly important role in in insecure situations. Here, we aimed to identify predictors of relationship quality during unstable and stressful times. The present study began as strict...
Article
Full-text available
Background Moral injury (MI) is consistently associated with adverse mental health outcomes, including the development of posttraumatic stress disorder (PTSD) and suicidality. Methods We investigated neural activation patterns associated with MI event recall using functional magnetic resonance imaging in participants with military and public safet...
Article
Full-text available
Real-time fMRI neurofeedback is an increasingly popular neuroimaging technique that allows an individual to gain control over his/her own brain signals, which can lead to improvements in behavior in healthy participants as well as to improvements of clinical symptoms in patient populations. However, a considerably large ratio of participants underg...
Article
Full-text available
During medical pandemics, protective behaviors need to be motivated by effective communication , where finding predictors of fear and perceived health is of critical importance. The varying trajectories of the COVID-19 pandemic in different countries afford the opportunity to assess the unique influence of 'macro-level' environmental factors and 'm...
Article
Full-text available
Background: Several intrinsic networks in the brain, including the default mode network, the salience network, and the central executive network, have shown to be critical to higher cognitive functioning. Importantly, these networks have been demonstrated to be compromised in psychopathology, including posttraumatic stress disorder (PTSD) (Akiki, A...
Method
Full-text available
This document contains translations of the Identification with all humanity (IWAH) scale (McFarland et al., 2012) to German, Spanish, Polish and Czech, as used first in Eder et al., 2021. For information on scoring, please read the original publication (open access) and the many publications that have used the scale. The temporal stability of the...
Method
Full-text available
This document contains translations of the Perceived vulnerability to disease (PVD) scale (Duncan et al., 2009) to German, Spanish, Polish and Czech, as used first in Eder et al., 2021a and 2021b. Importantly, the PVD scale consists of two different subscales (see Duncan et al., 2009): Germ aversion and Infectability. The temporal stability of the...
Article
Full-text available
These authors contributed equally to this work. All other authors are listed in reverse alphabetical order. Neurofeedback has begun to attract the attention and scrutiny of the scientific and medical mainstream. Here, neurofeedback researchers present a consensus-derived checklist that aims to improve the reporting and experimental design standards...
Preprint
Full-text available
Real-time fMRI neurofeedback is an increasingly popular neuroimaging technique that allows an individual to gain control over his/her own brain signals, which can lead to improvements in behavior in healthy participants as well as to improvements of clinical symptoms in patient populations. However, a considerably large ratio of participants underg...
Preprint
**Please refer to the final version (open access!): www.frontiersin.org/articles/10.3389/fpsyg.2021.647956/full ** The COVID-19 pandemic along with the restrictions that were introduced within Europe starting in spring 2020 allows for the identification of predictors for relationship quality during unstable and stressful times.The present study beg...
Preprint
This preprint has since been published in PLOS ONE: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247997 (open access!) During medical pandemics, protective behaviors need to be motivated by effective communication, where finding predictors of fear and perceived health is of critical importance. The varying trajectories of the...
Article
Full-text available
Self-related processes define assorted self-relevant or social-cognitive functions that allow us to gather insight and to draw inferences related to our own mental conditions. Self-related processes are mediated by the default mode network (DMN), which, critically, shows altered functionality in participants with posttraumatic stress disorder (PTSD...
Article
Full-text available
Positive‐social emotions mediate one's cognitive performance, mood, well‐being, and social bonds, and represent a critical variable within therapeutic settings. It has been shown that the upregulation of positive emotions in social situations is associated with increased top‐down signals that stem from the prefrontal cortices (PFC) which modulate b...
Article
Full-text available
Intrinsic connectivity networks (ICNs), including the default mode network (DMN), central executive network (CEN), and salience network (SN) have been shown to be aberrant in patients with posttraumatic stress disorder (PTSD). The purpose of the current study was to a) compare ICN functional connectivity between PTSD, dissociative subtype PTSD (PTS...
Article
Full-text available
Neurofeedback has begun to attract the attention and scrutiny of the scientific and medical mainstream. Here, neurofeedback researchers present a consensus-derived checklist that aims to improve the reporting and experimental design standards in the field.
Article
Full-text available
Introduction: Recently, there has been substantial interest in exploring the heterogeneity of posttraumatic stress disorder (PTSD) on a neurobiological level, as individuals with PTSD, including military members and Veterans, vary in their presentation of symptoms. Methods: Critically, a dissociative subtype of PTSD (PTSD+DS) has been defined, wher...
Article
Full-text available
Neurofeedback is emerging as a psychophysiological treatment where self-regulation is achieved through online feed­back of neural states. Novel personalized medicine approaches are particularly important for the treatment of posttrau­matic stress disorder (PTSD), as symptom presentation of the disorder, as well as responses to treatment, are highly...
Article
Full-text available
Background: Asylum seekers and refugees are at great risk for developing mental disorders. Afghan refugees are a particularly vulnerable group with a low average education and mental health literacy level. Traumatic experiences and hardship before and during migration are predictive of mental health problems. However, post-migration living difficu...
Article
Full-text available
Objective: The default-mode network (DMN) and salience network (SN) have been shown to display altered connectivity in posttraumatic stress disorder (PTSD). Restoring aberrant connectivity within these networks with electroencephalogram neurofeedback (EEG-NFB) has been shown previously to be associated with acute decreases in symptoms. Here, we co...
Preprint
Full-text available
Background: Asylum seekers and refugees are at great risk for developing mental disorders. Afghan refugees are a particularly vulnerable group with a low average education and mental health literacy level. Traumatic experiences and hardship before and during migration are predictive of mental health problems. However, post-migration living difficul...
Preprint
Background Asylum seekers and refugees are at great risk for developing mental disorders. Afghan refugees are a particularly vulnerable group with a low average educational and mental health literacy level. Traumatic experiences and hardship pre- and during migration are predictive of mental health problems. However, post-migration living difficult...
Article
Individuals with post-traumatic stress disorder (PTSD) typically experience states of reliving and hypervigilance; however, the dissociative subtype of PTSD (PTSD+DS) presents with additional symptoms of depersonalization and derealization. Although the insula is critical to emotion processing, its association with these contrasting symptom profile...
Preprint
Full-text available
This checklist is intended to encourage robust experimental design and clear reporting for clinical and cognitive-behavioural neurofeedback experiments.
Preprint
Full-text available
This checklist is intended to encourage robust experimental design and clear reporting for clinical and cognitive-behavioural neurofeedback experiments. Available at https://psyarxiv.com/nyx84
Article
Full-text available
Dissociative experiences have been associated with increased disease severity, chronicity, and, in some cases, reduced treatment response across trauma-related and other psychiatric disorders. A better understanding of the neurobiological mechanisms through which dissociative experiences occur may assist in identifying novel pharmacological and non...
Article
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Background The field of psychiatry would benefit significantly from developing objective biomarkers that could facilitate the early identification of heterogeneous subtypes of illness. Critically, although machine learning pattern recognition methods have been applied recently to predict many psychiatric disorders, these techniques have not been ut...
Article
Full-text available
Posttraumatic stress disorder (PTSD) has been associated with a disturbance in neural intrinsic connectivity networks (ICN), including the central executive network (CEN), default mode network (DMN), and salience network (SN). Here, we conducted a preliminary investigation examining potential changes in ICN recruitment as a function of real‐time fM...
Article
Background: The vestibular system integrates multisensory information to monitor one's bodily orientation in space, and is influenced by interoceptive awareness. Post-traumatic stress disorder (PTSD) involves typically alterations in interoceptive and bodily self-awareness evidenced by symptoms of hyperarousal, as well as of emotional detachment,...
Article
Objective: Posttraumatic stress disorder (PTSD) is associated with decreased top-down emotion modulation from medial prefrontal cortex (mPFC) regions, a pathophysiology accompanied by hyperarousal and hyperactivation of the amygdala. By contrast, PTSD patients with the dissociative subtype (PTSD + DS) often exhibit increased mPFC top-down modulati...
Article
Background: Large scale neural networks, such as the default mode network (DMN), salience network (SN), and central executive (CE) network, have been shown to be altered in patients with posttraumatic stress disorder (PTSD), where electroencephalography neurofeedback has been shown to plastically modulate these networks. Using real-time fMRI neurof...
Article
OBJECTIVES: Although dysfunctional emotion regulatory capacities are increasingly recognized as contributing to posttraumatic stress disorder (PTSD), little work has sought to identify biological markers of this vulnerability. Heart rate variability (HRV) is a promising biomarker that, together with neuroimaging, may assist in gaining a deeper unde...
Article
Amygdala dysregulation has been shown to be central to the pathophysiology of posttraumatic stress disorder (PTSD) representing a critical treatment target. Here, amygdala downregulation was targeted using real-time fMRI neurofeedback (rt-fMRI-nf) in patients with PTSD, allowing them to examine further the regulation of emotional states during symp...
Article
Full-text available
Objective: Electroencephalogram (EEG) neurofeedback aimed at reducing the amplitude of the alpha-rhythm has been shown to alter neural networks associated with posttraumatic stress disorder (PTSD), leading to symptom alleviation. Critically, the amygdala is thought to be one of the central brain regions mediating PTSD symptoms. In the current study...
Article
Full-text available
Previous studies point towards differential connectivity patterns among basolateral (BLA) and centromedial (CMA) amygdala regions in patients with posttraumatic stress disorder (PTSD) as compared to controls. Here, we describe the first study to compare directly connectivity patterns of the BLA and CMA complexes between PTSD patients with and witho...

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Project (1)
Project
We created German, Spanish, Polish & Czech versions of the Perceived Vulnerability to Disease Scale (Duncan et al., 2009), reviewed by native speakers and used by Eder et al. (2020) in a population of 254 individuals from Austria, Spain, Poland, and Czech Republik. Basic information and internal consistencies are reported. The translated questionnaires are openly available on OSF (https://osf.io/2a4rc/) and here.